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Chemoprevention of Lung Cancer using Epidermal Growth Factor Receptor Transgenic Mice

Research Project

Project/Area Number 19590895
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionOkayama University

Principal Investigator

KIURA Katsuyuki  Okayama University, 大学院・医歯薬学総合研究科, 准教授 (10243502)

Co-Investigator(Kenkyū-buntansha) TAKIGAWA Nagio  岡山大学, 医学部・歯学部附属病院, 助教 (60325107)
Co-Investigator(Renkei-kenkyūsha) TAKATA Minoru  京都大学, 教授 (30281728)
YOSHINO Tadashi  岡山大学, 大学院・医歯薬学総合研究科, 教授 (70183704)
Research Collaborator 大橋 圭明  岡山大学, 大学院・医歯薬学総合研究科, 大学院生
頼 冠明  岡山大学, 大学院・医歯薬学総合研究科, 大学院生
市原 英基  岡山大学, 大学院・医歯薬学総合研究科, 大学院生
高田 三郎  岡山大学, 大学院・医歯薬学総合研究科, 大学院生
大澤 昌宏  岡山大学, 大学院・医歯薬学総合研究科, 大学院生
武田 洋昌  岡山大学, 大学院・医歯薬学総合研究科, 大学院生
藤井 昌学  岡山大学, 大学院・医歯薬学総合研究科, 大学院生
久保 寿夫  岡山大学, 大学院・医歯薬学総合研究科, 大学院生
柏原 宏美  岡山大学, 大学院・医歯薬学総合研究科, 大学院生
原田 大二郎  岡山大学, 大学院・医歯薬学総合研究科, 大学院生
越智 宣昭  岡山大学, 大学院・医歯薬学総合研究科, 大学院生
八杉 昌幸  岡山大学, 大学院・医歯薬学総合研究科, 大学院生
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords肺癌 / 腺癌 / 非喫煙者 / 化学予防 / 遺伝子改変マウス / 上皮成長因子受容体 / ゲフィチニブ / バンデタニブ / 肺腺癌 / 血管内皮細胞成長因子受容体 / 分子標的化学予防 / ZD6474 / 非喫煙 / EGFR / SP-C
Research Abstract

肺癌の粗死亡数は増加しているが、喫煙率低下に伴い年齢調整死亡率は低下傾向にある。肺癌患者の男性30%、女性70%は非喫煙者である。非喫煙者肺癌の病因探求およびその予防の研究目的で、上皮成長因子受容体(EGFR)遺伝子改変マウスを作製し、非喫煙関連肺癌マウスモデルを樹立した。ヒトEGFR遺伝子改変マウスは5-6週で多発性の異型腺腫様過形成、肺腺癌が出現し、30週前後で腫瘍死する。これらの肺発癌をgefitinibが効果的に予防することを証明した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (14 results)

All 2009 2008 2007

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Effects of vandetanib on lung adenocarcinoma cells emerging an acquired EGFR T790M mutation2009

    • Author(s)
      Ichihara E, Ohashi K, Takigawa N, Osawa M, Ogino A, Tanimoto M, Kiura K
    • Journal Title

      in vivo Cancer Res (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of gefitinib on N-nitrosamine-4-(methylnitrosamino)-1 -(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mice2009

    • Author(s)
      Kishino D, Kiura K, Takigawa N, Katayama H, Kuyama S, Sato K, Okada T, Ohashi K, Tanimoto M
    • Journal Title

      Lung Cancer (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive analysis of EGFR signaling pathways in Japanese patients with non-small cell lung cancer2009

    • Author(s)
      Hosokawa S, Toyooka S, Fujiwara Y, Tokumo M, Soh J, Takigawa N, Hotta K, Yoshino T, Date H, Tanimoto M, Kiura K
    • Journal Title

      Lung Cancer (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of gefitinib on N-nitrosamine-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mice2009

    • Author(s)
      Kishino D, Kiura K, Takigawa N., et al
    • Journal Title

      Lung Cancer (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of lung adenocarcinoma in transgenic mice expressing activated EGFR driven by the SP-C promoter2008

