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Role and Action of New Stimulants and inhibitors on Bone Metabolism in Chronic Kidney Disease

Research Project

Project/Area Number 19590950
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionKobe University

Principal Investigator

FUKAGAWA Masafumi  Kobe University, 医学部附属病院, 准教授 (00211516)

Co-Investigator(Kenkyū-buntansha) HAMADA Yasuhiro  神戸大学, 医学部附属病院, 特定助教 (30397830)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords人工透析学 / 骨代謝 / 腎不全 / 副甲状腺ホルモン / 糖尿病 / 酸化ストレス / インドキシル硫酸 / 骨芽細胞 / AGE / RAGE / 賢不全
Research Abstract

慢性腎臓病(Chronic Kidney Disease: CKD)とその最大の原因である糖尿病における骨代謝異常の機序,特に骨の副甲状腺ホルモン(PTH)に対する抵抗性と骨芽細胞機能抑制の発症機序について検討したところ,尿毒症物質であるインドキシル硫酸が有機酸トランスポーターを通じて細胞内に入り,酸化ストレスを惹起して,PTHの作用を減弱させることを示した.また,酸化ストレスは,糖尿病における骨芽細胞機能低下にも大きな役割を果たしていることが,糖尿病動物モデルや抗酸化物質過剰発現マウスを用いた実験で明らかになった.これらの知見は,CKDおける骨回転の調節異常の治療法につながると考えられる.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (60 results)

All 2009 2008 2007 Other

All Journal Article (32 results) (of which Peer Reviewed: 32 results) Presentation (21 results) Book (7 results)

  • [Journal Article] The calcimimetic R-568 retards progression of uremia-enhanced vascular calcification and atherosclerosis in apolipoprotein E deficient (apoE-/-) mice. Atherosclerosis2009

    • Author(s)
      Ivanovski O, Nikolov IG, Joki N, Caudrillier A, Phan O, Mentaverri R, Maizel J, Nguyen-Khoa T, Fukagawa M, Kamel S, Lacour B, Drueke TB, Massy Z
    • Pages
      0-0
    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oral charcoal adsorbent (AST-120) prevents the progression of cardiac damage in chronic kidney disease through the suppression of oxidative stress. Nephrol Dial Transplant2009

    • Author(s)
      Fujii H, Nishijima F, Goto S, Sugano M, Yamato H, Kitazawa R, Kitazawa S, Fukagawa M
    • Pages
      0-0
    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetic target for ciclosporin A-based regimens in renal transplantation: Implications of maintaining 1,25-dihydroxyvitamin D3 synthesis. Clin Transplant2009

    • Author(s)
      Sato T, Fukagawa M, Uchida K, Katayama A, Nagasaka T, Matsuoka S, Goto N, Tominaga Y, Kobayashi T, Nakao A
    • Journal Title

      23

      Pages: 368-374

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thioredoxin-1 overexpression in transgenic mice attenuates streptozotocin-induced diabetic oeteoporosis: A novel role of oxidative stress and therapeutic implications. Bone2009

    • Author(s)
      Hamada Y, Fujii H, Kitazawa R, Yodoi J, Kitazawa S, Fukagawa M
    • Journal Title

      44

      Pages: 936-941

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cinacalcet (KRN 1493) effectively decreases serum intact PTH level with favorable control of serum phohphorus and calcium levels in Japanese dialysis patients. Nephrol Dial Transplant2008

    • Author(s)
      Fukagawa M, Yumita S, Akizawa T, Uchida E, Tsukamoto Y, Iwasaki M, Koshikawa S, and KRN1493 study group
    • Journal Title

      23

      Pages: 328-335

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct calcitriol or its analogue injection improves abnormal gene expression of hyperplastic parathyroid gland in secondary hyperparathyroidism. Am J Nephrol2008

    • Author(s)
      Shiizaki K, Fukagawa M, Yuan Q, Hatamura I, Nii-Kono T, Saji F, Shigematsu T, Akizawa T
    • Journal Title

