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Development of novel therapy which targets B lymphocytes against antiphospholipid syndrome

Research Project

Project/Area Number 19591101
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionKanazawa University

Principal Investigator

YAMAZAKI Masahide  Kanazawa University, 医学系, 講師 (50242558)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords抗リン脂質抗体症候群 / B細胞 / APSモデルマウス / 実験的APSモデルマウス / マウス抗マウスCD20モノクローナル抗体 / MB20-11
Research Abstract

抗リン脂質抗体症候群(APS)は抗リン脂質抗体の存在により, 反復性血栓症・不育症を来す自己免疫疾患であるがその根治療法は確立していない. 本研究において, 実験的APSモデルマウスを用い, B細胞を傷害することにより抗リン脂質抗体の発現抑制・臨床症状の発症を抑制可能であることが確認された. 以上の検討結果より, B細胞発現抑制療法により, APSの病態制御が可能である可能性が示唆された.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (82 results)

All 2009 2008 2007

All Journal Article (42 results) (of which Peer Reviewed: 27 results) Presentation (35 results) Book (5 results)

  • [Journal Article] Differences in anti-phosphatidylserine-prothrombin complex antibodies and cutaneous vasculitis between regular livedo reticularis and livedo racemosa2009

    • Author(s)
      Kawakami T, Yamazaki M, Mizoguchi M, Soma Y.
    • Journal Title

      Rheumatology(Oxford) (Epub ahead of print)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ホスファチジルセリン依存性抗プロトロンビン(aPS/PT)抗体が養成であったLivedoid Vasculopathy の1例2009

    • Author(s)
      田畑伸子, 早坂薫, 石橋昌也, 山崎雅英
    • Journal Title

      皮膚科の臨床 51(2)

      Pages: 139-141

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] High titer of serum antiphospholipid antibody levels in adult Henoch-Schonlein purpura and cutaneous leukocytoclastic angitis2008

    • Author(s)
      Kawakami T, Yamazaki M, Mizoguchi M, Soma Y.
    • Journal Title

      Arthritis Rheumatism 59(4)

      Pages: 561-567

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 網状皮斑および皮膚潰瘍患者におけるループス抗凝固因子2008

    • Author(s)
      井出葉子, 高田実, 武藤美香, 村田浩, 宇原久, 斎田俊明, 山崎雅英
    • Journal Title

      日本皮膚科学会雑誌 118(8)

      Pages: 1519-1526

    • NAID

      10025377178

    • Related Report
      2008 Annual Research Report 2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased macrophage colony-stimulating factor levels in patients with Graves' disease2008

    • Author(s)
      Morishita E, Sekiya A, Hayashi T, Kadohira Y, Maekawa M, Yamazaki M, Asakura H, Nakao S, Ohtake S.
    • Journal Title

      Int J Hematol 88(3)

      Pages: 272-277

    • NAID

      10023970229

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in molecular markers of hemostatic and fibrinolytic activation under various sampling conditions using vacuum tube samples from healthy volunteers2008

    • Author(s)
      Omote M, Asakura H, Takamichi S, Shibayama M, Yoshida T, Kadohira Y, Maekawa M, Yamazaki M, Morishita E, Nakao S, Wada T.
    • Journal Title

      Thromb Res 123(2)

      Pages: 390-395

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of annexin II in human atherosclerotic abdominal aortic aneurysms2008

    • Author(s)
      Hayashi T, Morishita E, Ohtake H, Oda Y, Ohta K, Arahata M, Kadohira Y, Maekawa M, Ontachi Y, Yamazaki M, Asakura H, Takami A, Nakao S.
    • Journal Title

      Thromb Res 123(2)

      Pages: 274-280

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary hemorrhage, due to rupture of small muscular arteries, in an autopsy case of systemic lupus erythematosus with antiphospholipid antibodies2008

    • Author(s)
      Nakaya I, Toyama T, Uchiyama A, Miwa A, Kawabata M, Yamazaki M, Iida H.
    • Journal Title

      Mod Rheumatol 18

      Pages: 529-531

    • NAID

      10024374468

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of argatroban on rheumatoid vasculitis with antiphosphatidylserine-prothrombin complex antibody2008

    • Author(s)
      Kawakami T, Yamazaki M, Kawasaki K, Mizoguchi M, Soma Y.
    • Journal Title

      Arch Dermatol 144(8)

      Pages: 1075-1076

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 抗リン脂質抗体症候群の診断と治療2008

    • Author(s)
      山崎雅英
    • Journal Title

      Monthly Book Derma 136

      Pages: 47-54

    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Journal Article] 臨床検査 : 現状と展望5. 血液疾患2)凝固・線溶系2008

    • Author(s)
      山崎雅英, 朝倉英策, 尾崎由基男
    • Journal Title

      日本内科学会雑誌 97(12)

      Pages: 2974-2982

    • Related Report
      2008 Final Research Report
  • [Journal Article] 免疫抑制療法患者の感染対策2008

    • Author(s)
      山崎雅英, 安納美知子
    • Journal Title

      Circles for the future of quality care 10(3)

      Pages: 12-18

    • Related Report
      2008 Final Research Report
  • [Journal Article] Remission of hepatitis B virus-related cryoglobulinemic vasculitis with entecavir2008

    • Author(s)
      Kawakami T, Ohka S, Mizoguchi M, Soma Y, Yamazaki M.
    • Journal Title

      Ann Intern Med 149(12)

      Pages: 911-912

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] High titer of serum antiphpspholipid antibody levels in adult Henoch-Schonlein purpura and cutaneous leukocytoclastic angitis.2008

    • Author(s)
      Kawakami T, Yamazaki M, Mizoguchi M, Soma Y
    • Journal Title

      Arthritis Rheumatism 59(4)

      Pages: 561-567

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased macrophage colony-stimulating factor levels in patients with Graves' disease.2008

    • Author(s)
      Morishita E, Sekiya A, Hayashi T, Kadohira Y, Maekawa M, Yamazaki M, Asakura H, Nakao S, Ohtake S.
    • Journal Title

      Int J Hematol 88(3)

      Pages: 272-277

    • NAID

      10023970229

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in molecular markers of hemostatic and fibrinolytic activation under various sampling conditions using vacuum tubesamples from healthy volunteers.2008

    • Author(s)
      Omote M, Asakura H, Takamichi S, Shibayama M, Yoshida T, Kadohira Y, Maekawa M, Yamazaki M, Morishita E, Nakao S, Wada T.
    • Journal Title

      Thromb Res 123(2)

      Pages: 390-395

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of annexin II in human atherosclerotic abdominal aortic aneurysms.2008

    • Author(s)
      Hayashi T, Morishita E, Ohtake H, Oda Y, Ohta K, Arahata M, Kadohira Y, Maekawa M, Ontachi Y, Yamazaki M, Asakura H, Takami A, Nakao S.
    • Journal Title

      Thromb Res 123(2)

      Pages: 274-280

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary hemorrhage, due to rupture of small muscular arteries, in an autopsy case of systemic lupus erythematosus with antiphospholipid antibodies2008

    • Author(s)
      Nakaya I, Toyama T, Uchiyama A, Miwa A, Kawabata M, Yamazaki M, Iida H
    • Journal Title

      Mod Rheumatol 18

      Pages: 529-531

    • NAID

      10024374468

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of argatroban on rheumatoid vasculitis with antiphosphatidylserine-prothrombin complex antibody.2008

    • Author(s)
      Kawakami T, Yamazaki M, Kawasaki K, Mizoguchi M, Soma Y
    • Journal Title

      Arch Dermatol 144(8)

      Pages: 1075-1076

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 臨床検査 : 現状と展望5. 血液疾患2)凝固・線溶系2008