    • Author(s)
      Ohashi K, Rai K, Fujiwara Y, Osawa M, Hirano S, Takata K, Kondo E, Yoshino T, Takata M, Tanimoto M, Kiura K
    • Journal Title

      99

      Pages: 1747-1753

    • NAID

      10024010760

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of lung adenocarcinoma in transgenic mice expressing activated EGFR driven by the SP-C promoter.2008

    • Author(s)
      Ohashi K, Rai K, Kiura K., et al
    • Journal Title

      Cancer Sci1747-53 99

      Pages: 1747-1753

    • NAID

      10024010760

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice. Lung Cancer.2007

    • Author(s)
      Hisamoto A, Kondo E, Kiura K, Okada T, Hosokawa S, Mimoto J, Takigawa N, Tabata M, Tanimoto M:
    • Journal Title

      Lung Cancer 58

      Pages: 15-20

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of downstream epidermal growth factor receptor (EGFR) signaling provides gefitinib-resistance in cells carrying EGFR mutation2007

    • Author(s)
      Uchida A, Hirano S, Kitao H, Ogino A, Rai K, Toyooka S, Takigawa N, Tabata M, Takata M, Kiura K, Tanimoto M
    • Journal Title

      Cancer Sci. 98

      Pages: 357-363

    • NAID

      10019481589

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line.2007

    • Author(s)
      Ogino A, Kitao H, Hirano S, Uchida A, Ishiai M, Kozuki T, Takigawa N, Takata M, Kiura K, Tanimoto M
    • Journal Title

      Cancer Res. 67

      Pages: 7807-7814

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Chemopreventive effect of vandetanib on tumorigenesis in a mouse model of non-smoking related lung cancer AACR Annual Meeting 20092009

    • Author(s)
      Kubo T, Ohashi K, Osawa M, Takeda H, Ichihara E, Fujii M, Kashihara H, Takigawa N, Tanimoto , Kiura K
    • Organizer
      Biological Mechanisms and Molecular Markers of Prevention(米国癌学会総会, ミニシンポジウム)
    • Place of Presentation
      Colorado Convention Center, Denver, CO Abstract#4783 Minisymposium
    • Related Report
      2008 Final Research Report
  • [Presentation] Chemopreventive effect of gefitinib on tumorgenesis in smoking unrelated lung cancer mouse model AACR Annual Meeting 20082008

    • Author(s)
      Ohashi K, Kiura K, Osawa M, Takeda H, Kubo T, Ichihara E, Takigawa N, Hirano S, Tanimoto M, Takata M
    • Organizer
      米国癌学会総会, ミニシンポジウム
    • Place of Presentation
      San Diego, CA Abstract # 4186 Minisymposium
    • Related Report
      2008 Final Research Report
  • [Presentation] Chemopreventive effect of gefitinib on tumorgenesis in smoking unrelated lung cancer mouse model (Abstract # 4186 Minisymposium)2008

    • Author(s)
      Ohashi K, Kiura K, Osawa M., et al.
    • Organizer
      AACR Annual Meeting 2008 (2008年米国癌学会)
    • Place of Presentation
      San Diego, CA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Transgenic mice with mouse EGFR mutation developed lung adenocarcinoma.2007

    • Author(s)
      Ohashi K, Rai K, Kiura K, Osawa M, Hirano S, Fujiwara Y, Yoshino T, Takigawa N, Takata M, Tanimoto M
    • Organizer
      2007 AACR Annual Meeting 米国癌学会
    • Place of Presentation
      Los Angeles, CA, 米国
    • Year and Date
      2007-04-17
    • Related Report
      2007 Annual Research Report
  • [Book] Advanced Non-Small Cell Lung Carcinoma Acquired Resistance to Gefitinib (Methods of Cancer Diagnosis, Therapy and Prognosis : General Methods and Overviews, Lung Carcinoma and Prostate Carcinoma (Methods of Cancer Diagnosis, Therapy and Prognosis)2008

    • Author(s)
      Kiura K, Takigawa N, Segawa Y
    • Publisher
      Hayat, M. A. (EDT)
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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