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Retrograde bone mallow mono nuclear cells implantation via coronary vein for the patients with no-option angina pector is

Research Project

Project/Area Number 19590873
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNihon University

Principal Investigator

TAKAYAMA Tadateru  Nihon University, 医学部, 助教 (10366601)

Co-Investigator(Kenkyū-buntansha) HONYE Junko  日本大学, 医学部, 講師 (80256841)
HIRAYAMA Atsushi  日本大学, 医学部, 教授 (50459880)
SAITO Satoshi  日本大学, 医学部, 特任教授 (10130501)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords再生医療 / 経冠静脈による骨髄細胞移植 / カテーテル治療 / 心筋SPECT慢性虚血性心疾患 / no-option angina / 虚血性心不全 / 心筋SPECT / 虚血性心疾患 / 経冠静脈動による骨髄細胞移植
Research Abstract

慢性虚血性心疾患に対し経冠静脈カテーテルを用い骨髄単核球移植治療を行った。自覚症状は、大部分の症例に改善が認められた。骨髄単核球の細胞数の少ない1例では、心筋シンチでの改善は認めなかった。またCD34陽性細胞数と虚血改善効果は心筋シンチの結果では相関することが明らかとなった。治療不応性慢性心筋虚血に対する虚血改善効果が示唆された。しかし治療効果が長期に維持されるのか、予後は改善するかなどについては今後も継続的に検討が必要である。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (5 results)

All 2009 2008

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Low invasive angiogenic therapy for myocardial infarction by retrograde transplantation of mononuclear cells expressing the VEGF gene2009

    • Author(s)
      Hagikura k, Fukuda N, Yokoyama S, Yuxin L, Kusumi Y, Matsumoto T, Ikeda Y, Kunimoto S, Takayama T, Jumabay M, Mitsumata M, Saito s, Hirayama A, Mugishima H
    • Journal Title

      Int J Cardiol Epub ahead of print

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] 心臓再生医療の臨床応用-血管新生療法-2008

    • Author(s)
      高山忠輝
    • Organizer
      第22回日本冠疾患学会学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2008-12-13
    • Related Report
      2008 Final Research Report
  • [Presentation] 心臓再生医療の臨床応用 -血管新生療法-2008

    • Author(s)
      高山 忠輝
    • Organizer
      第22回日本冠疾患学会学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2008-12-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Efficacy of cell therapy for ischemic cardiomyopathy using a retrograde injection method through coronary vein with a novel catherter2008

    • Author(s)
      渡辺康夫(代表)
    • Organizer
      第72回日本循環器学会総会・学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] The efficacy of cell therapy for ischemic cardiomyopathy using a retrograde injection method through coronary vein with a novel catheter2008

    • Author(s)
      Tadateru Takayama
    • Organizer
      The 72nd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Fukuoka
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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