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The Role of Internal Biological Clock in the Cardiovascular Diseases and the Development of New Therapeutic Strategy

Research Project

Project/Area Number 19590853
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNagasaki University (2008)
The University of Tokyo (2007)

Principal Investigator

MAEMURA Koji  Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (90282649)

Co-Investigator(Kenkyū-buntansha) WATANABE Masafumi  東京大学, 医学部附属病院, 助教 (60360096)
NAGAI Ryozo  東京大学, 医学部附属病院, 教授 (60207975)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords循環器 / 高血圧 / 体内時計 / 概日リズム / 循環器・高血圧 / 薬理学 / 生理学
Research Abstract

循環器疾患の発症には概日リズムが認められる。本研究は循環器疾患発症の概日リズムを体内時計の観点で明らかにし、時間を考慮した視点からの循環器疾患の予防法、治療法の開発をめざして遂行した。まず末梢の体内時計によりコントロールされている遺伝子群の候補として転写因子、分泌タンパク、膜受容体など28個の遺伝子が同定され、体内時計がこれらの遺伝子発現を通じて循環器疾患発症に関与していることが示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (33 results)

All 2009 2008 2007

All Journal Article (26 results) (of which Peer Reviewed: 11 results) Presentation (7 results)

  • [Journal Article] サーカディアンリズムを考慮した心血管イベントの発症抑制2009

    • Author(s)
      前村浩二
    • Journal Title

      Pharma Medica 27

      Pages: 153-156

    • Related Report
      2008 Final Research Report
  • [Journal Article] サーカディアンリズムを考慮した心血管イベントの発症抑制2009

    • Author(s)
      前村 浩二
    • Journal Title

      Pharma Medica 27

      Pages: 153-156

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Genetic variations of Mrf-2/ ARID5B confer risk of coronary atherosclerosis in the Japanese population2008

    • Author(s)
      Wang G, Watanabe M, Imai Y, Hara K, Manabe I, Maemura K, Horikoshi M, Kohro T, Amiya E, Sugiyama T, Fujita T, Kadowaki T, Yamazaki T, Nagai R
    • Journal Title

      Int Heart J 49

      Pages: 313-327

    • NAID

      130000069020

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin antagonizes stimulatory effect of tumor necrosis factor-alpha on vascular smooth muscle cell calcification : regulation of growth arrest-specific gene 6-mediated survival pathway by adenosine 5'-monophosphate-activated protein kinase2008

    • Author(s)
      Son BK, Akishita M, Iijima K, Kozaki K, Maemura K, Eto M, Ouchi Y
    • Journal Title

      Endocrinology 149

      Pages: 1646-1653

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta2008

    • Author(s)
      Oishi Y, Manabe I, Tobe K, Ohsugi M, Kubota T, Fujiu K, Maemura K, Kubota N, Kadowaki T, Nagai R
    • Journal Title

      Nat Med 14

      Pages: 656-666

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 動脈硬化の診断法としての血液マーカー2008

    • Author(s)
      網谷英介, 前村浩二
    • Journal Title

      内分泌・糖尿病科 27

      Pages: 407-416

    • Related Report
      2008 Final Research Report
  • [Journal Article] 心房細動の抗凝固療法と出血性疾患2008

    • Author(s)
      渡辺昌文,前村浩二
    • Journal Title

      medicina 45

      Pages: 1673-1677

    • Related Report
      2008 Final Research Report
  • [Journal Article] A diponectin antagonizes stimulatory effect of tumor necrosis factor-alpha on vascular smooth muscle cell calcification : regulation of growth arrest-specific gene 6-mediated survival pathway by adenosine 5'-mono phosphate-activated protein kinase.2008

    • Author(s)
      Son BK
    • Journal Title

      Endocrinology 149

      Pages: 1646-1653

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta2008

    • Author(s)
      Oishi Y
    • Journal Title

      Nat Med. 14

      Pages: 656-666

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thrombomodulin is a clock-controlled gene in vascular endothelial cells2007

    • Author(s)
      Takeda N, Maemura K, Horie S, Oishi K, Imai Y, Harada T, Saito T, Shiga T, Amiya E, Manabe I, Ishida N, Nagai R
    • Journal Title

      J Biol Chem 282

      Pages: 32561-32567

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circadian rhythms in the CNS and peripheral clock disorders : role of the biological clock in cardiovascular diseases2007

    • Author(s)
      Maemura K, Takeda N, Nagai R
    • Journal Title

      J Pharmacol Sci 103

      Pages: 134-138

    • NAID

      10024312305

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronobiology of acute myocardial infarction-molecula biology2007

    • Author(s)
      Takeda N, Maemura K
    • Journal Title

      Biol Rhythms Res 38

      Pages: 233-245

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 動脈硬化のトータルマネジメント2007

    • Author(s)
      前村浩二
    • Journal Title

      medicina 44

      Pages: 1441-1441

    • Related Report
      2008 Final Research Report
  • [Journal Article] Editorial 動脈硬化の病態と臨床像2007

    • Author(s)
      前村浩二
    • Journal Title

      medicina 44

      Pages: 1442-1444

    • Related Report
      2008 Final Research Report
  • [Journal Article] 急性冠症候群の診断 血液生化学検査の解釈2007

