Investigation for the pathogenesis of neurological disorders due to Desert hedgehog gene mutation and development of new treatment
Project/Area Number |
19591000
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Kagoshima University |
Principal Investigator |
UMEHARA Fujio Kagoshima University, 大学院医歯学総合研究科, 講師 (20271140)
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Co-Investigator(Kenkyū-buntansha) |
HASHIGUCHI Teruto 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (70250917)
ARIMURA Kimiyoshi 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (30140908)
有村 公良 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (20159510)
|
Project Period (FY) |
2007 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | Desert hedgehog / 末梢神経障害 / 遺伝子治療 / シュワン細胞 / 遺伝子変異 / desert hedgehog / 末梢神経 / 再生医療 |
Research Abstract |
ヒトDHH遺伝子発現プラズミドの作成に成功し、COS細胞への遺伝子導入によるDHH蛋白の産生・分泌を確認したこと。さらに、このプラズミドをラット坐骨神経損傷モデルにおいて、intraneural injection を行い、その効果を検討した。ラット末梢神経損傷モデルにおいて、pHDHHの神経束内注入法では、一部には再生促進効果がみられたものの、対象に比べ統計学的に優位な再生促進効果は確認できていない。より有効な投与方法の改良が今後の課題である。
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Expression of the heparin-binding growth factor midkine in the cerebrospinal fluid of patients with neurological disorders2008
Author(s)
Yoshida Y, Ikematsu S, Muramatsu H, Sakakima H, Mizuma N, Matsuda F, Sonoda K, Umehara F, Ohkubo R, Matsuura E, Goto M, Osame M, Muramatsu T.
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Journal Title
Intern Med 47
Pages: 83-89
NAID
Related Report
Peer Reviewed
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[Journal Article] Inclusion body myositis associated with human T-lymphotropic virus-type I infection: eleven patients from an endemic area in Japan2008
Author(s)
Matsuura E, Umehara F*, Nose H, Higuchi I, Matsuoka E, Izumi K, Kubota R, Saito M, Izumo S, Arimura K, Osame M.
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Journal Title
J Neuropathol Exp Neurol 67
Pages: 41-49
Related Report
Peer Reviewed
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[Journal Article] Inclusion body myositis associated with human T-lymphotropic virus-type I infection : eleven patients from an endemic area in Japan.2008
Author(s)
Matsuura E, Umehara F^*, Nose H, Higuchi I, Matsuoka E, Izumi K, Kubota R, Saito M, Izumo S, Arimura K, Osame M.
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Journal Title
J Neuropathol Exp Neurol 67
Pages: 41-49
Related Report
Peer Reviewed
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[Journal Article] Inclusion body myositis associated with human T-lymphotropic virus-type I infection: eleven patients from an endemic area in Japan.2008
Author(s)
Matsuura E, Umehara F*, Nose H, Higuchi I, Matsuoka E, Izumi K, Kubota R, Saito M, Izumo S, Arimura K, Osame M.
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Journal Title
J Neuropathol Exp Neurol 67
Pages: 41-49
Related Report
Peer Reviewed
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[Journal Article] Expression of the heparin-binding growth factor midkine in the cerebrospinal fluid of patients with neurological disorderS.2008
Author(s)
Yoshida Y, Ikematsu S, Muramatsu H, Sakakima H, Mizuma N, Matsuda F, Sonoda K, Umehara F, Ohkubo R, Matsuura E, Goto M, Osame M, Muramatsu T.
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Journal Title
Intern Med 47
Pages: 83-89
NAID
Related Report
Peer Reviewed
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[Journal Article] Spinocerebellar ataxia with axonal neuropathy : consequence of a Tdp1 recessive neomorphic mutation2007
Author(s)
Hirano R, Interthal H, Huang C, Nakamura T, Deguchi K, Choi K, Bhattacharjee MB, Arimura K, Umehara F, Izumo S, Northrop JL, Salih MA, Inoue K, Armstrong DL, Champoux JJ, Takashima H, Boerkoel CF
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Journal Title
EMBO J. 26
Pages: 4732-4743
Related Report
Peer Reviewed
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