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Unique secretory dynamics of tissue plasminogen activator and vascular function

Research Project

Project/Area Number 19590858
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

SUZUKI Yuko  Hamamatsu University School of Medicine, 医学部, 助教 (20345812)

Co-Investigator(Kenkyū-buntansha) URANO Tetsumei  浜松医科大学, 医学部, 教授 (50193967)
MOGAMI Hideo  浜松医科大学, 医学部, 准教授 (90311604)
WATANABE Hiroshi  浜松医科大学, 医学部, 教授 (50262803)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords組織型プラスミノゲンアクチベーター / 血管内皮細胞 / 開口放出 / 全反射蛍光顕微鏡 / プラスミノゲンアクチベーターインヒビター1 / 線溶活性 / 組織プラスミノーゲンアクチベーター / 反射蛍光顕微鏡 / プラスミノーゲンアクチベーターインヒビター1 / 血管トーヌス
Research Abstract

近年、生活習慣病などに起因する心血管病の増加とともに、その病態基盤として血管内皮傷害が注目されている。正常血管内皮細胞は血栓形成を抑制し生じた血栓を溶解する機能を有するが、傷害内皮ではこれらの機能に異常をきたす。本研究では血栓溶解を担う線溶活性化因子に着目し、その内皮細胞からの分泌動態を蛍光顕微鏡によりリアルタイムに解析し、新たな線溶活性調節機構を見いだした。これにより内皮傷害の病態解明、傷害の予防などへ繋がることが期待できる。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report

Research Products

(27 results)

All 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (16 results) Book (1 results)

  • [Journal Article] Unique secretory dynamics of tissue plasminogen activator and its modulation by plasminogen activator inhibitor-1 in vascular endothelial cells2009

    • Author(s)
      Suzuki Y, Mogami H, Ihara Y, Urano T.
    • Journal Title

      Blood 113

      Pages: 470-478

    • NAID

      120005313162

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of platelet activation by P2Y12 receptor in the development of transplant arteriosclerosis in mice2009

    • Author(s)
      Yashiro K, Matsumoto Y, Ihara H, Suzuki Y, Kondo K, Urano T, Umemura K.
    • Journal Title

      Transplantation 87(3)

      Pages: 660-667

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unique secretory dynamics of tissue plasminogen activator and its modulation by plasminogen activator inhibitor-lin vascular endothelial cells.2009

    • Author(s)
      Suzuki Y
    • Journal Title

      Blood 113

      Pages: 470-478

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time analysis of platelet aggregation and procoagulant activity during thrombus formation in vivo2008

    • Author(s)
      Hayashi T, Mogami H, Murakami Y, Nakamura T, Kanayama N, Konno H, Urano T.
    • Journal Title

      Pflugers Arch 456(6)

      Pages: 1239-51

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-cyclic citrullinated peptide antibodies in lung diseases associated with rheumatoid arthritis2008

    • Author(s)
      Inui N, Enomoto N, Suda T, Kageyama Y, Watanabe H, Chida K.
    • Journal Title

      Clin Biochem 41(13)

      Pages: 1074-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intraperitoneal infusion of recombinant plasminogen activator inhibitor type 2 induced apoptosis in implanted human colon cancer and inhibited its growth and liver metastasis2008

    • Author(s)
      Suwa D, Konno H, Tanaka T, Urano T
    • Journal Title

      Anticancer Res 28(2A)

      Pages: 693-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenese-dependent vasoconstricting factor(s)in remodeled rat femoral arteries2008

    • Author(s)
      Hirao A, Kondo K, Takeuchi K, Inui N, Umemura K, Ohashi K, Watanabe H
    • Journal Title

      Cardiovasc Res 79(1)

      Pages: 161-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Misinterpretation of the effect of amylodipine on systolic calcium concentration with fura-2 fluorospectrometry2008

    • Author(s)
      Asai M, Watanabe H(他7名)
    • Journal Title

      Naunun Schmiedebergs Arch Parmacol 377(4-6)

      Pages: 423-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The CYP2A6*4 allele is determinant of S-1 pharmacokinetics in Japanese patients with non-small-cell lung cancer2008

    • Author(s)
      Kaida Y, Inui N, Suda T, Nakamura H, Watanabe H, Chida K.
    • Journal Title

      Clin Pharmacol Ther 83(4)

      Pages: 589-94

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 血漿tPA及びPAI-1抗原量測定の意義-新たな知見からの再考察-2007

    • Author(s)
      鈴木優子、浦野哲盟
    • Journal Title

      日本血栓止血学会雑誌 18(3)

      Pages: 247-254

    • NAID

      10026114815

    • Related Report
      2008 Final Research Report
  • [Presentation] Dynamics of Platelet-vessel Wall Interactions2009

    • Author(s)
      Urano T, Rybaltowski M, Hayashi T, Suzuki Y, Mogami H.
    • Organizer
      5th General Assembly Asian Hematology Association
    • Place of Presentation
      Kobe
    • Related Report
      2008 Final Research Report
  • [Presentation] 血管内皮細胞におけるtPA開口放出とその活性発現2008

    • Author(s)
      鈴木優子, 浦野哲盟
    • Organizer
      第31回日本血栓止血学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-22
    • Related Report
      2008 Final Research Report
  • [Presentation] 血管内皮細胞におけるtPAの開口放出とその活性発現2008

    • Author(s)
      鈴木優子
    • Organizer
      第31回日本血栓止血学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血管内線溶ポテンシャルと活性発現調節機構2008

    • Author(s)
      浦野哲盟
    • Organizer
      第31回日本血栓止血学会学術集会教育講演
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] シンポジウム『深部静脈血栓症の病態生理とその予防』血液及び血管内皮から見た血栓症リスク2008

    • Author(s)
      浦野 哲盟、鈴木 優子、井原 勇人、最上 秀夫
    • Organizer
      第85回日本生理学会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Unique exocytotic dynamics of tissue plasminogen activator(tPA)from vascular endothelial cells(VECs)and its modification by PAI-12008

    • Author(s)
      Suzuki Y, Urano T.
    • Organizer
      The 5th Congress of the Asian-Pacific Society on Thrombosis and Haemostasis
    • Place of Presentation
      Singapore
    • Related Report
      2008 Final Research Report
  • [Presentation] Secretary dynamics of tPA from vascular endothelial cells and its modification by PAI-12008

    • Author(s)
      Suzuki Y, Urano T.
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] Fibrinolytic activity on vascular endothelial cells : secretory dynamics of tPA and its modification by PAI-12008

    • Author(s)
      Suzuki Y, Urano T.
    • Organizer
      第6回血液・血管オルビス
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Unique exocytotic dynamics of tissue plasminogen activator (tPA) from vascular endothelial cells (VECs) and its modification by PAI-1.2008

    • Author(s)
      Urano T
    • Organizer
      The 5th Congress of the Asian-Pacific Society on Thrombosis and Haemostasis.
    • Place of Presentation
      Singapore
    • Related Report
      2008 Annual Research Report
  • [Presentation] Fibrinolytic activity on vascular endothelial cells : secretory dynamics of tPA and its modification by PAI-1.2008

    • Author(s)
      Urano T
    • Organizer
      第6回血液・血管オルビス 招請講演
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Secretary dynamics of tPA from vascular endothelial cells and its modification by PAI-1.2008

    • Author(s)
      Urano T
    • Organizer
      第70回日本而液学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] Modification by PAI-1 of slow exocytotic dynamics of tissue plasminogen activator(tPA)and its activity on vascular endothelial cells(VECS)2007

    • Author(s)
      T. Urano, Y. Suzuki, H. Ihara, H. Mogami
    • Organizer
      XXIth Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Geneva
    • Year and Date
      2007-07-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Unique secretory Dynamics of Tissue Plasminogen Activator(tPA)Is Beneficial to Maintain Fibrinolytic Activity on Cell Surface2007

    • Author(s)
      Suzuki Y, Ihara H, Mogami H, Urano T.
    • Organizer
      XIth International Workshop on Molecular and Cellular Biology of Plasminogen Activation
    • Place of Presentation
      Stockholm
    • Year and Date
      2007-06-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Unique secretory Dynamics of Tissue Plasminogen Activator (tPA)Is Beneficial to Maintain Fibrinolytic Activity on Cell Surface2007

    • Author(s)
      Suzuki Y, Ihara H, Mogami H, Urano T.
    • Organizer
      Xlth International Workshop on Molecular and Cellular Biology of Plasminogen Activation
    • Place of Presentation
      Stockholm
    • Year and Date
      2007-06-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] Modification by PAI-1 of slow exocytotic dynamics of tissue plasminogen activator (tPA)and its activity on vascular endothelial cells(VECS)2007

    • Author(s)
      T.Urano, Y.Suzuki, H.Ihara, H.Mogami
    • Organizer
      XXIth Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Geneva
    • Year and Date
      2007-02-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] 血液及び血管内皮から見た血栓症リスク2007

    • Author(s)
      浦野哲盟、鈴木優子、井原勇人、最上秀夫
    • Organizer
      第85回日本生理学会、シンポジウム『深部静脈血栓症の病態生理とその予防』
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Book] Role of tPA in the neural system. In Recent Advances in Thrombosis and Hemostasis2008

    • Author(s)
      Nagai, N. and Urano, T.
    • Publisher
      Edited by K. Tanaka and E. W. Davie. Springer, Tokyo pp
    • Related Report
      2008 Final Research Report

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Published: 2007-03-31   Modified: 2016-04-21  

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