    • Author(s)
      前村浩二、志賀太郎
    • Journal Title

      Current Therapy 25

      Pages: 22-26

    • Related Report
      2008 Final Research Report
  • [Journal Article] 生活リズムとストレス-生活リズムとメタボリックシンドロームの関係について2007

    • Author(s)
      前村浩二
    • Journal Title

      肥満と糖尿病 6

      Pages: 797-798

    • Related Report
      2008 Final Research Report
  • [Journal Article] 血管病研究の現在と未来ー冠動脈疾患急性期治療の進歩2007

    • Author(s)
      前村浩二
    • Journal Title

      ACROSS 17

      Pages: 16-17

    • Related Report
      2008 Final Research Report
  • [Journal Article] 時計遺伝子研究の最前線ー心血管疾患と概日リズム2007

    • Author(s)
      前村浩二
    • Journal Title

      Clinical Neuroscience 25

      Pages: 1147-1149

    • Related Report
      2008 Final Research Report
  • [Journal Article] 循環器系のサーカディアン調節オーバービュー2007

    • Author(s)
      前村浩二
    • Journal Title

      血管医学 8

      Pages: 337-339

    • Related Report
      2008 Final Research Report
  • [Journal Article] 動脈硬化のトータル管理2007

    • Author(s)
      前村浩二
    • Journal Title

      くらしとからだ 54

      Pages: 3-5

    • Related Report
      2008 Final Research Report
  • [Journal Article] 生活習慣病と体内時計2007

    • Author(s)
      前村浩二
    • Journal Title

      Medical View point 28

      Pages: 3-3

    • Related Report
      2008 Final Research Report
  • [Journal Article] スタチンのコレステロールを介さない細胞生物学的作用2007

    • Author(s)
      網谷英介、前村浩二
    • Journal Title

      Journal of Integrated Medicine 17

      Pages: 669-671

    • Related Report
      2008 Final Research Report
  • [Journal Article] 動脈硬化の炎症マーカー(CRP, PTX3 など)2007

    • Author(s)
      志賀太郎、前村浩二
    • Journal Title

      The Lipid 18

      Pages: 26-31

    • Related Report
      2008 Final Research Report
  • [Journal Article] Thrombomodulin is a clock-controlled gene in vascular endothelial cells.2007

    • Author(s)
      Takeda N
    • Journal Title

      J Biol Chem 282

      Pages: 32561-32567

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronobiology of acute myocardial infarctionmolecular biology2007

    • Author(s)
      Takeda N
    • Journal Title

      Biological Rhythm Research 38

      Pages: 233-245

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circadian rhythms in the CNS and peripheral clock disorders: role of the biological clock in cardiovascular diseases2007

    • Author(s)
      Maemura K
    • Journal Title

      J Pharmacol Sci. 103

      Pages: 134-138

    • NAID

      10024312305

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 心血管系の時計遺伝子の意義2008

    • Author(s)
      前村浩二
    • Organizer
      第49回日本脈管学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] シンポジウム「動脈硬化に関与する新しい分子機構」時計遺伝子の病態への関与2007

    • Author(s)
      前村浩二
    • Organizer
      第15回日本血管生物学会
    • Place of Presentation
      福岡
    • Year and Date
      2007-11-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] 生活習慣病と体内時計2007

    • Author(s)
      前村浩二
    • Organizer
      第3回Summer Vascular Conference
    • Place of Presentation
      東京
    • Year and Date
      2007-09-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 血管内皮機能から見た循環器疾患ー炎症、血管新生、体内時計ー2007

    • Author(s)
      前村浩二
    • Organizer
      第6回分子心血管カンファランス
    • Place of Presentation
      山形
    • Year and Date
      2007-05-25
    • Related Report
      2008 Final Research Report
  • [Presentation] シンポジウム「動脈硬化に関与する新しい分子機構」時計遺伝子の病態への関与2007

    • Author(s)
      前村浩二
    • Organizer
      第15 回日本血管生物学会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] Long Pentraxin 3 Is More Specific Than C-reactive Protein as a Marker for Vascular Inflammation2007

    • Author(s)
      Shiga T, Maemura K, Imai Y, Kawanami D, Takeda N, Ando J, Morita T, Manabe I, Hayashi D, Ohtsu H, Sugiyama A, Miyamoto K, Sagara M, Ito Y, Reid PC, Yamazaki T, Hirata Y, Kodama T, Nagai R
    • Organizer
      American College of Cardiology 2007 Scientific Sessions
    • Place of Presentation
      New Orleans, LO
    • Related Report
      2008 Final Research Report
  • [Presentation] Long Pentraxin3 (PTX3) is More Specific than CRP as a Marker for Vascular Inflammation2007

    • Author(s)
      Shiga T, Maemura K, Imai Y, Kawanami D, Takeda N, Ando J, Morita T, Manabe I, Hayashi D, Ohtsu H, Hashimoto H, Sugiyama A, Miyamoto K, Sagara M, Ito Y, Reid PC, Yamazaki T, Hirata Y, Kodama T, Nagai R
    • Organizer
      American Heart Association 80 th Scientific Sessions
    • Place of Presentation
      Orland, FL
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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