Exploration of the genes that repress indefinite proliferation of lung cancer cells

• Project/Area Number: 19590897
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hiroshima University
• Principal Investigator: HIYAMA Keiko Hiroshima University, 原爆放射線医科学研究所, 准教授 (60253069)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 肺癌 / 不死化 / 分子標的 / テロメラーゼ / 抗癌剤 / 気道上皮 / 幹細胞 / 遺伝子導入 / 癌抑制遺伝子

Research Abstract

肺癌細胞株の網羅的発現解析により、肺癌の無限増殖を抑制する新たな分子標的候補を絞り込むと同時に、遺伝子導入により、その評価に有用な正常と不死化がん細胞の中間に位置すると考えられる気道上皮細胞を樹立した。これらは癌幹細胞にも有効な無限増殖を抑制する新たな抗癌剤の開発への展開が期待された。さらに、p16/RB経路の不活化のないテロメラーゼ活性化が幹細胞に由来する肺癌のマーカーである可能性を示した。

Research Products

• [Journal Article] Detection of CpG island hypermethylation of caspase-8 in neuroblastoma using an oligonucleotide array (2009)
  • Author(s): Kamimatsuse A, Matsuura K, Moriya S, Fukuba I, Yamaoka H, Fukuda E, Kamei N, Hiyama K, Sueda T, Hiyama E
  • Journal Title: Pediatr Blood Cancer 52 Pages: 777-783
  • Peer Reviewed
• [Journal Article] EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma (2009)
  • Author(s): Fumoto S, Hiyama K, Tanimoto K, Noguchi T, Hihara J, Hiyama E, Noguchi T, Nishiyama M
  • Journal Title: Cancer Letters 274 Pages: 25-32
  • Peer Reviewed
• [Journal Article] Detection of CpG island hypermethylation of caspase-8 in neuroblastoma using an oligonucleotide array. (2009)
  • Author(s): Kamimatsuse A
  • Journal Title: Pediatr Blood Cancer (印刷中)
  • Peer Reviewed
• [Journal Article] EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma. (2009)
  • Author(s): Fumoto s.
  • Journal Title: Cancer Letters 274(2009) Pages: 25-32
  • Peer Reviewed
• [Journal Article] Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors (2008)
  • Author(s): Nakamura H, Tanimoto K, Hiyama K, Yunokawa M, Kawamoto T, Kato Y, Yoshiga K, Poellinger L, Hiyama E, Nishiyama M.
  • Journal Title: DEC1 and DEC2. Oncogene 27 Pages: 4200-4209
  • Peer Reviewed
• [Journal Article] Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts (2008)
  • Author(s): Hiyama K, Tanimoto K, Nishimura Y, Tsugane M, Fukuba I, Sotomaru Y, Hiyama E, Nishiyama M
  • Journal Title: Exp Lung Res 34 Pages: 373-390
  • NAID: 120001092454
  • Peer Reviewed
• [Journal Article] Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts. (2008)
  • Author(s): Hiyama K.
  • Journal Title: Experimental Lung Research. 34(7) Pages: 373-390
  • NAID: 120001092454
  • Peer Reviewed
• [Journal Article] Human mismatch repair gene, MLHl, is transcriptionally repressed by hypoxia-inducible transcription factors, DEC1 and DEC2. (2008)
  • Author(s): Nakamura H.
  • Journal Title: Oncogene 27(30) Pages: 4200-4209
  • Peer Reviewed
• [Journal Article] 肺癌とテロメア・テロメラーゼ, 肺癌-基礎・臨床研究のアップデートー, 疫学・基礎研究II., 分子生物学 (2008)
  • Author(s): 檜山 桂子
  • Journal Title: 日本臨床 66(6) Pages: 59-64
• [Journal Article] 肺癌の分子生物学(1)-carcinogenesisとはなにか-. 特集「肺癌のUp-To-Date」. (2008)
  • Author(s): 檜山 桂子
  • Journal Title: THE LUNG perspectives 16(4) Pages: 503-507
• [Journal Article] 日本における遺伝子診療・研究の現状 (2008)
  • Author(s): 檜山 桂子
  • Journal Title: 腫瘍内科 2(5) Pages: 433-439
• [Journal Article] 総合内科医とサブスペシャリティ-女性医師の役割-. (2008)
  • Author(s): 檜山 桂子
  • Journal Title: 日本内科学会雑誌 97(11) Pages: 194-199
  • Peer Reviewed
• [Journal Article] Selection of a novel drug-response predictor in esophageal cancer: A novel screening method using microarray and identification of IFITMI as a potent marker gene of CDDP response. (2008)
  • Author(s): Fumoto S.
  • Journal Title: Int. J. Oncol. 32(2) Pages: 413-423
  • Peer Reviewed
• [Journal Article] Human mismatch repair gene, MLH1, is transcriptionally repressed by hypoxia-inducible transcription factors, DEC1 and DEC2 (2008)
  • Author(s): Nakamura H.
  • Journal Title: Oncogene (印刷中)
  • Peer Reviewed
• [Journal Article] 固形癌の治療抵抗性に関わる低酸素応答分子機構 (2008)
  • Author(s): 谷本 圭司
  • Journal Title: 癌の臨床 54(2) Pages: 91-96
• [Journal Article] 固形癌の治療抵抗性に関わる低酸素応答分子機構 (2008)
  • Author(s): 谷本 圭司
  • Journal Title: 放射線生物研究 43(1) Pages: 54-67
• [Journal Article] Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas (2007)
  • Author(s): Yunokawa M, Tanimoto K, Nakamura H, Nagai N, Kudo Y, Kawamoto T, Kato Y, Hiyama E, Hiyama K, Nishiyama M
  • Journal Title: Oncol Rep 17 Pages: 871-878
  • Peer Reviewed
• [Journal Article] EGFR activating aberration occurs independently of other genetic aberrations or telomerase activation in adenocarcinoma of the lung (2007)
  • Author(s): Arifin M, Hiyama K, Tanimoto K, Wiyono WH, Hiyama E, Nishiyama M
  • Journal Title: Oncol Rep 17 Pages: 1405-1411
  • Peer Reviewed
• [Journal Article] Selection of a novel drug-response predictor in esophageal cancer : a novel screening method using microarray and identification of IFITM1 as a potent marker gene of CDDP response (2007)
  • Author(s): Fumoto S, Shimokuni T, Tanimoto K, Hiyama K, Otani K, Ohtaki M, Hihara J, Yoshida K, Hiyama E, Noguchi T, Nishiyama M
  • Journal Title: Int J Oncol 32 Pages: 413-423
  • NAID: 120006340785
  • Peer Reviewed
• [Journal Article] Telomere and telomerase in stem cells (2007)
  • Author(s): Hiyama E, Hiyama K
  • Journal Title: Br J Cancer 96 Pages: 1020-1024
  • NAID: 120000876074
  • Peer Reviewed
• [Journal Article] A mathematical model for affymetrix genechip probe level data (2007)
  • Author(s): Otani K, Hiyama K, Satoh K, Shimamoto T, Mohamad D, Ando M, Tonda T, Kohda M, Okazaki Y, Nishiyama M, Hiyama E, Ohtaki M
  • Journal Title: JP Journal of Biostatics 1 Pages: 283-306
  • Peer Reviewed
• [Journal Article] Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas. (2007)
  • Author(s): Yunokawa M.
  • Journal Title: Oncol. Rep. 17(4) Pages: 871-878
  • Peer Reviewed
• [Journal Article] EGFR activating aberration occurs independently of other genetic aberrations or telomerase activation in adenocarcinoma of the lung. (2007)
  • Author(s): Arjfin M.
  • Journal Title: Oncol. Rep. 17(6) Pages: 1405-1411
  • Peer Reviewed
• [Journal Article] Telomere and telomerase in stem cells. (2007)
  • Author(s): Hiyama E.
  • Journal Title: Br. J. Cancer 96(7) Pages: 2020-2024
  • NAID: 120000876074
  • Peer Reviewed
• [Journal Article] A mathematical model for affymetrix genechip probe level data (2007)
  • Author(s): Otani K.
  • Journal Title: JP Journal of Biostatics 1(13) Pages: 283-306
  • Peer Reviewed
• [Journal Article] 乳がんのハイリスク患者とその診断 (2007)
  • Author(s): 檜山 桂子
  • Journal Title: Medicina 44(13) Pages: 2301-2303
• [Journal Article] EMP3 as a candidate tumor suppressor gene for solid tumors
  • Author(s): Fumoto S, Tanimoto K, Hiyama E, Noguchi T, Nishiyama M, Hiyama K
  • Journal Title: Expert Opinion On Therapeutic Targets (in press)
  • Peer Reviewed
• [Presentation] 膠原病とテロメア. (2009)
  • Author(s): 檜山 桂子
  • Organizer: 第38回広島リウマチ研究会
  • Place of Presentation: 広島
  • Year and Date: 2009-02-21
• [Presentation] A new concept of carcinogenesis (2009)
  • Author(s): Hiyama K, Tanimoto K
  • Organizer: Symposium in University of Andalas
  • Place of Presentation: Padang, Indonesia
  • Year and Date: 2009-02-16
• [Presentation] A new concept of carcinogenesis. (2009)
  • Author(s): Hiyama K.
  • Organizer: Symposium in University of Andalas
  • Place of Presentation: Padang, Indonesia
  • Year and Date: 2009-02-16
• [Presentation] Oncogenic addiction in lung cancer. Plenary Symposium (2009)
  • Author(s): Hiyama K, Arifin M, Hiyama E
  • Organizer: The 7^<th> Scientific Respiratory Medicine Meeting PIPKRA2009
  • Place of Presentation: Jakarta, Indonesia
  • Year and Date: 2009-02-15
• [Presentation] Hypoxic signaling in cancers. Plenary Symposium (2009)
  • Author(s): Tanimo K, Hiyama K
  • Organizer: The 7^<th> Scientific Respiratory Medicine Meeting PIPKRA2009
  • Place of Presentation: Jakarta, Indonesia
  • Year and Date: 2009-02-15
• [Presentation] Oncogenic addiction in lung cancer. (2009)
  • Author(s): Hiyama K.
  • Organizer: The 7^<th> Scientific Respiratory Medicine Meeting PIPKRA2009
  • Place of Presentation: Jakarta, Indonesia
  • Year and Date: 2009-02-15
• [Presentation] Hypoxic signaling in cancers. (2009)
  • Author(s): Tanimoto K.
  • Organizer: The 7^<th> Scientific Respiratory Medicine Meeting PIPKRA2009
  • Place of Presentation: Jakarta, Indonesia
  • Year and Date: 2009-02-15
• [Presentation] Interstitial Lung Diseases (ILD) update. Plenary Symposium (2009)
  • Author(s): Hiyama K, Arifin M, Tanimoto K
  • Organizer: The 7^<th> Scientific Respiratory Medicine Meeting PIPKRA2009
  • Place of Presentation: Jakarta, Indonesia
  • Year and Date: 2009-02-14
• [Presentation] Diagnostic factors in cancers. Satellite Symposium (2009)
  • Author(s): Tanimoto K, Hiyama K
  • Organizer: The 7^<th>Scientific Respiratory Medicine Meeting PIPKRA2009
  • Place of Presentation: Jakarta, Indonesia
  • Year and Date: 2009-02-14
• [Presentation] Interstitial Lung Diseases (ILD) update. (2009)
  • Author(s): Hiyama K.
  • Organizer: The 7^<th> Scientific Respiratory Medicine Meeting PIPKRA2009
  • Place of Presentation: Jakarta, Indonesia
  • Year and Date: 2009-02-14
• [Presentation] Diagnostic factors in cancers. (2009)
  • Author(s): Tanimoto K.
  • Organizer: The 7^<th> Scientific Respiratory Medicine Meeting PIPKRA2009
  • Place of Presentation: Jakarta, Indonesia
  • Year and Date: 2009-02-14
• [Presentation] Molecular basics of lung cancer. Workshop (2009)
  • Author(s): Hiyama K, Tanimoto K, Hiyama E
  • Organizer: The 7^<th> Scientific Respiratory Medicine Meeting PIPKRA2009
  • Place of Presentation: Jakarta, Indonesia
  • Year and Date: 2009-02-13
• [Presentation] Molecular basics of lung cancer. (2009)
  • Author(s): Hiyama K.
  • Organizer: The 7^<th> Scientific Respiratory Medicine Meeting PIPKRA2009
  • Place of Presentation: Jakarta, Indonesia
  • Year and Date: 2009-02-13
• [Presentation] 制癌剤ゲノム創薬に向けた分子標的の策定 (2008)
  • Author(s): 檜山 桂子
  • Organizer: 第1回発酵イノベーションフォーラム
  • Place of Presentation: 広島
  • Year and Date: 2008-12-18
• [Presentation] 軟骨細胞における低酸素応答遺伝子発現変動. (2008)
  • Author(s): 白倉 麻耶
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-14
• [Presentation] がん細胞における低酸素誘導性EFEMP機能解析. (2008)
  • Author(s): 谷本 圭司
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] テロメアと加齢の科学 (2008)
  • Author(s): 檜山 桂子
  • Organizer: 第2回広島抗加齢医学研究会
  • Place of Presentation: 広島
  • Year and Date: 2008-12-05
• [Presentation] 軟骨細胞における転写因子HIF-1活性化と破骨細胞誘導機構. (2008)
  • Author(s): 白倉 麻耶
  • Organizer: 第6回がんとハイポキシア研究会
  • Place of Presentation: 広島
  • Year and Date: 2008-11-30
• [Presentation] トランスジェニックマウスを用いたHIF1αによる腫瘍原性の解析 (2008)
  • Author(s): 末岡 栄三郎
  • Organizer: 第6回がんとハイポキシア研究会
  • Place of Presentation: 広島
  • Year and Date: 2008-11-30
• [Presentation] 低酸素下癌細胞におけるDNA修復遺伝子群の発現動態および制御機構 (2008)
  • Author(s): 中村 秀明
  • Organizer: 第6回がんとハイポキシア研究会
  • Place of Presentation: 広島
  • Year and Date: 2008-11-29
• [Presentation] Exploration of the genes associated with chemosensitivity and indefinite proliferation of lung cancer cells (2008)
  • Author(s): Hiyama K, Arifin M, Tanimoto K, Otani k, Ohtaki M, Hiyama E, Nishiyama M
  • Organizer: The 13^<th> Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2008-11-20
• [Presentation] Telomere shortening and genetic variations in telomerase components and metabolic enzymes in Japanese patients with COPD (2008)
  • Author(s): Arifin M, Tanimoto K, Budhi A, Hiyama E, Nishiyama M, Hiyama K
  • Organizer: The 13^<th> Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2008-11-20
• [Presentation] Exploration of the genes associated with chemosensitivity and indefinite proliferation of lung cancer cells. (2008)
  • Author(s): Hiyama K.
  • Organizer: The 13^<th> Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2008-11-20
• [Presentation] Telomere shortening and genetic variations in telomerase components and metabolic enzymes in Japanese patients with COPD. (2008)
  • Author(s): Arifin M.
  • Organizer: The 13^<th> Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2008-11-20
• [Presentation] 神経芽腫の発生・進展に関わるepithelial membrane protein 3 (EMP3)遺伝子発現とその制御機構としてのメチル化の関与. (2008)
  • Author(s): 福場郁子
  • Organizer: 第46回日本癌治療学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-01
• [Presentation] 卵巣癌におけるEMP3遺伝子発現について. (2008)
  • Author(s): 山本 弥寿子
  • Organizer: 第46回日本癌治療学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-31
• [Presentation] 食道癌における新規抗癌剤効果規定遺伝子の同定. (2008)
  • Author(s): 麓 祥一
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-30
• [Presentation] E2-EPF/UBE2Sによる癌抑制遺伝子産物pVHL制御機構. (2008)
  • Author(s): 谷本 圭司
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] ヒトthymidylate synthase遺伝子5 〓UTR領域のtandem repeat近傍の新規塩基置換の同定. (2008)
  • Author(s): 和田 真由子
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 膵癌細胞株における不死化関連遺伝子の役割. (2008)
  • Author(s): 江口英孝
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 癌細胞における不死化関連遺伝子SFRS10の選択的スプライシングに関わる機能ネットワークとその役割. (2008)
  • Author(s): 和田 智
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 肺癌発生機序の組織学的差異. (2008)
  • Author(s): Arifin M.
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Genes commonly upregulated in immortal cancer cells are novel molecular targets for universal anti-cancer strategy (2008)
  • Author(s): Hiyama K, Tanimoto K, Hiyama E, Nishiyama M
  • Organizer: Ehrlich II- 2^<nd> World Conference on Magic Bullets
  • Place of Presentation: Nurnberg, Germany
  • Year and Date: 2008-10-04
• [Presentation] Effectiveness and complications of treatment childhood liver tumors-from the experience of JPLT(Japanese Study Group for Pediatric Liver Tumor) (2008)
  • Author(s): Hiyama E, Yamaoka H, Nishimura S, Hishiki T, Hiyama K, Sasaki F, Horie E, Ohnuma N
  • Organizer: Ehrlich II- 2^<nd> World Conference on Magic Bullets
  • Place of Presentation: Nurnberg, Germany
  • Year and Date: 2008-10-04
• [Presentation] Genes commonly unregulated in immortal cancer cells are novel molecular targets for universal anti-cancer strategy. (2008)
  • Author(s): Hiyama K.
  • Organizer: Ehrlich II-2^<nd> World Conference on Magic Bullets
  • Place of Presentation: Nurnberg, Germany
  • Year and Date: 2008-10-04
• [Presentation] Effectiveness and complications of treatment childhood liver tumors-from the experience of JPLT (2008)
  • Author(s): Hiyama E.
  • Organizer: Ehrlich II-2^<nd> World Conference on Magic Bullets
  • Place of Presentation: Nurnberg, Germany
  • Year and Date: 2008-10-04
• [Presentation] 成人固形がん : テロメラーゼ陽性“幹細胞"からの発がん機構 (2008)
  • Author(s): 檜山 桂子
  • Organizer: 第26回日本ヒト細胞学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-08-30
• [Presentation] 間葉系幹細胞とがん発生. (2008)
  • Author(s): 檜山 英三
  • Organizer: 第26回日本ヒト細胞学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-08-30
• [Presentation] 胃癌Paclitaxel療法 : 新規効果予測遺伝子の同定と生存期間予測. (2008)
  • Author(s): 和田 智
  • Organizer: 第19回消化器癌発生学会総会
  • Place of Presentation: 大分
  • Year and Date: 2008-08-28
• [Presentation] HIF-1-DEC経路によるDNA修復遺伝子発現制御. (2008)
  • Author(s): 谷本 圭司
  • Organizer: 第12回がん分子標的治療研究会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-27
• [Presentation] Genetic Variations in TERT/TERC Genes in Japanese Patients with Pulmonary or Collagen Diseases with Telomere Shortening. (2008)
  • Author(s): Arifin M.
  • Organizer: The 48^<th> Annual Meeting of The Japanese Respiratory Society
  • Place of Presentation: 神戸
  • Year and Date: 2008-06-17
• [Presentation] Telomere shortening and TERT/TERC genetic variations in patients with collagen diseases (2008)
  • Author(s): Hiyama K, Arifin M, Uchida A, Ozawa Y, Tanimoto K., Hirai Y, Yamanishi Y, Hiyama E, Nishiyama M
  • Organizer: Annual European Congress of Rheumatology
  • Place of Presentation: Paris, France
  • Year and Date: 2008-06-11
• [Presentation] Telomere shortening and TERT/TERC genetic variations in patients with collagen diseases. (2008)
  • Author(s): Hiyama K.
