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A novel regulatory role of IgG Fc receptor IIB in Flt3L-mediated dendritic cell development

Research Project

Project/Area Number 19591181
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionJuntendo University

Principal Investigator

HIROSE Sachiko  Juntendo University, 医学部, 准教授 (00127127)

Co-Investigator(Kenkyū-buntansha) NISHIMURA Hiroyuki  桐蔭横浜大学, 医用工学部, 教授 (60189313)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords樹上細胞 / Fc・RIIB / Flt3 / SLE / 樹状細胞 / FcγRIIB / Akt
Research Abstract

Fms-like tyrosine kinase receptor 3 ligand (Flt3L)は前駆細胞を樹状細胞に分化させる増殖分化因子である。我々は今回、Fc・RIIB欠損マウスでは、抹消にCD11c+CD11b+CD8-の形質を持つmyeloid系樹状細胞が、正常マウスに比較して有意に増加していることを発見した。Flt3Lを添加した骨髄細胞培養系で解析した結果、Fc・RIIB欠損マウスの骨髄細胞培養では正常マウスに比較して、有意に多くの樹状細胞が得られた。その原因は、Flt3Lによる増殖能の亢進ではなく、アポトーシス抵抗性の亢進によることが示された。従って、Fc・RIIB分子には、Flt3Lによる樹状細胞分化過程において、アポトーシスを亢進することで増殖抑制に働くという、今まで知られていなかった機能が存在する可能性が示された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (30 results)

All 2009 2008 2007

All Journal Article (18 results) (of which Peer Reviewed: 15 results) Presentation (12 results)

  • [Journal Article] Fc・R-dependent expansion of a hyperactive monocyte subset in lupus-prone mice2009

    • Author(s)
      Santiago-Raber M-L, Amano H, Amano E, Baudino L, Otani M, Lin Q, Nimmerjahn F, Sjef Verbeek J, Ravetch JV, Takasaki Y, Hirose S, and Izui S
    • Journal Title

      Arthritis Rheum (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ankylosing enthesitis associated with up-regulated IFN- and IL-17 production in (BXSB x NZB) F1 male mice ; a new mouse model2009

    • Author(s)
      Abe Y, Ohtsuji M, Ohtsuji N, Lin Q, Tsurui H, Nakae S, Shirai T, Sudo K, and Hirose S
    • Journal Title

      Mod. Rheum (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 自己免疫の発症とFcgレセプター臨床免疫・アレルギー科2009

    • Author(s)
      広瀬幸子、林青順
    • Journal Title

      科学評論社 (印刷中)

    • Related Report
      2008 Final Research Report
  • [Journal Article] Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD. CD72^b congenic mice2009

    • Author(s)
      Hou R, Ohtsuji M, Ohtsuji N , Zhang L, Adachi T, Hirose S, Tsubata. T
    • Journal Title

      Biochem. Biophys. Res. Commun 380

      Pages: 193-197

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant genetic control of invariant TCR-bearing NKT cell function in New Zealand mouse strains : possible involvement in SLE pathogenesis2008

    • Author(s)
      Tsukamoto H, Ohtsuji M, Shiroiwa W, Lin Q, Nakamura K, Tsurui H, Jiang Y, Sudo K, Nishimura H, Shirai T, and Hirose S
    • Journal Title

      J. Immunol 180

      Pages: 4530-4539

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice2008

    • Author(s)
      Moriyama Y, Sekine C, Koyanagi A, Koyama N, Ogata H, Chiba S, Hirose S, Okumura K, and Yagita H
    • Journal Title

      Int. Immunol 20

      Pages: 763-773

    • NAID

      10021241547

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Jorgensen, TN, Tucker RM, Roark CL, Kotzin BL, Evans LH, and Izui S. Dissection of genetic mechanisms governing the expression of serum retroviral gp70 implicated in murine lupus nephritis2008

    • Author(s)
      Baudino L, Yoshinobu K, Morito N, Kikuchi S, Fossati-Jimack L, Morley BJ, Vyse TJ, Hirose S
    • Journal Title

      J. Immunol 181

      Pages: 2846-2854

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Splenic phagocytes promotes to nucleosomes in (NZB x NZW) F1 mice2008

    • Author(s)
      Okamoto A, Fujio K, van Rooijen N, Tsuno NH, Takahashi T, Tsurui H, Hirose S, Elkon KB, and Yamamoto K
    • Journal Title

      J. Immunol 181

      Pages: 5264-5271

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant genetic control of invariant TCR-bearing NKT cell function in New Zealand mouse strains : possible involvement in SLE pathogenesis.2008

    • Author(s)
      Tsukamoto H, et al.
    • Journal Title

      J. Immunol. 180

      Pages: 4530-4539

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Delta-like I is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice.2008

    • Author(s)
      Moroyama Y, et al.
    • Journal Title

      Int. Immunol. 20

      Pages: 763-773

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dissection of genetic mechanisms governing the expression of serum retroviralgp70 implicated in murine lupus nephritis.2008

