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Development of multi-functional intravascular ultrasound imaging for assessing coronary plaque vulnerability

Research Project

Project/Area Number 19590819
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNihon University (2008)
Yamaguchi University (2007)

Principal Investigator

HIRO Takafumi  Nihon University, 医学部, 准教授 (10294638)

Co-Investigator(Kenkyū-buntansha) FUJII Takashi  山口大学, 大学院・医学系研究科・器官病態内科学 (60228947)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords血管内エコー法 / 動脈硬化 / プラーク / シェアストレス / 急性冠症候群
Research Abstract

本研究を通じて、血管内エコー法を用いて、血管内腔表面にかかるシェアストレスのカラーマッピングを行うことに成功した。その結果、シェアストレスの局所集中点が将来の破裂点になる可能性が高いことが示唆され、冠動脈粥腫の不安定性を定量評価できる方法の一つを確立したことになる。さらに期間後半では、プラーク破裂の3次元的メカニズムの解明やMDCTの画像上でもシェアストレスの分布を表示できる方法を確立した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (10 results)

All 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results)

  • [Journal Article] Localized elevation of shear stress is related to coronary plaque rupture: A three-dimensional intravascular ultrasound study with in vivo color mapping of shear stress distribution2008

    • Author(s)
      Fukumoto Y, Hiro T, Fujii T, Hashimoto G, Fujimura T, Yamada J, Okamura T, Matsuzaki M
    • Journal Title

      Journal of the American College of Cardiology 第51巻

      Pages: 645-650

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Localized elevation of shear stress is related to coronary plaque rupture:A three-dimensional intravascular ultrasound study with in vivo color mapping of shear stress distribution2008

    • Author(s)
      Yusaku Fukumoto
    • Journal Title

      Journal of the American College of Cardiology 51

      Pages: 645-650

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Asymmetrical distribution of shear stress is related to plaque accumulation in coronary atherosclerosis2009

    • Author(s)
      Yusaku Fukumoto, Takafumi Hiro, 他
    • Organizer
      The 58th Annual Scientific Session of the American College of Cardiology
    • Place of Presentation
      Orlando, U.S.A.
    • Year and Date
      2009-03-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Asymmetrical distribution of shear stress is related to plaque accumulation in coronary atherosclerosis2009

    • Author(s)
      Yusaku Fukumoto, Takafumi Hiro, 他
    • Organizer
      The 58^<th> Annual Scientific Session of the American College of Cardiology
    • Place of Presentation
      Orlando, U.S.A.
    • Year and Date
      2009-03-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Three-dimensional morphologic analysis of ccronary plaque rupture using intravascular ultrasound2009

    • Author(s)
      Tatushiro Fujimura, Takafumi Hiro, 他
    • Organizer
      The 58th Annual Scientific Session of the American College of Cardiology
    • Year and Date
      2009-03-29
    • Related Report
      2008 Final Research Report
  • [Presentation] Three-dimensional morphologic analysis of coronary plaque rupture using intravascular ultrasound2009

    • Author(s)
      Tatushiro Fujimura, Takafumi Hiro, 他
    • Organizer
      The 58^<th> Annual Scientific Session of the American College of Cardiology
    • Place of Presentation
      Orlando, U.S.A.
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Comprehensive multifactorial approach to plaque vulner-ability using a novel modality of intravascular imaging2009

    • Author(s)
      Takafumi Hiro, 他
    • Organizer
      The 73rd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Osaka
    • Year and Date
      2009-03-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Comprehensive multifactorial approach to plaque vulner-ability using a novel modality of intravascular imaging2009

    • Author(s)
      Takafumi Hiro, 他
    • Organizer
      The73rd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Seeking New Era of Atherosclerotic Plaque Imaging: An Attempt to Develop a Hybrid IVUS-OCT System2008

    • Author(s)
      Orlando, U.S.Atakafumi Hiro
    • Organizer
      The 72nd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Fukuoka
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Seeking New Era of Atherosclerotic Plaque Imaging:An Attempt to Develop a Hybrid IVUS-OCT System2008

    • Author(s)
      Takafumi Hiro
    • Organizer
      The 72nd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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