Expression of caveolin-1 in adult T-cell leukemia

• Project/Area Number: 19591123
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: University of the Ryukyus
• Principal Investigator: MORI Naoki University of the Ryukyus, 医学研究科, 教授 (10220013)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: HTLV-I / ATL / カベオリン / シグナル伝達 / 発現制御

Research Abstract

細胞膜の陥凹構造カベオラの主要構成タンパク質としてカベオリン-1(Cav-1)が同定されている。Cav-1は、膜タンパク質であり、種々のシグナル伝達分子と会合し、細胞増殖などの機能制御を行う。シグナル伝達分子との会合には、Cav-1のリン酸化が重要である。成人T細胞白血病(ATL)の原因ウイルスHTLV-Iの感染やHTLV-Iのトランスフォーミングタンパク質Taxの発現誘導がCD4+T細胞にCav-1の発現を誘導し、HTLV-I感染T 細胞株やATL白血病細胞はCav-1を高発現していた。感染T細胞株で発現しているCav-1はリン酸化していた。TaxによるCav-1発現の誘導には、NF-κBとCREB経路の活性化が重要であったが、Tax応答領域の同定は今後の課題である。Cav-1はI型TGF-β受容体と会合し、TGF-βシグナルを抑制することで、感染T細胞に特徴的なTGF-β不応性を誘導した。さらに、精製Cav-1はCD4+T細胞の増殖を促進した。ウェスタンブロットにて、ATL患者血漿中に健常人に比べて高濃度の可溶型Cav-1を検出し、リン酸化を認めた。Tax誘導性のCav-1はTGF-β不応性や細胞増殖を誘導し、発がんに関与すると考えられる。

Research Products

• [Journal Article] Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol (2009)
  • Author(s): Machijima Y, Ishikawa C, Sawada S, Okudaira T, Uchihara J, Tanaka Y, Taira N, Mori N.
  • Journal Title: Retrovirology 6 : 7
  • NAID: 120001374893
  • Peer Reviewed
• [Journal Article] Overexpression of aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-κB activity (2009)
  • Author(s): Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara J-N, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N.
  • Journal Title: Int J Cancer 124 Pages: 2607-2615
  • Peer Reviewed
• [Journal Article] Cell signaling modifiers for molecular targeted therapy in ATLL (2009)
  • Author(s): Mori N
  • Journal Title: Front Biosci 14 Pages: 1479-1489
  • NAID: 120001374979
• [Journal Article] Overexpression of aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-кB activity (2009)
  • Author(s): Mariko Tomita
  • Journal Title: International Journal of Cancer 124 Pages: 2607-2615
  • Peer Reviewed
• [Journal Article] Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol (2009)
  • Author(s): Yoshiaki Machijima
  • Journal Title: Retrovirology 6 Pages: 7-7
  • Peer Reviewed
• [Journal Article] Cell signaling modifiers for molecular targeted therapy in ATLL (2009)
  • Author(s): Naoki Mori
  • Journal Title: Frontiers in Bioscience 14 Pages: 1479-1489
  • NAID: 120001374979
• [Journal Article] Application of signal transduction inhibition as a therapeutic strategy for adult T-cell leukemia (2008)
  • Author(s): Mori N.
  • Journal Title: Austral-Asian Journal of Cancer 7 Pages: 21-28
  • NAID: 120001374895
• [Journal Article] Application of signal transduction inhibition as a therapeutic strategy for adult T-cell leukemia (2008)
  • Author(s): Mori N
  • Journal Title: Recent Advances and Research Updates 9 Pages: 47-58
  • NAID: 120001374895
• [Journal Article] Human T-cell leukemia virus type I can infect human lung epithelial cells and induce gene expression of cytokines, chemokines and cell adhesion molecules (2008)
  • Author(s): Teruya H, Tomita M, Senba M, Ishikawa C, Tamayose M, Miyazato A, Yara S, Tanaka Y, Iwakura Y, Fujita J, Mori N.
  • Journal Title: Retrovirology 5 Pages: 86-86
  • Peer Reviewed
• [Journal Article] Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol (2008)
  • Author(s): Ishikawa C, Tafuku S, Kadekaru T, Sawada S, Tomita M, Okudaira T, Nakazato T, Toda T, Uchihara J, Taira N, Ohshiro K, Yasumoto T, Ohta T, Mori N
  • Journal Title: Int J Cancer 123 Pages: 2702-2712
  • Peer Reviewed
• [Journal Article] Anti-adult T-cell leukemia effects of a novel synthetic retinoid, Am80 (Tamibarotene) (2008)
  • Author(s): Nakazato T, Okudaira T, Ishikawa C, Nakama S, Sawada S, Tomita M, Uchihara J, Taira N, Masuda M, Tanaka Y, Ohshiro K, Takasu N, Mori N.
  • Journal Title: Cancer Sci 99 Pages: 2286-2294
  • NAID: 10024013445
  • Peer Reviewed
• [Journal Article] Rearranged NF-κB2 gene in the adult T-cell leukemia cell line (2008)
  • Author(s): Isogawa M, Higuchi M, Takahashi M, Oie M, Mori N, Tanaka Y, Aoyagi Y, Fujii M
  • Journal Title: Cancer Sci 99 Pages: 792-798
  • NAID: 10024005182
  • Peer Reviewed
• [Journal Article] HTLV-1による細胞死制御異常の分子機構 (2008)
  • Author(s): 森直樹, 富田真理子
  • Journal Title: 臨床血液 49 Pages: 215-224
  • NAID: 10021257414
• [Journal Article] ATLにおける腫瘍化の機序] (2008)
  • Author(s): 森直樹
  • Journal Title: 血液・腫瘍科 56 Pages: 491-502
  • NAID: 40019063471
• [Journal Article] Rearranged NF-KB2 gene in the adult T-cell leukemia cell line (2008)
  • Author(s): Masato Isogawa
  • Journal Title: Cancer Science 99 Pages: 792-798
  • Peer Reviewed
• [Journal Article] Anti-adult T-cell leukemia effects of a novel synthetic retinoid, Am80 (Tamibarotene) (2008)
  • Author(s): Tetsuro Nakazato
  • Journal Title: Cancer Science 99 Pages: 2286-2294
  • Peer Reviewed
• [Journal Article] Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol (2008)
  • Author(s): Chie Ishikawa
  • Journal Title: International Journal of Cancer 123 Pages: 2702-2712
  • Peer Reviewed
• [Journal Article] Human T-cell leukemia virus type I can infect human lung epithelial cells and induce gene expression of cytokines, chemokines and cell adhesion molecules (2008)
  • Author(s): Hiromitsu Teruya
  • Journal Title: Retrovirology 5 Pages: 86-86
  • Peer Reviewed
• [Journal Article] Application of signal transduction inhibition as a therapeutic strategy for adult T-cell leukemia (2008)
  • Author(s): Naoki Mori
  • Journal Title: Recent Advances and Research updates 9 Pages: 47-58
  • NAID: 120001374895
• [Journal Article] Application of signal transduction inhibition as a therapeutic strategy for adult T-cell leukemia (2008)
  • Author(s): Naoki Mori
  • Journal Title: Austral-Asian Journal of Cancer 7 Pages: 21-28
  • NAID: 120001374895
• [Journal Article] HTLV-1による細胞死制御異常の分子機構 (2008)
  • Author(s): 森 直樹
  • Journal Title: 臨床血液 49 Pages: 215-224
  • NAID: 10021257414
• [Journal Article] ATLにおける腫瘍化の機序 (2008)
  • Author(s): 森 直樹
  • Journal Title: 血液・腫瘍科 56 Pages: 491-502
  • NAID: 40019063471
• [Journal Article] Rearranged NF-κB2 gene in the adult T-cell leukemia cell line (2008)
  • Author(s): Masato Isogawa
  • Journal Title: Cancer Science 99 Pages: 792-798
  • Peer Reviewed
• [Journal Article] Application of signal transduction inhibition as a therapeutic strategy for adult T-cell leukemia. (2008)
  • Author(s): Naoki Mori
  • Journal Title: Recent Advances and Research Updates 9 Pages: 47-58
  • NAID: 120001374895
• [Journal Article] Cell signaling modifiers for molecular targeted therapy in adult T-cell leukemia/lymphoma. (2008)
  • Author(s): Naoki Mori
  • Journal Title: Frontiers in Bioscience (印刷中)
• [Journal Article] HTLV-1による細胞死制御異常の分子機構. (2008)
  • Author(s): 森 直樹
  • Journal Title: 臨床血液 (印刷中)
  • NAID: 10021257414
• [Journal Article] ATLにおける腫瘍化の機序. (2008)
  • Author(s): 森 直樹
  • Journal Title: 血液・腫瘍科 (印刷中)
  • NAID: 40019063471
• [Journal Article] Activation of hypoxia-inducible factor 1 in human T-cell leukemia virus type 1-infected cell lines and primary adult T-cell leukemia cells (2007)
  • Author(s): Tomita M, Semenza GL, Michiels C, Matsuda T, Uchihara J, Okudaira T, Tanaka Y, Taira N, Ohshiro K, Mori N.
