• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Activation of NF-kB2 in adult T-cell leukemia

Research Project

Project/Area Number 19591099
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionNiigata University

Principal Investigator

FUJII Masahiro  Niigata University, 医歯学系, 教授 (30183099)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsHTLV-1 / ATL / NF-Kb / CD4 / NF-kB / NF-kB2 / WNK1 / Rel / 遺伝子変異 / 染色体転座
Research Abstract

成人T細胞白血病(ATL)は極めて悪性の白血病であり、有効な抗がん剤も開発されていない.ATLの発症に転写因子NF-kBの異常活性化が関与することが知られているが、その分子機構は不明である.ATL細胞から染色体転座に伴う活性化型NF-kB2遺伝子(NF-kB2/p58)を単離した.正常なNF-kB2とは異なり、NF-kB2/p58は恒常的に遺伝子発現を誘導することが示された.以上の結果は、NF-kB2の遺伝子異常が一部のATL発症に関与する可能性を示している.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report

Research Products

(29 results)

All 2009 2008 2007

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (13 results) Book (4 results)

  • [Journal Article] Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-{kappa} B2009

    • Author(s)
      Zhao T, Yasunaga JI, Satou Y, Nakao M, Takahashi M, Fujii M, Matsuoka M
    • Journal Title

      Blood 113(12)

      Pages: 2755-2764

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human T-cell leukemia virus type 1 Tax induces an aberrant clustering of the tumor suppressor Scribble through the PDZ domain binding motif dependent and independent interaction2008

    • Author(s)
      Okajima M, Takahashi M, Masaya Higuchi, Ohsawa T, Yoshida S, Yoshida Y, Oie M, Tanaka T, Gejyo F, Fujii M
    • Journal Title

      Virus Genes 37(2)

      Pages: 231-240

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Knockdown of synapse-associated protein D1g1 reduces syncytium formation induced by human T-cell leukemia virus type 12008

    • Author(s)
      Yoshida S, Higuchi M, Shoji T, Yoshita M, Ishioko K, Takahashi M, Oie M, Tanaka Y, Uchiyama M, Fujii M
    • Journal Title

      Virus Genes 37(1)

      Pages: 9-15

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rearranged NF-kappa B2 gene in an adult T-cell leukemia cell line2008

    • Author(s)
      Isogawa M, Higuchi M, Takahashi M, Oie M, Mori N, Tanaka Y, Aoyagi Y, Fujii M
    • Journal Title

      Cancer Science 99(4)

      Pages: 792-798

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia2008

    • Author(s)
      Nakayawa T, Hieshima K, Arao T, Jin Z, Nagakubo D, Shirakawa AK, Yamada Y, Fujii M, Oiso N, Kawada A, Nishio K, Yoshie O
    • Journal Title

      Oncogene 27(23)

      Pages: 3221-3232

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rearranged NF-kB2 gene in an adult T-cell leukemia cell line2008

    • Author(s)
      Isogawa M
    • Journal Title

      Cancer Science 99(4)

      Pages: 792-798

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rearranged NF-kB2 gene in an adult T-cell leukemia cell line2008

    • Author(s)
      Isogawa M
    • Journal Title

      Cancer Science (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cooperation of NF-kB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV) Taxl but not HTLV-2 Tax2 is crucial for interleukin-2 independent growth transformation of a T cell line2007

    • Author(s)
      Higuchi M, Tsubata C, Kondo R, Yoshida S, Takahashi M, Oie M, Tanaka Y, Mahieux R, Matsuoka M, Fujii M
    • Journal Title

      J Virol. 81(21)

      Pages: 11900-11907

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cooperation of NF-kB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV) Taxl but not HTLV-2 Tax2 is crucial for interleukin-2 independent growth transformation of a T cell line2007

    • Author(s)
      Higuchi M
    • Journal Title

      J Virol. 81

      Pages: 11900-11907

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia2007

    • Author(s)
      Nakayama T
    • Journal Title

      Oncogene (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and characterization of a novel human parechovirus from various clinical samples2007

    • Author(s)
      Watanabe K
    • Journal Title

      Emerg. Inf. Dis. 13

      Pages: 889-895

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel KRAB-Zinc finger protein interacts with latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus and activates transcription viaterminal repeat sequences2007

    • Author(s)
      Watanabe A
    • Journal Title

      Virus Genes 34

      Pages: 127-136

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Identification of a critical region of HTLV-1 Taxl for NF-kB2/p100 activation2008

    • Author(s)
      樋口雅也
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] Activation of PI3k/Akt substitues a function of PDZ domain binding motif of HTLV-1 Tax in its T-cell transformation2008

    • Author(s)
      藤井雅寛
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] HTLV-1Taxl と HTLV-2Tax2によるIL-2非依存性細胞増殖誘導能の違い2008

    • Author(s)
      藤井雅寛
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2008-10-26
    • Related Report
      2008 Final Research Report
  • [Presentation] HTLV-1 感染伝播へのPDZドメイン蛋白D1g1の関与2007

    • Author(s)
      樋口雅也
    • Organizer
      第55回日本ウイルス会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-22
    • Related Report
      2008 Final Research Report
  • [Presentation] HILV-1感染伝播へのPDZドメイン蛋白Dlg1の関与2007

    • Author(s)
      樋口雅也
    • Organizer
      第55回日本ウイルス会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新型ヒトパレコウイルス6型の性状解析と新潟県におけるヒトパレコウイルスの分離状況2007

    • Author(s)
      渡邉香奈子
    • Organizer
      第55回日本ウイルス会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Distinct T-cell transformation mechanisms of HTLV-1 Taxl and HTLV-2 Taxl22007

    • Author(s)
      藤井雅寛
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] HTLV-1 b ZIP factor suppresses canonical pathway of NF-kB by physical interaction with the p652007

    • Author(s)
      Tiejun Zhao
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Isolation of a rearranged NF-kB2 gene from an adult T cell leukemia cell line2007

    • Author(s)
      樋口雅也
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Heterodimer formation of Fra-2 and JunD promotes CCR4 expression and proliferation in adult T-cell leukemia2007

    • Author(s)
      Takashi Nakayama
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Distinct T-cell transformation mechanisms of HTLV-1 Tax1 and HTLV-2 Tax22007

    • Author(s)
      藤井雅寛
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Activation of NF-kB2/p100 by human T-cell leukemia virus type 1 (HTLV-1) Taxl but not HTLV-2 Tax2 is crucial for interleukin-2 independent growth transformation of a T-cell line2007

    • Author(s)
      Masaya Higuchi
    • Organizer
      13^<th> international conference of human retrovirology HTLV and related viruses
    • Place of Presentation
      箱根
    • Year and Date
      2007-05-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Activation of NF-kB2/p100 by human T-cell leukemia virus type 1(HTLV-1)Taxl but not HTLV-2 Tax2 is crucial for interleukin-2 independent growth transformation of a T-cell line2007

    • Author(s)
      Masaya Higuchi
    • Organizer
      13th international conference of human retrovirology HTLV and related viruses
    • Place of Presentation
      箱根
    • Year and Date
      2007-05-22
    • Related Report
      2007 Annual Research Report
  • [Book] ヒトT細胞白血病ウイルス2007

    • Author(s)
      藤井雅寛
    • Publisher
      医薬ジャーナル社
    • Related Report
      2008 Final Research Report
  • [Book] HTLV-1と疾患2007

    • Author(s)
      藤井雅寛
    • Publisher
      文光堂
    • Related Report
      2008 Final Research Report
  • [Book] ヒトT細胞白血病ウイルス(HTLV-1の分子生物学)2007

    • Author(s)
      藤井雅寛
    • Publisher
      医薬ジャーナル社
    • Related Report
      2007 Annual Research Report
  • [Book] HTLV-1と疾患(HTLV-2)2007

    • Author(s)
      藤井雅寛
    • Publisher
      文光堂
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-03-31   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi