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A study for the etiology of the metabolic syndrome in childhood focusing on hereditary obesity

Research Project

Project/Area Number 19591207
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionTottori University

Principal Investigator

HANAKI Keiichi  Tottori University, 医学部, 教授 (20238041)

Co-Investigator(Kenkyū-buntansha) NAGAISHI Junichi  鳥取大学, 医学部附属病院, 講師 (90346354)
NAGATA Ikuo  鳥取大学, 医学部, 准教授 (50252846)
KANZAKI Susumu  鳥取大学, 医学部, 教授 (90224873)
KINOSHITA Tomoe  鳥取大学, 医学部附属病院, 助教 (80444636)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsメタボリックシンドローム / 小児肥満 / 遺伝性肥満 / アディポネクチン / 子宮内発育不全 / 糖尿病 / シグナル伝達
Research Abstract

The aim of this study was to elucidate the mechanism by which the metabolic syndrome developed, especially in Alstroem syndrome, a hereditary obesity inevitably developing the metabolic syndrome. Several findings were obtained focusing on the insulin/IGF-1 action in the Alstroem syndrome, a relationship between SNPs for obesity-related genes and blood chemistry, and a relationship between high-molecular adiponectin and intra/extra uterine growth.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (58 results)

All 2010 2009 2008 2007 Other

All Journal Article (31 results) (of which Peer Reviewed: 13 results) Presentation (13 results) Book (14 results)

  • [Journal Article] 小児肥満の管理-介入・治療における留意点2010

    • Author(s)
      花木啓一、岩谷有里子、長石純一、神崎晋
    • Journal Title

      日本臨床 68(増刊号2)

      Pages: 692-696

    • Related Report
      2009 Final Research Report
  • [Journal Article] Alstroem症候群2010

    • Author(s)
      木下朋絵、花木啓一、神崎晋
    • Journal Title

      日本臨床 68(増刊号2)

      Pages: 501-505

    • Related Report
      2009 Final Research Report
  • [Journal Article] メタボリックシンドロームの発症要因:遺伝要因2010

    • Author(s)
      花木啓一
    • Journal Title

      小児科診療 47(2)

      Pages: 211-216

    • Related Report
      2009 Final Research Report
  • [Journal Article] 小児肥満の管理-介入・治療における留意点2010

    • Author(s)
      花木啓一, 他
    • Journal Title

      日本臨床肥満症(日本臨床社)

      Pages: 692-696

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Alstroem症候群2010

    • Author(s)
      木下朋絵, 他
    • Journal Title

      日本臨床肥満症(日本臨床社)

      Pages: 501-505

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Late-onset adrenal hypoplasia congenita caused by a novel mutation of the DAX-1 gene2009

    • Author(s)
      Yang F, Hanaki K, Kinoshita T, Kawashima Y, Nagaishi J, Kanzaki S.
    • Journal Title

      Eur J Pediatr 168(3)

      Pages: 329-31

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] San-in Asthma Research Group. Environmental tobacco smoke and its effect on the symptoms and medication in children with asthma2009

    • Author(s)
      Yamasaki A, Hanaki K, Tomita K, Watanabe M, Hasagawa Y, Okazaki R, Igishi T, Horimukai K, Fukutani K, Sugimoto Y, Yamamoto M, Kato K, Ikeda T, Konishi T, Tokuyasu H, Yajima H, Sejima H, Isobe T, Shimizu E
    • Journal Title

      Int J Environ Health Res 19(2)

      Pages: 97-108

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytochrome P450 oxidoreductase deficiency: identification and characterization of biallelic mutations and genotype-phenotype correlations in 35 Japanese patients2009

    • Author(s)
      Fukami M, Nishimura G, Homma K, Nagai T, Hanaki K, Uematsu A, Ishii T, Numakura C, Sawada H, Nakacho M, Kowase T, Motomura K, Haruna H, Nakamura M, Ohishi A, Adachi M, Tajima T, Hasegawa Y, Hasegawa T, Horikawa R, Fujieda K, Ogata T.
    • Journal Title

      J Clin Endocrinol Metab 94(5)

      Pages: 1723-31

    • Related Report
      2009 Final Research Report
  • [Journal Article] Cytochrome P450 oxidoreductase deficiency : identification and characterization of biallelic mutations and genotype-phenotype correlations in 35 Japanese patients2009

    • Author(s)
      Fukami M, et al
    • Journal Title

      J Clin Endocrinol Metab 94(5)

      Pages: 1723-1731

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Environmental tobacco smoke and its effect on the symptoms and medication in children with asthma2009

    • Author(s)
      Yamasaki A, et al
    • Journal Title

      Int J Environ Health Res 19(2)

      Pages: 97-108

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ホルモンの分泌調節2009

    • Author(s)
      花木啓一
    • Journal Title

      小児内分泌学(日本小児内分泌学会編)(診断と治療社)

      Pages: 8-11

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ホルモンの生合成と代謝2009

    • Author(s)
      花木啓一
    • Journal Title

      小児内分泌学(日本小児内分泌学会編)(診断と治療社)

      Pages: 11-14

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 視床下部・下垂体障害による内分泌疾患2009

    • Author(s)
      花木啓一
    • Journal Title

      小児内分泌学(日本小児内分泌学会編)(診断と治療社)

      Pages: 217-219

    • Related Report
      2009 Annual Research Report
  • [Journal Article] メタボリックシンドローム2009

    • Author(s)
      花木啓一
    • Journal Title

      小児内分泌学(日本小児内分泌学会編)(診断と治療社)

      Pages: 505-508

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Late-onset adrenal hypoplasia congenita caused by a novel mutation of the DAX-1gene2009

    • Author(s)
      Yang F, Hanaki K, et al
    • Journal Title

      Eur J Pediatr 168

      Pages: 329-31

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytochrome P450 Oxidoreductase Deficiency : Identification and Characterization of Biallelic Mutations and Genotype-Phenotype Correlations in 35 Japanese Patients.2009

    • Author(s)
      Fukami M, Hanaki K, Hasegawa T, Horikawa R, Fujieda K, Ogata T.
    • Journal Title

      J Clin Endocrinol Metab 168(Epub)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mental retardation, spasticity, basal ganglia calcification, cerebral white matter lesions, multiple endocrine defects, telangiectasia and atrophic skin: a new syndrome?2008

    • Author(s)
      Saito Y, Toyoshima M, Oka A, Zhuo L, Moriwaki S, Yamamoto O, Kanzaki S, Hanaki K, Ninomiya H, Nanba E, Kondo A, Maegaki Y, Ohno K.
    • Journal Title

      Brain Dev 30(3)

      Pages: 221-5

    • NAID

      10025169655

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小児内分泌の進歩2008

    • Author(s)
      神崎晋、鞁嶋有紀、藤本正伸、横山美由紀、長石純一、花木啓一
    • Journal Title

      日本内分泌学会雑誌 84

      Pages: 22-24

    • NAID

      10021262945

    • Related Report
      2009 Final Research Report
  • [Journal Article] Variation analysis of beta3-adrenergic receptor and melanocortin-4 Receptor genes in childhood obesity2007

    • Author(s)
      Kinoshita T, Hanaki K, Nagaishi J, Kawashima Y, Adachi K, Nanba, Kanzaki S.
    • Journal Title

      Pediatrics International 49(2)

      Pages: 133-137

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lower brainstem dysfunction in an infant with persistent primitive trigeminal artery2007

    • Author(s)
      Okanishi T, Saito Y, Miki S, Nagaishi J, Hanaki K, Tomita Y, Fukuda C, Fujii S, Fujiwara K, Kawamoto K, Hata F, Maegaki Y, Ohno K.
    • Journal Title

      Brain Dev 29(3)

      Pages: 189-92

    • NAID

      10024135285

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 味覚と月経周期・体組成との関連2007

    • Author(s)
      山根美智子、花木啓一、佐々木くみ子、西村正子、前田隆子
    • Journal Title

      米子医誌 58

      Pages: 141-146

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 正期産児における臍帯血アディポサイトカインの研究:子宮内発育と臍帯血多量体アディポネクチン・レプチン値の検討2007

    • Author(s)
      三浦真澄、長石純一、船田裕昭、上山潤一、堂本友恒、河場康郎、美野陽一、木下朋絵、鞁嶋有紀、長田郁夫、花木啓一、神崎晋. 早産児
    • Journal Title

      米子医学雑誌 58(2)

      Pages: 50-62

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肥満児の心理特性と親の育児姿勢2007

    • Author(s)
      南前恵子、石原千絵子、花木啓一
    • Journal Title

      臨床栄養 110(7)

