Induction of antitumor immunity by fusions of dendritic cells and pancreatic cancer stem cells
Project/Area Number |
19590793
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Jikei University School of Medicine |
Principal Investigator |
KOIDO Shigeo Jikei University School of Medicine, 医学部, 講師 (70266617)
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Co-Investigator(Kenkyū-buntansha) |
HONMA Sadamu 東京慈恵会医科大学, 医学部, 准教授 (50192323)
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Project Period (FY) |
2007 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 樹状細胞 / がんワクチン / 膵がん / 癌ワクチン / 融合細胞 / 細胞障害性T細胞 / 癌幹細胞 |
Research Abstract |
1. 成熟樹状細胞と熱処理した癌細胞を細胞融合させた新規癌ワクチンを作成した。2. 融合細胞から癌拒絶抗原を同定する新技術を開発した。3. CD133陽性の膵臓癌細胞は癌幹様細胞の特徴を有していた。4. 癌ワクチンは、免疫抑制状態を改善する治療法と併用することが望ましい。 5. 進行膵臓癌において塩酸ゲムシタビンと癌ワクチン療法の併用療法により、相乗的治療効果が得られた。
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] Antigenic stimulation with cytochrome P450 2J expressed in mouse hepatocellular carcinoma cells regulates host antitumor immunity2009
Author(s)
Homma S, Koido S, Sagawa Y, Suzuki H, Komita H, Nagasaki E, Takahara A, Horiguchi-Yamada J, Tajiri H, Zeldin D, Obata T.
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Journal Title
Clin Exp Immunol (in press)
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[Journal Article] In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells2008
Author(s)
Koido S, Homma S, Hara E, Mitsunaga M, Namiki Y, Takahara A, Nagasaki E, Komita H, Sagawa Y, Ohkusa T, Fujise K, Gong J, Tajiri H.
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Journal Title
J Transl Med 6
Pages: 51-51
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[Journal Article] Synergistic induction of antigen-specific CTL by fusions of TLR-stimulated dendritic cells and heat-stressed tumor cells2007
Author(s)
Koido S, Hara E, Homma S, Mitsunaga M, Takahara A, Nagasaki E, Kawahara H, Watanabe M, Toyama Y, Yanagisawa S, Kobayashi S, Yanaga K, Fujise K, Gong J, Tajiri H.
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Journal Title
J Immunol 179
Pages: 4874-83
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[Presentation] Synergistic induction of antigen-specific CTL by fusions of TLR-stimulated dendritic cells and heat-stressed tumor cells2008
Author(s)
Shigeo Koido, Eiichi Hara, Sadamu Homma, Makoto Mitsunaga, Akitaka Takahara, Eiichiro Nagasaki, Hidejiro kawahara, Yoichi Toyama, Hideo Komita, Susumu Kobayashi, Katsuhiko Yanaga, Toshifumi Ohkusa, Hisao Tajiri
Organizer
第67回日本癌学会学術総会
Place of Presentation
名古屋
Year and Date
2008-10-28
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