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Clinical application of anti-CADM-140 antibodies detected inpatients with dermatomyositis

Research Project

Project/Area Number 19591178
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionKeio University

Principal Investigator

SATO Shinji  Keio University, 医学部, 助教 (90276238)

Co-Investigator(Kenkyū-buntansha) FUJITA Tomonobu  慶應義塾大学, 医学部, 助教 (20199334)
高橋 一夫  横浜市立大学, 医学部, 准教授 (40264618)
Co-Investigator(Renkei-kenkyūsha) TAKAHASHI Kazuo  横浜市立大学, 医学部, 准教授 (40264618)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsMyopathies / Autoimmune Diseases / Melanoma Differentiation-Associated Gene 5(MDA5) / Clinically Amyopathic Dermatomyositis(C-ADM) / Interstitial Lung Disease(ILD) / 自己抗体 / Clinically amyopathic dermatomyositis / 多発性筋炎・皮膚筋炎 / 急速進行性間質性肺炎 / 抗CADM-140抗体 / Viral infection / MDA5(Melanoma Differentiation-Associated Gene 5) / 自己抗体皮膚筋炎 / Clinicall amyopathic dermatomyositis
Research Abstract

臨床的に筋炎症状に乏しい皮膚筋炎(C-ADM)に見出された抗CADM-140抗体の対応抗原がMDA5(Melanoma Differentiation-Associated Gene 5)であることを明らかにし, 同抗体測定ELISAを確立した. 同抗体陽性例は, 急速進行性間質性肺炎(RP-ILD)を有意に併発していた. 今回の研究成果は, 予後不良のRP-ILD併発C-ADMの早期診断に有用で, 予後の改善につながることが期待される.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (15 results)

All 2009 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (8 results) Book (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] RNA Helicase Encoded by Melanoma Differentiation? Associated Gene 5 isa Major Autoantigen in Patients with Clinically Amyopathic Dermatomyositis2009

    • Author(s)
      Sato S, Hoshino K, Satoh T, FujitaT, Kawakami Y, Fujita T, Kuwana M
    • Journal Title

      Arthritis&Rheum (In press)

    • Related Report
      2008 Final Research Report
  • [Journal Article] RNA Helicase Encoded by Melanoma Differentiation-Associated Gene 5 is a Major Autoantigen in Patients with Clinically Amyopathic Dermatomyositis2009

    • Author(s)
      Shinji Sato, et al
    • Journal Title

      Arthritis & Rheumatism In press

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 皮膚筋炎と抗CADM-140抗体2008

    • Author(s)
      佐藤慎二
    • Journal Title

      リウマチ科 40

      Pages: 231-238

    • Related Report
      2008 Final Research Report
  • [Journal Article] 皮膚筋炎と抗CADM-140抗体2008

    • Author(s)
      佐藤 慎二
    • Journal Title

      リウマチ科 40

      Pages: 231-238

    • Related Report
      2008 Annual Research Report
  • [Presentation] MDA5 (Melanoma Differentiation-Associated Gene 5) as an Autoantigen Recognized by Anti-CADM-140 Antibody in Patients with Clinically Amyopathic Dermatomyositis2008

    • Author(s)
      Sato S, Hoshino K, Satoh T, Yamaguchi Y, Hirakata M, Kuwana M
    • Organizer
      ermatomyositis. The 72nd ACR Annual scientific meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] MDA5 (Melanoma-Differentiation Associated Gene 5) as anantigen recognized by anti-CADM-140 antibody in patients with clinically amyopathic dermatomyositis.2008

    • Author(s)
      Shinji Sato, et al
    • Organizer
      The 72th Annual Scientific Meeting of American Collage of Rheumatology
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] シンポジウム15自己抗体研究の進歩 : 皮膚筋炎に見出された抗CADM-140抗体の病因的・臨床的意義2008

    • Author(s)
      佐藤慎二, 星野香菜, 佐藤隆司, 桑名正隆
    • Organizer
      第52回日本リウマチ学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-04-23
    • Related Report
      2008 Final Research Report
  • [Presentation] 皮膚筋炎に見出された抗CADM-140抗体の病因的・臨床的意義2008

    • Author(s)
      佐藤慎二, 他
    • Organizer
      第52回日本リウマチ学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-04-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 皮膚筋炎に見出された抗CADM-140抗体の病因的・臨床的意義2008

    • Author(s)
      佐藤慎二
    • Organizer
      第15回自己抗体と自己免疫シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-02-16
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Classification of dermatomyositis using myositis-specific autoantibodies and newly found autoantibodies in patients with dermatomyositis2007

    • Author(s)
      Sato S, Hoshino K, Satoh T, Yamaguchi Y, Hirakata M, Kuwana M
    • Organizer
      The 71nd ACR Annual scientific meeting
    • Place of Presentation
      Boston
    • Year and Date
      2007-11-10
    • Related Report
      2008 Final Research Report
  • [Presentation] 皮膚筋炎に見出される自己抗体による皮膚筋炎の病型分類および病型別の治療戦略2007

    • Author(s)
      佐藤慎二, 星野香菜, 佐藤隆司, 平形道人, 桑名正隆
    • Organizer
      第57回日本アレルギー学会秋季学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-11-02
    • Related Report
      2008 Final Research Report
  • [Presentation] 筋炎特異および関連自己抗体を用いた皮膚筋炎の病型分類の検討2007

    • Author(s)
      佐藤慎二, 星野香菜, 佐藤隆司, 山口由衣, 諏訪昭, 平形道人, 桑名正隆
    • Organizer
      第51回日本リウマチ学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-04-27
    • Related Report
      2008 Final Research Report
  • [Book] 皮膚筋炎で見出された抗CADM-140抗体の臨床的・病因的意義. 第15回「自己抗体と自己免疫」シンポジウム : 筋炎と自己免疫講演録集2008

    • Author(s)
      佐藤慎二
    • Publisher
      株式会社医学生物学研究所
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 皮膚筋炎の診断方法および診断キット2008

    • Inventor(s)
      佐藤慎二、桑名正隆、藤田尚志
    • Industrial Property Rights Holder
      学校法人慶應義塾
    • Filing Date
      2008-09-01
    • Related Report
      2008 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 皮膚筋炎の診断方法および診断キット2008

    • Inventor(s)
      佐藤慎二桑名正隆藤田尚志
    • Industrial Property Rights Holder
      学校法人慶應義塾
    • Filing Date
      2008-09-01
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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