• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Novel therapeutic conceot of dementia through vascular axis

Research Project

Project/Area Number 19590861
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionOsaka University

Principal Investigator

NAKAGAMI Hironori  Osaka University, 医学系研究科, 助教 (20325369)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords脱ユビキチン化酵素 / 血管リモデリング / 認知症 / 動脈硬化 / ユビキチン / パーキンソン病
Research Abstract

パーキンソン病の原因遺伝子であるubiquitin carboxyl-terminal esterase L1(UCHL1)、が血管細胞に発現し脱ユビキチン化作用によって抗炎症作用を所持していた。また血管に存在するその他の脱ユビキチン化酵素であるCYLD(cylindromatosis)に関しても同様に血管で脱ユビキチン化作用を介して血管リモデリングを抑制した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (8 results)

All 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results)

  • [Journal Article] Potential role of CYLD(Cylindromatosis)as a deubiquitinating enzyme in vascular cells2008

    • Author(s)
      Takami Y, Nakagami H, Morishita R, Katsuya T, Hayashi H, Mori M, Koriyama H, Baba Y, Yasuda O, Rakugi H, Ogihara T, Kaneda Y.
    • Journal Title

      Am J Pathol 172(3)

      Pages: 818-29

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential role of CYLD (Cylindromatosis)as a deubiquitinating enzyme in vascular cells.2008

    • Author(s)
      Takami Y, Nakagami H, et al.
    • Journal Title

      Am J Pathol. 172

      Pages: 818-829

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ubiquitin carboxyl-terminal hydrolae L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kB activation2007

    • Author(s)
      Takami Y, Nakagami H, Morishita R, Katsuya T, Cui TX, Ichikawa T, Saito Y, Hayashi H, Kikkuchi Y, Nishikawa T, Baba Y, Yasuda O, Rakugi H, Ogihara T, Kaneda Y.
    • Journal Title

      Arterioscler Thromb Vasc Biol 27(10)

      Pages: 2184-90

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ubiquitin carboxyl-terminal hydrolae L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kB activation2007

    • Author(s)
      Takami Y, Nakagami H, et. al.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 27(10)

      Pages: 2184-90

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Pivotal role of CYLD(Cylindromatosis)asa Deuhiquitinating enzyme in vasculature2008

    • Author(s)
      鷹見洋一、中神啓徳, 他
    • Organizer
      日本循環器学会
    • Place of Presentation
      マリンメッセ福岡
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 脱ユビキチン化酵素と動脈硬化2007

    • Author(s)
      中神啓徳
    • Organizer
      血管生物医学会
    • Place of Presentation
      日九州大学百年講堂
    • Year and Date
      2007-12-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Pivotal role of CYLD (Cylindromatosis) as a Deubiquitinating enzyme in vasculature2007

    • Author(s)
      Yoichi Takami, Hironori Nakagami, et.al.
    • Place of Presentation
      Orland, USA
    • Year and Date
      2007-11-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Ubiquitin carboxyl-terminal hydrolase Li, a novel deubiquitinating enzyme in vasculature2007

    • Author(s)
      Yoichi Takami, Hironori Nakagami, et.al.
    • Organizer
      plays a pivotal roles in vascular remodeling through the inhibition of NF-KB activation
    • Place of Presentation
      Orland, USA
    • Year and Date
      2007-11-04
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi