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The role of hnRNP B1, an inhibitor of DNA repair, in leukemogenesis and disease progression on adult T cell leukemia

Research Project

Project/Area Number 19591116
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionSaga University

Principal Investigator

SUEOKA Eizaburo  Saga University, 医学部, 准教授 (00270603)

Co-Investigator(Kenkyū-buntansha) ARAGANE Naoko  佐賀大学, 医学部, 講師 (20321846)
HISATOMI Takashi  佐賀大学, 医学部, 助教 (10398125)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords血液腫瘍学 / 遺伝子 / ウイルス / ATL / DNA修復 / hnRNP B1
Research Abstract

(1)ATL細胞におけるDNA修復阻害因子hnRNP B1の過剰発現とその意義
肺がんの早期から過剰発現することを見出したhnRNP B1タンパク質は、細胞内でDNA依存性キナーゼ複合体に結合することを見出している。hnRNP B1はATLの70%以上の症例において過剰発現していた。その発現は慢性期から増加し、急性期、リンパ腫型においては約8割の症例において発現亢進することが明らかになった。ATL細胞を用いた解析ではhnRNP B1はDNA依存性キナーゼに結合しその酵素活性を阻害すること、hnRNP B1の量と非相同末端修復(NHEJ)の活性は逆相関の傾向にあることを明らかにした。
(2)新規抗がん剤SMS-06によるATL細胞に対する抗腫瘍効果の解析
SMS-06はIC_<50>として50-100nMの濃度で種々のATL細胞の増殖を抑制した。その機序としてG2/M停止とその後のアポトーシスの誘導によることを明らかにした。またSMS-06はトポイソメラーゼIIの阻害作用に加えてhnRNP B1の存在下において放射線照射によるDNA修復を阻害する作用を持つことを新たに見出した。さらにSCIDマウスへのATL細胞の移植系において腫瘍の増殖を抑制作用を確認した。複数の分子標的を有するSMS-06はATLの治療薬剤開発のためのリード化合物として臨床応用への検討を進めている。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (65 results)

All 2008 2007 Other

All Journal Article (17 results) (of which Peer Reviewed: 16 results) Presentation (45 results) Remarks (3 results)

  • [Journal Article] Significantly increased antibody response to heterogeneous nuclear ribonucleoproteins in cerebrospinal fluid of multiple sclerosis patients but not in patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis2008

    • Author(s)
      Yukitake M, Sueoka E, Sueoka-Aragane N, Sato A, Ohashi H, Yakushiji Y, Saito M, Osame M, Izumo S, Kuroda Y.
    • Journal Title

      J Neurovirol 14,2

      Pages: 130-135

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exon 19 of EGFR mutation in relation to the CA-repeat polymorphism in intron 12008

    • Author(s)
      Sueoka-Aragane N, Imai K, Komiya K, Sato A, Tominasu R, Hisatomi T, Sakuragi T, Mitsuoka M, Hayashi S, Nakachi K, Sueoka E
    • Journal Title

      Cancer Sci 99,6

      Pages: 1080-1087

    • NAID

      10024007381

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a new method, transcription-reverse transcription concerted reaction, for detection of plasma hnRNP Bl mRNA, a biomarker of lung canxer2008

    • Author(s)
      Sato A, Sueoka-Aragane N, Saitoh J, Komiya K, Hisatomi T, Tomimasu R, Hayashi S, Sueoka E
    • Journal Title

      J Cancer Res Clin Oncol 134

      Pages: 1191-1197

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exon 19 of EGFR mutation in relation to the CA-repeat polymorphism in intron 12008

    • Author(s)
      Sueoka-Aragane N, Imai K, Komiya K, Sato A, Tominasu R, Hisatorai T, Sakuragi T, Mitsuoka M, Hayashi S, Nakachi K, Sueoka E
    • Journal Title

      Cancer Sci 99

      Pages: 1080-1187

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significantly increased antibody response to heterogeneous nuclear ribonucleoproteins in cerebrospinal fluid of multiple sclerosis patients but not in patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis.2008

    • Author(s)
      Yuki take M, Sueoka E, Sueoka-Aragane N, Sato A, Ohashi H, Yakushiji Y, Saito M, Osame M, Izumo S, Kuroda Y.
    • Journal Title

