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Myocardial injury due to anti-receptor autoimmunity:Development of Immunoabsorption therapy and drug delivery

Research Project

Project/Area Number 19590836
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKanazawa Medical University

Principal Investigator

MATSUI Shinobu  Kanazawa Medical University, 付置研究所, 教授 (00064600)

Co-Investigator(Kenkyū-buntansha) 勝田 省吾  金沢医科大学, 医学部, 教授 (40110613)
長尾 嘉信  金沢医科大学, 付置研究所, 准教授 (90131028)
早瀬 満  金沢医科大学, 医学部, 講師 (90064592)
栗原 孝行  金沢医科大学, 付置研究所, 講師 (20064595)
Co-Investigator(Renkei-kenkyūsha) KATSUDA Syougo  金沢医科大学, 医学部, 教授 (40110613)
NAGAO Yoshinobu  金沢医科大学, 付置研究所, 准教授 (90131028)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords拡張型心筋症 / 心筋膜受容体 / 自己抗体 / 抗体吸着療法 / 免疫学 / 心筋症 / モノクローナル抗体 / ELISA / オートファジー / 吸着療法
Research Abstract

β1受容体抗体に対する選択的自己抗体吸着体を用い、実験的自己免疫性心筋症家兎に対する吸着実験を行った。その結果、吸着実験3ヶ月後には心肥大ならびに心拡大の改善と心機能の回復を認め、自己抗体吸着療法の有効性が確認された。 また、抗β1受容体抗体による心筋障害の発症メカニズムとしては、 抗β1抗体による細胞障害はオートファジィーによる可能性が高いこと、および、抗体自体が直接心筋細胞にはたらくためでないことが明らかとなった。これらの研究に関連して、β1およびM2 受容体に対するモノクローナル抗体を作成し、診断薬や治療薬としての可能性を検討中である。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2008 2007

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (2 results)

  • [Journal Article] Amlioration of myocarditis by statin through inhibiting cross-talk between antigen presenting cells and lymphocytes in rats.2008

    • Author(s)
      Wu JL, Matsui S, Zong ZP, Nishikawa K, Sun BG, Katsuda S, Fu M.
    • Journal Title

      Journal of Molecular and Cellular Cardiology 25

      Pages: 501-506

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple shRNA expression in a single plasmid vector improved RNAi against the XPA gene.2008

    • Author(s)
      Nagao A, Zhao X, Takegami T, Nakagawa H, Matsui S, Matsunaga T, Ishigaki Y.
    • Journal Title

      Biochemical and Biophysical Research Communications 37

      Pages: 301-305

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of thymus in amiodaron-treated autoimmune myocarditis in rats.2008

    • Author(s)
      Zong ZP, Matsui S, Han TF, Katsuda S, Fu ML.
    • Journal Title

      International Journal of Cardiology 125

      Pages: 122-129

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amelioration of myocarditis by statin through inhibiting cross-talk between antigen presenting cells and lymphocytes in rats.2008

    • Author(s)
      Wu J
    • Journal Title

      Journal of Molecular and Cellular Cardiology 25

      Pages: 501-506

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple shRNA expressions in a single plasmid vector Improve RNAi against the XPA gene2008

    • Author(s)
      Nagao A
    • Journal Title

      Biochemical and Biophysical Research Communications 370

      Pages: 301-305

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of thymus in amiodarone-treated autoimmune Myocarditis in rats.2008

    • Author(s)
      Zone ZP
    • Journal Title

      International Journal of Cardiology 125

      Pages: 122-129

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of thymus in amiodarone-treated autoimmune myocarditis in rats.2008

    • Author(s)
      Zong Z, Matsui S, et. al.
    • Journal Title

      International Journal of Cardiology 125

      Pages: 122-129

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 拡張型心筋症に対する抗心筋膜受容体抗体吸着療法2007

    • Author(s)
      松井 忍
    • Organizer
      第28 回日本アフェレシス学会
    • Place of Presentation
      久留米
    • Related Report
      2008 Final Research Report
  • [Presentation] Specific removal of β1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune cardiomyopathy improved cardiac Structure and function.2007

    • Author(s)
      Matsui S
    • Organizer
      6th World Congress of the International Society for Apheresis
    • Place of Presentation
      Yokohama
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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