Mutations in genes encoding the K_<ATP> channel and their influence on efficacy of insulinotropic agents.
Project/Area Number |
19591047
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
|
Research Institution | Kyoto University |
Principal Investigator |
NAGASHIMA Kazuaki Kyoto University, 大学院・医学研究科, 助教 (40324628)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 糖尿病学 / 糖尿病 / 遺伝子 / 薬剤反応性 |
Research Abstract |
Kir6.2, together with SUR1, forms an ATP-sensitive potassium (K_<ATP>) channel that plays a key role in insulin secretion from pancreatic ss-cells. In this study, we carried out functional analyses including electrophysiological analysis, and found significant differences in ATP-sensitivity, sulfonylurea-sensitivity, and membrane surface expression among the mutants. Furthermore, it is possible to evaluate the potential efficacy of these insulinotropic agents in patients with the mutation by using in vitro analyses.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species2010
Author(s)
Fujita Y, Hosokawa M, Fujimoto S, Mukai E, Abudukadier A, Obara A, Ogura M, Nakamura Y, Toyoda K, Nagashima K, Seino Y, Inagaki N.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism2010
Author(s)
Shimodahira M, Fujimoto S, Mukai E, Nakamura Y, Nishi Y, Sasaki M, Sato Y, Sato H, Hosokawa M, Nagashima K, Seino Y, Inagaki N.
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Journal Title
J Endocrinol 204(1)
Pages: 37-46
Related Report
Peer Reviewed
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[Journal Article] Sulfonylurea and glinide reduce insulin content, functional expression of KATP channels, and accelerate apoptotic β-cell death in the chronic phase2007
Author(s)
Takahashi A, Nagashima K, Hamasaki A, Kuwamura N, Kawasaki Y, Ikeda H, Yamada Y, Inagaki N, Seino Y.
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Journal Title
Diabetes Res Clin Pract 77(3)
Pages: 343-50
Related Report
Peer Reviewed
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[Book] 治療学2010
Author(s)
長嶋一昭
Total Pages
4
Publisher
ライフサイエンス出版
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