      J Neurovirol. 14

      Pages: 130-135

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase II study of chemotherapy and stem cell transplantation for adult acute lymphoblastic leukemia or lymphoblastic lymphoma : Japan Clinical Oncology Group study 90042007

    • Author(s)
      K Tobinai, K Takeyama, F Arima, T Kobayashi, S Hanada, M Kasai, S Ogura, E Sueoka, K Mukai, K Tajima, H Fukuda, S Shirakawa, T Hotta, S Masanori
    • Journal Title

      Cancer Sci 98,9

      Pages: 1350-1357

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Non-germinal cell phenotype and bcl-2 expression in primary adrenal diffuse large B-cell lymphoma2007

    • Author(s)
      M Ide, N Fukushima, T Hisatomi, N Tsuneyoshi, M Tanaka, M Yokoo, R Tomimasu, N Funai, E Sueoka
    • Journal Title

      Leukemia Lymphoma 48,11

      Pages: 2244-2246

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Myc target gene mina53 in subtypes of human lymphoma2007

    • Author(s)
      K Teye, N Arima, Y Nakamura, K Sakamoto, E Sueoka, H Kimura, M Tsuneoka
    • Journal Title

      Oncol Rep 18,4

      Pages: 841-848

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression and production of aberrant PAX5 with deletion of exon 8 in B-lineage acute lymphoblastic leukaemia of children2007

    • Author(s)
      Sadakane Y, Zaitsu M, Nishi M, Sugita K, Mizutani S, Matsuzaki A, Sueoka E, Hamasaki Y, Ishii E
    • Journal Title

      Br J Haematol 136,2

      Pages: 297-300

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutation profile of EGFR gene detected by denaturing high-performance liquid chromatography in Japanese lung cancer patients2007

    • Author(s)
      Sueoka-Aragane N, Sato A, Eguchi H, Komiya K, Sakuragi T, Mitsuoka M, Satoh T, Hayashi S, Nakachi K, Sueoka E
    • Journal Title

      J Cancer Res Clin Oncol 133,2

      Pages: 93-102

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 多発性骨髄腫における貧血2007

    • Author(s)
      船井典子、末岡榮三朗
    • Journal Title

      治療 89,8

      Pages: 2450-2455

    • Related Report
      2008 Final Research Report
  • [Journal Article] Establishment of a new method, transcription-reverse transcription concerted reaction, for detection of plasma hnRNP B1 mRNA, a biomarker of lung canxer2007

    • Author(s)
      Sato A, Sueoka-Aragane N, Saitoh J, Komiya K, Hisatomi T, Tomimasu R, Hayashi S, Sueoka E
    • Journal Title

      J Cancer Res Clin Oncol 134,11

      Pages: 1191-1197

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Myc target gene mina53 in subtypes of human lymphoma2007

    • Author(s)
      K Teye, Arima N, Nakamura Y, Sakamoto K, Sueoka E, Kimura H, Tsuneoka M
    • Journal Title

      Oncology Reports 18

      Pages: 841-848

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-germinal cell phenotype and bcl-2 expression primary adrenal diffuse large B-cell lymphoma2007

    • Author(s)
      Ide M, Fukushima N, Hisatomi T, et. al.
    • Journal Title

      Leukemia Lymphoma 6

      Pages: 1-3

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase II study of chemotherapy and stem cell transplantation for adult acute lymphoblastic leukemia or lymphoblastic lymphoblastic lymphoma: Japan Clinical Oncology Group Study 90042007

    • Author(s)
      K Tobinai, K Takeyama, F Arima, et. al.
    • Journal Title

      Cancer Sci 98

      Pages: 1350-1357

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Myc target gene mina53 in subtypes of human lymphoma2007

    • Author(s)
      Sadakane Y, Zaitsu M, Nishi M, et. al.
    • Journal Title

      1 136

      Pages: 297-300

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation profile of EGFR gene detected by denaturing high-performance liquid chromatography in Japanese lung cancer patients2007

    • Author(s)
      Sueoka N, Sato A, Eguchi H, Komiya K, et. al.
    • Journal Title

      J Cancer Res Clin Oncol 133

      Pages: 93-102

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] DNA repair a molecular target of cancer prevention and treatment2008

    • Author(s)
      Sueoka E, Sueoka-Aragane N.
    • Organizer
      韓国がん学会
    • Place of Presentation
      ソウル
    • Year and Date
      2008-11-06
    • Related Report
      2008 Final Research Report
  • [Presentation] hnRNP B1 ; a key modulator of DNA repair in carcinogenesis2008

    • Author(s)
      Sueoka E, Sueoka-Aragane N.
    • Organizer
      韓国がん学会
    • Place of Presentation
      ソウル
    • Year and Date
      2008-11-06
    • Related Report
      2008 Final Research Report
  • [Presentation] DNA repair a molecular target of cancer prevention and treatment2008

    • Author(s)
      Sueoka E, Sueoka-Aragane N.
    • Organizer
      韓国がん学会
    • Place of Presentation
      韓国ソウル市
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] hnRNP Bl ; a key modulator of DNA repair in carcinogenesis2008

    • Author(s)
      Sueoka E, Sueoka-Aragane N.
    • Organizer
      韓国がん学会
    • Place of Presentation
      韓国ソウル市
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 同種造血幹細胞移植4年後に非肝硬変性食道静脈瘤を発症した未分化大細胞性リンパ腫の1例2008

    • Author(s)
      末岡榮三朗, 島川明子, 萬年孝太郎, 桑原伸夫, 船井典子, 福島伯泰, 水田敏彦, 藤本一真
    • Organizer
      第70回日本血液学会第50回日本臨床血液学会合同総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 佐賀大学病院における後期高齢者悪性リンパ腫の現状2008

    • Author(s)
      福島伯康, 田中麻里子, 横尾眞子, 出勝, 久富崇, 冨桝りか, 船井典子, 末岡榮三朗
    • Organizer
      第70回日本血液学会第50回日本臨床血液学会合同総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] HTLV-I抗体陽性慢性C型肝炎患者に対するpeg-IFNα+リバビリン療法におけるHTLV-I provirus量の変化2008

    • Author(s)
      船井典子, 田中麻里子, 横尾眞子, 出勝, 久富崇, 冨桝りか, 福島伯泰, 末岡榮三朗、水田敏彦
    • Organizer
      第70回日本血液学会第50回日本臨床血液学会合同総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] DNA修復阻害を標的としたATLの新たな治療法開発の試み2008

    • Author(s)
      久富崇, 冨桝りか, 荒金尚子, 佐藤明美, 田中麻里子, 横尾眞子, 出勝, 福島伯泰, 船井典子, 岡本一也, 末岡榮三朗
    • Organizer
      第70回日本血液学会第50回日本臨床血液学会合同総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 佐賀大学血液内科におけるClostridium difficile関連下痢症についての臨床疫学的検討2008

    • Author(s)
      出勝, 福岡麻美, 中島由佳里, 田中麻里子, 横尾眞子, 久富崇, 冨桝りか, 福島伯泰, 船井典子, 末岡榮三朗
    • Organizer
      第70回日本血液学会第50回日本臨床血液学会合同総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 非ホジキンリンパ腫を合併し、R-CHOPが有効であった自己免疫性溶血性貧血の一例2008

    • Author(s)
      田中麻里子, 出勝, 福島伯康, 冨桝りか, 横尾眞子, 船井典子, 佐野雅之, 末岡榮三朗
    • Organizer
      第70回日本血液学会第50回日本臨床血液学会合同総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 低侵襲的同種骨髄移植が著効した治療抵抗性Lymphoplasmacytic lymphoma(LPL) の一例2008

    • Author(s)
      冨桝りか, 田中麻里子, 横尾眞子, 出勝, 久富崇, 福島伯泰, 船井典子, 末岡榮三朗
    • Organizer
      第70回日本血液学会第50回日本臨床血液学会合同総会, 第70回日本血液学会第50回日本臨床血液学会合同総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 多施設共同臨床試験併合解析による末梢T/NK細胞リンパ腫の新たな予後予測モデル(JCOG0108A)2008

    • Author(s)
      塚崎邦弘, 渡辺隆, 吉村健一, 末岡榮三朗(16番目), 他
    • Organizer
      第70回日本血液学会第50回日本臨床血液学会合同総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Bernard-Soulier症候群(GPIX W126X)の機能解析2008

    • Author(s)
      高田由香, 金地泰典, 諸井将明, 関律子, 奥英二郎, 佐野雅之, 中里幸恵, 緒方秀章, 吉本幸治, 薬師寺和昭, 橋口道俊, 今村理恵, 大崎浩一, 大坪惟範, 森重聡, 出原賢治, 末岡榮三朗, 今村豊, 岡村孝
    • Organizer
      第70回日本血液学会第50回日本臨床血液学会合同総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 成人T細胞リンパ腫(ATL)における微小残存病変(MRD)検査法の臨床応用についての検討2008

    • Author(s)
      崔日承, 塚崎邦弘, 鵜池直邦, 末岡榮三朗(11番目), 他
    • Organizer
      第70回日本血液学会第50回日本臨床血液学会合同総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] NK314 as a new therapeutic agent of adult T cell leukemia America Association for Cancer2008

    • Author(s)
      Hisatomi T, Tomimasu R, Aragane N, Sato A, Komiya K, Okamoto K, Sueoka E
    • Organizer
      Research Annual Meeting 2008
    • Place of Presentation
      サンデイエゴ, USA
    • Year and Date
      2008-04-16
    • Related Report
      2008 Final Research Report
  • [Presentation] DNA修復阻害を標的としたATLの新たな治療法開発の試み2008

    • Author(s)
      久富崇, 冨桝りか, 荒金尚子, 佐藤明美, 小宮一利, 岡本一也, 末岡榮三朗
    • Organizer
      第67回日本癌学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] Myc標的遺伝子mina53の肺発がんにおける役割2008

    • Author(s)
      小宮一利, 荒金尚子, 佐藤明美, 冨桝りか, 久富崇, 林真一郎, 常岡誠, 末岡榮三朗
    • Organizer
      第67回日本癌学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] NK314 as a new therapeutic agent of adult T cell leukemia2008

    • Author(s)
      Hisatomi T, Tomimasu R, Aragane N, Sato A, Komiya K, Okamoto K, Sueoka E
    • Organizer
      America Association for Cancer Research Annual Meeting 2008
    • Place of Presentation
      アメリカ合衆国サンディエゴ市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 同種造血幹細胞移植4年後に非肝硬変性食道静脈瘤を発症した未分化大細胞性リンパ腫の1例2008

    • Author(s)
      末岡榮三朗, 島川明子, 萬年孝太郎, 桑原伸夫, 船井典子, 福島伯泰, 水田利彦, 藤本一真
    • Organizer
      第70回日本血液会第50回日本臨床血液学会合同総会
    • Place of Presentation
      京都市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 佐賀大学病院における後期高齢者悪性リンパ腫の現状2008

    • Author(s)
      福島伯泰, 田中麻里子, 横尾眞子, 出勝, 久富崇, 冨桝りか, 船井典子, 末岡榮三朗
    • Organizer
      第70回日本血液学会第50回日本臨床血液学会合同総会
    • Place of Presentation
      京都市
    • Related Report
      2008 Annual Research Report
  • [Presentation] HTLV-I抗体陽性慢性C型肝炎患者に対するpeg-IFN_α+リバビリン療法におけるHTLV-I provirus量の変化2008

    • Author(s)
      船井典子, 田中麻里子, 横尾眞子, 出勝, 久富崇, 冨桝りか, 福島伯泰, 末岡榮三朗, 水田敏彦
    • Organizer
      第70回日本血液学会 第50回日本臨床血液学会合同総会
    • Place of Presentation
      京都市
    • Related Report
      2008 Annual Research Report
  • [Presentation] DNA修復阻害を標的としたATLの新たな治療法開発の試み2008

    • Author(s)
      久富崇, 冨桝りか, 荒金尚子, 佐藤明美, 田中麻里子, 横尾眞子, 出勝, 福島伯泰, 船井典子, 岡本一也, 末岡榮三朗
    • Organizer
      第70回日本血液学会 第50回日本臨床血液学会合同総会
    • Place of Presentation
      京都市
    • Related Report
      2008 Annual Research Report
  • [Presentation] DNA修復阻害を標的としたATLの新たな治療法開発の試み2008

