Role of platelet derived microparticle in the local regulation of vessel function

• Project/Area Number: 19590871
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Tokai University
• Principal Investigator: GOTO Shinya Tokai University, 医学部, 教授 (50225653)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 血小板 / microparticle / 炎症性細胞 / 血栓 / 凝固系 / 心筋梗塞 / 脳梗塞 / 血管内皮細胞 / 血管 / 炎症細胞 / 単球

Research Abstract

動脈硬化巣周囲の血栓形成にて血小板は必須の役割を演じる。血管内皮細胞機能障害部位に集積した血小板は活性化しmicroparticleを放出する。これは血管内皮、炎症性細胞機能調節、凝固系活性化にも寄与する。産生されたトロンビンは、トロンビン受容体刺激を介してさらに血小板の活性化を促進させることを示した。また、血栓形成に関与する各種細胞機能が、活性化血小板から産生されたmicroparticleにより調節されるメカニズムを示した。また、細胞内小器官であるミトコンドリアの関与を示した。

Research Products

• [Journal Article] ADAMTS-13 attenuates thrombus formation on type I collagen surface and disrupted plaques under flow conditions (2009)
  • Author(s): Moriguchi-Goto S, Yamashita A, Tamura N, Soejima K, Takahashi M, Nakagaki T, Goto S, Asada Y.
  • Journal Title: Atherosclerosis 203 Pages: 409-16
  • Peer Reviewed
• [Journal Article] Important regulatory role of activated platelet-derived procoaulant activity in the propagation of thrombi for med under arteiral blood flow conditions (2009)
  • Author(s): Tamura N, Kitajima I, Kawamura Y, Toda E, Eguchi Y, Ishida H, Goto S
  • Journal Title: Circulation Journal 73 Pages: 540-548
  • Peer Reviewed
• [Journal Article] Metalloproteinase regulation improves in vitro generation of effi cacious platelets from mouse embryonic stem cells (2008)
  • Author(s): Nishikii H, Eto K, Tamura N, Hattori K, Heissig B, Kanaji T, Sawaguchi A, Goto S, Ware J, and Nakauchi H.
  • Journal Title: Journal of Experimental Medicine 205 Pages: 1917-27
  • Peer Reviewed
• [Journal Article] A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy : results of the OPTIMUS-2 study (2008)
  • Author(s): Angiolillo DJ, Capranzano P, Goto S, Aslam M, Desai B, Charlton RK, Suzuki Y, Box LC, Shoemaker SB, Zenni MM, Guzman LA, Bass TA.
  • Journal Title: European Heart Journal 29 Pages: 2202-11
  • Peer Reviewed
• [Journal Article] The challenge of monitoring platelet response after clopidogrel (2008)
  • Author(s): Serebruany VL and Goto S
  • Journal Title: European Heart Journal 100 Pages: 1093-1094
  • Peer Reviewed
• [Journal Article] Cardiovascular risk factors in patients at high risk of atherothrombosis (2008)
  • Author(s): Goto S.
  • Journal Title: What we learned from Registries? Thrombosis and Haemostasis 100 Pages: 611-3
  • Peer Reviewed
• [Journal Article] Blood constitution : platelet aggregatioin, bleeding, and involvement of leukocytes. Virchow's triad 2008 Caplan LR eds (2008)
  • Author(s): Goto S.
  • Journal Title: Reviews in Neurological Diseases(MedReviews) Vol5
• [Journal Article] Metalloproteinase regulation improves in vitro generation of effi cacious platelets from mouse embryonic stem cells. (2008)