    • Author(s)
      山峙雅英, 朝倉英策, 尾崎由基男
    • Journal Title

      日本内科学会雑誌 97(12)

      Pages: 2974-2982

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 免疫抑制療法患者の感染対策2008

    • Author(s)
      山峙雅英, 安納美知子
    • Journal Title

      Circles for the future of quality care 10(3)

      Pages: 12-18

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Remission of hepatitis B virus-related cryo-globulinemic vasculitis with entecavir.2008

    • Author(s)
      Kawakami T, Ohka S, Mizoguchi M, Soma Y, Yamazaki M
    • Journal Title

      Ann Intern Med 149(12)

      Pages: 911-912

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 止血薬, 抗線溶薬2008

    • Author(s)
      山崎雅英
    • Journal Title

      救急・集中治療「やさしく学べる血小板・血栓止血の管理」 20(5, 6)

      Pages: 791-797

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement : the METHRO II randomized trial2007

    • Author(s)
      山崎雅英
    • Journal Title

      血栓と循環「データブック血栓症の大規模臨床試験PART2」 15

      Pages: 523-525

    • Related Report
      2008 Final Research Report
  • [Journal Article] 2. 血栓・塞栓症診断の血液検査5)血栓性素因の検査(2)APSの検査. 血栓・塞栓症の病態・検査・治療2007

    • Author(s)
      山崎雅英
    • Journal Title

      Medical Technology 35

      Pages: 1371-1379

    • Related Report
      2008 Final Research Report
  • [Journal Article] 5. おもな血栓・塞栓症の病態と検査3)抗リン脂質抗体症候群2007

    • Author(s)
      山崎雅英
    • Journal Title

      Medical Technology 35

      Pages: 1462-1470

    • Related Report
      2008 Final Research Report
  • [Journal Article] 抗リン脂質抗体症候群の検査と診断2007

    • Author(s)
      山崎雅英
    • Journal Title

      Medical Technology 35

      Pages: 149-160

    • Related Report
      2008 Final Research Report
  • [Journal Article] プロトロビン時間正常かつトロンボテスト低値の症例のループスアンチコアグラント2007

    • Author(s)
      高道小百合, 表美香, 朝倉英策, 御舘靖雄, 林朋恵, 山崎雅英, 森下英理子, 吉田知孝, 藤田信一, 中尾眞二
    • Journal Title

      日本検査血液学会雑誌 8

      Pages: 28-35

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 汎血球減少症の鑑別診断2007

    • Author(s)
      杉盛千春, 田中政彰, 竹越國夫, 山内高弘, 山崎雅英
    • Journal Title

      日本内科学会雑誌 96

      Pages: 1235-1242

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ループス抗凝固因子陽性患者に生じた難治性下腿潰瘍の1例2007

    • Author(s)
      袖本衣代, 川友香, 田朋子, 田郁代, 原拓郎, 崎雅英, 田尚人
    • Journal Title

      皮膚科の臨床 49

      Pages: 1039-1041

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antiphospholipid antibodies in patients with autoimmune blistering disease2007

    • Author(s)
      Echigo T, Hasegawa M, Inaoki M, Yamazaki M, Sato S, Takehara K.
    • Journal Title

      J Am Acad Dermatol 57

      Pages: 397-400

    • NAID

      120001135248

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Y.High titer of anti-phosphatidylserine-prothrombin complex antibodies in patients with cutaneous polyarteritis nodosa2007

    • Author(s)
      Kawakami T, Yamazaki M, Mizoguchi M, Soma Y.
    • Journal Title

      Arthritis Rheumatism 57

      Pages: 1507-1513

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 抗リン脂質抗体症候群の検査と診断2007

    • Author(s)
      山崎 雅英
    • Journal Title

      Medical Technology 35

      Pages: 149-160

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 5.おもな血栓・塞栓症の病態と検査3)抗リン脂質抗体症候群2007

    • Author(s)
      山崎 雅英
    • Journal Title

      Medical Technology臨時増刊「血栓・塞栓症の病態・検査・治療」 35

      Pages: 1462-1470

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 2,血栓・塞栓症診断の血液検査5)血栓性素因の検査(2)APSの検査2007

    • Author(s)
      山崎 雅英
    • Journal Title

      Medical TechnQlogy臨時増刊「血栓・塞栓症の病態・検査・治療」 35

      Pages: 1371-1379

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement:the METHRO IIrandomized trial2007

    • Author(s)
      山崎 雅英
    • Journal Title

      血栓と循環「デ「タブック血栓症の大規模臨床試験PART2」 15

      Pages: 523-525

    • Related Report
      2007 Annual Research Report
  • [Journal Article] プロトロビン時間正常かつトロジボテスト低値の症例のループスアンチコアグラント2007

    • Author(s)
      高道 小百合, 表 美香, 朝倉 英策, 御舘 靖雄, 林 朋恵, 山崎 雅英, 森下 英理子, 吉田 知孝, 藤田 信一, 中尾 眞ニ
    • Journal Title

      日本検査血液学会雑誌 8

      Pages: 28-35

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 汎血球減少症の鑑別診断2007

    • Author(s)
      杉盛 千春, 田中 政彰, 竹越 國夫, 山内 高弘, 山崎 雅英
    • Journal Title

      日本内科学会雑誌 96

      Pages: 1235-1242

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ル-プス抗凝固因子陽性患者に生じた難治性下腿潰瘍の1例2007

    • Author(s)
      袖本 衣代, 伊川 友香, 村田 朋子, 冨田 郁代, 金原 拓郎, 山崎 雅英, 人田 尚人
    • Journal Title

      皮膚科の臨床 49

      Pages: 1039-1041

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiphospholipid antibodies in patients with autoimmune blistering disease2007

    • Author(s)
      Echigo T, Hasegawa M, Inaoki M, Yamazaki M, Sato S, Takehara K
    • Journal Title

      J Am Acad Dermatol 57

      Pages: 397-400

    • NAID

      120001135248

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High titer of anti-phosphatidylserine-prothrQmbin complex antibodies inpatients with cutaneous polyarteritis nodosa2007

    • Author(s)
      Kawakami T, Yamazaki M, MizoguchiM, Soma Y
    • Journal Title

      Arthritis Rheumatism 57

      Pages: 1507-1513

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 抗リン脂質抗体症候群の診断と治療2007

    • Author(s)
      山崎 雅英
    • Journal Title

      Monthly Book Derma「皮膚科医による膠原病診断と治療」 136

      Pages: 47-54

    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規抗リン脂質抗体「フォスファアチジルセリン依存性IgM型抗プロトロンビン抗体の臨床的意義. 厚生労働省「強皮症における病因解明と根治的治療法の開発」2009

    • Author(s)
      山崎雅英, 長谷川稔, 藤本学, 竹原和彦
    • Organizer
      研究班2008年度班会議・第12回強皮症研究会議合同会議
    • Place of Presentation
      東京・エーザイ東京コミュニケーションオフィス会議室
    • Year and Date
      2009-01-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 新規抗リン脂質抗体「フォスファアチジルセリン依存性IgM型抗プロトロンビン抗体の臨床的意義2009

    • Author(s)
      山峙雅英, 長谷川稔, 藤本学, 竹原和彦.
    • Organizer
      厚生労働省「強皮症における病因解明と根治的治療法の開発」研究班2008年度班会議・第12回強皮症研究会議合同会議.
    • Place of Presentation
      東京・エーザイ東京コミュニケーションオフィス会議室
    • Year and Date
      2009-01-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗リン脂質抗体症候群の最近の話題2008

    • Author(s)
      山崎雅英
    • Organizer
      第1回神経脈管エコー検査セミナー
    • Place of Presentation
      仙台・広南病院
    • Year and Date
      2008-12-13
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗リン脂質抗体症候群の最近の話題.2008

    • Author(s)
      山崎雅英
    • Organizer
      第1回神経脈管エコー検査セミナー.
    • Place of Presentation
      仙台・広南病院
    • Year and Date
      2008-12-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] ステロイド投与により輸血非依存性MDSに改善した急性骨髄性白血病の1例2008

    • Author(s)
      山崎雅英, 中村万理, 中村國雄
    • Organizer
      第19回日本老年医学会北陸地方会
    • Place of Presentation
      富山・富山大学杉谷キャンパス
    • Year and Date
      2008-11-15
    • Related Report
      2008 Final Research Report
  • [Presentation] ステロイド投与により輸血非依存性MDSに改善した急性骨髄性白血病の1例2008

    • Author(s)
      山峙雅英, 中村万理, 中村國雄.
    • Organizer
      第19回日本老年医学会 北陸地方会、
    • Place of Presentation
      富山・富山大学杉谷キャンパス
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 後天性血友病の診断2008

    • Author(s)
      山崎雅英
    • Organizer
      第1回石川県ヘモフィリア懇話会
    • Place of Presentation
      金沢・金沢都ホテル
    • Year and Date
      2008-09-27
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 出血・血栓症状を認め,APTT延長・血小板減少を伴い診断に苦慮した1例2008

    • Author(s)
      山崎 雅英, 門平 靖子, 奥村 利矢, 古市 賢吾, 村光 弘, 和田 隆志
    • Organizer
      第47回日本臨床検査医学会東海北陸支部総会・第316回日本臨床化学会東海北陸支部例会
    • Place of Presentation
      富山
    • Year and Date
      2008-03-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] 脳梗塞を有する強皮症症例に対する抗血栓療法とその評価の指標としての血小板由来マイクロパ-ティクル(PDMP)の有用性2008

    • Author(s)
      山崎 雅英, 長谷 川稔, 竹原 和彦
    • Organizer
      厚生労働省「強皮症における病因解明と根治的治療法の開発」研究班2007年度班会議・第11回強皮症研究会議合同会議
    • Place of Presentation
      東京
    • Year and Date
      2008-01-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗血小板療法モニタリングとしての血小板由来マイクロパーティクル(PDMP)の有用性2008

    • Author(s)
      山崎雅英, 門平靖子, 前川実生, 林朋恵, 御舘靖雄, 森下英理子, 朝倉英策, 中尾眞二
    • Organizer
      第31回日本血栓止血学会学術集会SPCシンポジウム
    • Place of Presentation
      大阪・大阪国際交流センター
    • Related Report
      2008 Final Research Report
  • [Presentation] IgM-aPS/PT Induces to Recurrent Abortions by Microcirculatory Disturbance2008

    • Author(s)
      Yamazaki M, Y.Kadohira, M.Maekawa, E.Morishita, H.Asakura, S.Nakao
    • Organizer
      5th Congress of the Asian-Pacific Soceity on Thrombosis and Haemostasis
    • Place of Presentation
      Singapore・Grand Copthorne Waterfront Hotel
    • Related Report
      2008 Final Research Report
  • [Presentation] Plasma Level of Platelet-Derived Microparticles(PDMP)may be a Useful Indicator of Antiplatelet Therapy2008

    • Author(s)
      Yamazaki M, Y.Kadohira, M.Maekawa, E.Morishita, H.Asakura, S.Nakao
    • Organizer
      The Third United Kingdom - Japan Platelet Conference
    • Place of Presentation
      Singapore・Grand Copthorne Waterfront Hotel
    • Related Report
      2008 Final Research Report
  • [Presentation] IgM型抗プロトロンビン抗体は微小循環障害を惹起し,妊娠初期習慣性流産の原因となる2008

    • Author(s)
      山崎雅英, 門平靖子, 前川実生, 林朋恵, 御舘靖雄, 森下英理子, 朝倉英策, 中尾眞二
    • Organizer
      第60回日本血液学会総会
    • Place of Presentation
      京都・京都国際会議場
    • Related Report
      2008 Final Research Report
  • [Presentation] 血栓, 出血症状をともに認めたAPTT延長, 血小板減少例2008

    • Author(s)
      山崎雅英, 門平靖子, 前川実生, 林朋恵, 森下英理子, 朝倉英策, 中尾眞二
    • Organizer
      第9回日本検査血液学会学術集会
    • Place of Presentation
      三重・三重県総合文化センター
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗血小板療法モニタリングとしての血小板由来マイクロパーティクル(PDMP)の有用性.2008

    • Author(s)
      山崎雅英, 門平靖子, 前川実生, 林朋恵, 御舘靖雄, 森下英理子, 朝倉英策, 中尾眞二.
    • Organizer
      第31回日本血栓止血学会学術集会 SPCシンポジウム
    • Place of Presentation
      大阪・大阪国際交流センター
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血栓, 出血症状をともに認めたAPTT延長, 血小板減少例2008

    • Author(s)
      山崎雅英, 門平靖子, 前川実生, 林朋恵, 森下英理子, 朝倉英策, 中尾眞二.
    • Organizer
      第9回日本検査血液学会学術集会.
    • Place of Presentation
      三重・三重県総合文化センター
    • Related Report
      2008 Annual Research Report
  • [Presentation] Plasma Level of Platelet-Derived Microparticles (PDMP) may be a Useful Indicator of Antiplatelet Therapy2008

    • Author(s)
      M. Yamazaki, Y. Kadohira, M. Maekawa, E. Morishita, H. Asakura, S. Nakao
    • Organizer
      The Third United Kingdom-Japan Platelet Conference
    • Place of Presentation
      Singapore・Grand Copthorne Waterfront Hotel
    • Related Report
      2008 Annual Research Report
  • [Presentation] IgM型抗プロトロンビン抗体は微小循環障害を惹起し, 妊娠初期習慣性流産の原因となる.2008

    • Author(s)
      山崎雅英, 門平靖子, 前川実生, 林朋恵, 御舘靖雄, 森下英理子, 朝倉英策, 中尾眞二
    • Organizer
      第60回日本血液学会総会
    • Place of Presentation
      京都・京都国際会議場
    • Related Report
      2008 Annual Research Report
  • [Presentation] IgM-aPS/PT Induces to Recurrent Abortions by MicrocirculatoryDisturbance.2008

    • Author(s)
      M. Yamazaki, Y. Kadohira, M. Maekawa, E. Morishita, H. Asakura, S. Nakao
    • Organizer
      5th Congress of the Asian-Pacific Soceity on Thrombosis and Haemostasis.
    • Place of Presentation
      Singapore・Grand Copthorne Waterfront Hotel
    • Related Report
      2008 Annual Research Report
  • [Presentation] 初発時に播種性血管内凝固(DIC)を合併しなかった急性前骨髄性白血病(APL)2007

    • Author(s)
      山崎雅英, 島樋茂, 山崎宏人, 高見昭良, 奥村廣和, 西川晋吾, 中尾眞二
    • Organizer
      第202回日本内科学会北陸地方会
    • Place of Presentation
      福井
    • Year and Date
      2007-06-10
    • Related Report
      2008 Final Research Report
  • [Presentation] 初発時に播種性血管内凝固(DIC)を合併しなかった急性前骨髄性白血病(APL).2007

    • Author(s)
      山崎 雅英, 島樋 茂, 山崎 宏人, 高見 昭良, 奥村 廣和, 西川 晋吾, 中尾 眞二.
    • Organizer
      第202回日本内科学会北陸地方会
    • Place of Presentation
      福井
    • Year and Date
      2007-06-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] PATHOPHYSIOLOGICAL MECHANISMS OF VASCULOPATHY IN SYSTEMIC SCLERODERMA(SSC) : PLATELET ACTIVATION INDUCED BY APL IS ASSOCIATED WITH ARTERIAL THROMBOSES AND DIGITAL PITTING SCAR IN SSC PATIENTS2007

