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Repetitive transcranial magnetic stimulation in Spinocerebellar Degeneration : Search for better methods using functional magnetic resonance imaging

Research Project

Project/Area Number 19591020
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKurume University

Principal Investigator

TANIWAKI Takayuki  Kurume University, 医学部, 教授 (80284496)

Co-Investigator(Kenkyū-buntansha) MURAOKA Norihiro  久留米大学, 医学部, 助教 (80352160)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords脊髄小脳変性症 / 反復経頭蓋磁気刺激 / 機能的MRI / 大脳基底核運動回路 / 小脳-大脳運動回路 / 運動課題 / ネットワーク解析 / 小脳-大脳運動皮質回路
Research Abstract

In order to know the best stimulation site of repetitive transcranial magnetic stimulation (rTMS) for spinocerebellar degeneration (SCD), we analyzed it using functional magnetic resonance imaging (fMRI). Twelve SCD patients were scanned while performing motor task. In SCD patients, network analysis showed significant interaction from the supplementary motor area (SMA) to the sensory motor cortex compared with control groups, suggesting the SMA as a best stimulation site for rTMS. Next, low-frequency rTMS over the SMA was performed in two SCD patients. Sub-analysis of International Cooperative Ataxia Rating Scale (ICRS) revealed that rTMS over SMA improved "Posture and Gait", and "Coordination movement in limbs" in SCD. These results suggested the efficiency and theoretical background of rTMS over SMA in SCD.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (31 results)

All 2010 2009 2008 2007 Other

All Journal Article (23 results) (of which Peer Reviewed: 19 results) Presentation (5 results) Remarks (3 results)

  • [Journal Article] 機能的MRI (fMRI)の応用2010

    • Author(s)
      谷脇考恭
    • Journal Title

      臨床神経生理学 38巻

      Pages: 50-59

    • NAID

      10027056721

    • Related Report
      2009 Final Research Report
  • [Journal Article] Dietary fat intake and risk of Parkinson's disease : a case-control study in Japan2010

    • Author(s)
      Miyake Y, 他13名, Fukuoka Kinki Parkinson's Disease Study Group(Taniwaki T)
    • Journal Title

      Journal of the Neurological Sciences 288

      Pages: 117-122

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 機能的MRI(fMRI)の応用2010

    • Author(s)
      谷脇考恭
    • Journal Title

      臨床神経生理学 38

      Pages: 50-59

    • NAID

      10027056721

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 運動発現の脳イメージング2009

    • Author(s)
      谷脇考恭
    • Journal Title

      久留米医学会雑誌 72巻

      Pages: 185-190

    • NAID

      130004388067

    • Related Report
      2009 Final Research Report
  • [Journal Article] Taniwaki T、Expansion of the phenotypic spectrum of SCA14 caused by the Gly128Asp mutation in PRKCG2009

    • Author(s)
      Miura S, 他9名
    • Journal Title

      Clinical Neurology Neurosurgery 111巻

      Pages: 211-215

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Taniwaki T、Machado-Joseph disease/SCA3 and myotonic dystrophy type 1 in a single patient2009

    • Author(s)
      Miura S, 他6名
    • Journal Title

      Clinical Neurology Neurosurgery 111巻

      Pages: 791-794

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expansion of the phenotypic spectrum of SCA14 caused by the Gly128Asp mutation in PRKCG2009

    • Author(s)
      Miura S, 他9名, Taniwaki T
    • Journal Title

      Clinical Neurology Neurosurgery 111

      Pages: 211-215

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Machado-Joseph disease/SCA3 and myotonic dystrophy type 1 in a single patient2009

    • Author(s)
      Miura S, 他6名, Taniwaki T
    • Journal Title

      Clinical Neurology Neurosurgery 111

      Pages: 791-794

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parkinsonism and ataxia associated with an intracranial dural arteriovenous fistula presenting with heperintense basal ganglia in T1- weighted MRI2009

    • Author(s)
      Miura S, 他7名, Taniwaki T
    • Journal Title

      Journal of clinical Neuroscience 16

      Pages: 341-343

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Symmetrical brainstem encephalitis caused by herpes simplex virus2009

    • Author(s)
      Miura S, 他4名, Taniwaki T
    • Journal Title

      Journal of clinical Neuroscience 16

      Pages: 589-590

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 運動発現の脳イメージング2009

    • Author(s)
      谷脇考恭
    • Journal Title

      久留米医学会雑誌 72

      Pages: 185-190

    • NAID

      130004388067

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Differential contributions of spinal and cortical motoneurons to input-output properties of human small hand muscle2008

    • Author(s)
      Oishi A, Tobimatsu S, Ogata K, Taniwaki T, 他3名
    • Journal Title

      Neurological Research 30巻

      Pages: 1106-1113

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hereditary motor and sensory neuropathy with proximal dominancy in the lower extremities, urinary disturbance, and paroxysmal dry cough2008

    • Author(s)
      Miura S, 他8名, Taniwaki T, Fukumaki Y
    • Journal Title

      Journal of the Neurological Sciences 273巻

      Pages: 88-92

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 162008

    • Author(s)
      Iwaki A, 他7名, Taniwaki T, Kira J, Fukumaki Y
    • Journal Title

      Journal of Medical Genetics 45巻

      Pages: 32-35

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 162008

    • Author(s)
      Iwaki A, 他7名, Taniwaki T, Kira J, Fukumaki Y
    • Journal Title

      Journal of Medical Genetics 45

      Pages: 32-35

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hereditary motor and sensory neuropathy with proximal dominancy in the lower extremities, urinary disturbance, and paroxysmal dry cough.2008

    • Author(s)
      Miura S, 他8名, Taniwaki T, Fukumaki Y
    • Journal Title

      Journal of the Neurological Sciences 273

      Pages: 88-92

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential contributions of spinal and cortical motoneurons to input-output properties of human small hand muscle.2008

    • Author(s)
      Oishi A, Tobimatsu S, Ogata K, Taniwaki T, 他3名
    • Journal Title

      Neurological Research 30

      Pages: 1106-1113

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraneuronal amyloid 42 enhanced by heating but counteracted by formic acid2007

    • Author(s)
      Ohyagi Y, Tsuruta Y, Motomura K, Miyoshi K, Kikuchi H, Iwaki T, Taniwaki T, 他1名
    • Journal Title

      Journal of Neuroscience Method 159巻

      Pages: 134-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered soleus responses to magnetic stimulation in pure cerebellar ataxia2007

    • Author(s)
      Kurokawa-Kuroda T、Ogata K、Suga R、Goto Y、Taniwaki T, 他2名
    • Journal Title

      Clinical Neurophysiology 118巻

      Pages: 1198-1203

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-related alterations of the functional interactions within the basal ganglia and cerebellar motor loops in vivo2007

    • Author(s)
      Taniwaki. T, 他10名
    • Journal Title

      Neuroimage 36巻

      Pages: 1263-1276

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-related alterations of the functional interactions within the basal ganglia and cerebellar motor loops in vivo2007

    • Author(s)
      Taniwaki.T, 他10名
    • Journal Title

      Neuroimage 36

      Pages: 1263-1276

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered soleus responses to magnetic stimulation in pure cerebellar ataxia2007

    • Author(s)
      Kurokawa-Kuroda T, Ogata K, Suga R, Goto Y, Taniwaki T, 他2名
    • Journal Title

      Clinical Neurophysiology 118

      Pages: 1198-1203

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraneuronal amyloid β42 enhanced by heating but counteracted by formic acid2007

    • Author(s)
      Ohyagi Y, Tsuruta Y, Motomura K, Miyoshi K, Kikuchi H, Iwaki T. Taniwaki T, 他1名
    • Journal Title

      Journal of Neuroscience Method 159

      Pages: 134-138

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 早期診断と鑑別診断(MRI、MIBG)2009

    • Author(s)
      谷脇考恭
    • Organizer
      Expert Meeting:パーキンソン病における脳機能評価
    • Place of Presentation
      東京
    • Year and Date
      2009-11-14
    • Related Report
      2009 Final Research Report
  • [Presentation] 早期診断と鑑別診断(MRI・MIBG)2009

    • Author(s)
      谷脇考恭
    • Organizer
      Expert Meeting : パーキンソン病における脳機能画像評価
    • Place of Presentation
      東京
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 機能的MRI (fMRI)の応用2009

    • Author(s)
      谷脇考恭
    • Organizer
      久留米医学会総会
    • Place of Presentation
      久留米
    • Year and Date
      2009-04-20
    • Related Report
      2009 Final Research Report
  • [Presentation] 機能的MRI(fMRI)の応用2009

    • Author(s)
      谷脇考恭
    • Organizer
      久留米医学会総会
    • Place of Presentation
      久留米
    • Year and Date
      2009-04-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脊髄小脳変性症における大脳基底核運動回路と小脳-大脳運動回路のネットワーク解析2007

    • Author(s)
      谷脇考恭、岡山晶、飛松省三、吉良潤一
    • Organizer
      第48回日本神経学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-05-17
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Remarks]

    • URL

      http://research.kurume-u.ac.jp/K10FRM.php

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://research.kurume-u.ac.jp/K10FRM.php

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://research.kurume-u.ac.jp/K10FRM.php

    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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