  • Organizer: Annual European Congress of Rheumatology
  • Place of Presentation: Paris, France
  • Year and Date: 2008-06-11
• [Presentation] EMP3 may be a tumor suppressor gene in late stage of neuroblastoma development (2008)
  • Author(s): Fukuba I, Hiyama K, Kamimatsuse A, Yamaoka H, Fukuda E, Tazaki T, Hiyama E
  • Organizer: Advances in Neuroblastma Research 2008(ANR)
  • Place of Presentation: Chiba, Japan
  • Year and Date: 2008-05-22
• [Presentation] High-Resolution mapping of single nucleotide polymorphisms and DNA methylation in human nueroblastoma using oligonucleotide microarray (2008)
  • Author(s): Hiyama E, Yamaoka H, Fukuba I, Fukuda E, Kamimatsuse A, Kamei N, Onitake Y, Hiyama K, Sueda T
  • Organizer: Advances in Neuroblastma Research 2008(ANR)
  • Place of Presentation: Chiba, Japan
  • Year and Date: 2008-05-22
• [Presentation] Identification of candidate genes involving in Neuroblastoma Using a New Mathematical model for genechip data (2008)
  • Author(s): Kamei N, Hiyama E, Otani K, Hiyama K, Kamimatsuse A, Yamaoka H, Ohtaki M
  • Organizer: Advances in Neuroblastma Research 2008(ANR)
  • Place of Presentation: Chiba, Japan
  • Year and Date: 2008-05-22
• [Presentation] EMP3 may be a tumor suppressor gene in late stage of neuroblastoma development. (2008)
  • Author(s): Fukuba I.
  • Organizer: Advances in Neuroblastma Research 2008 (ANR)
  • Place of Presentation: Chiba
  • Year and Date: 2008-05-22
• [Presentation] High-Resolution mapping of single nucleotide polymorphisms and DNA methylation in human nueroblastoma using oligonucleotide microarray. (2008)
  • Author(s): Hiyama E.
  • Organizer: Advances in Neuroblastma Research 2008 (ANR)
  • Place of Presentation: Chiba
  • Year and Date: 2008-05-22
• [Presentation] Identification of candidate genes involving in Neuroblastoma Using a New Mathematical model for genechip data. (2008)
  • Author(s): Kamei. N.
  • Organizer: Advances in Neuroblastma Research 2008 (ANR)
  • Place of Presentation: Chiba
  • Year and Date: 2008-05-22
• [Presentation] HIF-1-DEC pathway regulates expressions of DNA repair genes (2008)
  • Author(s): Tanimoto K, Nakamura H, Fumoto S, Hiyama E, Yoshiga K, Eguchi H, Nishiyama M, Hiyama K
  • Organizer: Annual Meeting of Am. Assoc. Cancer Res 2008
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2008-04-14
• [Presentation] EMP3, as a candidate of tumor suppressor gene for esophageal squamous cell carcinoma(ESCC) (2008)
  • Author(s): Fumoto S, Tanimoto K, Arifin M, Noguchi T, Noguchi T, Hiyama E, Eguchi H, Nishiyama M, Hiyama K
  • Organizer: Annual Meeting of Am. Assoc. Cancer Res 2008
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2008-04-14
• [Presentation] HIF-1-DEC pathway regulates expressions of DNA repair genes. (2008)
  • Author(s): Tanimoto K.
  • Organizer: Annual Meeting of Am. Assoc. Cancer Res 2008
  • Place of Presentation: San Diego, USA
  • Year and Date: 2008-04-14
• [Presentation] EMP3, as a candidate of tumor suppressor gene for esophageal squamouscell carcinoma (ESCC). (2008)
  • Author(s): Fumoto S.
  • Organizer: Annual Meeting of Am. Assoc. Cancer Res 2008
  • Place of Presentation: San Diego, USA
  • Year and Date: 2008-04-14
• [Presentation] マイクロアレイからのがん個別化医療とゲノム創薬展開 (2008)
  • Author(s): 檜山 桂子
  • Organizer: 第48回遺伝子・細胞治療センターセミナー
  • Place of Presentation: 岡山
  • Year and Date: 2008-02-22
• [Presentation] Possible mechanism of lung adenocarcinoma development from telomerase-positive "stem cells"free from cellular senescence. The Fifth International Symposium of 21^<st> Century COE Program (2008)
  • Author(s): Arifin M, Hiyama K, Tanimoto K, Hiyama E, Nishiyama M
  • Organizer: Hiroshima University Radiation Casualty Medical Research Center
  • Place of Presentation: Hiroshima, Japan
  • Year and Date: 2008-01-23
• [Presentation] EMP3 may be a tumor suppressor gene in late stage of neuroblastoma development. The Fifth International Symposium of 21^<st> Century COE Program (2008)
  • Author(s): Fukuba I, Hiyama K, Kamimatsuse A, Tazaki T, Yamaoka H, Fukuda E, Arifin M, Fumoto S, Tanimoto K, Nishiyama M, Hiyama E
  • Organizer: Hiroshima University Radiation Casualty Medical Research Center
  • Place of Presentation: Hiroshima, Japan
  • Year and Date: 2008-01-23
• [Presentation] Possible mechanism of lung adenocarcinoma development from telomerase-positive "stem cells" free from cellular senescence. (2008)
  • Author(s): Arifin M.
  • Organizer: The Fifth International Symposium of 21st Century COE Program. Hiroshima University Radiation Casualty Medical Research Center.