    • Author(s)
      Yamazaki M, Kadohira Y, Maekawa M, Arahata M, Ontachi Y, Morishita E, Asakura H, Nakao S.
    • Organizer
      XXIst Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2008 Final Research Report
  • [Presentation] CLINICAL SIGNIFICANCE OF PLATELET-DERIVED MICROPARTICLE(PDMP)IN APS : PLASMA LEVELS OF PDMP WERE SIGNIFICANTLY ELEVATED IN APS PATIENTS WITH ARTERIAL THROMBOSES2007

    • Author(s)
      Yamazaki M, Kadohira Y, Maekawa M, Arahata M, Ontachi Y, Morishita E, Asakura H, Nakao S.
    • Organizer
      XXIst Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2008 Final Research Report
  • [Presentation] Pathophysiological mechanisms of vasculopathy in systemic scleroderma(SSc) : Platelet activation induced by antiphospholipid antibody(aPL)is associated with arterial thromboses and digital pitting scar in SSc patients. Professor E2007

    • Author(s)
      Yamazaki M Kadohira Y, Hasegawa M, Fujimoto M, Takehara K, Nakao S.
    • Organizer
      Carwile LeRoy Memorial International Workshop on Scleroderma
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] PATHOPHYSIOLOGICAL MECHANISMS OF VASCULOPATHY IN SYSTEMIC SCLERODERMA(SSc) : PLATELET ACTIVATION INDUCED BY aPL IS ASSOCIATED WITH ARTERIAL THROMBOSES AND DIGITAL PITTING SCAR IN SSc PATIENTS2007

    • Author(s)
      Yamazaki M, Kadohira Y, Ontachi Y, Asakura H, Nakao S.
    • Organizer
      12th International Congress on Antiphospholipid Antibodies
    • Place of Presentation
      Florence, Italy
    • Related Report
      2008 Final Research Report
  • [Presentation] PHOSPHATIDYLSERINE-DEPENDENT ANTI-PROTHROMBIN ANTIBODY-IgM ISASSOCIATED WITH LIVEDO RETICULOPATHY2007

    • Author(s)
      Yamazaki M, Kadohira Y, Maekawa M, Ontachi Y, Asakura H, Nakao S.
    • Organizer
      12th International Congress on Antiphospholipid Antibodies
    • Place of Presentation
      Florence, Italy
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗リン脂質抗体症候群に対する抗血栓療法の相違による血小板由来マイクロパーティクルと臨床症状の関連2007

    • Author(s)
      山崎雅英, 門平靖子, 前川実生, 荒幡昌久, 御舘靖雄, 森下英理子, 朝倉英策, 中尾眞二
    • Organizer
      第30 回日本血栓止血学会
    • Place of Presentation
      伊勢志摩
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗リン脂質抗体症候群に対する抗血栓療法の相違による血小板由来マイクロパーティクルと臨床症状の関連2007

    • Author(s)
      山崎雅英, 門平靖子, 前川実生, 御舘靖雄, 森下英理子, 朝倉英策, 中尾眞二
    • Organizer
      第69回日本血液学会・第49回日本臨床血液学会合同総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] ループスアンチコアグラント(LA)確認試験標準化の試み2007

    • Author(s)
      山崎雅英, 門平靖子, 御舘靖雄, 渥美達也, 家子正裕, 朝倉英策
    • Organizer
      日本検査血液学会第8回学術集会
    • Place of Presentation
      福井
    • Related Report
      2008 Final Research Report
  • [Presentation] Pathophysiological mechanisms of vasculopathy in systemic scleroderma (SSc):Platelet activation induced by antiphospholipid antibody (aPL) is associated with arterial thromboses and digitalpitting scar in SScpatients2007

