Development of novel therapy which targets B lymphocytes against antiphospholipid syndrome
| Project/Area Number |
19591101
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kanazawa University |
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Principal Investigator |
YAMAZAKI Masahide Kanazawa University, 医学系, 講師 (50242558)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 抗リン脂質抗体症候群 / B細胞 / APSモデルマウス / 実験的APSモデルマウス / マウス抗マウスCD20モノクローナル抗体 / MB20-11 |
|---|
| Research Abstract |
抗リン脂質抗体症候群(APS)は抗リン脂質抗体の存在により, 反復性血栓症・不育症を来す自己免疫疾患であるがその根治療法は確立していない. 本研究において, 実験的APSモデルマウスを用い, B細胞を傷害することにより抗リン脂質抗体の発現抑制・臨床症状の発症を抑制可能であることが確認された. 以上の検討結果より, B細胞発現抑制療法により, APSの病態制御が可能である可能性が示唆された.
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Report
(3 results)
Research Products
(82 results)
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[Journal Article] Changes in molecular markers of hemostatic and fibrinolytic activation under various sampling conditions using vacuum tube samples from healthy volunteers2008
Author(s)
Omote M, Asakura H, Takamichi S, Shibayama M, Yoshida T, Kadohira Y, Maekawa M, Yamazaki M, Morishita E, Nakao S, Wada T.
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Journal Title
Thromb Res 123(2)
Pages: 390-395
Related Report
Peer Reviewed
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[Journal Article] Expression of annexin II in human atherosclerotic abdominal aortic aneurysms2008
Author(s)
Hayashi T, Morishita E, Ohtake H, Oda Y, Ohta K, Arahata M, Kadohira Y, Maekawa M, Ontachi Y, Yamazaki M, Asakura H, Takami A, Nakao S.
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Journal Title
Thromb Res 123(2)
Pages: 274-280
Related Report
Peer Reviewed
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[Journal Article] Changes in molecular markers of hemostatic and fibrinolytic activation under various sampling conditions using vacuum tubesamples from healthy volunteers.2008
Author(s)
Omote M, Asakura H, Takamichi S, Shibayama M, Yoshida T, Kadohira Y, Maekawa M, Yamazaki M, Morishita E, Nakao S, Wada T.
-
Journal Title
Thromb Res 123(2)
Pages: 390-395
Related Report
Peer Reviewed
-
[Journal Article] Expression of annexin II in human atherosclerotic abdominal aortic aneurysms.2008
Author(s)
Hayashi T, Morishita E, Ohtake H, Oda Y, Ohta K, Arahata M, Kadohira Y, Maekawa M, Ontachi Y, Yamazaki M, Asakura H, Takami A, Nakao S.
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Journal Title
Thromb Res 123(2)
Pages: 274-280
Related Report
Peer Reviewed
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