  • Journal Title: Biochem J 406 Pages: 317-323
  • Peer Reviewed
• [Journal Article] A modified version of galectin-9 suppresses cell growth and induces apoptosis of human T-cell leukemia virus type I-infected T-cell lines (2007)
  • Author(s): Okudaira T, Hirashima M, Ishikawa C, Makishi S, Tomita M, Matsuda T, Kawakami H, Taira N, Ohshiro K, Masuda M, Takasu N, Mori N.
  • Journal Title: Int J Cancer 120 Pages: 2251-2261
  • NAID: 120001371849
  • Peer Reviewed
• [Journal Article] Inhibition of heat shock protein 90 modulates multiple functions required for survival of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells (2007)
  • Author(s): Kawakami H, Tomita M, Okudaira T, Ishikawa C, Matsuda T, Tanaka Y, Nakazato T, Taira N, Ohshiro K, Mori N.
  • Journal Title: Int J Cancer 120 Pages: 1811-1820
  • NAID: 120001371787
  • Peer Reviewed
• [Journal Article] Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway (2007)
  • Author(s): Ishikawa C, Matsuda T, Okudaira T, Tomita M, Kawakami H, Tanaka Y, Masuda M, Ohshiro K, Ohta T, Mori N.
  • Journal Title: Br J Haematol 136 Pages: 424-432
  • NAID: 120001372397
  • Peer Reviewed
• [Journal Article] ATLの分子標的療法 (2007)
  • Author(s): 森直樹
  • Journal Title: VIRUSREPORT 4 Pages: 60-71
  • Peer Reviewed
• [Journal Article] 成人T細胞白血病・リンパ腫の分子標的療法 (2007)
  • Author(s): 森直樹
  • Journal Title: 『日本臨牀』2007年増刊「造血器腫瘍-基礎・臨床研究における最新の研究動向-」日本臨牀 65 Pages: 709-718
• [Journal Article] Activation of hypoxia-inducible factor 1 in human T-cell leukemia virus type 1-infected cell lines and primary adult T-cell leukemia cells. (2007)
  • Author(s): Mariko Tomita
  • Journal Title: Biochemical Journal 406 Pages: 317-323
  • Peer Reviewed
• [Journal Article] A modified version of galectin-9 suppresses cell growth and induces apoptosis of human T-cell leukemia virus type I-infected T-cell lines. (2007)
  • Author(s): Taeko Okudaira
  • Journal Title: International Journal of Cancer 120 Pages: 2251-2261
  • Peer Reviewed
• [Journal Article] Inhibition of heat shock protein 90 modulates multiple functions required for survival of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells. (2007)
  • Author(s): Hirochika Kawakami
  • Journal Title: International Journal of Cancer 120 Pages: 1811-1820
  • Peer Reviewed
• [Journal Article] Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway. (2007)
  • Author(s): Chie Ishikawa
  • Journal Title: British Journal of Haematology 136 Pages: 424-432
  • Peer Reviewed
• [Journal Article] 成人T細胞白血病・リンパ腫の分子標的療法. (2007)
  • Author(s): 森 直樹
  • Journal Title: 日本臨牀 65 Pages: 709-718
• [Journal Article] ATLの分子標的療法. (2007)
  • Author(s): 森 直樹
  • Journal Title: VIRUS REPORT 4 Pages: 60-71
• [Presentation] Human T-cell leukemia virus type 1 Tax activates caveolin-1 gene expression (2008)
  • Author(s): Sawada S.
  • Organizer: 50th Annual Meeting of the American Society of Hematology
  • Place of Presentation: San Francisco, California
• [Presentation] HTLV-1 transforming protein Tax induces cellular micrRNA miR-146a through NF-κB signaling pathway. Hong Kong Cancer Institute/AACR (2008)
  • Author(s): Tomita M
  • Organizer: International Conference, Infection and Cancer : Biology, Therapeutics, and Prevention
  • Place of Presentation: Hong Kong SAR, China
• [Presentation] The role of ARK5 on survival of HTLV-1-infected T cells against glucosedeprivation (2008)
  • Author(s): Tomita M
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Expression of caveolin-1 in HTLV-1-infected T-cell lines and primary ATL cells (2008)
  • Author(s): Sawada S
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Anti-ATL effect of natural product hippuristanol (2008)
  • Author(s): Machijima Y
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] HTLV-1感染T細胞の生存におけるARK5の役割 (2008)
  • Author(s): 富田真理子
  • Organizer: 第56回日本ウイルス学会学術集会
  • Place of Presentation: 岡山
• [Presentation] 成人T細胞白血病におけるTwistの発現異常 (2008)
  • Author(s): 丹治弘江
  • Organizer: 第56回日本ウイルス学会学術集会
  • Place of Presentation: 岡山
• [Presentation] 成人T細胞白血病におけるカベオリン-1の発現異常 (2008)
  • Author(s): 澤田茂樹
  • Organizer: 第56回日本ウイルス学会学術集会
  • Place of Presentation: 岡山
• [Presentation] サンゴ由来タンパク質翻訳阻害剤hippuristanolによる成人T細胞白血病治療の可能性 (2008)
  • Author(s): 町島由章
  • Organizer: 第56回日本ウイルス学会学術集会
  • Place of Presentation: 岡山
• [Presentation] HTLV-1感染T細胞の新規生存シグナル分子 : ARK5 (2008)
  • Author(s): 森直樹
  • Organizer: 第70回血液学会総会
  • Place of Presentation: 京都
• [Presentation] サンゴ由来タンパク質翻訳阻害剤hippuristanolによる成人T細胞白血病治療の可能性 (2008)
  • Author(s): 町島由章
  • Organizer: 第45回日本ウイルス学会九州支部総会
  • Place of Presentation: 熊本
• [Presentation] 成人T細胞白血病におけるTwistの発現異常 (2008)
  • Author(s): 丹治弘江
  • Organizer: 第45回日本ウイルス学会九州支部総会
  • Place of Presentation: 熊本
• [Presentation] 成人T細胞白血病におけるカベオリン-1の発現異常 (2008)
  • Author(s): 澤田茂樹
  • Organizer: 第45回日本ウイルス学会九州支部総会
  • Place of Presentation: 熊本
• [Presentation] Overexpression and activation of hypoxia-inducible factor 1 through PI3K/Akt signaling pathway in human T-cell leukaemia virus type 1-infected T cells (2008)
  • Author(s): Tomita M.
  • Organizer: 20th Meeting of the European Association for Cancer Research
  • Place of Presentation: Lyon, France
• [Presentation] ARK5 regulates the growth of HTLV-1-infected T cells during glucose starvation (2008)
  • Author(s): Tomita M.
  • Organizer: Annual Meeting of the American Association for Cancer Research 2008
  • Place of Presentation: San Diego, California
• [Presentation] ARK5 regulates the growth of HTLV-1-infected T cells during glucose starvation (2008)
  • Author(s): Mariko Tomita
  • Organizer: Annual Meeting of the American Association for Cancer Research 2008
  • Place of Presentation: San Diego, California, USA
• [Presentation] Overexpression and activation of hypoxia-inducible factor 1 through PI3K/Akt signaling pathway in human T-cell leukaemia virus type 1-infected T cells (2008)
  • Author(s): Mariko Tomita
  • Organizer: 20^<th> Meeting of the European Association for Cancer Research
  • Place of Presentation: Lyon, France
• [Presentation] HTLV-1 transforming protein Tax induces cellular micrRNA miR-146a through NF-кB signaling pathway (2008)
  • Author(s): Mariko Tomita
  • Organizer: Hong Kong Cancer Institute/AACR International Conference
  • Place of Presentation: Hong Kong SAR, China
• [Presentation] Human T-cell leukemia virus type 1 Tax activates caveolin-1 gene expression (2008)