    • Author(s)
      Yamazaki M Kadohira Y, Hasegawa M, Fujimoto M, Takehara K, Nakao S.
    • Organizer
      Professor E.Carwile LeRoy Memorial International Workshop on Scleroderma
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] PATHOPHYSIOLOGICAL MECHANISMS OF VASCULOPATHY IN SYSTEMIC SCLERDDERMA (SSC):PLATELET ACTIVATI0N INDUCED BY APLISASSOCIATED WITH ARTERIAL THROMBOSES AND DIGITAL PITTING SCAR IN SSC PATIENTS.2007

    • Author(s)
      Yamazaki M, Kadohira Y, Maekawa M, Arahata M, Ontachi Y, Morishita E, Asakura H, Nakao S
    • Organizer
      XXISt Congress of the International Society onThrombosis and Haemostasis
    • Place of Presentation
      Geneva
    • Related Report
      2007 Annual Research Report
  • [Presentation] CLINICAL SIGNIFICANCE OF PLATELET-DERIVED MICROPARTICLE (PDMP)IN APS:PLASMA LEVELS OF PDMP WERE SIGNIFICANTLY ELEVATED IN APSPATIENTS WITHARTERIAL THROMBOSES.2007

    • Author(s)
      Yamazaki M, Kadohira Y, Maekawa M, Arahata M, Ontachi Y, Morishita E, Asakura H, Nakao S.
    • Organizer
      XXIst Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Geneva
    • Related Report
      2007 Annual Research Report
  • [Presentation] ル-プスアンチコアグラント(LA)確認試験標準化の試み2007

    • Author(s)
      山崎 雅英, 門平 靖子, 御舘 靖雄, 渥美 達也, 家子 正裕, 朝倉 英策
    • Organizer
      日本検査血液学会第8回学術集会
    • Place of Presentation
      福井
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗リン脂質抗体症候群に対する抗血栓療法の相違による血小板由来マイクロバ-ティクルと臨床症状の関連2007

    • Author(s)
      山崎 雅英, 門平 靖子, 前川 実生, 御舘 靖雄, 森下 英理子, 朝倉 英策, 中尾 眞二
    • Organizer
      第69回日本血液学会・第49回日本臨床血液学会合同総会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗リン脂質抗体症候群に対する抗血栓療法の相違による血小板由来マイクロパ-ティクルと臨床症状の関連2007

    • Author(s)
      山崎 雅英, 門平 靖子, 前川 実生, 荒幡 昌久, 御舘 靖雄, 森下 英理子, 朝倉 英策, 中尾 眞二
    • Organizer
      第30回日本血栓止血学会
    • Place of Presentation
      伊勢志摩
    • Related Report
      2007 Annual Research Report
  • [Book] 止血薬, 抗線溶薬,救急・集中治療「やさしく学べる血小板・血栓止血の管理」丸藤哲(編)2008

    • Author(s)
      山崎雅英
    • Publisher
      総合医学社, 東京
    • Related Report
      2008 Final Research Report
  • [Book] 第2部各疾患別ステロイド薬の使い方2. 血液疾患. ステロイド薬の選び方・使い方ハンドブック. 山本一彦(編)2007

    • Author(s)
      山崎雅英, 中尾眞二
    • Publisher
      羊土社, 東京
    • Related Report
      2008 Final Research Report
  • [Book] 免疫グロブリン製剤とG-CSF製剤. 新感染症症候群(上). 山口惠三(編)2007

    • Author(s)
      山崎雅英, 舟田久
    • Publisher
      日本臨床社, 大阪
    • Related Report
      2008 Final Research Report
  • [Book] 新感染症症候群(上)2007

    • Author(s)
      山崎 雅英, 舟田 久
    • Total Pages
      682
    • Publisher
      日本臨床社
    • Related Report
      2007 Annual Research Report
  • [Book] ステロイド薬の選び方・使い方ハンドブック2007

    • Author(s)
      山崎 雅英, 中尾 眞二
    • Total Pages
      332
    • Publisher
      羊土社
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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