HDL generation as an effector against inflammation and atherosclerosis
Project/Area Number |
19591063
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Nagoya City University |
Principal Investigator |
ABE-DOHMAE Sumiko Nagoya City University, 大学院・医学研究科, 准教授 (70227700)
|
Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Shinji 名古屋市立大学, 大学院・医学研究科, 教授 (10142192)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | HDL / ABCA1 / ABCA7 / SAA |
Research Abstract |
各種培養細胞および遺伝子改変マウスを用い、α1アドレナリンレセプター阻害薬doxazosinのHDL上昇作用ならびに急性期反応における血中SerumamyloidAの濃度上昇が、いずれもABCA1を介したアポリポタンパク質依存性HDL新生反応の結果であることを示し、各々のメカニズムを明らかにした
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines2008
Author(s)
Nishimaki-Mogami T, Tamehiro N, Sato Y, Okuhira KI, Sai K, Kagechika H, Shudo K, Abe-Dohmae S, Yokoyama S, Ohno Y, Inoue K, and Sawada JI
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Journal Title
Biochem Pharmacol 76
Pages: 1006-1013
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[Presentation] 急性炎症期のS晶産生2007
Author(s)
胡魏, 堂前純子, 岩本紀之, 荻久保修, 大塚隆信, 横山信治
Organizer
血中濃度上昇とABCA1
Place of Presentation
浜松
Year and Date
2007-10-25
Related Report
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