• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effect of thyroid hormone on bone formation and metabolism by regulating the expression of the calcineurin-regulating protein

Research Project

Project/Area Number 19591074
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionNagoya University

Principal Investigator

MURATA Yoshiharu  Nagoya University, 環境医学研究所, 教授 (80174308)

Co-Investigator(Kenkyū-buntansha) KANOU Yasuhiko  名古屋大学, 環境医学研究所, 助教 (50252292)
TAKAGISHI Yoshiko  名古屋大学, 環境医学研究所, 助教 (50024659)
HAYASHI Yoshitaka  名古屋大学, 環境医学研究所, 准教授 (80420363)
KAMBE Fukushi  名古屋大学, 環境医学研究所, 准教授 (00211871)
Research Collaborator WILLIAMS Graham  インペリアルカレッジロンドン校, 教授
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords甲状腺ホルモン / カルシニューリン / ノックアウトマウス / 骨形成 / 骨代謝 / RCAN2 / 骨
Research Abstract

甲状腺ホルモン(T3)は骨の形成・代謝に大きな影響を及ぼす.T3 により発現が増加するRCAN2は、骨の形成・代謝にも重要な作用を及ぼすカルシニューリンの調節蛋白であることから、T3の骨に対する作用がRCAN2 発現調節を介するものであるかを検討した.その結果、新生仔期に於いてはT3 が骨でのRCAN2 発現を調節し、RCAN2 ノックアウトマウスで骨形成が遅延することが示された.したがって、新生仔期におけるT3 の骨形成に対する作用の一部はRCAN2 の発現調節を介していると考えられた.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (18 results)

All 2009 2008 2007 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (3 results) Remarks (2 results)

  • [Journal Article] Folic acid prevents congenital malformations in the offspring of diabetic mice2009

    • Author(s)
      Oyama K, Murata Y(7人中7番目), 他5名
    • Journal Title

      Endocrine Journal 56

      Pages: 29-37

    • NAID

      10025610068

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term amiodarone treatment causes cardioselective hypothyroid-like alteration in gene expression profile2008

    • Author(s)
      Shi R, Lee J-K, Hayashi Y, Takeuchi Y, Kambe F, Futaki S, Seo H, Murata Y, Kodama I
    • Journal Title

      European Journal of Pharmacology 578(2-3)

      Pages: 270-278

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Insertion of an intracisternal A particle retrotransposon element in plasma membrane calcium ATPase 2 gene attenuates its expression and produces an ataxic phenotype in joggle mutant mice2008

    • Author(s)
      Sun X-y, Chen Z-y, Hayashi Y, Kanou Y, Takagishi Y, Oda S, Murata Y
    • Journal Title

      Gene 411(1-2)

      Pages: 94-102

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of genes differentially expressed in mouse fetuses form streptozotocin-induced diabetic pregnancy by cDNA subtraction2008

    • Author(s)
      Sato N, Sugimura Y, Hayashi Y, Murase T, Kanou Y, Kikkawa F, Murata Y
    • Journal Title

      Endocrine Journal 55(2)

      Pages: 317-323

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of genes differentially expressed in mouse fetuses form streptozotocin-induced diabetic pregnancy by cDNA subtraction2008

    • Author(s)
      Sato N, Murata Y(7人中7番目), 他5名
    • Journal Title

      Endocrine Journal 55

      Pages: 317-323

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of aquaporin-3 (AQP3) in the epidermis of DHCR24 knockout mice2008

    • Author(s)
      Mirza R, Murata Y (7人中6番目), 他5名
    • Journal Title

      British Journal of Dermatology 158

      Pages: 679-684

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ong-term amiodarone treatment causes cardioselective hypothyroid-like alteration in gene expression profile.2008

    • Author(s)
      Shi R-q, Murata Y(9人中8番目)他7名
    • Journal Title

      European Journal of Pharmacology 578・2-3

      Pages: 270-278

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insertion of an intracisternal A particle retrotransposon element in plasma membrane calcium ATPase 2 gene attenuates its expression and produces an ataxic phenotype in joggle mutant mice.2008

    • Author(s)
      Sun X-y, Murata Y(7人中7番目)他5名
    • Journal Title

      Gene 411

      Pages: 94-102

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity2007

    • Author(s)
      Kanou Y, Hishinuma A, Tsunekawa K, Seki K, Mizuno Y, Fujisawa H, Imai T, Miura Y, Nagakawa T, Yamada C, Ieiri T, Murakami M, Murata Y
    • Journal Title

      Journal of Clinical Endocrinology & Metabolism 92(4)

      Pages: 1451-1457

    • NAID

      120000975200

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diminished climbing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats2007

    • Author(s)
      Takagishi Y, Hashimoto K, Kayahara T, Watanabe M, Otsuka H, Mizoguchi A, Kano M, Murata Y
    • Journal Title

      Developmental Neurobiology 67(7)

      Pages: 909-923

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothy ronine deiodinase activity.2007

    • Author(s)
      Kanou Y, Murata Y(13人中13番目)他11名
    • Journal Title

      Journal of Clinical Endocrinology & Metabolism 92-4

      Pages: 1451-1457

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diminished climbing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats.2007

    • Author(s)
      Takagishi Y, Murata Y(8人中8番目)他6名
    • Journal Title

      Developmental Neurobiology 67-7

      Pages: 909-923

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in Ucp1, D2 (Dio2) and Glut4 (Slc2a4) mRNA expression in response to shot-term cold exposure in the house musk shrew (Suncus murinus).2007

    • Author(s)
      Suzuki D, Murata Y, Oda S.
    • Journal Title

      Experimental Animals 56・4

      Pages: 279-288

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Altered expression and distribution of mRNA-binding motif protein 3 (RBM3) in the brain of myosin Va null mutant rats2007

    • Author(s)
      Takagishi Y, Sun X-y, Hayashi Y, Murata Y
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, California, U.S.A.
    • Year and Date
      2007-11-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 甲状腺ホルモン応答性遺伝子ZAKI-4 の脳発達過程における発現と高次機能における役割 : ZAKI-4 ノックアウトマウスを用いた検討2007

    • Author(s)
      加納安彦, 早坂靜, 孫暁陽, 唐亜平, 高岸芳子, 林良敬, 村田善晴
    • Organizer
      第80 回日本内分泌学会学術総会 (シンポジウム)
    • Place of Presentation
      東京
    • Year and Date
      2007-06-14
    • Related Report
      2008 Final Research Report
  • [Presentation] 甲状腺ホルモン応答性遺伝子ZAKI-4の脳発達過程における発現と高次機能における役割:ZAKI-4ノックアウトマウスを用いた検討2007

    • Author(s)
      加納安彦、村田善晴(7人中7番目), 他5名
    • Organizer
      第80回日本内分泌学会学術総会
    • Place of Presentation
      東京フォーラム(東京)
    • Year and Date
      2007-06-14
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.riem.nagoya-u.ac.jp/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.riem.nagoya-u.ac.jp/

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi