Role and Action of New Stimulants and inhibitors on Bone Metabolism in Chronic Kidney Disease
| Project/Area Number |
19590950
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kobe University |
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Principal Investigator |
FUKAGAWA Masafumi Kobe University, 医学部附属病院, 准教授 (00211516)
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| Co-Investigator(Kenkyū-buntansha) |
HAMADA Yasuhiro 神戸大学, 医学部附属病院, 特定助教 (30397830)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 人工透析学 / 骨代謝 / 腎不全 / 副甲状腺ホルモン / 糖尿病 / 酸化ストレス / インドキシル硫酸 / 骨芽細胞 / AGE / RAGE / 賢不全 |
|---|
| Research Abstract |
慢性腎臓病(Chronic Kidney Disease: CKD)とその最大の原因である糖尿病における骨代謝異常の機序,特に骨の副甲状腺ホルモン(PTH)に対する抵抗性と骨芽細胞機能抑制の発症機序について検討したところ,尿毒症物質であるインドキシル硫酸が有機酸トランスポーターを通じて細胞内に入り,酸化ストレスを惹起して,PTHの作用を減弱させることを示した.また,酸化ストレスは,糖尿病における骨芽細胞機能低下にも大きな役割を果たしていることが,糖尿病動物モデルや抗酸化物質過剰発現マウスを用いた実験で明らかになった.これらの知見は,CKDおける骨回転の調節異常の治療法につながると考えられる.
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Report
(3 results)
Research Products
(60 results)
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[Journal Article] The calcimimetic R-568 retards progression of uremia-enhanced vascular calcification and atherosclerosis in apolipoprotein E deficient (apoE-/-) mice. Atherosclerosis2009
Author(s)
Ivanovski O, Nikolov IG, Joki N, Caudrillier A, Phan O, Mentaverri R, Maizel J, Nguyen-Khoa T, Fukagawa M, Kamel S, Lacour B, Drueke TB, Massy Z
Pages
0-0
Related Report
Peer Reviewed
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[Journal Article] Pharmacokinetic target for ciclosporin A-based regimens in renal transplantation: Implications of maintaining 1,25-dihydroxyvitamin D3 synthesis. Clin Transplant2009
Author(s)
Sato T, Fukagawa M, Uchida K, Katayama A, Nagasaka T, Matsuoka S, Goto N, Tominaga Y, Kobayashi T, Nakao A
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[Journal Article] Overexpression of thioredoxin 1 in transgenic mice suppresses development of diabetic nephropathy. Nephrol Dial Transplant2007
Author(s)
Hamada Y, Miyata S, Nii-Kono T, Kitazawa R, Kitazawa S, Higo S, Fukunaga M, Ueyama S, Nakamura H, Yodoi J, Fukagawa M, Kasuga M
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[Presentation] Functional induction of target genes in parathyroid cell by direct injection2008
Author(s)
Shiizaki K, Hatamura I, Nakazawa E, Saji F, Imazu Y, Watanabe Y, Ueda Y, Fukagawa M, Akizawa T, Kusano E
Organizer
American Society of Nephrology
Place of Presentation
Philadelphia, USA
Year and Date
2008-11-07
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