Dynamic neuropathology on cognition of the cases with pure Lewy body disease
Project/Area Number |
19591022
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurology
|
Research Institution | Tokyo Metropolitan Institute of Gerontology |
Principal Investigator |
SAITO Yuko Tokyo Metropolitan Institute of Gerontology, 研究員 (60344066)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 臨床神経形態学 / αシヌクレイン / アミロイドβ蛋白 / タウ / レビー小体 / 老人班 / 神経原線維変化 / 11C-PIB PET / 11C-CFT PET / レヴィー小体 / パーキンソン病 / 認知症 / 髓液バイオマーカー / PET |
Research Abstract |
純粋レビー小体病の認知障害について、臨床・画像・病理学的に明かにすることを目的とし、後方視研究をもとに前方視研究を行った。後方視的なデータ解析を行うことで、臨床例での純粋レビー小体病症例の抽出、認知障害の特徴、経過観察を行うことが可能となった。
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Report
(3 results)
Research Products
(91 results)
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[Journal Article] The incidence and extent of Lewy- body related alpha- synucleinopathy in human aging olfactory bulb2008
Author(s)
Sengoku R, Saito Y, Ikemura M, Sakiyama Y, Hatsuta H, Kanemaru K, Sawabe M, Arai T, Mochizuki H, Inoue K, Murayama S
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Journal Title
J Neuropath Exp Neurol 67
Pages: 1072-1083
Related Report
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[Journal Article] Lewy body pathology involves cutaneous nerves2008
Author(s)
Ikemura M, Saito Y, Sengoku R, Sakiyama Y, Hatsuta H, Kanemaru K, Sawabe M, Arai T, Ito G, Iwatsubo T, Fukayama M, Murayama S
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Journal Title
J Neuropath Exp Neurol 67
Pages: 945-953
Related Report
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[Journal Article] Presynaptic and postsynaptic nigrostriatal dopaminergic functions in multiple system atrophy2008
Author(s)
Hashimoto M, Kawasaki K, Suzuki M, Mitani K, Murayama S, Mishina M, Oda K, Kimura Y, Ishiwata K, Ishii K, Inoue K
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Journal Title
Neuroreport 19
Pages: 145-150
Related Report
Peer Reviewed
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[Journal Article] Lewy body pathology involves cutaneous nerves2008
Author(s)
Ikemura M, Saito Y, Sengou R, Sakiyama Y, Hatsuta H, Kanemaru K, Sawabe M, Arai T, Ito G, Iwatsubo T, Fukayama M, Murayama S
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Journal Title
J Neuropath Exp Neurol 67
Pages: 945-953
Related Report
Peer Reviewed
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[Journal Article] Prostaglandin D2 receptor, DP1 is selectively up-regulated in microglia and astrocytes within senile plaques from human patients and a mouse model of Alzheimer's disease2007
Author(s)
Mohri I, Kadoyama K, Kanekiyo T, Sato Y, Kagitani-Shimono K, Saito Y, Suzuki K, Kudo T, Takeda M, Urade Y, Murayama S, Taniike M
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Journal Title
J Neuropath Exp Neurol 66
Pages: 469-480
Related Report
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[Journal Article] Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in Lesy body disease2007
Author(s)
Fumimura Y, Ikemura M, Saito Y, Sengoku R, Kanemaru K, Sawabe M, Arai T, Ito G, Iwatsubo T, Fukayama M, Mizusawa H, Murayama S
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Journal Title
J Neuropath Exp Neurol 66
Pages: 469-480
Related Report
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[Journal Article] Interleukin-1 upregulates TACE to enhance α-cleavage of APP in neurons : resulting decrease in A Production2007
Author(s)
Tachida Y, Nakagawa K, Saito T, Saido TC, Honda T, Saito Y, Murayama S, Endo T, Sakaguchi G, Kato A, Kitazume S, Hashimoto Y
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Journal Title
J Neurochem 104
Pages: 1387-1393
Related Report
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[Journal Article] Prostaglandin D_2 receptor, DP_1 is selectively up-regulated in microglia and astrocytes within senile plaques from human patients and a mouse model of Alzheimer's disease2007
Author(s)
Mohri I, Kadoyama K, Kanekiyo T, Sato Y, Kagitani-Shimono K, Saito Y, Suzuki K, Kudo T, Takeda M, Urade Y, Murayama S, Taniike
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Journal Title
J Neuropath Exp Neurol 66
Pages: 469-480
Related Report
Peer Reviewed
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[Presentation] The incidence and extent of Lewy- body related alpha- synucleinopathy in human aging olfactory bulb2008
Author(s)
Sengoku R, Saito Y, Ikemura M, Sakiyama Y, Hatsuta H, Kanemaru K, Sawabe M, Arai T, Mochizuki H, Inoue K, Murayama S
Organizer
2008 Annual Meeting of the American Association for Neuropathologists
Place of Presentation
SanDiego, U.S.A
Year and Date
2008-04-08
Related Report
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[Presentation] 高齢者認知症の原因としてのいわゆる海馬硬化とは? (会)2008
Author(s)
齊藤祐子, 池村雅子, 崎山快夫, 足立正, 仙石錬平, 初田裕幸, 山寺みさき, 沢辺元司, 徳丸阿耶, 金丸和富, 村山繁雄
Organizer
第49回日本神経病理学会総会学術研究会
Place of Presentation
東京
Related Report
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[Presentation] Characterization of therapeutic antibody against Aβ oligomers for Alzheimer's disease2007
Author(s)
Sun, H., Okamoto Y., Kawarabayashi, Kawarabayashi, T., Yokoseki, T., M. Shibata, M., Morishima, Saito, Y., Murayama, S., Ihara, Y., Shoji, M., Hoji, M., Michikawa, M., Matsubara, E.
Organizer
2007 Society for Neuroscience
Place of Presentation
San Diego
Year and Date
2007-11-05
Related Report
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[Presentation] The Brain Bank for Aging Research2007
Author(s)
Murayama S, Saito Y, et. al. Kanamaru K, Ishii K, Tokumaru A
Organizer
2007 World Congress of International Brain Research Organization, Melbourne
Place of Presentation
Melbourne
Year and Date
2007-07-14
Related Report
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[Presentation] 高齢者ブレインバンク、年次報告2007
Author(s)
齊藤 祐子, 崎山 快夫, 仙石 錬平, 初田 裕幸, 池村 雅子, 金丸 和富, 加藤 貴行, 徳丸 阿耶, 石井 賢二, 村山 繁雄
Organizer
第47回日本神経病理学会総会
Place of Presentation
東京
Year and Date
2007-05-30
Related Report
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[Presentation] アミロイド・イメージング (会)2007
Author(s)
石井賢二, 橋本昌也, 石渡喜一, 木村裕一, 織田圭一, 齊藤祐子, 徳丸阿耶, 金丸和富, 村山繁雄
Organizer
第48回日本神経学会総会
Place of Presentation
名古屋
Year and Date
2007-05-16
Related Report
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