Clinicopathological role of kl-6/muc1 with selectin ligand

• Project/Area Number: 19590898
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kochi University
• Principal Investigator: YOKOYAMA Akihito Kochi University, 教育研究部医療学系, 教授 (30191513)
• Co-Investigator(Kenkyū-buntansha): KOHNO Nobuoki 広島大学, 医歯薬学総合研究科, 教授 (80215194) ; HATTORI Noboru 広島大学, 医歯薬学総合研究科, 准教授 (00283169) ; ISHIKAWA Nobuhisa 広島大学, 附属病院, 助教 (90423368) ; IWAMOTO Hiroshi 高知大学, 教育研究部医療学系, 助教 (60457398) ; SAKAI Mizu 高知大学, 医学部附属病院, 医員 (40403886) ; OHNISHI Hiroshi 高知大学, 教育研究部医療学系, 助教 (90553876)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: MUC1ムチン / KL-6 / 急性呼吸窮迫症候群 / セレクチン / 汎発性血管内凝固症候群 / 成人呼吸促迫症候群

Research Abstract

KL-6/MUC1 is a sensitive biomarker for interstitial pneumonias. We found KL-6/MUC1mucins with selectin ligand (designated as SLAK). SLAK was found to be significantly elevated in ARDS patients. Furthermore, SLAK was discovered to be a sensitive, specific and independent predictor for DIC complication in ARDS. Therefore, measurement of SLAK level at diagnosis may be able to predict accurately future complications of DIC in ARDS. Early intervention with anti-DIC medication such as low-molecular-weight heparin in the patients with elevated level of SLAK may improve the prognosis of ARDS, which is currently extremely poor.

Research Products

• [Journal Article] Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis. (2010)
  • Author(s): Senoo T, Hattori N, Tanimoto T, Furonaka M, Ishikawa N, Fuji taka K, Haruta. Y, Murai H, Yokoyama A, Kohno N
  • Journal Title: Thorax 65 Pages: 334-40
• [Journal Article] Productive cough is an independent risk factor for the development of COPD in former smokers (2010)
  • Author(s): Yamane T, et al.
  • Journal Title: Respirology 15 Pages: 313-8
  • Peer Reviewed
• [Journal Article] Airflow Limitation in Smokers is Associated with Subcli ni cal Atherosclerosis. (2009)
  • Author(s): Iwamoto H, Yokoyama A, 他7名
  • Journal Title: Am J Respir Crit Care Med 479 Pages: 35-40
• [Journal Article] IL-42p40 is Essential for the Down-regulation of Airway Hyperresponsiveness in a Mouse Model of Bronchi al Asthma with Prolonged Antigen Exposure. (2009)
  • Author(s): Onari Y, Yokoyama A, 他5名
  • Journal Title: Clin Exp Allergy 39 Pages: 290-8
• [Journal Article] Genetic ablation of the Bach1 gene reduces hyperoxic lung injury in mice : role of IL-6 (2009)
  • Author(s): Tanimoto T, et al.
  • Journal Title: Free Radic Biol Med 46 Pages: 1119-26
  • Peer Reviewed
• [Journal Article] Lymphocyte transformation test is not helpful for the diagnosis of methotrexate-induced pneumonitis in patients with rheumatoid arthritis (2009)
  • Author(s): Hirata S, et al.
  • Journal Title: Clin Chim Acta 407 Pages: 25-9
  • Peer Reviewed
• [Journal Article] Immunohistochemi cal localization of surfactant proteins A and D, and KL-6 in pulmonary alveolar protei nos is. (2008)
  • Author(s): Ohtstuki Y, Kobayashi, M, Yoshida. S, Ki shi mot-N, Kubo K, Yokoyama A, Lee G-H, Furihata, M
  • Journal Title: Pathology 40 Pages: 536-539
• [Journal Article] Circulating KL-6/MUC1 as an independent predictor for disseminated intravascular coagulation in acute respiratory distress syndrome. (2008)
  • Author(s): Nakashima T, Yokoyama. A, 他6名
  • Journal Title: J Intern Med 263 Pages: 432-9
• [Journal Article] Usefulness of monitoring the circulating Krebs von den Lungen-6 levels to predict the clinical outcome of patients with advanced nonsmall cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors. (2008)
  • Author(s): Ishikawa N, Hattori N, Yokoyama A, 他9名
  • Journal Title: Int J Cancer 122 Pages: 2612-20
• [Journal Article] Suppressor of cytokine signalingl inhibits pulmonary inflammation and fibrosis. (2008)
  • Author(s): Nakashima T, Yokoyama A, 他7名
  • Journal Title: J Allergy Clin Immunol 121 Pages: 1269-76
• [Journal Article] Circulating KL-6/MUC1 as an independent predictor for disseminated intravascular coagulation in acute respiratory distress syndrome. (2008)
  • Author(s): Nakashima T, Yokoyama A, et al.
  • Journal Title: Journal of Internal Medicine 263 Pages: 432-439
  • Peer Reviewed
• [Journal Article] Circulating KL-6/MUC1 mucin carrying sialyl Lewisa oligcsaccharide is an independent prognostic factor in patients with lung adenocarcinoma (2007)
  • Author(s): Inata J, Hattori N, Yokoyama A, Ohshimo S, Doi M, Ishikawa N, Hamada H, Kohno N
  • Journal Title: Int J Cancer 120 Pages: 2643-2649
• [Journal Article] Circulating KL-6/MUCl as an independent predictor for disseminated intravascular coagulation in acute respiratory distress syndrome
  • Author(s): Nakashima T, Yokoyama A, et. al.
  • Journal Title: Journal of Internal Medicine (in press)
  • Peer Reviewed
• [Presentation] KL-6/MUCIの基礎と臨床. (2009)
  • Author(s): 横山彰仁
  • Organizer: 第68回日本癌学会学術総会ランチョンセミナー
  • Place of Presentation: 横浜
  • Year and Date: 20091001-20091003
• [Presentation] 間質性肺炎の血清マーカーUpToDate (2008)
  • Author(s): 横山彰仁
  • Organizer: 第61回日本呼吸器学会・日本結核病学会九州支部秋季学術講演会モーニングセミナー
  • Place of Presentation: 沖縄
  • Year and Date: 2008-11-07
• [Book] グッドパスチャー症候群。今日の治療指針2009(山口徹総編集) (2009)
  • Author(s): 横山彰仁
  • Total Pages: 598
  • Publisher: 医学書院、東京
• [Book] 「正常構造」「好酸球性肺炎」「肺性心」「アスピリン喘息」ほか。「まんがで読み解く呼吸器疾患100」(河野修興監修、横山彰仁、服部登編) (2009)
  • Author(s): 横山彰仁
  • Publisher: メディカルビュー者、東京