• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Pathologic roles of MIF in the development and progression ofglomerulonephritis and therapeutic applicatoin of MIF inhibition

Research Project

Project/Area Number 19590928
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionHokkaido University

Principal Investigator

SASAKI Satoshi  Hokkaido University, 北海道大学病院, 講師 (70312345)

Co-Investigator(Kenkyū-buntansha) ONODERA Shin  北海道大学, 大学院・医学研究科, 特任講師 (00359481)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords糸球体腎炎 / 腎不全 / サイトカイン / マクロフアージ遊走阻止因子 / CD74 / 慢性腎炎 / 情報伝達
Research Abstract

MIF(マクロファージ遊走阻止因子)は、自然免疫を司る上流因子として知られるが、最近様々な疾患の発症や進展に関わりが深い分子である事が数多く報告されている。本研究では、MIFが、MIF 受容体や幾つか関連分子(CD74 など)と結合した結果生まれる情報伝達が、腎臓疾患に関わる機構を明らかにする事を試みた。糸球体硬化症の動物モデルであるマウス腎症やシクロスポリン腎症のモデルを用いてMIF の腎炎における役割を研究を進める中、シクロスポリン腎症における新たな病態と治療法開発の可能性についても解明し得た。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (10 results)

All 2009 2008 2007

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Effective and safetreatment with cyclosporine innephrotic children : a prospective, randomized multicenter trial2008

    • Author(s)
      Ishikura K、Sasaki S、Honda M、他
    • Journal Title

      Kidney International 73

      Pages: 1167-1173

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pediatric kidneytransplantation is safe and availablefor patients with urological anomaliesas well as those with primary renaldiseases2008

    • Author(s)
      Morita K、Sasaki S、Nonomura K、他
    • Journal Title

      Pediatric Transplantation 13

      Pages: 200-205

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Active immunizationagainst macrophage migrationinhibitory factor using a nove dNAvaccine prevents ovariectomy-inducedbone loss in mice2008

    • Author(s)
      Onodera S、Oshima S、Koyama Y、他
    • Journal Title

      Vaccine 26

      Pages: 829-836

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effective and safe treatment with cyclosporine in nephrotic children : a prospective, randomized multicenter trial2008

    • Author(s)
      Ishikura K, Ikeda M, Hattori S, Yoshikawa N, Sasaki S, et.al.
    • Journal Title

      Kidney Int 73

      Pages: 1167-1173

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pediatric kidney transplantation is safe and available for patients with urological anomalies as well as those with primary renal diseases2008

    • Author(s)
      Morita K, Iwami D, Hotta K, Shimoda N, Sasaki S, et.al.
    • Journal Title

      Pediatr Transplant 13

      Pages: 200-205

    • NAID

      120005315202

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effective and safe treatment with cyclosporine in nephrotic children: A prospective, randomized multicenter trial2008

    • Author(s)
      Ishikura K, Sasaki S, et. al.
    • Journal Title

      Kidney Int (on line publication)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腎泌尿器疾患診療マニュアル小児から成人まで・主要症候・検査から腎尿路系疾患を見つけ出す・電解質異常Na・Clの異常(小児)2007

    • Author(s)
      佐々木聡
    • Journal Title

      日本医師会雑誌 36

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] エリスロポエチン誘導体は、シクロスポリン腎症の進展を抑制し得る2009

    • Author(s)
      伊東広臨、佐々木聡、岡本孝之、有賀正
    • Organizer
      第44回日本小児腎臓病学会
    • Place of Presentation
      東京都
    • Year and Date
      2009-06-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 重症ループスエリテマトーデス若年症例における低用量シクロフォスファミドパルス療法(EURO-Lupus)による寛解導入2008

    • Author(s)
      中島泰志、佐々木聡、伊東広臨、有賀正
    • Organizer
      第43回日本小児腎臓病学会
    • Place of Presentation
      福岡市
    • Year and Date
      2008-06-13
    • Related Report
      2008 Final Research Report
  • [Book] Annual Review 腎臓 2007(御手洗哲也ら編)2007

    • Author(s)
      佐々木 聡
    • Total Pages
      308
    • Publisher
      微小変化型ネフローゼ症候群とポドサイトB7-1 protein
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi