• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of myocyte autophagy on cardiac diseases and search for therapeutic target associated with autophagy

Research Project

Project/Area Number 19590837
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

KOBARA Miyuki  Kyoto Pharmaceutical University, 薬学部, 准教授 (80275198)

Co-Investigator(Kenkyū-buntansha) MATOBA Satoaki  京都府立医科大学, 医学系研究科, 助教 (10305576)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords心筋細胞 / アポトーシス / オートファジー / チロシンキナーゼ阻害薬 / 培養心筋細胞 / 心アミロイドーシス
Research Abstract

心不全時の病態にかかわる神経体液性因子や、チロシンキナーゼ阻害抗がん剤は、心筋細胞にオートファジーを誘導した。少量のオートファジーは細胞保護的に働き、心筋アポトーシス回避効果を有するが、大量のオートファジーは細胞死を誘導する。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (7 results)

All 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] Spironolactone exhibits direct renoprotective effects and inhibits renal rennin-angiotensin-aldosterone system in diabetic rats2008

    • Author(s)
      Taira M, Toba H, Murakami M, Iga I, Serizawa R, Murata S, Kobara M, and Nakata T
    • Journal Title

      Eur. J. Phamacol 589

      Pages: 264-271

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis2008

    • Author(s)
      Hayashi H, Kobara M (他8人)
    • Journal Title

      Hypertens. Res 31

      Pages: 363-375

    • NAID

      10024360250

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apoptotic myocytes generate monocyte chemoattractant protein-1 and mediate macrophage recruitment. J. Appl2008

    • Author(s)
      Kobara M, Sunagawa N, (他8人)
    • Journal Title

      hysiol 104

      Pages: 601-60

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Imatinib Induces Autophagy-Mediated Cell Death in Cardiac Myocytes2009

    • Author(s)
      Miyuki Kobara, Shota Tsujimoto, Yugo Uchida,Kenta Tanaka, Makoto Ohigashi, Hiroe Toba, Tetsuo Nakata
    • Organizer
      The 73^<nd> Annual Scientific Meeting of theJapanese Circulation Society
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Imatinib Induces Autophagy-Mediated Cell Death in Cardiac Myocytes2009

    • Author(s)
      小原, 辻本, 内田, 田中, 大東, 鳥羽, 中田
    • Organizer
      第73回日本循環器学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Short-Term caloric restriction improves mitochondrial oxidative stress and myocyte apoptosis in cardiac pressure-overload hypertrophy2008

    • Author(s)
      Miyuki Kobara, Mihoko Matsumura, Akiko Furumori, Junichi Hamada, Miho Kitamura, Kazuki Noda,, Hiroe Toba,, Hiroaki Matsubara, and Tetsuo Nakata
    • Organizer
      The 72^<nd> Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Aldosterone activates apoptosis signal-regulating kinase 1(ASK-1) through nongenomical ROS production and induces myocyte apoptosis2008

    • Author(s)
      Makoto Ohigashi, Miyuki Kobara, Hironori Hayashi, Yuugo Uchida, Kenta Tanaka, Nana Tanaka, Masaki Abe, Hiroe Toba, Hiroaki Matsubara, and Tetsuo Nakata
    • Organizer
      The 72^<nd> Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi