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Development of a new approach to therapy for diabetes mellitus using leptin

Research Project

Project/Area Number 19591048
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionKyoto University

Principal Investigator

EBIHARA Ken  Kyoto University, 医学研究科, 産学官連携講師 (70362514)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsレプチン / 2型糖尿病 / ストレプトゾトシン / 高脂肪食 / レプチン抵抗性 / AMPK / メラノコルチン
Research Abstract

2型糖尿病におけるレプチンの抗糖尿病薬としての有用性についてストレプトゾトシンと高脂肪食負荷による2型糖尿病モデルマウス(STZ/HFDマウス)を作製し検討した。またレプチンの糖脂質代謝改善における作用メカニズムについて脂肪萎縮症モデルA-ZIPマウスにおける骨格筋および肝臓におけるAMPK活性を検討した。今回の検討により、2型糖尿病におけるレプチンの抗糖尿病薬としての有用性が示された。またレプチンは骨格筋のみならず肝臓AMPKに対しても活性化作用を示し、作用メカニズムの一部を担っている者と考えられた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (30 results)

All 2009 2008 2007 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (18 results) Remarks (1 results)

  • [Journal Article] Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet2009

    • Author(s)
      T. Kusakabe, K. Ebihara, K. Nakao
    • Journal Title

      Diabetologia 52

      Pages: 675-683

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Orexins increase mRNA expressions of neurotrophin-3 in rat primary cortical neuron cultures2009

    • Author(s)
      N. Yamada, K. Ebihara, K. Nakao
    • Journal Title

      Neurosci Lett 30

      Pages: 132-135

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet.2009

    • Author(s)
      Tom Kusakabe, Ken Ebihara, et al.
    • Journal Title

      Diabetologia 52

      Pages: 675-683

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orexins increase mRNA expressions of neurotrophin-3 in rat primary cortical neuron cultures.2009

    • Author(s)
      Nobuko Yamada, Ken Ebihara, et al.
    • Journal Title

      Neurosci Lett 30

      Pages: 132-135

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orexin decreases mRNA expressions of NMDA and AMPA receptor subunits in rat primary neuron cultures2008

    • Author(s)
      N. Yamada, K. Ebihara, K. Nakao
    • Journal Title

      Peptides 29

      Pages: 1582-1587

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Orexin decreases mRNA expressions of NMDA and AMPA receptor subunits in rat primary neuron cultures.2008

    • Author(s)
      Nobuko Yamada, Ken Ebihara, et al.
    • Journal Title

      Peptides 29

      Pages: 1582-1587

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-fat diet impairs the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle2007

    • Author(s)
      S. Tanaka, K. Ebihara, K. Nakao
    • Journal Title

      Metabolism 56

      Pages: 1719-1728

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Central melanocortin signaling restores skeletal muscle AMP-activated protein kinase phosphorylation in mice fed a high-fat diet2007

    • Author(s)
      T. Tanaka, K. Ebihara, K. Nakao
    • Journal Title

      Cell Metab 55

      Pages: 395-402

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of acute activation of 5'-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle2007

    • Author(s)
      L. Miyamoto, K. Ebihara, K. Nakao
    • Journal Title

      J Appl Physiol 102

      Pages: 1007-1013

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy2007

    • Author(s)
      K. Ebihara, K. Nakao
    • Journal Title

      J Clin Endocrinol Metab 92

      Pages: 532-541

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Central Melanocortin Signaling Restores Skeletal Muscle AMP-Activated Protein Kinase Phosphorylation in Mice Fed a High-Fat diet2007

    • Author(s)
      Tanaka T, Ebihara K, et. al.
    • Journal Title

      Cell Metab 5

      Pages: 395-402

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肥満を伴った糖尿病モデルマウスにおけるレプチンの治療効果2008

    • Author(s)
      青谷大介
    • Organizer
      第29回日本肥満学会
    • Place of Presentation
      大分
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Dunnigan型家族性部分性脂肪萎縮症日本人症例におけるLMNA遺伝子変異の同定2008

    • Author(s)
      海老原健
    • Organizer
      第29回日本肥満学会
    • Place of Presentation
      大分
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] メタボリックシンドロームにおける改良Dual VF-BIA法による経時的内臓脂肪蓄積測定の臨床的意義2008

    • Author(s)
      平田雅一
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] もやもや病を合併した部分型脂肪委縮性糖尿病の1例2008

    • Author(s)
      陳文
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 肥満を伴った糖尿病モデルマウスにおけるレプチンの治療効果2008

    • Author(s)
      青谷大介
    • Organizer
      第81回日本内分泌学会学術総会
    • Place of Presentation
      青森
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Outcome from leptin therapy for five years in Japanese patients with generalized lipodystrophy.2008

    • Author(s)
      Daisuke Aotani, Ken Ebihara, et al.
    • Organizer
      ICE08
    • Place of Presentation
      リオデジャネイロ
    • Related Report
      2008 Annual Research Report
  • [Presentation] Leptin treatment Enhances Insulin Sensitivity and Improves Glucose and Lipid Metabolism in a Mouse Model of Type2 Diabetes.2008

    • Author(s)
      Toru Kusakabe, Ken Ebihara, et al.
    • Organizer
      ENDO08
    • Place of Presentation
      サンフランシスコ
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Efficacy of Leptin Treatment on Glucose and Lipid Metabolism in a Mouse Model of Type 2 Diabetes.2007

    • Author(s)
      Kusakabe T, Ebihara K, et. al.
    • Organizer
      ENDO 07
    • Place of Presentation
      トロント
    • Year and Date
      2007-06-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] レプチンと脂肪毒性2007

    • Author(s)
      海老原健
    • Organizer
      第28回日本肥満学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] メタボリックシンドロームにおける改良Dual VF-BIA法による経時的内臓脂肪蓄積測定の臨床的意義2007

    • Author(s)
      平田雅一
    • Organizer
      第28回日本肥満学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 2型糖尿病モデルマウスにおけるレプチンの摂食・体重調節、糖脂質代謝改善作用2007

    • Author(s)
      日下部徹
    • Organizer
      第28回日本肥満学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 全身性脂肪萎縮症に対するレプチン補償療法の食欲抑制効果2007

    • Author(s)
      髭秀樹
    • Organizer
      第28回日本肥満学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 脂肪萎縮症における組織内中性脂肪含有量に対するレプチンの治療効果2007

    • Author(s)
      青谷大介
    • Organizer
      第80回日本内分泌学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 2型糖尿病におけるレプチンの糖脂質代謝改善作用の検討2007

    • Author(s)
      日下部徹
    • Organizer
      第80回日本内分泌学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒトにおけるレプチンの生理的意義2007

    • Author(s)
      海老原健
    • Organizer
      第50回日本糖尿病学会年次学術集会
    • Place of Presentation
      仙台
    • Related Report
      2008 Final Research Report
  • [Presentation] 内臓脂肪蓄積に基づく腹部肥満判定基準のIDFおよびAHA/NHBIメタリックシンドローム診断基準での利用の妥当性の検討2007

    • Author(s)
      平田雅一
    • Organizer
      第50回日本糖尿病学会年次学術集会
    • Place of Presentation
      仙台
    • Related Report
      2008 Final Research Report
  • [Presentation] 先天性全身性脂肪萎縮症における原因遺伝子の検討2007

    • Author(s)
      髭秀樹
    • Organizer
      第50回日本糖尿病学会年次学術集会
    • Place of Presentation
      仙台
    • Related Report
      2008 Final Research Report
  • [Presentation] 2型糖尿病に対するレプチンの糖尿病治療薬としての有用性の検討2007

    • Author(s)
      日下部徹
    • Organizer
      第50回日本糖尿病学会年次学術集会
    • Place of Presentation
      仙台
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~med2/index-jp.html

    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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