  • Author(s): Shigeki Sawada
  • Organizer: 50^<th> Annual Meeting of the American Society of Hematology
  • Place of Presentation: San Francisco, California, USA
• [Presentation] 成人T細胞白血病におけるカベオリン-1の発現異常 (2008)
  • Author(s): 澤田茂樹
  • Organizer: 第45回日本ウイルス学会九州支部総会
  • Place of Presentation: 熊本県熊本市熊本大学医学部附属病院山崎記念会館
• [Presentation] 成人T細胞白血病におけるTwistの発現異常 (2008)
  • Author(s): 丹治弘江
  • Organizer: 第45回日本ウイルス学会九州支部総会
  • Place of Presentation: 熊本県熊本市熊本大学医学部附属病院山崎記念会館
• [Presentation] サンゴ由来タンパク質翻訳阻害剤hippuristanolによる成人T細胞白血病治療の可能性 (2008)
  • Author(s): 町島由章
  • Organizer: 第45回日本ウイルス学会九州支部総会
  • Place of Presentation: 熊本県熊本市熊本大学医学部附属病院山崎記念会館
• [Presentation] HTLV-1感染T細胞の新規生存シグナル分子 : ARK5 (2008)
  • Author(s): 森 直樹
  • Organizer: 第70回血液学会総会
  • Place of Presentation: 京都府京都市国立京都国際会館
• [Presentation] サンゴ由来タンパク質翻訳阻害剤hippuristanolによる成人T細胞白血病治療の可能性 (2008)
  • Author(s): 町島由章
  • Organizer: 第56回日本ウイルス学会学術集会
  • Place of Presentation: 岡山県岡山市岡山コンベンションセンター
• [Presentation] 成人T細胞白血病におけるカベオリン-1の発現異常 (2008)
  • Author(s): 津田茂樹
  • Organizer: 第56回日本ウイルス学会学術集会
  • Place of Presentation: 岡山県岡山市岡山コンベンションセンター
• [Presentation] 成人T細胞白血病におけるTwistの発現異常 (2008)
  • Author(s): 丹治弘江
  • Organizer: 第56回日本ウイルス学会学術集会
  • Place of Presentation: 岡山県岡山市岡山コンベンションセンター
• [Presentation] HTLV-1感染T細胞の生存におけるARK5の役割 (2008)
  • Author(s): 富田真理子
  • Organizer: 第56回日本ウイルス学会学術集会
  • Place of Presentation: 岡山県岡山市岡山コンベンションセンター
• [Presentation] Anti-ATL effect of natural product hippuristanol (2008)
  • Author(s): Yoshiaki Machijima
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋県名古屋市名古屋国際会議場
• [Presentation] Expression of caveolin-1 in HTLV-1-infected T-cell lines and primary ATL cells (2008)
  • Author(s): Shigeki Sawada
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋県名古屋市名古屋国際会議場
• [Presentation] The role of ARK5 on survival of HTLV-1-infected T cells against glucose deprivation (2008)
  • Author(s): Mariko Tomita
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋県名古屋市名古屋国際会議場
• [Presentation] インドール3カルビノールによる成人T細胞白血病治療の可能性 (2007)
  • Author(s): 町島由章
  • Organizer: 第55回日本ウイルス学会学術集会
  • Place of Presentation: 札幌
• [Presentation] 成人T細胞白血病におけるChfrおよびAurora Aの役割 (2007)
  • Author(s): 富田真理子
  • Organizer: 第55回日本ウイルス学会学術集会
  • Place of Presentation: 札幌
• [Presentation] ATL におけるMMP-7の発現異常 (2007)
  • Author(s): 中里哲郎
  • Organizer: 第69回日本血液学会・第49回日本臨床血液学会合同総会
  • Place of Presentation: 横浜
• [Presentation] ATLにおけるM期チェックポイント遺伝子CHFRとAuroraキナーゼの発現制御異常 (2007)
  • Author(s): 森直樹
  • Organizer: 第69回日本血液学会・第49回日本臨床血液学会合同総会
  • Place of Presentation: 横浜
• [Presentation] HTLV-1 による細胞死制御異常の分子機構 (2007)
  • Author(s): 森直樹
  • Organizer: 第69回日本血液学会・第49回日本臨床血液学会合同総会
  • Place of Presentation: 横浜
• [Presentation] Overexpression of MMP-7 in ATL (2007)
  • Author(s): Nakazato T
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Anti-ATL effect of brown algae fucoxanthin and its deacetylated product, fucoxanthinol (2007)
  • Author(s): Ishikawa C
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Bidens pilosa induces apoptosis of HTLV-1-infected T-cell lines and ATL cells (2007)
  • Author(s): Nakama S
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Dysregulation of mitotic checkpoint proteins Chfr and Aurora kinase in HTLV-1-infected T cells (2007)
  • Author(s): Tomita M
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Anti-ATL effects of a novel synthetic retinoid, Am80 (Tamibarotene) through inhibition of NF-κB (2007)
  • Author(s): Nakazato T.
  • Organizer: 13th International Conference on Human Retrovirology
  • Place of Presentation: Hakone, Japan
• [Presentation] HTLV-1 Tax activates CD69 gene expression (2007)
  • Author(s): Ishikawa C.
  • Organizer: 13th International Conference on Human Retrovirology
  • Place of Presentation: Hakone, Japan
• [Presentation] HTLV-1 can infect human lung epithelial cells and induce gene expression of cytokines, chemokines, and cell adhesion molecules (2007)
  • Author(s): Teruya H.
  • Organizer: 13th International Conference on Human Retrovirology
  • Place of Presentation: Hakone, Japan
• [Presentation] Dysregulation of mitotic checkpoint proteins Chfr and Aurora A in HTLV-I-infected T-cells (2007)
  • Author(s): Tomita M.
  • Organizer: 13th International Conference on Human Retrovirology
  • Place of Presentation: Hakone, Japan
• [Presentation] HTLV-1関連呼吸器疾患における肺上皮細胞の役割 (2007)
  • Author(s): 照屋宏充
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
• [Presentation] Dysregulation of mitotic checkpoint proteins Chfr and Aurora A inHTLV-I-infected T-cells (2007)
  • Author(s): Tomita M.
  • Organizer: Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Los Angeles, California
• [Presentation] Dysregulation of mitotic checkpoint proteins Chfr and Aurora A in HTLV-I-infected T-cells. (2007)
  • Author(s): Mariko Tomita
  • Organizer: Annual Meeting of the American Association for Cancer Research 2007
  • Place of Presentation: Los Angeles
• [Presentation] Anti-ATL effects of a novel synthetic retinoid, Am80 (Tamibarotene) through inhibition of NF-κB. (2007)
  • Author(s): Tetsuro Nakazato
  • Organizer: 13th International Conference on Human Retrovirology
  • Place of Presentation: Hakone
• [Presentation] HTLV-1 Tax activates CD69 gene expression. (2007)
  • Author(s): Chie Ishikawa
  • Organizer: 13th International Conference on Human Retrovirology
  • Place of Presentation: Hakone
• [Presentation] HTLV-1 can infect human lung epithelial cells and induce gene expression of cytokines, chemokines, and cell adhesion molecules. (2007)
  • Author(s): Hiromitsu Teruya
  • Organizer: 13th International Conference on Human Retrovirology
  • Place of Presentation: Hakone
• [Presentation] Dysregulation of mitotic checkpoint proteins Chfr and Aurora A in HTLV-I-infected T-cells. (2007)
  • Author(s): Mariko Tomita
  • Organizer: 13th International Conference on Human Retrovirology
  • Place of Presentation: Hakone
• [Presentation] HTLV-1関連呼吸器疾患における肺上皮細胞の役割. (2007)
  • Author(s): 照屋宏充
  • Organizer: 第47回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
• [Presentation] Dysregulation of mitotic checkpoint proteins Chfr and Aurora kinase in HTLV-1-infected T cells. (2007)
  • Author(s): Mariko Tomita
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Bidens pilosa induces apoptosis of HTLV-1-infected T-cell lines and ATL cells. (2007)
  • Author(s): Shiji Nakama
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Anti-ATL effect of brown algae fucoxanthin and its deacetylated product, fucoxanthinol. (2007)
  • Author(s): Chie Ishikawa
