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Mutual interaction of enteric bacteria and immune cells of the gut

Research Project

Project/Area Number 19591184
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionTokyo Medical University

Principal Investigator

MATSUMOTO Tetsuya  Tokyo Medical University, 医学部, 教授 (10256688)

Co-Investigator(Kenkyū-buntansha) 古賀 泰裕  東海大学, 医学部, 教授 (60170221)
Co-Investigator(Renkei-kenkyūsha) KOGA Yasuhiro  東海大学, 医学部, 教授 (60170221)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords感染症学 / 消化管免疫 / 腸内細菌 / 腸管免疫 / bacterial translocation / CDld / NKT細胞 / germ-free / プロバイオティクス / 緑膿菌 / CD1d
Research Abstract

本研究では消化管粘膜免疫におけるCD1d およびNKT 細胞の役割について検討を行った. CD1d ノックアウトマウスを無菌化して経口的に大腸菌や黄色ブドウ球菌を接種後, 腸管内の菌数の変化を調べたところ, 野生型マウスに比べて腸管内の急激な菌数の増加が認められた. 腸管の電顕像においてCD1d ノックアウトマウスはパネート細胞内の分泌顆粒が減少していることが明らかとなり、NKT 細胞がデフェンシンなどの抗菌物質の分泌に影響を与え, 腸管の粘膜免疫に重要な役割を果たしていることが示唆された.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2009 2008 2007 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (1 results) Book (1 results) Remarks (2 results)

  • [Journal Article] CD1d-dependent regulation of bacterial colonization in the intestine2009

    • Author(s)
      Edward E.S. Nieuwenhuis, Tetsuya Matsumoto, Dicky Lindenbergh, Rob Willemsen, Arthur Kaser, Ytje Simons-Oosterhuis, Sylvia Brugman, Keizo Yamaguchi, Hiroki Ishikawa, Yuji Aiba, Yasuhiro Koga, Janneke Samsom, Kenshiro Oshima, Mami Kikuchi, Johanna C. Escher, Masahira Hattori, Andrew B. Onderdonk, Richard S. Blumberg
    • Journal Title

      Journal of Clinical Investigation (in print)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cdld-dependent regulation of bacterial colonization in the intestine of mice2009

    • Author(s)
      E. E. S. Nieuwenhuis*, T. Matsumoto*, et al. (* : equally contributed)
    • Journal Title

      Journal of Clinical Investigation (in print)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral administration of Bifidobacterium longum prevents gut-derived Pseudomonas aeruginosa sepsis in mice2008

    • Author(s)
      Matsumoto T
    • Journal Title

      J.Applied Microbiol. 104

      Pages: 672-680

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Bacteriophage Therapy against Gut-Derived Sepsis Caused by Pseudomonas aeruginosa in Mice2007

    • Author(s)
      Watanabe R
    • Journal Title

      Antimicrob.Agents Chemother. 51

      Pages: 446-452

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine.2007

    • Author(s)
      Saha S
    • Journal Title

      J Immunol. 179

      Pages: 1147-1154

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 腸内細菌のコントロールによる感染症の制御2007

    • Author(s)
      松本 哲哉
    • Organizer
      第10回日本臨床腸内微生物学会
    • Place of Presentation
      長崎
    • Year and Date
      2007-09-08
    • Related Report
      2007 Annual Research Report
  • [Book] 内科学 第9版2007

    • Author(s)
      松本 哲哉
    • Total Pages
      2008
    • Publisher
      朝倉書店
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.tokyo-med.ac.jp/microbiology/publication2.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.tokyo-med.ac.jp/microbiology/publication2.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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