  • Author(s): Nishikii H, Eto K, Tamura N, Hattori K, Heissig B, Kanaji T, Sawaguchi A, Goto S, Ware J, Nakauchi H.
  • Journal Title: Journal of Experimental Medicine 205 Pages: 1917-27
  • Peer Reviewed
• [Journal Article] A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy : results of the OPTIMUS-2 study. (2008)
  • Author(s): Angiolillo DJ, Capranzano P, Goto S, Aslam M, Desai B, Charlton RK, Suzuki Y, Box LC, Shoemaker SB, Zenni MM, Guzman LA, Bass TA.
  • Journal Title: European Heart Journal. 2008 29 Pages: 2202-11
  • Peer Reviewed
• [Journal Article] Protective effect of tetramethyprazine and salvianalic acid B on apotasis of rat cerebral micorvascular endothehal cell under high shear stress. (2008)
  • Author(s): Li M, Zhao MQ, Kumar SS, Xi LX, Zhang HX, Kum WF, Goto S, and Liao FL.
  • Journal Title: Clin Hemorl Microcirc 38 Pages: 177-187
  • Peer Reviewed
• [Journal Article] Risk Factor Profile and Management of Cerebrovascular Patients in the REACH Registry. (2008)
  • Author(s): Roether J, Alberts MJ, Touzec E, Mas JL, Hill MD, Michele P, Bhatt DL, Aichner FT, Goto S, Matsumoto M, Ohman EM, Okada Y, Uchiyama S, D'Agostinom R, Hirsch AT, Wilson PWF, Steg PG, on behalf of the REACH Registry Investigators.
  • Journal Title: Cerebrovascular Disease 25 Pages: 366-374
  • Peer Reviewed
• [Journal Article] Are Japanese patients more prone to gastro-duodenal mucosal injury and bleeding with the use of antiplatelet agents? (2007)
  • Author(s): Goto S.
  • Journal Title: Tbromb Res 120 Pages: 463-4
  • Peer Reviewed
• [Journal Article] Important regulatory role of activated platelet-derived procoaulant activity in the propagation of thrombi formed under arteiral blood flow conditions
  • Author(s): Tamura N, Kitajima I, Kawamura Y, Toda E, Eguchi Y, Ishida H, Goto S
  • Journal Title: Circulation Journal 73 Pages: 540-548
  • Peer Reviewed
• [Presentation] mini debate 1 : 血小板機能のモニターリングは患者予後を改善する?-機能評価を実地臨床に持ち込むのは早計である (2008)
  • Author(s): 後藤信哉
  • Organizer: 第8回日本心血管カテーテル治療学会シンポジウム5PCIと抗血小板療法
  • Place of Presentation: 京都
  • Year and Date: 2008-11-24
• [Presentation] 抗血栓療法 : 日本と海外とのギャップは埋めるべきか? (2008)
  • Author(s): 後藤信哉
  • Organizer: 第8回日本心血管カテーテル治療学会シンポジウム3急性冠症候群の包括的管理
  • Place of Presentation: 京都
  • Year and Date: 2008-11-24
• [Presentation] 静脈血栓予防介入のメリットとデメリット-各種抗凝固薬の差異- (2008)
  • Author(s): 後藤信哉
  • Organizer: 第31回日本血栓止血学会学術集会会長要望シンポジウム2 : 日本の周術期静脈血栓塞栓症予防の行方を考える
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-22
• [Presentation] Atheroclerosis and use of anti-platelet agent in Asia. : (2008)
  • Author(s): Goto s.
  • Organizer: 6th Congress of the Asian Pacific Society of Vascular Disease (APSAVD)
  • Place of Presentation: Hong Kong
  • Year and Date: 2008-09-29
• [Presentation] Atheroclerosis and use of anti-platelet agent in Asia (2008)
  • Author(s): Goto S.
  • Organizer: 6th Congress of the Asian Pacific Society of Vascular Disease(APSAVD) Symposium 9 : Cardiometabolic Risks and Atherothrombosis