      28

      Pages: 59-66

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone formation in the newly established non-obese type 2 diabetic model rats; Spontaneously Diabetic Torii (SDT) rats. Bone2008

    • Author(s)
      Fujii H, Hamada Y, Fukagawa M
    • Journal Title

      42

      Pages: 372-379

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of serum levels of calcium, phosphorus, and intact PTH on survival in chronic hemodialysis patients in Japan. Ther Aphr Dial2008

    • Author(s)
      Nakai S, Akiba T, Kazama JJ, Yokoyama K, Fukagawa M. Tominaga Y, Iseki K, Tsubakihara Y
    • Journal Title

      12

      Pages: 49-54

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of duodenal iron absorption in adenine-induced renal failure rats: a possible mechanism of iron deficiency in chronic kidney disease patients with erythropoietin treatment. Nephrol Dial Transplant2008

    • Author(s)
      Hamada Y, Nii-Kono T, Moriguchi Y, Higuchi M, Fukagawa M
    • Journal Title

      23

      Pages: 1886-1891

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum hepcidin as an indicator of iron status in dialysis patients. Ther Aphr Dial2008

    • Author(s)
      Tsuchihashi D, Abe T, Komaba H, Fujii H, Hamada Y, Nii-Kono T, Tanaka M, Fukagawa M
    • Journal Title

      12

      Pages: 226-231

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Putative role of asymmetric dimethylarginine in microvascular disease of kidney and heart in hypertensive patients, Am J Hypertension2008

    • Author(s)
      Fujii H, Takiuchi S, Kawano Y, Fukagawa M
    • Journal Title

      21

      Pages: 650-656

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Putative role of endothelial lipase in cardiovascular disease in dialysis patients with malnutrition and inflammation. Am J Nephrol2008

    • Author(s)
      Fujii H, Fukuda A, Tanaka M, Kojima Y, Ishida T, Hirata K, Fukagawa M
    • Journal Title

      28

      Pages: 974-981

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Percutaneous ethanol injection therapy for advanced renal hyperparathyroidism in Japan: A 2004 survey by the Japanese Society for Parathyroid Intervention. NDT Plus (Supple)2008

    • Author(s)
      Kakuta T, Fukagawa M, Kitaoka M, Koiwa F, Onoda N, Tominaga Y, Akizawa T, Kurokawa K
    • Journal Title

      1

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term prognosis (over 5 years) of parathyroid function in chronic dialysis patients after PEIT guided by ultrasonography. NDT Plus (Supple)2008

    • Author(s)
      Tanaka R, Kakuta T, Koiwa F, Fukagawa M, Saito A
    • Journal Title

      1

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between long-term efficacy of cinacalcet and parathyroid gland volume in haemodialysis patients with secondary hyperparathyroidism. NDT Plus (Supple)2008

    • Author(s)
      Tanaka M, Nakanishi S, Komaba H, Itoh K, Matsushita K, Fukagawa M
    • Journal Title

      1

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The whole-PTH/intact-PTH ratio is a useful predictor of severity of secondary hyperparathyroidism. NDT Plus (Supple)2008

    • Author(s)
      Tanaka M, Komaba H, Itoh K, Matsushita K, Matsushita K, Hamada Y, Fujii H, Fukagawa M
    • Journal Title

      1

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between the weight of parathyroid glands and their secretion of parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism. Ther Aphre Dial2008

    • Author(s)
      Kakuta T, Tanaka R, Kanai G, Miyamoto Y, Inagaki M, Suzuki H, Fukagawa M, Saito A
    • Journal Title

      12

      Pages: 385-390

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone formation in the newly established non-obese type 2 diabetic model rats ; Spontaneously Diabetic Torii (SDT)rats.2008

    • Author(s)
      Fujii H, et al
    • Journal Title

      Bone 42

      Pages: 372-379

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of duodenal iron absorption in adenine-induced renal failurerats : a possible mechanism of iron deficiency in chronic kidney disease patients with erythropoietin treatment.2008

    • Author(s)
      Hamada Y, et al
    • Journal Title

      Nephrol Dial Transplant 23

      Pages: 1886-1891

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between the weight of parathyroid glands and their secretion of parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism.2008

    • Author(s)
      Kakuta T, et al
    • Journal Title

      Ther Aphre Dial 12

      Pages: 385-390

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Putative role of asymmetric dimethylarginine in microvascular disease of kidney and heart in hypertensive patients.2008

    • Author(s)
      Fujii H, et al
    • Journal Title

      Am J Hypertens 21

      Pages: 650-656

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The wholo-PTH/intact-PTH ratio is a useful predictor of severity of secondary hyperparathyroidism.2008

    • Author(s)
      Tanaka M, et al
    • Journal Title

      NDT Plus 1 (Supple)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced dialysate calcium improves mineral metabolism in hemodialysis patients. Clin Nephrol2007

    • Author(s)
      Fujimori A, Yorifuji M, Sakai M, Fukagawa M
    • Journal Title

      67

      Pages: 20-24

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Possible role of thioredoxine interacting protein in the pathogenesis of streptozotocin-induced diabetic nephropathy. Kobe J Med Sci2007

    • Author(s)
      Hamada Y, Fukagawa M
    • Journal Title

      53

      Pages: 53-61

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Indoxyl sulfate induced skeletal resistance to PTH in osteoblastic cells, Kidney Int2007

    • Author(s)
      Nii-Kono T, Iwasaki Y, Yamato H, Fukagawa M
    • Journal Title

      71

      Pages: 738-743

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histomorphometric analysis of diabetic osteopenia in streptozotocin-induced diabetic mice: a possible role of oxidative stress. Bone2007

    • Author(s)
      Hamada Y, Kitazawa S, Kitazawa R, Fujii H, Kasuga M, Fukagawa M
    • Journal Title

      40

      Pages: 1408-1414

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of thioredoxin 1 in transgenic mice suppresses development of diabetic nephropathy. Nephrol Dial Transplant2007

    • Author(s)
      Hamada Y, Miyata S, Nii-Kono T, Kitazawa R, Kitazawa S, Higo S, Fukunaga M, Ueyama S, Nakamura H, Yodoi J, Fukagawa M, Kasuga M
    • Journal Title

      22

      Pages: 1547-1557

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fibroblast growth factor-23 (FGF-23) in patints with transient hypoparathyroidism: Its important role in serum phosphate regulation. Endocrine J2007

    • Author(s)
      Yamashita H, Yamazaki Y, Hasagawa H, Yamashita T, Fukumoto S, Shigematsu T, Kazama JJ, Fukagwa M, Noguchi S
    • Journal Title

      54

      Pages: 465-470

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between parathyroid hormone and cardiac abnormalities in chronic dialysis patients without cardiac disease, Internal Med2007

    • Author(s)
      Fujii H, Kim J-I, Abe T, Umezu M, Fukagawa M
    • Journal Title

      46

      Pages: 1507-1512

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Indoxyl sulfate induced skeletal resistance to PTH in osteoblastic cells2007

    • Author(s)
      Nii-Kono T, et. al.
    • Journal Title

      Kidney International 71

      Pages: 738-743

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histomorphometric analysis of diabetic osteopenia in streptozotocin-induced diabet ic mice: a possible role of oxidative stress2007

    • Author(s)
      Hamada Y, et. al.
    • Journal Title

      Bone 40

      Pages: 1408-1414

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of thioredoxin I in transgenic mice suppresses development of diabetic nephropathy2007

    • Author(s)
      Hamada Y, et. al
    • Journal Title

      Nephrol Dial Transplant 22

      Pages: 1547-1557

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] V International Symposium: Advances in Bone and Mineral Disorders in CKD2009

    • Author(s)
      Fukagawa M
    • Organizer
      FGF23, phosphate, and VDRE in dialysis
    • Place of Presentation
      Oviedo, Spain
    • Year and Date
      2009-05-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Workshop of Earthquake Related AKI, co-organized ISN COMGAN & Chinese Society of Nephrology2008

    • Author(s)
      Fukagawa M
    • Organizer
      Nephrology in earthquakes: Sharing experiences and information
    • Place of Presentation
      Chengdu, China
    • Year and Date
      2008-12-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Vitamin D receptor activator (VDRA) treatment attenuate increased oxidative stress in hemodialysis patients2008

    • Author(s)
      Tanaka M, Tokunaga T, Komaba H, Itoh K, Matsushita K, Maruyama T, Otagiri M, Fukagawa M
    • Organizer
      America Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2008-11-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Functional induction of target genes in parathyroid cell by direct injection2008

    • Author(s)
      Shiizaki K, Hatamura I, Nakazawa E, Saji F, Imazu Y, Watanabe Y, Ueda Y, Fukagawa M, Akizawa T, Kusano E
    • Organizer
      American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2008-11-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Different roles of oxidative stress and asymmetric dimethylarginine for the progression of diabetic nephropathy in the newly established non-obese type 2 diabetic model rata: Spontaneously Diabetic Torii (SDT) rats2008

    • Author(s)
      Fujii H, Hamada Y, Komaba H, Kitazawa R, Kitazawa S, Fukagawa M
    • Organizer
      American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2008-11-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Sevelamer hydrochloride elevates serum homocysteine levels through inhibiting absorption of folic acid in chronic dialysis2008

    • Author(s)
      Goto S, Fujii H, Kim J-I, Fukagwa M
    • Organizer
      American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2008-11-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Putative roles of receptors for AGEs (RAGE) in bone metabolism under non-diabetic and diabetic2008

    • Author(s)
      Hamada Y, Goto S, Komaba H, Fujii H, Fukagawa M
    • Organizer
      American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2008-11-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Treatment of various rebal involvements associated with multicentric Castleman's disease with anti-interleukin-6 receptor antibody (Tocilzumab)2008

    • Author(s)
      Komaba H, Nakazawa T, Tsuji G, Yamaguchi Y, Kumagai S, Fukagawa M
    • Organizer
      American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2008-11-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Putative roles of receptors for AGEs (RAGE) in bone metabolism under non-diabetic and diabetic condition2008

    • Author(s)
      Hamada Y, et al
    • Organizer
      American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Vitamin D receptor activator (VDRA)treatment attenuate increased oxidative stress in hemodialysis patients2008

    • Author(s)
      Tanaka M, el al
    • Organizer
      American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Functional induction of target genes in parathyroid cell by direct injection technique.2008

    • Author(s)
      Shiizaki K, et al
    • Organizer
      American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Sevelamer hydrochloride elevates serum homocycteine levels through in hibiting absorption of folic acid in chronic dialysis patients.2008

    • Author(s)
      Goto S, et al
    • Organizer
      American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Kidney dysfunction distuebs collagen maturation in adynamic bone disease as assessed by confocal laser raman spectroscopy2008

    • Author(s)
      Iwasaki Y, Yamato H, Fukagawa M
    • Organizer
      American Society for Bone and Mineral Research
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2008-09-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Functional induction of target genes in parathyroid cell by direct injection technique2008

    • Author(s)
      Shiizaki K, Hatamura I, Nalazawa E, Iwazu Y, Watanabe Y, Fukagawa M, Akizawa T, Kusano E
    • Organizer
      American Society for Bone and Mineral Research
    • Place of Presentation
      Montreal Canada
    • Year and Date
      2008-09-14
    • Related Report
      2008 Final Research Report
  • [Presentation] FGF-23 in CKD, ectopic calcification, post-transplantation hypophosphatemia, and nephrolitiasis.2008

    • Author(s)
      Fukagawa M
    • Organizer
      Symposium, XLV ERA-EDTA Congress
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2008-05-12
    • Related Report
      2008 Final Research Report
  • [Presentation] CKD-MBD in diabetes: from bench to bedside2008

    • Author(s)
      Fukagawa M
    • Organizer
      Updates on CKD-MBD, Korea University
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-04-26
    • Related Report
      2008 Final Research Report
  • [Presentation] PTH assay: from pronciple to practice2008

    • Author(s)
      Fukagawa M
    • Organizer
      Updates on CKD-MBD, Korea University, Seoul
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-04-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Overexpression of Thioredoxin-1, a Major Intracellular Antioxidant, Attenuates Streptozotocin-Induced Diabetic Osteopenia2007

    • Author(s)
      Hamada Y, et. al.
    • Organizer
      アメリカ腎臓学会
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2007-11-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] Asymmetric dimethylarginine reflects an incipient atherosclerosis in both kidney and heart2007

    • Author(s)
      Fujii H, Takiuchi S, Kawano Y, Fukagawa M
    • Organizer
      ERA-EDTA Congress
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2007-06-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Randomized, placebo-controlled trial of cinacalcet (KRN1493) in Japanese dialysis patients with more severe hyperparathyroidism and longer dialysis2007

    • Author(s)
      Fukagawa M, Yumita S, Akizawa T, Tsukamoto Y, Uchida E, Iwasaki M, Koshikawa S
    • Organizer
      ERA-EDTA Congress
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2007-06-22
    • Related Report
      2008 Final Research Report
  • [Presentation] 1-84PTH/intact PTH ratio is a useful predictor of the severity of secondary hyperparathyroidism2007

    • Author(s)
      Tanaka M, Itoh K, Matsushita K, Matsushita K, Hamada Y, Fujii H, Fukagawa M
    • Organizer
      ERA-EDTA Congress
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2007-06-22
    • Related Report
      2008 Final Research Report
  • [Book] Fluid & Electrolyte Disorders, in 2008 Current Medical Diagnosis & Treatment(McPhee SJ, Papadakis, MA)2009

    • Author(s)
      Cho KC, Fukagawa M, Kurokawa K
    • Publisher
      Lange Medical Books/McGrow Hill, New York
    • Related Report
      2008 Final Research Report
  • [Book] Fluid & Electrolyte Disorders, in 2008 Current Medical Diagnosis & Treatment(McPhee SJ, Papadakis, MA)2008

    • Author(s)
      Fukagawa M, Kurokawa K, Papadakis MA
    • Publisher
      Lange Medical Books/McGrow Hill, New York
    • Related Report
      2008 Final Research Report
  • [Book]2008

    • Author(s)
      Fukagawa M, Tanaka M
    • Publisher
      Hypophosphatemia, Encyclopedic reference of molecular mechanism of disease,
    • Related Report
      2008 Final Research Report
  • [Book] 副甲状腺インターペンションガイド2008

    • Author(s)
      副甲状腺インターペンション研究会
    • Total Pages
      64
    • Publisher
      文光堂
    • Related Report
      2008 Annual Research Report
  • [Book] Fluid & Electrolyte Disorders, in 2007 Current Medical Diagnosis & Treatment(Tierney LM Jr, McPhee SJ,Papadakis MA)2007

    • Publisher
      Lange Medical Books/McGrow Hill, New York
    • Related Report
      2008 Final Research Report
  • [Book] ガイドラインサポートブック:慢性腎臓病に伴う骨ミネラル代謝異常2007

    • Author(s)
      深川雅史
    • Total Pages
      344
    • Publisher
      医薬ジャーナル社
    • Related Report
      2007 Annual Research Report
  • [Book] Imaging of intervension pf parathyroid hyperplasia, in Spectrum of Renal Osteodystrophy and Vascular Caicification in Uremia( Olgaar K, Silver J, Salusky I)

    • Author(s)
      Komaba H, Tanaka M, Fukagawa M
    • Publisher
      Oxford University Press
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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