Investigation of membrane receptor Ryk on bone metabolism and the therapeutic application to osteoporosis

• Project/Area Number: 19591081
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Kyushu University
• Principal Investigator: OHNAKA Keizo Kyushu University, 大学院・医学研究院, 講師 (30325518)
• Co-Investigator(Kenkyū-buntansha): TAKAYANAGI Ryoichi 九州大学, 大学院・医学研究院, 教授 (30154917)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 骨芽細胞 / Wntシグナル / Ryk

Research Abstract

The Wnt/LRP5 signal plays important roles in promoting bone formation in rodents and human. This study investigated the involvement of Wnt co-receptor Ryk (receptor-related tyrosine kinase) in Wnt-induced bone formation signaling in cultured osteoblastic cells. Association study between the SNPs in Wnt signal-related genes and bone mineral density (BMD) was performed in postmenopausal Japanese women.

Research Products

• [Journal Article] Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women (2009)
  • Author(s): Ohnaka K, Yamamoto K, Nakamura K, Adachi M, Kawate H, Kono S, Takayanagi R.
  • Journal Title: Geriatr Gerontrol Int 9(3) Pages: 304-309
  • NAID: 10025638117
  • Peer Reviewed
• [Journal Article] 日本人の骨密度関連遺伝子の網羅的解析:福岡骨粗鬆症コホート研究 (2009)
  • Author(s): 大中佳三
  • Journal Title: 日本老年医学会雑誌 46(2) Pages: 114-116
  • NAID: 10024963960
  • Peer Reviewed
• [Journal Article] アンドロゲン、エストロゲンと骨代謝マーカー (2009)
  • Author(s): 大中佳三、高柳涼一
  • Journal Title: CLINICAL CALCIUM 19(8) Pages: 1118-1124
• [Journal Article] Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women (2009)
  • Author(s): Ohnaka K, et al
  • Journal Title: Geriatr Gerontrol Int 9(3) Pages: 304-309
  • NAID: 10025638117
  • Peer Reviewed
• [Journal Article] アンドロゲン、エストロゲンと骨代謝マーカー (2009)
  • Author(s): 大中佳三, 高柳涼一
  • Journal Title: CLINICAL CALCIUM 19(8) Pages: 1118-1124
• [Journal Article] 閉経後のステロイド性骨粗鬆症に対するラロキシフェンとビスフォスフォネートの臨床効果比較 (2008)
  • Author(s): 高柳涼一、大中佳三
  • Journal Title: Osteoporosis Japan 16(4) Pages: 298-301
• [Journal Article] Adiponectin and colorectal adenomas : Self Defense Forces Health Study. (2008)
  • Author(s): Fukumoto J, et al
  • Journal Title: Cancer Sci 99 Pages: 781-786
  • Peer Reviewed
• [Journal Article] 閉経後のステロイド性骨粗鬆症に対するラロキシフェンとビスフォスフォネートの臨床効果の比較 (2008)
  • Author(s): 高柳涼一, 大中佳三
  • Journal Title: Osteoporosis Japan 16 Pages: 298-301
• [Journal Article] Adiponectin and colorectal adenomas:Self Defense Forces Health Study (2008)
  • Author(s): Fukumoto J
  • Journal Title: Cancer Sci 99 Pages: 781-786
  • Peer Reviewed
• [Journal Article] ステロイド骨粗鬆症の予防と治療 (2007)
  • Author(s): 大中 佳三
  • Journal Title: 医学のあゆみ 221 Pages: 113-118
• [Journal Article] Cyclooxygenase-2 inductuion by lysophosphatidylcholine in cultured ratvascular smooth muscle cells:involvement of the p38MAPK pathway (2007)
  • Author(s): Yamakawa T
  • Journal Title: Biomed Res 29 Pages: 1-8
  • Peer Reviewed
• [Presentation] Wntシグナル関連遺伝子の一塩基多型(SNPs)と骨密度の相関解析 (2008)
  • Author(s): 大中佳三、河手久弥、高柳涼一
  • Organizer: 第25回日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-29
• [Presentation] Wntシグナル関連遺伝子の一塩基多型(SNでPs)と骨密度の相関解析 (2008)
  • Author(s): 大中佳三, 他
  • Organizer: 第25回日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-29
• [Presentation] 日本人の骨密度関連遺伝子の網羅的解析(高密度SNP):福岡骨粗鬆症コホート研究 (2008)
  • Author(s): 大中佳三
  • Organizer: 第50回日本老年医学会学術総会-シンポジウム「骨粗鬆症と変形性関節症:研究と診療の最前線」-
  • Place of Presentation: 千葉
  • Year and Date: 2008-06-21
• [Presentation] Glucocorticoid Enhances the Expression of a Wnt Antagonist, Secreted Frizzled-Related Protein 3, in Cultured Human Osteoblasts (2007)
  • Author(s): 大中佳三
  • Organizer: American Society for Bone and Mineral Research 29th Annual Meeting. Working Group on Osteoporosis and Rheumatic Diseases : Glucocorticoid-Induced Osteoporosis (GIOP)
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2007-09-17
• [Presentation] グルココルチコイドは培養骨芽細胞においてsecreted frizzled-related protein 3(Sfrp3)の発現を増加させる (2007)
  • Author(s): 大中佳三、河手久弥、高柳涼一
  • Organizer: 第25回日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-19
• [Presentation] Wntシグナル遺伝子の一塩基多型(SNPs)と骨密度の関連解析 (2007)
  • Author(s): 大中佳三、足立雅広、河手久弥、高柳涼一
  • Organizer: 第49回日本老年医学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2007-06-21
• [Book] 別冊・医学のあゆみ「骨粗鬆症-臨床と研究の最新動向」(福本誠二編集 ステロイド骨粗鬆症の予防と治療) (2008)
  • Author(s): 大中佳三、高柳涼一
  • Publisher: 医歯薬出版株式会社