  • Place of Presentation: Hiroshima
  • Year and Date: 2008-01-23
• [Presentation] EMP3 may be a tumor suppressor gene in late stage of neuroblastoma development. (2008)
  • Author(s): Fukuba I.
  • Organizer: The Fifth International Symposium of 21st Century COE Program.
  • Place of Presentation: Hiroshima
  • Year and Date: 2008-01-23
• [Presentation] Novel hypoxia inducible genes as molecular targets for anti-cancer therapy (2008)
  • Author(s): Tanimoto K, Nakamura H, Fumoto S, Hiyama E, Yoshiga K, Eguchi H, Nishiyama M, Hiyama K
  • Organizer: The 5^<th> International Symposium of Hiroshima University 21th Century COE Program, Radiation Casualty Medical Research Center
  • Place of Presentation: Hiroshima, Japan
  • Year and Date: 2008-01-19
• [Presentation] Hypoxia-inducible transcription factors, DEC1 and DEC2, suppress expressions of DNA repair genes in cancer cells (2008)
  • Author(s): Tanimoto K, Nakamura H, Hiyama E, Nishiyama M, Hiyama K
  • Organizer: Keystone Symposia on Molecular and Cellular Biology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2008-01-19
• [Presentation] Novel hypoxia inducible genes as molecular targets for anti-cancer therapy. (2008)
  • Author(s): Tanimoto K.
  • Organizer: The 5th International Symposium of Hiroshima University 21th Century COE Program, Radiation Casualty Medical Research Center.
  • Place of Presentation: Hiroshima
  • Year and Date: 2008-01-19
• [Presentation] Hypoxia-inducible transcription factors, DEC1 and DEC2, suppress expressions of DNA repair genes in cancer cells. (2008)
  • Author(s): Tanimoto K.
  • Organizer: Keystone Symposia on Molecular and Cellular Biology
  • Place of Presentation: Canada
  • Year and Date: 2008-01-19
• [Presentation] ゲノム創薬標的の同定と機能解析〜遺伝子ネットワークの解析から (2007)
  • Author(s): 和田 智
  • Organizer: 第30回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] 新規低酸素誘導性遺伝子human EFEMP2によるP53機能抑制 (2007)
  • Author(s): 中村秀明
  • Organizer: 第30回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
• [Presentation] Development of Telomerase-Positive Lung Adenocarcinomas without Inactivation of p16/Rb Pathway (2007)
  • Author(s): Hiyama K, Arifin M, Tanimoto K, Hiyama E, Nishiyama M
  • Organizer: The Role of Telomeres and Telomerase in Cancer Research
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2007-12-07
• [Presentation] Immortalization and cancer formation of human mesenchymal stem cells (2007)
  • Author(s): Hiyama E, Onitake Y, Fukuba I, Fukuda E, Sudo T, Sueda T, Sotomaru Y, Hiyama K
  • Organizer: The Role of Telomeres and Telomerase in Cancer Research
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2007-12-07
• [Presentation] Development of Telomerase-Positive Lung Adenocarcinomas without Inactivation of p16/Rb Pathway. (2007)
  • Author(s): Hiyama K
  • Organizer: The Role of Telomeres and Telomerase in Cancer Research
  • Place of Presentation: San Francisco
  • Year and Date: 2007-12-07
• [Presentation] Immortalization and cancer formation of human mesenchymal stem cells. (2007)
  • Author(s): Hiyama, E.
  • Organizer: The Role of Telomeres and Telomerase in Cancer Research
  • Place of Presentation: San Francisco
  • Year and Date: 2007-12-07
• [Presentation] Inactimation of P16/RB pathway is not a prerequisite for half of lung adenocarcinoma with high telomerase activity (2007)
  • Author(s): Arifin M, Hiyama K, Tanimoto K, Hiyama E, Nishiyama M
  • Organizer: The 15^<th> Anniversary of Hiroshima Cancer Seminar Foundation. The 17^<th> Internatl. Symposium. "Radiation Therapy for Cancer"
  • Place of Presentation: Hiroshima, Japan
  • Year and Date: 2007-11-11
• [Presentation] Inactivation of p16/RB pathway is not a prerequisite for half of lung adenocarcinoma with high telomerase activity. (2007)
  • Author(s): Arifin M.
