Diet treatment by flavonoid for allergic diseases
| Project/Area Number |
19591165
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Osaka University |
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Principal Investigator |
TANAKA Toshio Osaka University, 医学系研究科, 准教授 (40273651)
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| Co-Investigator(Kenkyū-buntansha) |
HIRANO Toru 大阪大学, 医学部附属病院, 医員 (10437402)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アレルギー / 食事療法 / フラボノイド / 補完代替療法 |
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| Research Abstract |
フラボノイドの適切な摂取によるアレルギー疾患に対する食事療法の開発を目指し、以下の事を明らかした。
・スギ花粉症患者を対象として、2重盲検プラセボ比較対照試験において、プラセボと比較して酵素処理イソケルシトリン(ケルセチン配糖体)100mg/日摂取群においては、結膜炎症状が軽減することが明らかとなった。
・喘息及びアトピー性皮膚炎モデルマウスにおいて、酵素処理イソケルシトリンの経口投与で、それぞれ気道過敏性と皮膚炎症が低下する傾向が観察された。
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Report
(3 results)
Research Products
(39 results)
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[Journal Article] Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis2009
Author(s)
T. Hirano, M. Kawai, J. Arimitsu, M. Ogawa, Y. Kuwahara, K. Hagihara, Y. Shima, M. Narazaki, A. Ogata, M. Koyanagi, T. Kai, R. Shimizu, M. Moriwaki, Y. Suzuki, S. Ogino, I. Kawase, T. Tanaka
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Journal Title
Allergology International 58 [Equb ahead of print]
NAID
Related Report
Peer Reviewed
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[Journal Article] Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis : a randomized double-blind placebo-controlled trial2009
Author(s)
M. Kawai, T. Hirano, J. Arimitsu, S. Higa, Y. Kuwahara, K. Hagihara, M. Narazaki, A. Ogata, M. Koyanagi, T. Kai, R. Shimizu, M. Moriwaki, Y. Suzuki, S. Ogino, I. Kawase, T. Tanaka
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Journal Title
Int Arch Allergy Immunol 149
Pages: 359-368
Related Report
Peer Reviewed
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[Journal Article] Flavonoids and related compounds as anti-allergic substances2007
Author(s)
M. Kawai, T. Hirano, S. Higa, J. Arimitsu, M. Maruta, Y. Kuwahara, T. Ohkawara, K. Hagihara, T. Yamadori, Y. Shima, A. Ogata, I. Kawase, T. Tanaka
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Journal Title
Allergology International 56
Pages: 113-123
NAID
Related Report
Peer Reviewed
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[Presentation] Flavonoids and related compounds as anti-allergic substances2007
Author(s)
T. Tanaka, T. Hirano, M. Kawai, S. Higa, J. Arimitsu, K. Nananishi, Y. Kuwahara, T. Ohkawara, K. Hagihara, Y. Shima, M. Narazaki, A. Ogata, I. Kawase
Organizer
World Allergy Organization Congress-XX ICACI
Place of Presentation
Bangkog, Thailand
Related Report
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