• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of hybrid kidney for removal of protein-bound anionic uremic toxins

Research Project

Project/Area Number 19590961
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionUniversity of Tsukuba

Principal Investigator

TSURUOKA Shuichi  University of Tsukuba, 大学院・人間総合科学研究科, 准教授 (50285798)

Co-Investigator(Kenkyū-buntansha) FUJIMURA Akio  自治医科大学, 医学部, 教授 (90156901)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords慢性腎不全 / バイオ人工臓器 / 尿毒症性物質 / 有機アニオン輸送体
Research Abstract

We developed hybrid kidney with renal cell over-expressed human organic anion transporters. We found that this system can selectively remove protein-bound uremic toxins, such as indoxyl sulfate, in animal model of chronic renal failure. We also found that some protein-bound uremic toxins directly stimulate proliferation of vascular smooth muscle cells in vitro.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (37 results)

All 2010 2009 2008 2007

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (15 results)

  • [Journal Article] Statins inhibited erythropoietininduced proliferation of rat vascular smooth muscle cells.2010

    • Author(s)
      Kaneda T, Tsuruoka S, Fujimura A.
    • Journal Title

      Eur J Pharmacol. 649

      Pages: 38-43

    • NAID

      120007137842

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recovery from acidosis : changes in anion exchanger distribution and expression are major components of reversible adaptation to metabolic acidosis in the cortical collecting duct.2010

    • Author(s)
      Purkerson JM, Tsuruoka S
    • Journal Title

      Kidney Int. 78

      Pages: 993-1005

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drug interaction between celecoxib and methotrexate in organic anion transporter 3-transfected renal cells and in rats in vivo.2010

    • Author(s)
      Maeda A, Tsuruoka S
    • Journal Title

      Eur J Pharmacol. 640

      Pages: 168-171

    • NAID

      120007137989

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drug interaction between celecoxib and methotrexate in organic anion transporter 3-transfected renal cells and in rats in vivo.2010

    • Author(s)
      Maeda A, Tsuruoka S., et al
    • Journal Title

      Eur J Pharmacol

      Volume: 640 Pages: 168-171

    • NAID

      120007137989

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recovery from acidosis : changes in anion exchanger distribution and expression are major components of reversible adaptation to metabolic acidosis in the cortical collecting duct.2010

    • Author(s)
      Purkerson JM, Tsuruoka S., et al.
    • Journal Title

      Kidney Int.

      Volume: 78 Pages: 993-1005

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] tatins inhibited erythropoietin-induced proliferation of rat vascular smooth muscle cells2010

    • Author(s)
      Kaneda T, Tsuruoka S, et al
    • Journal Title

      Eur J Pharmacol

      Volume: 649 Pages: 38-43

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypertension Induced by Erythropoietin Has a Correlation With Truncated Erythropoietin Receptor mRNA in Endothelial Progenitor Cells of Hemodialysis Patients.2009

    • Author(s)
      Ioka T, Tsuruoka S
    • Journal Title

      Clin Pharmacol Ther. 86(2)

      Pages: 154-159

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Basolateral Na(+)/H(+) exchange maintains potassium secretion during diminished sodium transport in the rabbit cortical collecting duct.2009

    • Author(s)
      Muto S, Tsuruoka S
    • Journal Title

      Kidney Int. 75(1)

      Pages: 25-30

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypertension Induced by Erythropoietin Has a Correlation With Truncated Erythropoietin Receptor mRNA in Endothelial Progenitor Cells of Hemodialysis Patients2009

    • Author(s)
      Ioka T, Tsuruoka S, Ito C, Iwaguro H, Asahara T, Fujimura F, Kusano E.
    • Journal Title

      Clin Pharmacol Ther. 86(2)

      Pages: 154-9

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Basolateral Na(+)/H(+) exchange maintains potassium secretion during diminished sodium transport in the rabbit cortical collecting duct2009

    • Author(s)
      Muto S, Tsuruoka S, Miyata Y, Fujimura A, Kusano E, Wang W, Seldin D, Giebisch G.
    • Journal Title

      Kidney Int. 75 (1)

      Pages: 25-30

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Basolateral Na(+)/H(+) exchange maintains potassium secretion during diminished sodium transport in the rabbit cortical collecting duct.2009

    • Author(s)
      Muto S, Tsuruoka S., et al
    • Journal Title

      Kidney Int. 75

      Pages: 25-30

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypertension Induced by Erythropoietin Has a Correlation With Truncated Erythropoietin Receptor mRNA in Endothelial Progenitor Cells of Hemodialysis Patients.2009

    • Author(s)
      Ioka T, Tsuruoka S., et al.
    • Journal Title

      Clin.Pharmacol.Ther. 86

      Pages: 154-159

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of Cd-induced inhibition of Na-glucose cotransporter in rabbit proximal tubule cells : Roles of luminal pH and membrane-bound carbonic anhydrase.2008

    • Author(s)
      Tsuruoka S, Swenson ER, Fujimura A, Imai M.
    • Journal Title

      Nephron Physiol. 110(2)

      Pages: 11-20

    • NAID

      120007138513

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human CYP3A4-introduced HepG2 cells : in vitro screening system of new chemicals for the evaluation of CYP3A4-inhibiting activity.2008

    • Author(s)
      Araki N, Tsuruoka S
    • Journal Title

      Xenobiotica. 38

      Pages: 1355-1364

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the interaction between nonsteroidal anti-inflammatory drugs and methotrexate using human organic anion transporter 3-transfected cells.2008

    • Author(s)
      Maeda A, Tsuruoka S
    • Journal Title

      Eur J Pharmacol. 31;596

      Pages: 166-172

    • NAID

      120007138515

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of Cd-induced inhibition of Na-glucose cotransporter in rabbit proximal tubule cells : Roles of luminal pH and membrane-bound carbonic anhydrase2008

    • Author(s)
      Tsuruoka S, Swenson ER, Fujimura A, Imai M.
    • Journal Title

      Nephron Physiol 110 (2)

      Pages: 11-20

    • NAID

      120007138513

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Mechanism of Cd-induced inhibition of Na-glucose cotransporter in rabbit proximal tubule cells: Roles of luminal pH and membrane-bound carbonic anhydrase.2008

    • Author(s)
      Tsuruoka S, Swenson ER, Fujimura A, Imai M.
    • Journal Title

      Nephron Physiol. 110 (2)

      Pages: 11-20

    • NAID

      120007138513

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dosing time-dependent variation of bone resorption by cyclosporin A in rats' femurs.2007

    • Author(s)
      Tsuruoka S, Kaneda T, Maeda A, Ioka T, Fujimura A.
    • Journal Title

      Eur J Pharmacol 564

      Pages: 226-231

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRPV4 as a flow sensor in flow-dependent K+ secretion from the cortical collecting duct.2007

    • Author(s)
      Taniguchi J, Tsuruoka S, Mizuno A, Sato J, Fujimura A, Suzuki M.
    • Journal Title

      Am J Physiol Renal Physiol 292

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRPV4 as a flow sensor in flow-dependent K+secretion from the cortical collecting duct.2007

    • Author(s)
      Taniguchi J, Tsuruoka S, ほか4名
    • Journal Title

      Am J Physiol Renal Physiol 292

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clearance of imidapril, an Angiotensin-converting enzyme inhibitor, during hemodialysis in hype2007

    • Author(s)
      Tsuruoka S, 他6名
    • Journal Title

      J Clin Pharmacol 47

      Pages: 259-263

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dosing time-dependent variation of bone resorption by cyclosporin A in rats' femurs.2007

    • Author(s)
      Tsuruoka S, 他6名
    • Journal Title

      Eur J Pharmacol 564

      Pages: 226-231

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Drug interaction between celecoxib and methotrexate in organic anion transporter 3-transfected renal cells and in rats.2010

    • Author(s)
      Maeda A, Tsuruoka S
    • Organizer
      American Society of Nephrology's 43rd Annual Renal Week
    • Place of Presentation
      Denver CO, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Future blood purification system for AKI with hepatic failure .2010

    • Author(s)
      Tsuruoka S, Omasa T, Enosawa S, Yamagata K.
    • Organizer
      International Session of The 55th Congress of Japanese Society for Dialysis Therapy
    • Place of Presentation
      Kobe, Hyogo
    • Related Report
      2010 Final Research Report
  • [Presentation] Future blood purification system for AKI with hepatic failure.2010

    • Author(s)
      Tsuruoka S., et al.
    • Organizer
      International Session of The 55th Congress of Japanese Society for Dialysis Therapy
    • Place of Presentation
      Kobe, Hyogo
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dosing Time-Dependent Variation of Bone Resorption by Cyclosporin A in Rats Femurs.2009

    • Author(s)
      Tsuruoka S, Kaneko S, Yamagata K, Fujimura A
    • Organizer
      American Society of Nephrology's 42nd Annual Renal Week
    • Place of Presentation
      San Diego CA, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Dosing Time-Dependent Variation of Bone Resorption by Cyclosporin A in Rats Femurs2009

    • Author(s)
      Tsuruoka S, Kaneko S, Yamagata K, Fujimura A.
    • Organizer
      American Society of Nephrology's 42nd Annual Renal Week
    • Place of Presentation
      San Diego CA, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Dosing Time-Dependent Variation of Bone Resorption by Cyclosporin A in Rats Femurs.2009

    • Author(s)
      Tsuruoka S., et al.
    • Organizer
      American Society of Nephrology's 42nd Annual Renal Week,
    • Place of Presentation
      San Diego CA, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evaluation of the interaction between nonsteroidal anti-inflammatory drugs and methotrexate using human organic anion transporter 3-transfected cells.2008

    • Author(s)
      Maeda A, Tsuruoka S
    • Organizer
      American Society of Nephrology's 41st Annual Renal Week
    • Place of Presentation
      Philadelphia, PA, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Statin suppresses erythropoietin (EPO)-induced proliferation of vascular smooth muscle cells in vitro.2008

    • Author(s)
      Kaneda A, Tsuruoka S, Fujimura A
    • Organizer
      American Society of Nephrology's 41st Annual Renal Week
    • Place of Presentation
      Philadelphia, PA, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Plasticity of Intercalated cells in the Cortical Collecting Duct : Amelioration of Acidosis Restores the Phenotype of beta-intercalated cells.2008

    • Author(s)
      Purkerson JM, Tsuruoka S, Schwartz GJ.
    • Organizer
      American Society of Nephrology's 41st Annual Renal Week
    • Place of Presentation
      Philadelphia,PA, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] スタチンはエリスロポエチンによる培養血管平滑筋細胞増殖を抑制する2008

    • Author(s)
      金田多絵、鶴岡秀一、藤村昭夫
    • Organizer
      第51回日本腎臓学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report
  • [Presentation] Statin suppresses erythropoietin (EPO)-induced proliferation of vascular smooth muscle cells in vitro2008

    • Author(s)
      Kaneda A, Tsuruoka S, Fujimura A.
    • Organizer
      American Society of Nephrology's 41st Annual Renal Week
    • Place of Presentation
      Philadelphia, PA, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Statin suppresses erythropoietin (EPO)-induced proliferation of vascular smooth muscle cells in vitro.2008

    • Author(s)
      Kaneda A, Tsurupka S, Fujimura A.,
    • Organizer
      American Society of Nephrology's 41st Annual Renal Week,
    • Place of Presentation
      Philadelphia, PA, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Klothoマウス(K)は接合尿細管(CNT)のPTH依存性Ca再吸収能が消失している。2007

    • Author(s)
      鶴岡 秀一, 他6名
    • Organizer
      第49回日本腎臓学会学術総会
    • Place of Presentation
      浜松
    • Year and Date
      2007-05-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Mechanism of cadmium(Cd)-induced Na-glucose cotransporter inhibition in isolated perfused rabbit proximal tubule cells : Roles of luminal pH and luminal membrane-bound carbonic anhydrase (CA).2007

    • Author(s)
      Tsuruoka S, Swenson ER, Fujimura A, Imai M.
    • Organizer
      American Society of Nephrology's 40th Annual Renal Week
    • Place of Presentation
      San Francisco CA, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Erythropoietin-related cGMP production inversely correlated with the ratio of EPO receptor subtype mRNA in circulating endothelial progenitor cells of HD patients and HUVECs.2007

    • Author(s)
      Ioka T., Tsuruoka S.
    • Organizer
      American Society of Nephrology's 40th Annual Renal Week
    • Place of Presentation
      San Francisco CA, USA
    • Related Report
      2010 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi