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Role and therapeutic potential of SDF-1/CXCR4 system in cardiovascular diseases

Research Project

Project/Area Number 19590857
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionShinshu University

Principal Investigator

TAKAHASHI Masafumi  Shinshu University, 大学院・医学系研究科, 准教授 (40296108)

Co-Investigator(Kenkyū-buntansha) IKEDA Uichi  信州大学, 医学系・研究科, 教授 (30221063)
ISE Hirohiko  信州大学, 医学系・研究科, 助教 (10324253)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsケモカイン / 血管新生 / 虚血 / 骨髄細胞 / 炎症 / 移植 / サイトカイン / 心血管病 / 幹細胞
Research Abstract

我々は、自己骨髄細胞を用いて重症下肢虚血や心筋虚血患者を対象に血管再生療法を行い、その有効性と安全性を報告してきたが、本治療法では全身麻酔下で骨髄細胞を採取する必要があり侵襲が大きいことや、治療を行ってもその効果が十分ではない症例があることを経験してきた。そこで、治療の有効性を高め、かつ患者への侵襲の少ない新たな心血管再生療法の確立を目的として、ケモカインSDF-1とその受容体であるCXCR4(SDF-1/CXCR4システム)に着目して研究を行ってきた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (53 results)

All 2009 2008 2007

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (34 results)

  • [Journal Article] Bone marrow CXCR4 induction by cultivation enhances therapeutic angiogenesis2009

    • Author(s)
      Shiba Y, Takahashi M*, Hata T, Murayama H, Morimoto H, Ise H, Nagasawa T, Ikeda U
    • Journal Title

      Cardiovasc Res 81

      Pages: 169-177

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surface coating of bone marrow cells with N-acetylglucosamine for bone marrow implantation therapy2009

    • Author(s)
      Kobayashi S, Ise H*, Takahashi M, Goto M, Akaike T, Ikeda U
    • Journal Title

      Biomaterials 30

      Pages: 574-582

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow CXCR4 induction by cultivation enhances therapeutic angiogenesis.2009

    • Author(s)
      Shiba Y, Takahashi M, Hata T, Murayama H, Morimoto H, Ise H, Nagasawa T, Ikeda U.
    • Journal Title

      Cardiovasc Res 81

      Pages: 169-177

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surface coating of bone marrow cells with N-acetylglucosamine for bone marrow implantation therapy.2009

    • Author(s)
      Kobayashi s, Ise H, Takahashi M, Goto M, Akaike T, Ikeda U.
    • Journal Title

      Biomaterials 30

      Pages: 574-582

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of bone marrow-derived ASC, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice2008

    • Author(s)
      Takahashi M*, Yajima N(equally contribution), Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, J Sagara, Nakayama J, Taniguchi S, Ikeda U
    • Journal Title

      Circulation 117

      Pages: 3079-3087

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of tumor necrosis factor-alpha and interferon-gamma in bone marrow cells synergistically inhibits neointimal formation following vascular injury2008

    • Author(s)
      Murayama H, Takahashi M*, Takamoto M, Shiba Y, Ise H, Koyama J, Tagawa Y, Iwakura Y, Ikeda U
    • Journal Title

      Cardiovasc Res 80

      Pages: 175-180

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-mobility group box 1 protein(HMBG1)in ischemic heart disease: beneficial or deleterious2008

    • Author(s)
      Takahashi M*
    • Journal Title

      (Editorial)Cardiovasc Res 80

      Pages: 5-6

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] MCP-1 induces cardioprotection against ischemia/reperfusion injury : Role of reactive oxygen species2008

    • Author(s)
      Morimoto H, Hirose M, Takahashi M*, Kawaguchi M, Ise H, Kolattukudy PE, Yamada M, Ikeda U
    • Journal Title

      Cardiovasc Res 78

      Pages: 554-562

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Models for the study of angiogenesis2008

    • Author(s)
      Shiba Y*, Takahashi M, Ikeda U
    • Journal Title

      Curr Pharm Design 14

      Pages: 371-377

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of bone marrow-derived ASC, an inflammasome adaptormolecule, in neointimal formation after vascular injury in mice.2008

    • Author(s)
      Takahashi M^*, Yajima N (equallycontribution), Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, J Sagara, Nakayama J, Taniguchi S, Ikeda U.
    • Journal Title

      Circulation 117

      Pages: 3079-3087

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of tumor necrosis factor-alpha and interferon-gamma in bone marrow cells synergistically inhibits neointimal formation following vascular injury.2008

    • Author(s)
      Murayama H, Takahashi M^*. Takamoto M, Shiba Y, Ise H, Koyama J, Tagawa Y, Iwakura Y, Ikeda U.
    • Journal Title

      Cardiovasc Res 80

      Pages: 175-180

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-mobility group box 1 protein (HMBG1) in ischemic heart disease : beneficial or deleterious. (Editorial)2008

    • Author(s)
      Takahashi M^*.
    • Journal Title

      Cardiovasc Res 80

      Pages: 5-6

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MCP-1 induces cardioprotection against ischemia/reperfusion injury : Role of reactive oxygen species.2008

    • Author(s)
      Morimoto H, Hirose M, Takahashi M*. Kawaguchi M, Ise H, Kolattukudy PE, Yamada M, Ikeda U.
    • Journal Title

      Cardiovasc Res 78

      Pages: 554-562

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Models for the study of angiogenesis.2008

    • Author(s)
      Shiba Y^*, Takahashi M, Ikeda U.
    • Journal Title

      Curr Pharm Design 14

      Pages: 371-377

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] M-CSF accelerates neointimal formation in the early phase after vascular injury in mice: The critical role of the SDF-1-CXCR4system.2007

    • Author(s)
      Shiba Y, Takahashi M, Yoshioka T, Yajima N, Morimoto H, Izawa A, Ise H, Hatake K, Motoyoshi K, Ikeda U.
    • Journal Title

      Arterioscler Thromb Vase Biol 27

      Pages: 283-289

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow-derived CXCR4^+ cells mobilized by M-CSF participate in the prevention of cardiac dysfunction and remodeling after myocardial in farction in mice.2007

    • Author(s)
      Morimoto H, Takahashi M, Shiba Y, Izawa A, Ise H, Hongo M, Hatake K, Motoyoshi K, Ikeda U.
    • Journal Title

      Am J Pathol 171

      Pages: 755-766

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats.2007

    • Author(s)
      Ito T, Okada T, Mimuro J, Miyashita H, Uchibori R, Urabe M, Mizukami H, Kume A, Takahashi M, IKeda U, Sakata Y, Shimada K, Ozawa K.
    • Journal Title

      Hypertension 50

      Pages: 531-536

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erythropoietin attenuates the development of experimental autoimmune myocarditis.2007

    • Author(s)
      Hirose S, Takahashi M, Ogawa R, Morimoto H, Izawa A, Sato H, Ise H, Hongo M, Ikeda U
    • Journal Title

      Cardiovasc Drug Ther 21

      Pages: 17-27

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel sphingosine-l-phosphate receptor agonist KRP-203 attenuates ratautoimmune myocarditis.2007

    • Author(s)
      Ogawa R, Takahashi M, Hirose S, Morimoto H, Ise H, Murakami T, Yasue T, Kuriyama K, Hongo M, Kobayashi E, Ikeda U.
    • Journal Title

      Biochem Biophys Res Commun 36

      Pages: 621-628

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 人工的な糖鎖修飾を行った骨髄細胞の心筋組織へのターゲッティング法の開発2008

    • Author(s)
      小林聡、伊勢裕彦、高橋将文、後藤光昭、麻生真一、池田宇一
    • Organizer
      第31回日本分子生物学会・第18回日本生化学学会合大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] 人工的な糖鎖修飾を行った骨髄細胞の心筋組織へのターゲッティング法の開発2008

    • Author(s)
      小林聡、伊勢裕彦、高橋将文、後藤光昭、麻生真一、池田宇一
    • Organizer
      日本バイオマテリアル学会(シンポジウム)
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Therapeutic angiogenesis by mononuclear cell implantation for critical digit ischemia of patients with connective tissue diseases2008

    • Author(s)
      Takahashi M, Ishigatsubo Y, Fujimoto K, Miyamoto M, Minota S, Horie T, Aizawa Y, Amano J, Murohara T, Matsubara H, Ikeda U
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      New Orleans
    • Related Report
      2008 Final Research Report
  • [Presentation] Role of interleukin-6 and its crosstalk with AT1R in acute and chronic rejection of murine cardiac allografts2008

    • Author(s)
      Izawa A, Takahashi M, Ise H, Morimoto H, Yajima N, Tagawa Y, Ikeda U
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      New Orleans
    • Related Report
      2008 Final Research Report
  • [Presentation] Role of an Inflammasome adaptor molecule ASC in myocardial ischemia-reperfusion injury2008

    • Author(s)
      Kawaguchi M, Takahashi M, Hata T, Takahashi Y, Morimoto H, Ise H, Sagara J, Hongo M, Taniguchi S, Ikeda U
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      New Orleans
    • Related Report
      2008 Final Research Report
  • [Presentation] Critical role of Th17-CD4+ T cells in angiogenic response to hindlimb ischemia in mice2008

    • Author(s)
      Hata T, Takahashi M, Kawaguchi T, Kashima Y, Shiba Y, Ise H, Hida S, Iwakura Y, Taki S, Ikeda U
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      New Orleans
    • Related Report
      2008 Final Research Report
  • [Presentation] Double Deficiency of Tumour Necrosis Factor-α and Interferon-γ in Bone Marrow-derived Cells Prevents Neointimal formation in a Murine Model of Vascular Injury2008

    • Author(s)
      Murayama H, Takahashi M, Shiba Y, Ise H, Takamoto M, Tagawa Y, Iwakura Y, Ikeda U
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      New Orleans
    • Related Report
      2008 Final Research Report
  • [Presentation] 自己骨髄細胞移植による難治性血管炎に対する血管新生療法2008

    • Author(s)
      高橋将文、石ヶ坪良明、藤本和輝、宮本正章、相澤義房、天野純、簑田清次、室原豊明、松原弘明、池田宇一
    • Organizer
      第49回日本脈管学会総会(シンポジウム)
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 細胞骨格分子デスミン・ビメンチンの細胞膜上の発現とN-アセチルグルコサミン結合活性2008

    • Author(s)
      伊勢裕彦、小林聡、高橋将文、伊勢真美子、池田宇一
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Desmin and vimentin have N-acetylglucosamine-binding lectinic properties and are expressed on the cell surface2008

    • Author(s)
      Ise H, Kobayashi S, Takahashi M, Aso S, Akaike T, Ikeda U
    • Organizer
      第60回日本細胞生物学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] Impact of TNF-alpha and IFN-gamma on neointimal formation after vascular injury in mice2008

    • Author(s)
      Murayama T, Takahashi M, Shiba Y, Ise H, Tagawa Y, Takamoto M, Ikeda U
    • Organizer
      第72回日本循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] Upregulation of CXCR4 in bone marrow cells enhances the angiogenic potencyin a murine model of hindlimb ishemia2008

    • Author(s)
      Shiba Y, Takahashi M, Ise H, Ikeda U
    • Organizer
      第72回日本循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] Cardioprotection of MCP-1 against ischemia/reperfusion injury is mediated through a redox oxygen species (ROS)-dependent but KATP channel-independent pathway2008

    • Author(s)
      Morimoto H, Takahashi M, Hirose M, Kawaguchi M, Ise H, Yamada M, Ikeda U
    • Organizer
      第72回日本循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] Clinical Significance of sleep-desordered breathing(SDB)in a large population of Japanese patients : Efficacy of CPAP therapy in SDB-associated arrhythmias2008

    • Author(s)
      Abe H, Takahashi M, Tsukioka K, Kitahara H, Tsunemoto H, Suzuki J, Yaegashi H, Eda S, Yamazaki K, Kamikozawa M, Ikeda U
    • Organizer
      第72回日本循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] 人工的な糖鎖修飾を行った骨髄細胞の心筋組織へのターゲッティング法の開発2008

    • Author(s)
      小林聡、伊勢裕彦、高橋将文、後藤光昭、麻生真一、池田宇一
    • Organizer
      第7回日本再生医療学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] Therapeutic angiogenesis by mononuclear cell implantation for critical digit ischemia of patients with connective tissue diseases.2008

    • Author(s)
      Takahashi M, Ishigatsubo Y, Fujimoto K, Miyamoto M, Minota S, Horie T, Aizawa Y, Amano J, Murohara T, Matsubara H, Ikeda U.
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      New Orleans
    • Related Report
      2008 Annual Research Report
  • [Presentation] Role of interleukin-6 and its crosstalk with AT1R in acute andchronic rejection of murine cardiac allografts.2008

    • Author(s)
      Izawa A, Takahashi M, Ise H, Morimoto H, Yajima N, Tagawa Y, Ikeda U.
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      New Orleans
    • Related Report
      2008 Annual Research Report
  • [Presentation] Role of an Inflammasome adaptor molecule ASC in myocardial ischemia-reperfusion injury.2008

    • Author(s)
      Kawaguchi M, Takahashi M, Hata T, Takahashi Y, Morimoto H, Ise H, Sagara J, Hongo M, Taniguchi S, Ikeda U.
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      New Orleans
    • Related Report
      2008 Annual Research Report
  • [Presentation] Critical role of Thl7-CD4+T cells in angiogenic response to hindlimb ischemia in mice.2008

    • Author(s)
      Hata T, Takahashi M, Kawaguchi T, Kashima Y, Shiba Y, Ise H, Hida s, Iwakura Y, Taki S, Ikeda U.
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      New Orleans
    • Related Report
      2008 Annual Research Report
  • [Presentation] Double Deficiency of Tumour Necrosis Factor-□ and Interferon-□ in Bone Marrow-derived Cells Prevents Neointimal formation in a Murine Model of Vascular Injury.2008