    • Author(s)
      久富崇, 富桝りか, 荒金尚子, 佐藤明美, 小宮一利, 岡本一也, 末岡榮三朗
    • Organizer
      第67回日本癌学会
    • Place of Presentation
      名古屋市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 佐賀大学血液内科におけるClostridium difficile関連下痢症についての臨床疫学的検討2008

    • Author(s)
      出勝, 福岡麻美, 中島由佳里, 田中麻里子, 横尾眞子, 久富崇, 冨桝りか, 福島伯泰, 船井典子, 末岡榮三朗
    • Organizer
      第70回日本血液学会 第50回日本臨床血液学会合同総会
    • Place of Presentation
      京都市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Myc標的遺伝子mina53の肺発がんにおける役割2008

    • Author(s)
      小宮一利, 荒金尚子, 佐藤明美, 冨桝りか, 久富崇, 林真一郎, 常岡誠, 末岡榮三朗
    • Organizer
      第67回日本癌学会
    • Place of Presentation
      名古屋市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 非ホジキンリンパ腫を合併し、R-CHOPが有効であった自己免疫性溶血性貧血の一例2008

    • Author(s)
      田中麻里子, 出勝, 福島伯泰, 冨桝りか, 横尾眞子, 船井典子, 佐野雅之, 末岡榮三朗
    • Organizer
      第70回日本血液学会 第50回日本臨床血液学会 合同総会
    • Place of Presentation
      京都市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 成人T細胞リンパ腫(ATL)における微小残存病変(MRD)検査法の臨床応用についての検討2008

    • Author(s)
      崔日承, 塚崎邦弘, 鵜池直邦, 末岡榮三朗(11番目), 他
    • Organizer
      第70回日本血液学会 第50回日本臨床血液学会 合同総会
    • Place of Presentation
      京都市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Bernard-Soulier症候群(GPIX W126X)の機能解析2008

    • Author(s)
      高田由香, 金地泰典, 末岡榮三朗(13番目), 他16名
    • Organizer
      第70回日本血液学会 第50回日本臨床血液学会 合同総会
    • Place of Presentation
      京都市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 低侵襲的同種骨髄移植が著効した治療抵抗性Lymphoplasmacytic lymphoma(LPL)の一例2008

    • Author(s)
      冨桝りか, 田中麻里子, 横尾眞子, 出勝, 久富崇, 福島伯泰, 船井典子, 末岡榮三朗
    • Organizer
      第70回日本血液学会 第50回日本臨床血液学会 合同総会
    • Place of Presentation
      京都市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 多施設共同臨床試験併合解析による末梢T/NK細胞リンパ腫の新たな予後予測モデル(JCOG0108A)2008

    • Author(s)
      塚崎邦弘, 渡辺隆, 吉村健一, 末岡榮三朗(16番目), 他
    • Organizer
      第70回日本血液学会 第50回日本臨床血液学会 合同総会
    • Place of Presentation
      京都市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 同種骨髄移植を施行した若年発症ATLの一例2007

    • Author(s)
      木下麻悠子, 船井典子, 田中麻里子, 横尾眞子, 出勝, 久富崇, 冨桝りか, 福島伯泰, 末岡榮三朗
    • Organizer
      第69回日本血液学会第49回日本臨床血液学会合同総会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-10-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 同種骨髄移植を施行した若年発症ATLの一例2007

    • Author(s)
      木下 麻悠子, 船井 典子, 田中 麻里子, 他6名
    • Organizer
      第69回日本血液学会 第49回日本臨床血液学会 合同総会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-10-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Myc target gene, mina53, a role in lung carcinogenesis and its prognostic significance2007

    • Author(s)
      Komiya K, Aragane N, Satoh A, Tomimasu R, Hisatomi T, Hayashi S, Tsuneoka M, Sueoka E
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Overexpression of hnRNP B1 inhibits DNA repair system by interfering DNA-PK complex assembly in lung cancer cells2007

    • Author(s)
      Sato A, Aragane N , Iwanaga K, Tomimasu R, Hisatomi T, Komiya K, Sueoka E
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Overexpression of hnRNP B1 inhibits DNA repair system by interfering DNA-PK complex assembly in lung cancer cells2007

    • Author(s)
      Sato A, Aragane, Iwanaga K, Tomimasu R, Hisatomi T, Komiya K, Sueoka E
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Autoregulation of hnRNP A2/B1 promoter by hnRNP B12007

    • Author(s)
      Aragane N, Sato A, Iwanaga K, Komiya K, Sueoka E
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Carcinogenesis mediated through hnRNP B1 : Molecular target for early detection and treatment2007

    • Author(s)
      E Sueoka
    • Organizer
      The 8th Japan-Korea Joint Symposium on Cancer and Ageing Research
    • Place of Presentation
      Gifu, Japan
    • Year and Date
      2007-08-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Carcinogenesis mediated through hnRNP B1:Molecular target for early detection and treatment2007

    • Author(s)
      Sueoka E
    • Organizer
      he 8th Japan-Korea Joint Symposium on Cancer and Ageing Research
    • Place of Presentation
      岐阜市
    • Year and Date
      2007-08-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Inhibition of Double-strand DNA Break Repair by hnRNP B1 Meddiated through interactionwith DNA-dependent Protein Kinase Complex in Adult T-cell Leukemia2007

    • Author(s)
      E Sueoka, R Tomimasu, N Aragane, A Sato, T Hisatomi, K Komiya, N Fukushima, N Funai, N Kuwahara, M Ide
    • Organizer
      13th Int' l Conference on Human Retrovirology HTLV and related VIRUSES
    • Place of Presentation
      Hakone, Japan
    • Year and Date
      2007-05-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Inhibition of Double-strand DNA Break Repair by hnRNP B1 Meddiated through interaction with DNA-dependent Protein Kinase Complex in Adult T-cell Leukemia2007

    • Author(s)
      Sueoka E, Tomimasu R, Aragane N, Sato A, Hisatomi T, Komiya K, Fukushima N, Funai N, Kuwahara N, Ide M
    • Organizer
      13th Int'l Conference on Human Retrovirology HTLV and related VIRUSES
    • Place of Presentation
      箱根
    • Year and Date
      2007-05-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Inhibition of DNA repair system by hnRNP B1, an early detection marker for lung cancers, mediated through direct interaction with DNA-dependent protein kinase complex2007

    • Author(s)
      A Sato, N Sueoka-Aragane, K Iwanaga, R Tomimasu, T Hisatomi, K Komiya, E Sueoka
    • Organizer
      American Association for Cancer Research Annual Meeting
    • Place of Presentation
      Los Angels USA
    • Year and Date
      2007-04-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Autoregulation of hnRNP A2/B1 gene promoter by hnRNP B1 protein, an early detection marker for lung cancer, and down regulation by DNA-PK complex in lung cancer cells2007

    • Author(s)
      N Sueoka-Aragane, A Sato, K Iwanaga, K Komiya, T Kuzu, E Sueoka
    • Organizer
      American Association for Cancer Research Annual Meeting
    • Place of Presentation
      Los Angels USA
    • Year and Date
      2007-04-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Inhibition of DNA repair system by hnRNP B1, an early detection marker for lung cancers, mediated through direct interaction with DNA-dependent protein kinase complex2007

    • Author(s)
      Sato A, Sueoka N, Iwanaga K, Tomimasu R, Hisatomi T, Komiya K, Sueoka E
    • Organizer
      America Association for Cancer Research Annual Meeting 2007
    • Place of Presentation
      米国、ロサンゼルス
    • Year and Date
      2007-04-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Autoregulation of hnRNP A2/B1 gene promoter by hnRNP B1 protein,an early detection marker for lung cancer,and down regulation by DNA-PK complex in lung cancer cells2007

    • Author(s)
      Sueoka N, Sato, A Iwanaga K, Komiya K, Kozu T, Sueoka E
    • Organizer
      America Association for Cancer Research Annual Meeting 2007
    • Place of Presentation
      米国、ロサンゼルス
    • Year and Date
      2007-04-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] B細胞性リンパ腫におけるp63とbcl-6の発現の相関と臨床病理学的特徴2007

    • Author(s)
      福島 伯康, 佐藤 敏美, 荒金 尚子, 他10名
    • Organizer
      第5回日本臨床腫瘍学会学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2007-03-23
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://syllabus.dl.saga-u.ac.jp/res/jp/res_search_light_jp.html

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://syllabus.dl.saga-u.ac.jn/res/jp/res_search_light_jp.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://syllabus.dl.saga-u.ac.jp/res/jp/res_search_light_jp.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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