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Search and functional analysis for novel bioactive peptides related with lifestyle-related disease

Research Project

Project/Area Number 19591091
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

MIYAZATO Mikiya  National Cardiovascular Center Research Institute, 生化学部, 部長 (50291183)

Co-Investigator(Kenkyū-buntansha) 寒川 賢治  国立循環器病センター研究所, 研究所, 所長 (00112417)
伊達 紫  宮崎大学, フロンティア科学実験総合センター, 教授 (70381100)
Co-Investigator(Renkei-kenkyūsha) KANGAWA Kenji  国立循環器病センター研究所, 所長 (00112417)
DATE Yukari  宮崎大学, フロンティア科学実験総合センター, 教授 (70381100)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsペプチド / 生活習慣病 / 摂食調節 / グレリン / ニューロメジン
Research Abstract

生活習慣病に関連する新規生理活性ペプチドの探索と機能解析を目的として、生活習慣病に関わる組織で発現しているオーファン受容体の安定発現細胞株を作製するとともに、リガンドの探索ための新たな方法の開発を行い、新規生活習慣病関連ペプチドの探索を進めた。また、摂食促進ペプチド;グレリンの消化管における分泌調節と機能解析、グレリン受容体の発現調節機構を明らかにした。さらに、新規神経ペプチド;ニューロメジンS の神経内分泌的調節作用について明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (37 results)

All 2009 2008 2007 Other

All Journal Article (35 results) (of which Peer Reviewed: 32 results) Presentation (2 results)

  • [Journal Article] Ghrelin receptor (GHS-R)-like receptor and its genomic organisation in rainbow trout, Oncorhynchus mykiss2009

    • Author(s)
      Kaiya H, Mori T, Miyazato M, Kangawa K
    • Journal Title

      Comp Biochem Physiol A Mol Integr Physiol 153

      Pages: 438-450

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Purification and properties of ghrelin from the intestine of the goldfish, Carassius auratus2009

    • Author(s)
      Miura T, Maruyama K, Kaiya H, Miyazato M, Kangawa K, Uchiyama M, Shioda S, Matsuda K
    • Journal Title

      Peptides 30

      Pages: 758-765

    • NAID

      10020188361

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Purification and properties of ghrelin from the intestine of the goldfish, Carassius auratus2009

    • Author(s)
      Tohru Miura, et al.
    • Journal Title

      Peptides 30

      Pages: 758-765

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current knowledge of the roles of ghrelin in regulating food intake and energy balance in birds2009

    • Author(s)
      Hiroyuki Kaiya, et al.
    • Journal Title

      Gen. Comp. Endocrinol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and Genomic Sequence of Ghrelin Receptor (GHS-R)-like Receptor in the Mozambique Tilapia, Oreochromis mossambicus2009

    • Author(s)
      Hiroyuki Kaiya, et al.
    • Journal Title

      Zool. Sci. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] African lungfish, Protopterus annectens, possess an arginine vasotocin receptor homologous to the tetrapod V2-type receptor2009

    • Author(s)
      Norifumi Konnno, et al.
    • Journal Title

      J. Exp. Biol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ghrelin receptor (GHS-R)-like receptor and its genomic organisation in rainbow trout, Oncorhynchus mykiss2009

    • Author(s)
      Hiroyuki Kaiya, et al.
    • Journal Title

      Comp. Biochem. Physiol. A. Mol. Integr. Physiol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of neuromedin S in the oxytocin release response to suckling stimulus2008

    • Author(s)
      Sakamoto T, Mori K, Miyazato M, Kangawa K, Sameshima H, Nakahara K, Murakami N
    • Journal Title

      Biochem Biophys Res Commun 375

      Pages: 49-53

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic action of gastrin and ghrelin on gastric acid secretion in rats2008

    • Author(s)
      Fukumoto K, Nakahara K, Katayama T, Miyazato M, Kangawa K, Murakami N
    • Journal Title

      Biochem Biophys Res Commun 374

      Pages: 60-63

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Primary structure, tissue distribution and biological activity of chicken motilin receptor2008

    • Author(s)
      Yamamoto I, Kaiya H, Tsutsui C, Sakai Y, Sukada A, Miyazato M, Tanaka M
    • Journal Title

      Gen Comp Endocrinol 156

      Pages: 509-514

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart2008

    • Author(s)
      Tokudome T, Kishimoto I, Horio T, Arai A, Schwenke DO, Hino J, Okano I, Kawano Y, Kohno M, Miyazato M, Nakao K, Kangawa K
    • Journal Title

      Circulation 117

      Pages: 2329-2339

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuromedin S: Discovery and Functions. Results Probl Cell Differ2008

    • Author(s)
      Mori K, Miyazato M, Kangawa K
    • Journal Title

      Results Probl Cell Differ 46

      Pages: 201-212

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 食欲とホルモン-グレリンとニューロメジンU およびS について2008

    • Author(s)
      宮里幹也,寒川賢治
    • Journal Title

      綜合臨牀 57

      Pages: 433-436

    • Related Report
      2008 Final Research Report
  • [Journal Article] Identification and functional analysis of a novel ligand for G protein-coupled receptor2008

    • Author(s)
      Miyazato M, Mori K, Ida T, Kojima M, Murakami N, Kangawa K
    • Journal Title

      Neuromedin S. Regu. Pept 145

      Pages: 37-41

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A multifunctional hormone in non-mammalian vertebrates2008

    • Author(s)
      Kaiya H, Miyazato M, Kangawa K, Peter RE, Unniappan S. Ghrelin
    • Journal Title

      Comp Biochem Physiol A Mol Integr Physiol 149

      Pages: 109-128

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] RGS4 mediates anti-hypertrophic effect of locally secreted natriuretic peptides in the heart2008

    • Author(s)
      Takeshi Tokudome, et al.
    • Journal Title

      Circulation 117

      Pages: 2329-2339

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary structure, tissue distribution and biological activity of chicken motilin receptor2008

    • Author(s)
      Ichiro Yamamoto, et al.
    • Journal Title

      Gen. Comp. Endocrinol 156

      Pages: 509-514

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of neuromedin S in the oxytocin release response to suckling stimulus2008

    • Author(s)
      Takumi Sakamoto, et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 375

      Pages: 49-53

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic action of gastrin and ghrelin on gastric acid secretion in rats2008

    • Author(s)
      Kaori Fukumoto, et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 374

      Pages: 60-63

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and functional analysis of a novel ligand for G proteincoupled receptor, Neuromedin S.2008

    • Author(s)
      Mikiya Miyazato, et. al.
    • Journal Title

      Regul. Pept. 145

      Pages: 37-41

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ghrelin : A multifunctional hormone in non-mammalian vertebrates.2008

    • Author(s)
      Hiroyuki Kaiya, et. al.
    • Journal Title

      Comp. Biochem. Physiol. A 149

      Pages: 109-128

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 食欲とホルモン-グレリンとニューロメジンUおよびSについて2008

    • Author(s)
      宮里幹也, 他
    • Journal Title

      綜合臨床 57

      Pages: 433-436

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Neuromedin S : Discovery and Functions2008

    • Author(s)
      Kenji Mori, et. al.
    • Journal Title

      Results. Probl. Cell Differ. (in press)

    • Related Report
      2007 Annual Research Report
  • [Journal Article] RGS4 mediates anti-hypertrophic effect of locally secreted natriuretic peptides in the heart.2008

    • Author(s)
      Takeshi Tokudome, et. al.
    • Journal Title

      Circulation (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary structure, tissue distribution and biological activity of chicken motilin receptor.2008

    • Author(s)
      Ichiro Yamamoto, et. al.
    • Journal Title

      Gen. Comp. Endocrinol. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuromedin S exerts an antidiuretic action in rats2007

    • Author(s)
      Sakamoto T, Mori K, Nakahara K, Miyazato M, Kangawa K, Samejima H, Murakami N
    • Journal Title

      Biochem Biophys Res Commun 361

      Pages: 457-461

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of GH secretagogue receptor gene expression in the rat nodose ganglion2007

    • Author(s)
      Sato M, Nakahara K, Miyazato M, Kangawa K, Murakami N
    • Journal Title

      J Endocrinol 194

      Pages: 41-46

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a ghrelin-like peptide in two species of shark, Sphyrna lewini and Carcharhinus melanopterus2007

    • Author(s)
      Kawakoshi A, Kaiya H, Riley LG, Hirano T, Grau EG, Miyazato M, Hosoda H, Kangawa K
    • Journal Title

      Gen Comp Endocrinol 151

      Pages: 259-268

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuromedin S exerts an antidiuretic action in rats.2007

    • Author(s)
      Takumi Sakamoto, et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 361

      Pages: 457-461

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of GH secretagogue receptor gene expression in the rat nodose ganglion.2007

    • Author(s)
      Miho Sato, et. al.
    • Journal Title

      J. Endocrinol. 194

      Pages: 41-46

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a ghrelin-like peptide in two species of shark, Sphyrnalewini and Carcharhinus melanopterus.2007

    • Author(s)
      Akatsuki Kawakoshi, et. al.
    • Journal Title

      Gen. Comp. Endocrinol. 151

      Pages: 259-268

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purification and characterization of feline ghrelin and its possible role.2007

    • Author(s)
      Takanori Ida, et. al.
    • Journal Title

      Domest. Anim. Endocrinol. 32

      Pages: 93-105

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and genomic sequence of ghrelin receptor (GHS-R)-like receptor in the Mozambique Tilapia, Oreochromis mossambicus

    • Author(s)
      Kaiya H, Riley L, Janzen W, Hirano T, Grau EG, Miyazato M, Kangawa K
    • Journal Title

      Zool Sci (in press)

    • NAID

      40016725993

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] African lungfish, Protopterus annectens, possess an arginine vasotocin receptor homologous to the tetrapod V2-type receptor

    • Author(s)
      Konno N, Hyodo S, Yamaguchi Y, Kaiya H, Miyazato M, Matsuda K, Uchiyama M
    • Journal Title

      J Exp Biol (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Current knowledge of the roles of ghrelin in regulating food intake and energy balance in birds

    • Author(s)
      Kaiya H, Furuse M, Miyazato M, Kangawa K
    • Journal Title

      Gen Comp Endocrinol (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] グレリンの翻訳後修飾2008

    • Author(s)
      宮里幹也
    • Organizer
      大阪大学タンパク質研究所セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2008-01-11
    • Related Report
      2008 Final Research Report
  • [Presentation] グレリンの翻訳後修飾2008

    • Author(s)
      宮里 幹也
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2008-01-11
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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