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Role of cytosolic phospholipase A2 in intrarenalrenin-angiotensin system

Research Project

Project/Area Number 19590934
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

SEKI George  The University of Tokyo, 医学部・附属病院, 講師 (30206619)

Co-Investigator(Kenkyū-buntansha) YAMADA Hideomi  東京大学, 医学部・附属病院, 助教 (60396752)
NOIRI Eisei  東京大学, 医学部・附属病院, 準教授 (00301820)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
KeywordsアンジオテンシンII / ERK / PLA2 / 腎近位尿細管 / cPLA2
Research Abstract

本研究の目的は腎近位尿細管輸送に対するアンジオテンシンII(Ang I)の二相性作用の細胞内情報伝達系を明らかにすることである。詳細な検討により低濃度Ang IIによる刺激作用はERK 経路に依存しており、一方高濃度Ang IIによる阻害作用はERK 経路には依存せずグループIV細胞内ホスホリパーゼA2/アラキドン酸代謝経路に依存することが示された。さらに腎近位尿細管では細胞内ホスホリパーゼA2/アラキドン酸代謝経路はERK経路に対して抑制的に働くことが明らかになった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (20 results)

All 2009 2008 2007

All Journal Article (16 results) (of which Peer Reviewed: 15 results) Presentation (4 results)

  • [Journal Article] Roles ofMEK/ERK pathway in vascular and renaltubular actions of angiotensin II2009

    • Author(s)
      Seki G, Yamada H, Li Y, Horita S, Ishizaka N, Koike K and Fujita T
    • Journal Title

      Vascular Disease Prevention 6

      Pages: 154-159

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Arachidonic acid metabolitesinhibit the stimulatory effect of angiotensin II in renal proximal tubules2008

    • Author(s)
      Li Y, Yamada H, Kita Y, Suzuki M, EndoY, Horita S, Yamazaki O, Shimizu T, SekiG, Fujita T
    • Journal Title

      Hypertension Res 31

      Pages: 2155-2164

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation and Inactivation Mechanisms of Na-HCO3 Cotransporter NBC12008

    • Author(s)
      Seki G, Yamada H, Horita S, Suzuki M, Sekine T, Igarashi T and Fujita T
    • Journal Title

      J Epithelial Biology and Pharmacology 1

      Pages: 35-39

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Roles ofAbnormal Renal Sodium Handling inHypertension Associated with MetabolicSyndrome2008

    • Author(s)
      Seki G, Yamada H, Li Y, Horita S, Suzuki M and Fujita T
    • Journal Title

      Current Hypertension Reviews 4

      Pages: 197-202

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of ERK and cPLA2in the angiotensin II-mediated biphasicregulation of Na + - HCO3 - transport2008

    • Author(s)
      Li Y, Yamada H, Kita Y, Kunimi M, Horita S, Suzuki M, Endo Y, Shimizu T,Seki G, Fujita T
    • Journal Title

      J Am Soc Nephrol 19

      Pages: 252-259

    • Related Report
      2008 Final Research Report
  • [Journal Article] Functionalanalysis of a novel missense NBC1mutation and of other mutations causingproximal renal tubular acidosis2008

    • Author(s)
      Suzuki M, Vaisbich M, Yamada H,Horita S, Li Y, Sekine T, Moriyama N,Igarashi T, Endo Y, Cardoso T, de Sa L,Koch H, Seki G, Fujita, T
    • Journal Title

      Pflugers Arch 455

      Pages: 583-593

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of CigaretteSmoking with Chronic Kidney Disease in Japanese men2008

    • Author(s)
      Ishizaka N, Ishizaka Y, Toda E,Shimomura H, Koike K, Seki G, Nagai R, Yamakado M
    • Journal Title

      Hypertension Res 31

      Pages: 485-492

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Roles of Abnormal Renal Sodium Handling in Hypertension Associated with Metabolic Syndrome2008

    • Author(s)
      Seki G et al.
    • Journal Title

      Current Hypertension Reviews 4

      Pages: 197-202

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation and Inactivation Mechanisms of Na-HCO3 Cotransporter NBCl2008

    • Author(s)
      Seki G et al.
    • Journal Title

      J Epithelial Biology and Pharmacology 1

      Pages: 35-39

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arachidonic acid metabolites inhibit the stimulatory effect of angiot ensin II in renal proximal tubules2008

    • Author(s)
      Li Y et al.
    • Journal Title

      Hypertension Res 31

      Pages: 2155-2164

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of ERK and cPLA2 in the angiotensin II-mediated biphasic regulation of Na+-HCO3-transport2008

    • Author(s)
      Li Y, et. al.
    • Journal Title

      J Am Soc Nephrol 19

      Pages: 252-259

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of a novel missense NBC1 mutation and of other mutations causing proximal renal tubular acidosis2008

    • Author(s)
      Suzuki M, et. al.
    • Journal Title

      Pflugers Arch 455

      Pages: 583-593

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction ofmembrane skeletal protein, protein 4.1Band p55 and sodium-bicarbonatecotransporter1 in mouse renal S1-S2proximal tubules2007

    • Author(s)
      Terada N, Ohno N, Saitoh S, Seki G, Komada M, Suzuki T, Yamakawa H, Soleimani M, Ohno S
    • Journal Title

      J Histochem Cytochem 55

      Pages: 1199-1206

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associationbetween Obesity and Chronic KidneyDisease in Japanese : Differences in Genderand Hypertensive Status?2007

    • Author(s)
      Ishizaka N, Ishizaka Y, Koike K, Seki G, Nagai R, Yamakado M
    • Journal Title

      Hypertension Res 30

      Pages: 1059-1064

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between Chronic KidneyDisease and Carotid Intima-MediaThickening in Individuals withHypertension and Impaired GlucoseMetabolism2007

    • Author(s)
      Ishizaka N, Ishizaka Y, Toda E, KoikeK, Seki G, Nagai R, Yamakado M
    • Journal Title

      Hypertension Res 30

      Pages: 1035-1041

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of membrane skeletal protein, protein 4.1B and p55 and sodium-bicarbonate cotransporterl in mouse renal S1-S2 proximal tubules2007

    • Author(s)
      Terada N, et. al.
    • Journal Title

      J Histochem Cytochem 55

      Pages: 1199-1206

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] PPARg/EGFR/ERK経路を介したチアゾリンの近位尿細管作用2008

    • Author(s)
      遠藤陽子、山田秀臣、李月紅、鈴木正志、山崎修、門脇孝、関常司、藤田敏郎
    • Organizer
      第51回日本腎臓学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-06-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Physiology and pathophysiology of Na-HCO3 cotransporter NBC12008

    • Author(s)
      Seki G, H Yamada
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-25
    • Related Report
      2008 Final Research Report
  • [Presentation] 酸・塩基平衡関連分子の臨床2007

    • Author(s)
      関常司、堀田晶子、鈴木正志、山田秀臣
    • Organizer
      第37回日本腎臓学会東部会
    • Place of Presentation
      埼玉
    • Year and Date
      2007-10-06
    • Related Report
      2008 Final Research Report
  • [Presentation] 酸・塩基平衡関連分子の臨床2007

    • Author(s)
      関 常司
    • Organizer
      日本腎臓学会東部会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2007-10-06
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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