    • Author(s)
      Baudino L, et al.
    • Journal Title

      J. Immunol. 181

      Pages: 2846-2854

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Splenic phagocytes promotes to nucleosomes in(NZB x NZW)F1 mice.2008

    • Author(s)
      Okamoto A, et al.
    • Journal Title

      J. Immunol. 181

      Pages: 5264-5271

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant genetic control of invariant TCR-bearing NKT cell function in New Zealand mouse strains:possible involvement in SLE pathogenesis2008

    • Author(s)
      Tsukamoto K, et. al.
    • Journal Title

      J.Immunol 180

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-4R・polymorphism in regulation of IL-4 synthesis by T cells : implication in susceptibility to a subset of murine lupus2007

    • Author(s)
      Shiroiwa W, Tsukamoto K, Ohtsuji M, Lin Q, Ida A, Kodera S, Ohtsuji N, Nakamura K, Tsurui H, Kinoshita K, Nishimura H, Shirai T, and Hirose S
    • Journal Title

      Int. Immunol 19

      Pages: 175-183

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD3 and IgG Fc receptor regulate cerebellar functions2007

    • Author(s)
      Nakamura K, Hirai H, Torashima T, Miyazaki T, Tsurui H, Xiu Y, Ohtsuji M, Qing Shun Lin Q, Tsukamoto K, Nishimura H, Ono M, Watanabe M and Hirose S
    • Journal Title

      Mol. Cell. Biol 27

      Pages: 5128-5134

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 全身性自己免疫疾患とFc・レセプターによる免疫反応の正と負の調節2007

    • Author(s)
      林青順、広瀬幸子
    • Journal Title

      臨床免疫・アレルギー科科学評論社 47

      Pages: 545-550

    • Related Report
      2008 Final Research Report
  • [Journal Article] CD3 and IgG Fc receptor regulate cerebellar functions2007

    • Author(s)
      Nakamura K, et. al.
    • Journal Title

      Mol.Cell.Biol 27

      Pages: 5127-5134

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 全身性自己免疫疾患とFcγレセプターによる免疫反応の正と負の調節2007

    • Author(s)
      林 青順、広瀬 幸子
    • Journal Title

      臨床免疫・アレルギー科 47

      Pages: 545-550

    • Related Report
      2007 Annual Research Report
  • [Presentation] FcgR-dependent expansion of Gr-1- monocyte subset in lupus prone mice2008

    • Author(s)
      Amano H, Amano E, Lin Q. Ando S, Nishimura H, Moromoto S, Hirose S, Takasaki Y
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] (NZW x BXSB) F1マウスにおけるFcgr2bプロモーター領域の多型性の影響2008

    • Author(s)
      Lin Q、Tsurui H, Ohtsuji M, Amano H、Nishimura H, Shirai T, Hirose S
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] 抑制型IgG FcレセプターによるB細胞分化の制御2008

    • Author(s)
      林青順、天野浩文、天野恵理、白井俊一、広瀬幸子
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] SLE動物モデルにおけるT細胞の活性化2008

    • Author(s)
      藤尾圭志、岡本明子、鶴井博理、広瀬幸子、山本一彦
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] BXSBマウスの末梢血単球増加におけるFcγレセプターの役割2008

    • Author(s)
      天野浩文、天野恵理、安藤誠一郎、仲野総一郎、森本真司、戸叶嘉明、林青順、西村裕之、広瀬幸子、高崎芳成
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] (NZW x BXSB)F1マウスにおけるFcgr2bプロモーター領域の多型性の影響2008

    • Author(s)
      Lin Q, et al.
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] SLE動物モデルにおけるT細胞の活性化2008

    • Author(s)
      藤尾 圭志, 他
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] BXSBマウスの末梢血単球増加におけるFc γレセプターの役割2008

    • Author(s)
      天野 浩文, 他
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] Protection from autoimmune disease by restoration of impaired FcgRIIB expression2007

    • Author(s)
      Lin Q, Ohtsuji M, Amano H, Amano E, Tsurui H, Nishimura H, Shirai T, Hirose S
    • Organizer
      第37回日本免疫学会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Association of NKT cell function with systemic lupus erythematosus2007

    • Author(s)
      Hirose S, Tsukamoto K, Ohtsuj M, Lin Q, Tsurui H, Nishimura H, Shirai T
    • Organizer
      第37回日本免疫学会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] BXSBマウスの末梢血単核球増加におけるIgGFcレセプターの役割2007

    • Author(s)
      天野浩文、天野恵理、安藤誠一郎、仲野総一郎、森本真司、戸叶嘉明、林青順、西村裕之、広瀬幸子、高崎芳成
    • Organizer
      第37回日本免疫学会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 末梢性の免疫寛容誘導における抑制性Fc受容体FcgRIIBの役割2007

    • Author(s)
      軸丸由梨、藤井琢磨、池田賢一、大木麻紀子、吉澤侑也、小寺洋、広瀬幸子、白井俊一、西村裕之
    • Organizer
      第37回日本免疫学会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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