Exploration of the genes that repress indefinite proliferation of lung cancer cells
| Project/Area Number |
19590897
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
HIYAMA Keiko Hiroshima University, 原爆放射線医科学研究所, 准教授 (60253069)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 肺癌 / 不死化 / 分子標的 / テロメラーゼ / 抗癌剤 / 気道上皮 / 幹細胞 / 遺伝子導入 / 癌抑制遺伝子 |
|---|
| Research Abstract |
肺癌細胞株の網羅的発現解析により、肺癌の無限増殖を抑制する新たな分子標的候補を絞り込むと同時に、遺伝子導入により、その評価に有用な正常と不死化がん細胞の中間に位置すると考えられる気道上皮細胞を樹立した。これらは癌幹細胞にも有効な無限増殖を抑制する新たな抗癌剤の開発への展開が期待された。さらに、p16/RB経路の不活化のないテロメラーゼ活性化が幹細胞に由来する肺癌のマーカーである可能性を示した。
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Report
(3 results)
Research Products
(134 results)
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[Journal Article] Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors2008
Author(s)
Nakamura H, Tanimoto K, Hiyama K, Yunokawa M, Kawamoto T, Kato Y, Yoshiga K, Poellinger L, Hiyama E, Nishiyama M.
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Journal Title
DEC1 and DEC2. Oncogene 27
Pages: 4200-4209
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Peer Reviewed
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[Journal Article] Selection of a novel drug-response predictor in esophageal cancer : a novel screening method using microarray and identification of IFITM1 as a potent marker gene of CDDP response2007
Author(s)
Fumoto S, Shimokuni T, Tanimoto K, Hiyama K, Otani K, Ohtaki M, Hihara J, Yoshida K, Hiyama E, Noguchi T, Nishiyama M
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Journal Title
Int J Oncol 32
Pages: 413-423
NAID
Related Report
Peer Reviewed
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[Journal Article] A mathematical model for affymetrix genechip probe level data2007
Author(s)
Otani K, Hiyama K, Satoh K, Shimamoto T, Mohamad D, Ando M, Tonda T, Kohda M, Okazaki Y, Nishiyama M, Hiyama E, Ohtaki M
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Journal Title
JP Journal of Biostatics 1
Pages: 283-306
Related Report
Peer Reviewed
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[Presentation] EMP3, as a candidate of tumor suppressor gene for esophageal squamous cell carcinoma(ESCC)2008
Author(s)
Fumoto S, Tanimoto K, Arifin M, Noguchi T, Noguchi T, Hiyama E, Eguchi H, Nishiyama M, Hiyama K
Organizer
Annual Meeting of Am. Assoc. Cancer Res 2008
Place of Presentation
San Diego, CA, USA
Year and Date
2008-04-14
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[Presentation] EMP3 may be a tumor suppressor gene in late stage of neuroblastoma development. The Fifth International Symposium of 21^<st> Century COE Program2008
Author(s)
Fukuba I, Hiyama K, Kamimatsuse A, Tazaki T, Yamaoka H, Fukuda E, Arifin M, Fumoto S, Tanimoto K, Nishiyama M, Hiyama E
Organizer
Hiroshima University Radiation Casualty Medical Research Center
Place of Presentation
Hiroshima, Japan
Year and Date
2008-01-23
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[Presentation] Pharmacogenomic (PG) analysis for prediction of individual response to paclitaxel in 5-FU-refractory metastatic gastric cancer : Prediction formula of tumor response using novel marker genes and genotypes associated with the toxicity2007
Author(s)
Ikeda R, Yoshida K, Takagane A, Tsuburaya A, Kobayashi O, Sunouchi H, Matsukawa M, Tanimoto K, Hiyama K, Nishiyama M
Organizer
43^<rd> Annual Meeting of Am. Soc. Clin. Oncol.
Place of Presentation
Chicago, IL, USA
Year and Date
2007-06-03
Related Report
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[Presentation] Interferon induced transmembrane protein 1 (IFITM1) gene is a novel candidate as a CDDP sensitivity marker in esophageal squamous cell carcinoma (ESCC)2007
Author(s)
Fumoto S, Shimokuni T, Tanimoto K, Hiyama K, Noguchi T, Kawahara K, Otani K, Ohtaki M, Hiyama E, Nishiyama M
Organizer
98^<th> Annual Meeting of Am. Assoc. Cancer Res.
Place of Presentation
Los Angeles, CA, USA
Year and Date
2007-04-15
Related Report
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