  • Organizer: The 15th Anniversary of Hiroshima Cancer Seminar Foundation. The 17th Internatl. Symposium. "Radiation Therapy for Cancer
  • Place of Presentation: Hiroshima
  • Year and Date: 2007-11-11
• [Presentation] A gene identified as a novel tumor suppressor gene in esophageal cell carcinoma. (2007)
  • Author(s): 麓 祥一
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-05
• [Presentation] A novel hypoxia inducible gene, human EFEMP2, decreased p53 activity in cancer celles (2007)
  • Author(s): 中村秀明
  • Organizer: 66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Presentation] Relationship between p16 inactivation and telomerase activation mechanism in lung adenocarcinoma. (2007)
  • Author(s): Arifin M.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Presentation] 肺線維芽細胞増殖規定遺伝子の同定 (2007)
  • Author(s): 檜山 桂子
  • Organizer: 第10回間質性肺炎細胞分子病態研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-08-25
• [Presentation] 固形癌の治療抵抗性に関わる低酸素応答分子機構 (2007)
  • Author(s): 谷本 圭司
  • Organizer: 第37回放射線による制癌シンポジウム
  • Place of Presentation: 筑波
  • Year and Date: 2007-07-20
• [Presentation] 癌細胞におけるHIF-1α活性化機構の解析 (2007)
  • Author(s): 谷本 圭司
  • Organizer: 第11回がん分子標的治療研究会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-06
• [Presentation] Drug-Diagnostic Co-development Study:新規分子標的薬剤の開発に向けて (2007)
  • Author(s): 西山 正彦
  • Organizer: 第16回日本癌病態治療研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-27
• [Presentation] Pharmacogenomic (PG) analysis for prediction of individual response to paclitaxel in 5-FU-refractory metastatic gastric cancer : Prediction formula of tumor response using novel marker genes and genotypes associated with the toxicity (2007)
  • Author(s): Ikeda R, Yoshida K, Takagane A, Tsuburaya A, Kobayashi O, Sunouchi H, Matsukawa M, Tanimoto K, Hiyama K, Nishiyama M
  • Organizer: 43^<rd> Annual Meeting of Am. Soc. Clin. Oncol.
  • Place of Presentation: Chicago, IL, USA
  • Year and Date: 2007-06-03
• [Presentation] Pharmacogenomic (PG) analysis for prediction of individual response to paclitaxel in 5-FU-refractory metastatic gastric cancer: Prediction formula of tumor response using novel marker genes and genotypes associated with the toxicity. (2007)
  • Author(s): Ikeda, R
  • Organizer: 43rd Annual Meeting of Am. Soc. Clin. Oncol.
  • Place of Presentation: Chicago
  • Year and Date: 2007-06-03
• [Presentation] EGFR activating aberrations occurs independently with telomerase activation mechanisms in adenocarcinoma of the lung. English Mini-Sympoium (2007)
  • Author(s): Arifin M.
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-12
• [Presentation] POT1 transfection may cause shortening of telomere 3-overhang increasing chemoresistance and alternative lengthening of telomeres in cancer cell (2007)
  • Author(s): Hiyama K, Nishimura Y, Tanimoto K, Hiyama E, Nishiyama M
  • Organizer: Cold Spring Harbor Laboratory meeting on Telomeres & Telomerase
  • Place of Presentation: New York, USA
  • Year and Date: 2007-05-03
• [Presentation] Role of telomere and telomerase in human mesenchymal stem cells (2007)
  • Author(s): Hiyama E, Onitake T, Fukuba I, Fukuda E, Sudo T, Sueda T, Hiyama K
  • Organizer: Cold Spring Harbor Laboratory meeting on Telomeres & Telomerase
  • Place of Presentation: New York, USA
  • Year and Date: 2007-05-03
• [Presentation] POT1 transfection may cause shortening of telomere 3'overhang increasing chemoresistance and alternative lengthening of telomeres in cancer cell. (2007)
  • Author(s): Hiyama K
  • Organizer: Cold Spring Harbor Laboratory meeting on Telomeres & Telomerase
  • Place of Presentation: Cold Spring Harbor
  • Year and Date: 2007-05-03
• [Presentation] Role of telomere and telomerase in human mesenchymal stem cells. (2007)
  • Author(s): Hiyama, E.
  • Organizer: Cold Spring Harbor Laboratory meeting on Telomeres & Telomerase
  • Place of Presentation: Cold Spring Harbor
  • Year and Date: 2007-05-03
• [Presentation] Genome-wide single nucleotide polymorphism microarray mapping for prediction of outcome of neuroblastoma patients (2007)
  • Author(s): Hiyama E, Hiyama K, Yamaoka H, Nishiyama M., Reynolds CP, Sueda T
  • Organizer: 98^<th> Annual Meeting of Am. Assoc. Cancer Res.
  • Place of Presentation: Los Angeles, CA, USA
  • Year and Date: 2007-04-16
• [Presentation] Genome-wide single nucleotide polymorphism microarray mapping for prediction of outcome of neuroblastoma patients. (2007)
  • Author(s): Hiyama, E.
  • Organizer: 98th Annual Meeting of Am. Assoc. Cancer Res.
  • Place of Presentation: Los Angeles
  • Year and Date: 2007-04-16
• [Presentation] Exploring genes that regulate cellular proliferation and immortalization of human somatic cells (2007)
  • Author(s): Hiyama K, Tanimoto K, Hiyama E, Nishiyama M
  • Organizer: 98^<th> Annual Meeting of Am. Assoc. Cancer Res.
  • Place of Presentation: Los Angeles, CA, USA
  • Year and Date: 2007-04-15
• [Presentation] Mechanisms of transcriptional regulation of DNA repair genes under hypoxic conditions (2007)
  • Author(s): Tanimoto K, Nakamura H, Yoshiga K, Hiyama E, Hiyama K, Nishiyama M
  • Organizer: 98^<th> Annual Meeting of Am. Assoc. Cancer Res.
  • Place of Presentation: Los Angeles, CA, USA
  • Year and Date: 2007-04-15
• [Presentation] Interferon induced transmembrane protein 1 (IFITM1) gene is a novel candidate as a CDDP sensitivity marker in esophageal squamous cell carcinoma (ESCC) (2007)
  • Author(s): Fumoto S, Shimokuni T, Tanimoto K, Hiyama K, Noguchi T, Kawahara K, Otani K, Ohtaki M, Hiyama E, Nishiyama M
  • Organizer: 98^<th> Annual Meeting of Am. Assoc. Cancer Res.
  • Place of Presentation: Los Angeles, CA, USA
  • Year and Date: 2007-04-15
• [Presentation] Exploring genes that regulate cellular proliferation and immortalization of human somatic cells. (2007)
  • Author(s): Hiyama K.
  • Organizer: 98th Annual Meeting of Am. Assoc. Cancer Res.
  • Place of Presentation: Los Angeles
  • Year and Date: 2007-04-15
• [Presentation] Mechanisms of transcriptional regulation of DNA repair genes under hypoxic conditions. (2007)
  • Author(s): Tanimoto K.
  • Organizer: 98th Annual Meeting of Am. Assoc. Cancer Res.
  • Place of Presentation: Los Angeles,
  • Year and Date: 2007-04-15
• [Presentation] Interferon induced transmembrane protein 1 (IFITMl) gene is a novel candidate as a CDDP sensitivity marker in esophageal squamous cell carcinoma (ESCC) (2007)
  • Author(s): Fumoto S.
  • Organizer: 98th Annual Meeting of Am. Assoc. Cancer Res
  • Place of Presentation: Los Angeles
  • Year and Date: 2007-04-15
• [Presentation] 新規低酸素誘導遺伝子EFEMP2によるp53機能制御 (2007)
  • Author(s): 谷本 圭司
  • Organizer: 第5回がんとハイポキシア研究会
  • Place of Presentation: 柏
• [Book] Telomeres and Telomerase in Cancer (2009)
  • Author(s): Hiyama K ed.
  • Total Pages: 380
  • Publisher: Humana Press, Springer, New York, NY
• [Book] Telomere and telomerase for the regulation of stem cells(Rajasekhar VK, Vemuri MC(eds.), "Regulatory Networks in Stem Cells") (2009)
  • Author(s): Hiyama E, Hiyama K.
  • Publisher: Humana Press, Springer, New York, NY
• [Book] Telomeres and Telomerase in Cancer (2009)
  • Author(s): Hiyama K.
  • Total Pages: 380
  • Publisher: Springer (HUMANA press)
• [Book] Clinical application of molecular diagnosis in cancer, radiation effect, and human diseases (2009)
  • Author(s): Hiyama K.
  • Publisher: Research Signpost(印刷中)
• [Book] Regulatory networks in stem cells (2009)
  • Author(s): Hiyama E.
  • Publisher: Springer (HUMANA press)(印刷中)
• [Book] 熟練医から“日常診療のさまざまなコツ"を伝授 (2009)
  • Author(s): 檜山桂子
  • Total Pages: 261
  • Publisher: 南山堂
• [Book] Clinical application of molecular diagnosis in cancer, radiation effect, and human diseases
  • Author(s): Hiyama E and Hiyama K eds.
  • Publisher: Research Signpost, Kerala, India(in press)
• [Remarks] 食道正常上皮・癌細胞のマイクロアレイプロファイルデータベース登録 : GEO GES9982 2007.12.19.
  • URL: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE9982
• [Remarks] 不死化肺線維芽細胞のマイクロアレイプロファイルデータベース登録 : GEO GES9077 2007.9.18
  • URL: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE9077
• [Remarks] 不死化肺線維芽細胞のマイクロアレイプロファイル:GEO
  • URL: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE9077
• [Patent(Industrial Property Rights)] イリノテカンの感受性判定方法及びその利用 (2009)
  • Inventor(s): 西山正彦、檜山桂子、谷本圭司
  • Industrial Property Rights Holder: 学校法人埼玉医科大学
  • Filing Date: 2009-03-13
• [Patent(Industrial Property Rights)] 食道癌の予後診断マーカー遺伝子およびその利用 (2007)
  • Inventor(s): 西山正彦、檜山桂子、谷本圭司
  • Industrial Property Rights Holder: 国立大学法人広島大学
  • Filing Date: 2007-08-09
• [Patent(Industrial Property Rights)] ヒトがん細胞の不死化に関わる遺伝子およびその利用 (2007)
  • Inventor(s): 西山正彦、檜山桂子、谷本圭司、増子尋郎
  • Industrial Property Rights Holder: 国立大学法人広島大学、大鵬薬品工業株式会社
  • Filing Date: 2007-06-08
  • Overseas
• [Patent(Industrial Property Rights)] ヒトがん細胞の不死化に関わる遺伝子およびその利用 (2007)
  • Inventor(s): 西山正彦、檜山桂子、谷本圭司、増子尋郎
  • Industrial Property Rights Holder: 国立大学法人広島大学、大鵬薬品工業株式会社
  • Filing Date: 2007-06-08
  • Overseas