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The role of paracrine signal networks between myocardium and endothelium in the prevention of heart failure

Research Project

Project/Area Number 19590844
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionOsaka University

Principal Investigator

NAKAOKA Yoshikazu  Osaka University, 医学系研究科, 特任助教(常勤) (90393214)

Co-Investigator(Kenkyū-buntansha) 望月 直樹  国立循環器病センター研究所, 循環器形態部, 部長 (30311426)
Co-Investigator(Renkei-kenkyūsha) MOCHIZUKI Naoki  国立循環器病センター研究所, 循環器形態部, 部長 (30311426)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords心不全 / 心筋-内皮相互作用 / Gab ファミリー蛋白質 / angiopoietin-1 / neuregulin-1 / 心内膜弾性繊維症 / Gabファミリー蛋白質 / 心内膜線維弾性症
Research Abstract

Neuregulin-1(NRG-1)は心臓機能維持に必須の増殖因子であるが、その作用機序の詳細は明らかではなかった。我々は、内皮細胞から分泌されるNRG-1 が心筋細胞上のErbB 受容体に作用して心筋からのAngiopoietin-1(Ang1)の分泌を誘導して、心臓組織の内皮細胞系を安定化することにより心臓の機能維持に関わることを明らかにした。そこで我々はAng1 心筋特異的欠損マウスを作成した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (25 results)

All 2009 2008 2007 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (15 results) Book (1 results) Remarks (4 results)

  • [Journal Article] Interaction of Scaffolding Adaptor Protein Gab1 with Tyrosine Phosphatase SHP2 Negatively Regulates IGF-I-dependent Myogenic Differentiation via the ERK1/2 Signaling Pathway2008

    • Author(s)
      Koyama T¶, Nakaoka Y¶*, Fujio Y, Hirota H, Nishida K, Sugiyama S, Okamoto K, Yamauchi-Takihara K, Yoshimura M, Mochizuki S, Hori M, Hirano T, Mochizuki N.
    • Journal Title

      J. Biol. Chem(*corresponding author, ¶co-firstauthor) 283

      Pages: 24234-24244

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] サイトカインシグナルによる心不全の制御機構2008

    • Author(s)
      瀧原圭子、中岡良和
    • Journal Title

      心臓 40

      Pages: 181-186

    • Related Report
      2008 Final Research Report
  • [Journal Article] Interaction of Scaffolding Adaptor Protein Gab1 with Tyrosine Phosphatase SHP2 Negatively Regulates IGF-I-dependent Myogenic Differentiation via the ERK1/2 Signaling Pathway2008

    • Author(s)
      Koyama T. ^*, Nakaoka Y. ^*#, et al. (^*equal contribution; #corresponding author)
    • Journal Title

      Journal of Biological Chemistry 283

      Pages: 24234-24244

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gab family proteins are essential for postnatal maintenance of cardiac function through transmitting neuregulin-1/ErbB signaling2007

    • Author(s)
      Nakaoka Y*, Nishida K, Narimatsu M, Kamiya A, Minami T, Sawa H, Okawa K, Fujio Y, Koyama T, Maeda M, Sone M, Yamasaki S, Arai Y, Koh GY, Kodama T, Hirota H, Otsu K, Hirano T, and Mochizuki N*.
    • Journal Title

      J. Clin. Invest(*co-correspondingauthor) 117

      Pages: 1771-1781

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling2007

    • Author(s)
      Nakaoka Y., et. al.
    • Journal Title

      Journal of Clinical Investigation 117

      Pages: 1771-1781

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] The Novel Downstream Target of Neuregulin-1/ErbB Signaling Pathway For Maintenance of Cardiac Function2009

    • Author(s)
      Nakaoka Y.
    • Organizer
      第73回 日本循環器学会 (シンポジウム8)
    • Place of Presentation
      大阪国際会議場、大阪、日本
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Novel Downstream Target of Neuregulin-1-ErbB Signaling Pathway for Maintenance of Cardiac Function~Implication for New Treatment of Heart Failure~Symposium 82009

    • Author(s)
      Nakaoka Y.
    • Organizer
      第73回日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] Protein Gab1 is Essential for HGF-dependent Endothelial Signaling and Angiogenesis after Hindlimb Ischemia2009

    • Author(s)
      Shioyama W, Higuchi K, Hiramoto Y, Arita Y, Kuroda T, Fujio Y, Sanada F, Taniyama Y, Morishita R, Yamauchi-Takihara K, Hirano T, Hori M, Mochizuki N, and Nakaoka Y. Docking
    • Organizer
      第73回日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] Scaffolding Docking Protein Gab1 Is Essential for HGF-mediated Endothelial Signaling and Angiogenesis after Hind-Limb Ischemia2008

    • Author(s)
      Shioyama W., et al.
    • Organizer
      American Heart Association, Scientific Sessions 2008
    • Place of Presentation
      ニューオーリンズ、ルイジアナ州、米国
    • Year and Date
      2008-11-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] ドッキング蛋白質Gab1 は下肢虚血ストレス後の血管新生に必須である2008

    • Author(s)
      中岡良和、樋口香織、塩山渉、岡本紀太郎、有田陽、黒田忠、眞田文博、谷山義明、森下竜一、藤尾慈、瀧原圭子、平野俊夫、望月直樹
    • Organizer
      第12回Molecular Cardiovascular Conference
    • Place of Presentation
      北海道余市郡赤井川村
    • Year and Date
      2008-09-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Interaction of Scaffolding Adaptor Protein Gab1 with Tyrosine Phosphatase SHP2 Negatively Regulates IGF-I-dependent Myogenic Differentiation via ERK1/2 Signaling Pathway2008

