| Project/Area Number |
19590898
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kochi University |
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Principal Investigator |
YOKOYAMA Akihito Kochi University, 教育研究部医療学系, 教授 (30191513)
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| Co-Investigator(Kenkyū-buntansha) |
KOHNO Nobuoki 広島大学, 医歯薬学総合研究科, 教授 (80215194)
HATTORI Noboru 広島大学, 医歯薬学総合研究科, 准教授 (00283169)
ISHIKAWA Nobuhisa 広島大学, 附属病院, 助教 (90423368)
IWAMOTO Hiroshi 高知大学, 教育研究部医療学系, 助教 (60457398)
SAKAI Mizu 高知大学, 医学部附属病院, 医員 (40403886)
OHNISHI Hiroshi 高知大学, 教育研究部医療学系, 助教 (90553876)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | MUC1ムチン / KL-6 / 急性呼吸窮迫症候群 / セレクチン / 汎発性血管内凝固症候群 / 成人呼吸促迫症候群 |
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| Research Abstract |
KL-6/MUC1 is a sensitive biomarker for interstitial pneumonias. We found KL-6/MUC1mucins with selectin ligand (designated as SLAK). SLAK was found to be significantly elevated in ARDS patients. Furthermore, SLAK was discovered to be a sensitive, specific and independent predictor for DIC complication in ARDS. Therefore, measurement of SLAK level at diagnosis may be able to predict accurately future complications of DIC in ARDS. Early intervention with anti-DIC medication such as low-molecular-weight heparin in the patients with elevated level of SLAK may improve the prognosis of ARDS, which is currently extremely poor.
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