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Overexpression of MMP-7 in ATL. (2007)
  • Author(s): Tetsuro Nakazato
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] ATLにおけるM期チェックポイント遺伝子CHFRとAuroraキナーゼの発現制御異常. (2007)
  • Author(s): 森 直樹
  • Organizer: 第69回日本血液学会・第49回日本臨床血液学会合同総会
  • Place of Presentation: 横浜
• [Presentation] HTLV-1による細胞死制御異常の分子機構. (2007)
  • Author(s): 森 直樹
  • Organizer: 第69回日本血液学会・第49回日本臨床血液学会合同総会
  • Place of Presentation: 横浜
• [Presentation] ATLにおけるMMP-7の発現異常. (2007)
  • Author(s): 中里哲郎
  • Organizer: 第69回日本血液学会・第49回日本臨床血液学会合同総会
  • Place of Presentation: 横浜
• [Presentation] 成人T細胞白血病におけるChfrおよびAurora Aの役割. (2007)
  • Author(s): 富田真理子
  • Organizer: 第55回日本ウイルス学会学術集会
  • Place of Presentation: 札幌
• [Presentation] インドール3カルビノールによる成人T細胞白血病治療の可能性. (2007)
  • Author(s): 町島由章
  • Organizer: 第55回日本ウイルス学会学術集会
  • Place of Presentation: 札幌
• [Book] 医学書院, レトロウイルスと感染症 (2009)
  • Author(s): 森直樹
  • Publisher: 標準微生物学, 平松啓一, 中込治(編)
• [Book] Natural Products as Future Medicinal Agents (2009)
  • Author(s): Naoki Mori
  • Publisher: Research Signpost(印刷中)
• [Book] 標準微生物学 (2009)
  • Author(s): 森 直樹
  • Publisher: 医学書院
• [Book] 沖縄タイムス出版部, 沖縄のウイルスと細菌から太古のヒトの流れを知る (2008)
  • Author(s): 森直樹
  • Publisher: やわらかい南の学と思想-琉球大学の知への誘い, 琉球大学(編)
• [Book] やわらかい南の学と思想-琉球大学の知への誘い (2008)
  • Author(s): 森 直樹
  • Publisher: 沖縄タイムス出版部
• [Book] Natural Products-their current and future clinical uses- (2008)
  • Author(s): Naoki Mori
  • Publisher: Research Signpost(印刷中)
• [Book] やわらかい南の学と思想-琉球大学への知の誘い (2008)
  • Author(s): 森 直樹
  • Publisher: 沖縄タイムス出版部(印刷中)
• [Book] Nova Science Publishers Inc., Apoptosis-inducing effects of curcumin in adult T-cell leukemia cells (2007)
  • Author(s): Tomita M, Mori N.
  • Publisher: In : Taylor AW, editor. Cell Apoptosis and Cancer
• [Book] 東洋医学舎, Fucoidan Extracted From Cladosiphon Okamuranus Tokida Induces Apoptosis of Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines and Primary Adult T-Cell Leukemia Cells (2007)
  • Author(s): 森直樹
  • Publisher: ファイトケミカル研究要覧, ファイトケミカル研究会(編)
• [Book] 東洋医学舎, オキナワモズク由来フコイダンによる成人T細胞性白血病(ATL)の治療の可能性 (2007)
  • Author(s): 森直樹
  • Publisher: ファイトケミカル研究要覧, ファイトケミカル研究会(編)
• [Book] 文光堂, ヒトレトロウイルス研究の現状 (2007)
  • Author(s): 森直樹, 山本直樹
  • Publisher: HTLV-1 と疾患, 渡邊俊樹, 上平憲, 山口一成(編)
• [Book] 文光堂, HTLV-1TaxによるWntシグナル伝達経路の制御 (2007)
  • Author(s): 森直樹, 富田真理子
  • Total Pages: 2007
  • Publisher: HTLV-1と疾患, 渡邊俊樹, 上平憲, 山口一成(編)
• [Book] Cell Apoptosis and Cancer (2007)
  • Author(s): Mariko Tomita
  • Publisher: Nova Science Publishers, Inc.
• [Book] ファイトケミカル研究要覧 (2007)
  • Author(s): 森 直樹
  • Publisher: 東洋医学舎
• [Book] HTLV-1と疾患 (2007)
  • Author(s): 森 直樹
  • Publisher: 文光堂
• [Book] In : Hawthorne S, editor. Natural Products as Future Medicinal Agents
  • Author(s): Mori N, Machijima Y, Haneji K.
  • Publisher: Research Signpost, Anti-adult T-cell leukemia effects of fucoidan(印刷中)
• [Remarks] 新聞報道日本経済新聞夕刊(2008年12月18日)「医療・健康に海藻生かせ : 血液がんの予防食」
  • URL: http://www.cc.u-ryukyu.ac.jp/~virology/topall/topf.html
• [Remarks]
  • URL: http://www.cc.u-ryukyu.ac.jp/~virology/topall/topf.html
• [Remarks]
  • URL: http://www.cc.u-ryukyu.ac.jp/~virology/topall/topf.html