  • Place of Presentation: HongKong
  • Year and Date: 2008-09-28
• [Presentation] Phase II trial the novel antiplatelet agents, SCH530348, in Japanese patients with non-ST segment elevation acute coronary syndromes (NSTE ACS) (poster) (2008)
  • Author(s): Goto S.
  • Organizer: European Society of Cardiology Congress 2008
  • Place of Presentation: Munich 1.
  • Year and Date: 2008-09-02
• [Presentation] Very late stent thrombosisの発症機序と対策-血小板の立場から (2008)
  • Author(s): 後藤信哉
  • Organizer: 日本心血管インターベンション学会シンポジウムJSIC & JACC共同企画 : Verylate stent thrombosisの発症機序と対策
  • Place of Presentation: 名古屋
  • Year and Date: 2008-07-03
• [Presentation] 血管内皮傷害と血小板活性化 (2008)
  • Author(s): 後藤信哉
  • Organizer: 第17回日本脳ドック学会総会シンポジウム2「脳ドックは医療資源の有効活用に寄与しているか?」
  • Place of Presentation: 郡山(福島)
  • Year and Date: 2008-06-29
• [Presentation] Application of newly developed vlrtual discrete model of platelet adhesion and aggregation for assessment of thrombogenicity of stents (2008)
  • Author(s): Goto S, Kawahara H, Tamura N, Kawamura Y, and Suematsu M
  • Organizer: The SCAI Annual Scientific Sessions in Partnership with ACCi2 Summit
  • Place of Presentation: Chicago,US
  • Year and Date: 2008-03-28
• [Book] Platelet procoagulant activity appeared by exposure of platelets to blood flow conditions, Recent Advances in Thrombosis and Hemostasis 2008(In Tanaka K and Davie EW (eds)) (2008)
  • Author(s): Goto S.
  • Publisher: Springer
• [Book] in 抗凝固薬の適正な使い方 第2版, chapter 4抗血小板薬アスピリン (櫻川信男、上塚芳郎、和田英夫編集) (2008)
  • Author(s): 後藤信哉
  • Publisher: 医歯薬出版(株)
• [Book] in 抗凝固薬の適正な使い方第2版, chapter 4抗血小板薬チクロピジン、クロピトグレル、プラスグレル(櫻川信男、上塚芳郎、和田英夫編集) (2008)
  • Author(s): 後藤信哉
  • Publisher: 医歯薬出版(株)
• [Book] 抗血小板薬In心血管病薬物治療マニュアル(監修山口徹eds苅尾七臣、筒井裕之) (2008)
  • Author(s): 戸田恵理、後藤信哉
  • Publisher: 中山書店
• [Book] 循環器内科ゴールデンブック(改訂第2版) (2008)
  • Author(s): 半田俊之介、田邉晃久、伊苅裕二、後藤信哉監修
  • Publisher: 南江堂
• [Book] 血栓・塞栓症In病気と薬パーフェクトBOOK(池田宇一、大越教夫、横田千津子 eds.山田勝士、櫛田賢次、大井一弥、丸山徹、高村徳人、伊藤由紀) (2008)
  • Author(s): 後藤信哉
  • Publisher: 南江堂
• [Book] Recent Advances in Thrombosis and Hemostasis (2008)
  • Author(s): Goto S.
  • Total Pages: 642
  • Publisher: Platelet procoagulant activity appeared by exposure of platelets to blood flow conditions. In Tanaka K and Davie EW (eds)
• [Book] 薬剤師・薬学生のための臨床医学テキズト (2007)
  • Author(s): 後藤 信哉, eds 大野勧、柴崎 敏昭、平井 みどり、星 恵子、三木 知博、山下 直美
  • Total Pages: 485
  • Publisher: 薬事日報社
• [Remarks]
  • URL: http://www.med.u-tokai.ac.jp/daigakuin/web/taisya.html
• [Patent(Industrial Property Rights)] ステント形状最適化シミュレーター (2008)
  • Inventor(s): 後藤信哉/末松誠東海大学/慶應義塾大学
  • Industrial Property Number: 2008-059457
  • Filing Date: 2008-03-10
• [Patent(Industrial Property Rights)] 特許ステント形状最適化シミュレータ (2008)
  • Inventor(s): 後藤 信哉、末松 誠
  • Industrial Property Rights Holder: 学校法人東海大学、学校法人慶應義塾大学
  • Industrial Property Number: 2008-059457
  • Filing Date: 2008-03-10