    • Author(s)
      Nakaoka Y., et al.
    • Organizer
      Basic Cardiovascular Sciences Conference 2008
    • Place of Presentation
      キーストン、コロラド州、米国
    • Year and Date
      2008-07-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gab Family Scaffolding Adaptors Are Essential for Cardiac Maintenance via Transmitting Endothelial-Myocardial Crosstalk2008

    • Author(s)
      Nakaoka Y., et. al.
    • Organizer
      Keystone Symposia Molecular Mechanisms of Angiogenesis in Development and Disease
    • Place of Presentation
      Fairmont Hotel,バンクーバー、BC、カナダ
    • Year and Date
      2008-01-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] Scaffolding Docking Protein Gab1 is Essential for HGF-dependent Endothelial Signaling and Angiogenesis after Hindlimb Ischemia2008

    • Author(s)
      Shioyama W, Higuchi K, Okamoto K, Arita Y, Sanada F, Taniyama Y, Morishita R, Kuroda T, Fujio Y, Yamauchi-Takihara K, Mochizuki N, Nakaoka Y.
    • Organizer
      American Heart Association Scientific Sessions 2008
    • Place of Presentation
      New Ohleans
    • Related Report
      2008 Final Research Report
  • [Presentation] Interaction of Scaffolding Adaptor Protein Gab1 with Tyrosine Phosphatase SHP2 Negatively Regulates IGF-I-dependent Myogenic Differentiation via ERK1/2 Signaling 0Pathway2008

    • Author(s)
      Nakaoka Y, Koyama T, Okamoto K,Shioyama W, Fujio Y, Hirano T, Mochizuki N.
    • Organizer
      Basic Cardiovascular Sciences Conference 2008 Heart Failure : Molecular Mechanisms and Therapeutic Targets
    • Place of Presentation
      Keystone
    • Related Report
      2008 Final Research Report
  • [Presentation] Gab Family Scaffolding Adaptors are Essential for Cardiac Maintenance via Transmitting Endothelial-Myocardial Crosstalk2008

    • Author(s)
      Nakaoka Y, and Mochizuki N.
    • Organizer
      Keystone Symposia Molecular Mechanism of Angiogenesis in Development and Disease
    • Place of Presentation
      Vancouver
    • Related Report
      2008 Final Research Report
  • [Presentation] SHP2 Negatively Regulates Skeletal alpha-actin Gene Expression Downstream of LIF-dependent2008

    • Author(s)
      Shioyama W, Nakaoka Y, Fujio Y, Yamauchi-Takihara K, Mochizuki N.
    • Organizer
      Hypertrophic Signaling in Cardiomyocytes ISHR Japanese Section
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] Essential role of Gab2 for Angiopoietin-1/Tie2-dependent Signaling and Cytoprotection in the Endothelial Cells2008

    • Author(s)
      Okamoto K, Shioyama W, Higuchi K, Kuroda T, Fujio Y, Yamauchi-Takihara K, Hori M, Koh GY, Mochizuki N, Nakaoka Y.
    • Organizer
      第72回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] Gab Family Scaffolding Adaptor Proteins are Essential for Postnatal Maintenance of Cardiac Fuction via Neuregulin-1/ErbB Signaling2007

    • Author(s)
      Nakaoka Y., et. al.
    • Organizer
      American Heart Association, Scientific Sessions 2007
    • Place of Presentation
      オーランド、フロリダ、米国
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] 心臓組織内の心筋-内皮細胞間のサイトカインネットワークにおけるGab ファミリーアダプター蛋白質の役割2007

    • Author(s)
      圭吾、神谷厚範、澤洋文、小山達也、大津欣也、瀧原圭子、廣田久雄、平野俊夫、望月直樹
    • Organizer
      第11回Molecular Cardiovascular Conference
    • Place of Presentation
      北海道余市郡赤井川村
    • Year and Date
      2007-09-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Gab Family Scaffolding Adaptor Proteins are Essential for Postnatal Maintenance of Cardiac Function via Neuregulin-1/ErbB Signaling2007

    • Author(s)
      Nakaoka Y, Minami T, Sawa H, Fujio Y, Koyama T, Hirota H, Yamauchi-Takihara K, Otsu K, Hirano T, and Mochizuki N.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando
    • Related Report
      2008 Final Research Report
  • [Book] サイトカインシグナルによる心不全の制御機構2008

    • Author(s)
      瀧原圭子、中岡良和
    • Total Pages
      5
    • Publisher
      心臟 日本心臟財団
    • Related Report
      2007 Annual Research Report
  • [Remarks] 日本循環器学会第17回八木賞を下記論文にて中岡良和が受賞した。(2008年3月)論文 : Nakaoka Y* et.al. Gab family proteins are essential for postnatal maintenance of cardiac function through transmitting neuregulin-1/ErbB signaling. J. Clin. Invest. 117 : 1771-1781, 2007

    • Related Report
      2008 Final Research Report
  • [Remarks] 第34回佐藤賞(第73回日本循環器学会学術集会、2008 年3 月)を連携研究者の望月直樹が受賞した。タイトルは「循環器疾患病態理解のための分子イメージングによる血管内皮・心筋細胞の情報伝達解明」

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/imed3/lab_heart/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/imed3/lab_heart/

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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