      Pages: 819-822

    • Related Report
      2009 Final Research Report
  • [Journal Article] 肥満児への対応2007

    • Author(s)
      花木啓一
    • Journal Title

      小児外科 39(4)

      Pages: 358-360

    • Related Report
      2009 Final Research Report
  • [Journal Article] 低血糖症・インスリン過剰症2007

    • Author(s)
      花木啓一
    • Journal Title

      小児科 48(11)

      Pages: 1714-1720

    • Related Report
      2009 Final Research Report
  • [Journal Article] 母親から外来でときに聞かれること:肥満なのですが(5歳)2007

    • Author(s)
      花木啓一
    • Journal Title

      外科 39(4)

      Pages: 358-360

    • Related Report
      2009 Final Research Report
  • [Journal Article] 小児のメタボリックシンドローム発症と遺伝2007

    • Author(s)
      花木啓一
    • Journal Title

      アディポサイエンス 4(4)

      Pages: 369-375

    • Related Report
      2009 Final Research Report
  • [Journal Article] 健常小児と肥満児における血中多量体adiponectin値の検討2007

    • Author(s)
      長石純一, 船田裕昭, 木下朋絵, 鞁嶋有紀, 花木啓一, 神崎晋
    • Journal Title

      ホルモンと臨床 12

      Pages: 1189-1195

    • Related Report
      2009 Final Research Report
  • [Journal Article] ホルモンによる成長の制御2007

    • Author(s)
      神崎晋, 木下朋絵, 長石純一, 花木啓一
    • Journal Title

      小児科診療 70(10)

      Pages: 1615-1619

    • Related Report
      2009 Final Research Report
  • [Journal Article] Variation analysis of beta3-adrenergic receptor and melanocortin-4 Receptor genes in childhood obesity2007

    • Author(s)
      Kinoshita T, et. al.
    • Journal Title

      Pediatrics International 49

      Pages: 133-137

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胎児期・新生児期の体重増加量と周産期指標の関連

    • Author(s)
      遠藤有里, 他
    • Journal Title

      小児保健研究 (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] IGF-1R mutation and IUGR2010

    • Author(s)
      Kawashima Y, et al
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肥満の成因と小児メタボリックシンドローム・・・保健指導の新しいステップとして・・・2009

    • Author(s)
      花木啓一
    • Organizer
      第18回広島市医師会学校医部会総会:特別講演
    • Place of Presentation
      広島
    • Year and Date
      2009-05-29
    • Related Report
      2009 Final Research Report
  • [Presentation] 肥満の成因と小児メタボリックシンドローム2009

    • Author(s)
      花木啓一
    • Organizer
      第21回佐賀県医師会小児科医部会学術講演会:特別講演
    • Place of Presentation
      佐賀
    • Year and Date
      2009-05-16
    • Related Report
      2009 Final Research Report
  • [Presentation] 小児のメタボリックシンドローム2009

    • Author(s)
      花木啓一
    • Organizer
      第41回若年者心疾患対策協議会総会:ミートザエキスパート
    • Place of Presentation
      鳥取
    • Year and Date
      2009-01-31
    • Related Report
      2009 Final Research Report
  • [Presentation] 肥満関連遺伝子多型と今後の肥満小児への介入方法について2009

    • Author(s)
      花木啓一、木下朋絵、鞁嶋有紀、長石純一、神崎晋, 木村真司、朝山光太郎、有阪治、大関武彦、岡田知雄、衣笠昭彦、菊池透, 河野斉、杉原茂孝、玉井浩、土橋一重、中川祐一、原光彦、藤枝憲二、溝田美智代
    • Organizer
      第30回日本肥満学会:シンポジウム4
    • Place of Presentation
      浜松
    • Related Report
      2009 Final Research Report
  • [Presentation] Cord blood levels of adipocytokines in AGA infants and SGA infants2009

    • Author(s)
      Nagaishi J, et al
    • Organizer
      The 8th Joint Meeting of LWPES-ESPE
    • Place of Presentation
      New York City, NY, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肥満関連遺伝子多型と今後の肥満小児への介入方法について2009

    • Author(s)
      花木啓一, 他
    • Organizer
      第30回日本肥満学会シンポジウム
    • Place of Presentation
      浜松
    • Related Report
      2009 Annual Research Report
  • [Presentation] Overproduction of IL-6 due to Castleman's disease resulted in low serum IGF-1 levels and growth retardation : case report2008

    • Author(s)
      Nagaishi J, et al
    • Organizer
      The 90 th meeting of the Endocrine Society
    • Place of Presentation
      サンフランシスコ(米国)
    • Year and Date
      2008-06-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 幼児におけるメタボリックシンドローム関連指標の標準値2008

    • Author(s)
      堀米 仁志, 花木啓一, 他
    • Organizer
      第111回日本小児内分泌学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2008-04-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 幼児におけるメタボリックシンドローム関連指標と血液凝固線溶系2008

    • Author(s)
      堀米 仁志, 花木啓一, 他
    • Organizer
      第111回日本小児内分泌学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2008-04-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 母親の就業と小児の生活習慣の関連についての研究2007

    • Author(s)
      芦原綾乃, 他
    • Organizer
      第26回鳥取県小児保健学会
    • Place of Presentation
      米子市
    • Year and Date
      2007-12-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] インスリン自己抗体を認め血糖コントロールに難渋した1型糖尿病の幼児例2007

    • Author(s)
      長石純一、他
    • Organizer
      第41回日本小児内分泌学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-11-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cord Blood Levels of High Molecular Weight Form Adiponectin and Leptin in A ppropriate for Gestational Age Infants and Small for Gestational Age Infants.2007

    • Author(s)
      Nagaishi J, et. al.
    • Organizer
      The 89th meeting of the Endocrine Society
    • Place of Presentation
      トロント市(カナダ)
    • Year and Date
      2007-06-02
    • Related Report
      2007 Annual Research Report
  • [Book] ホルモンの分泌調節2009

    • Author(s)
      花木啓一
    • Publisher
      診断と治療社
    • Related Report
      2009 Final Research Report
  • [Book] ホルモンの生合成と代謝2009

    • Author(s)
      花木啓一
    • Publisher
      診断と治療社
    • Related Report
      2009 Final Research Report
  • [Book] 視床下部・下垂体障害による内分泌疾患2009

    • Author(s)
      花木啓一
    • Publisher
      診断と治療社
    • Related Report
      2009 Final Research Report
  • [Book] メタボリックシンドローム2009

    • Author(s)
      花木啓一
    • Publisher
      診断と治療社
    • Related Report
      2009 Final Research Report
  • [Book] メタボリックシンドロームの発症要因(生活習慣)2009

    • Author(s)
      花木啓一
    • Publisher
      中山書店
    • Related Report
      2009 Final Research Report
  • [Book] メタボリックシンドロームの現状. 小児科臨床ピクシス(大関武彦)2009

    • Author(s)
      花木啓一
    • Publisher
      永井書店
    • Related Report
      2009 Final Research Report
  • [Book] 小児科臨床ピクシス2009

    • Author(s)
      花木啓一
    • Publisher
      小児メタボリックシンドローム
    • Related Report
      2008 Annual Research Report
  • [Book] 小児のメタボリックシンドロームはなぜ生じるか:生活習慣. 小児のメタボリックシンドローム(岡田知雄)2008

    • Author(s)
      花木啓一
    • Publisher
      永井書店
    • Related Report
      2009 Final Research Report
  • [Book] 小児のメタボリックシンドロームはなぜ生じるか:生活習慣. 小児のメタボリックシンドローム2008

    • Author(s)
      花木啓一
    • Publisher
      診断と治療社
    • Related Report
      2009 Final Research Report
  • [Book] 幼児・学童・思春期の栄養, 小児科学(大関武彦・近藤直実)2008

    • Author(s)
      花木啓一
    • Publisher
      医学書院
    • Related Report
      2009 Final Research Report
  • [Book] 肥満, 小児科学(大関武彦・近藤直実)2008

    • Author(s)
      花木啓一
    • Publisher
      医学書院
    • Related Report
      2009 Final Research Report
  • [Book] 卵巣の異常, 小児科学(大関武彦・近藤直実)2008

    • Author(s)
      花木啓一
    • Publisher
      医学書院
    • Related Report
      2009 Final Research Report
  • [Book] 小児のメタボリックシンドロームはなぜ生じるか?2008

    • Author(s)
      花木啓一
    • Publisher
      診断と治療社
    • Related Report
      2008 Annual Research Report 2007 Annual Research Report
  • [Book] 小児のメタボリックシンドローム発症と遺伝2007

    • Author(s)
      花木啓一
    • Total Pages
      7
    • Publisher
      フジメデイカル出版
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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