    • Author(s)
      Murayama H, Takahashi M, Shiba Y, Ise H, Takamoto M, Tagawa Y, Iwakura Y, Ikeda U.
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      New Orleans
    • Related Report
      2008 Annual Research Report
  • [Presentation] 自己骨髄細胞移植による難治性血管炎に対する血管新生療法.2008

    • Author(s)
      高橋将文, 石ヶ良明, 藤本和輝, 宮本正章, 相澤義房, 天野純, 簑田清次, 室原豊明, 松原弘明, 池田宇一
    • Organizer
      第49回日本脈管学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 人工的な糖鎖修飾を行った骨髄細胞の心筋組織へのターゲッティング法の開発.2008

    • Author(s)
      小林聡, 伊勢裕彦, 高橋将文, 後藤光昭, 麻生真一, 池田宇一
    • Organizer
      日本バイオマテリアル学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Impact of TNF-alpha and IFN-gamma on neointimal formation after vascular injury in mice.2008

    • Author(s)
      Murayama T, Takahashi M, Shiba Y, Ise H, Tagawa Y, Takamoto M, Ikeda U
    • Organizer
      第72回日本循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] Upregulation of CXCR4 in bone marrow cells enhances the angiogenic potencyin a murine model of hindlimb ishemia.2008

    • Author(s)
      Shiba Y, Takahashi M, Ise H, Ikeda U
    • Organizer
      第72回日本循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cardioprotection of MCP-1 against ischemia/reperfusion injury is mediated through a redox oxygen species (ROS)-dependent but K_<ATP> channel-iadependent pathway.2008

    • Author(s)
      Morimoto H, Takahashi M, Hirose M, Kawaguchi M, Ise H, Yamada M, Ikeda U
    • Organizer
      第72回日本循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] Clinical Significance of sleep-desordered breathing (SDB)in a large population of Japanese patients : Efficacy of CPAP therapy in SDB-associated arrhythmias.2008

    • Author(s)
      Abe H, Takahashi M, Tsukioka K, Kitahara H, Tsunemoto H, Suzuki J, Yaegashi H, Eda S, Yamazaki K, Kamikozawa M, Ikeda U
    • Organizer
      第72回日本循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] Desmin and vimentin have N-acetylglucosamine-binding lectinic properties and are expressed on the cell surface.2008

    • Author(s)
      Ise H, Kobayashi S, Takahashi M, Aso S, Akaike T, Ikeda U
    • Organizer
      第60回日本細胞生物学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞骨格分子デスミン・ビメンチンの細胞膜上の発現とN-アセチルグルコサミン結合活性.2008

    • Author(s)
      伊勢裕彦, 小林聡, 高橋将文, 伊勢真美子, 池田宇一
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 人工的な糖鎖修飾を行った骨髄細胞の心筋組織へのターゲッティング法の開発.2008

    • Author(s)
      小林聡, 伊勢裕彦, 高橋将文, 後藤光昭, 麻生真一, 池田宇一
    • Organizer
      第7回日本再生医療学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] 人工的な糖鎖修飾を行った骨髄細胞の心筋組織へのターゲッティング法の開発.2008

    • Author(s)
      小林聡, 伊勢裕彦, 高橋将文, 後藤光昭, 麻生真一, 池田宇一
    • Organizer
      第31回日本分子生物学会・第18回日本生化学学会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] Apregulation of CXCR4+ in Bone Marrow Cells Enhanced the Angiogenic Potencyin a Murine Model of Hindlimb Ischemia.2008

    • Author(s)
      Shiba Y, Takahashi M, Ise H, lkeda U
    • Organizer
      第72回日本循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] CXCR4-posotive cells as a new souce for therapeutic angiogenesis.2007

    • Author(s)
      柴 祐司、高橋将文
    • Organizer
      第5回LifeScience Frontiers
    • Place of Presentation
      東京
    • Year and Date
      2007-07-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Bone marrow-derived CXCR4^+ cells a New Source for therapeutic angiogenesis.2007

    • Author(s)
      柴 祐司、高橋将文、山田亜衣、伊澤 淳、森本 創、伊勢裕彦、池田宇一
    • Organizer
      第7回心血管再生先端治療フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2007-06-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Bone Marrow-derived CXCR4+ Cells ax a New Source for Therapeutic Angiogenesis.2007

    • Author(s)
      Shiba Y, Takahashi M, Izawa A, Morimoto H, Ise H, Ikeda U
    • Organizer
      AHA 2007
    • Place of Presentation
      Orlando(USA)
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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