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Is Sprouty2 a candidate gene for growth hormone deficiency?

Research Project

Project/Area Number 19591222
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionJikei University School of Medicine

Principal Investigator

SUZUKI Hideaki  Jikei University School of Medicine, 医学部, 講師 (20206519)

Co-Investigator(Kenkyū-buntansha) OKABE Masataka  東京慈恵会医科大学, 医学部, 教授 (10300716)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords成長ホルモン / 染色体異常 / 下垂体 / 短指症
Research Abstract

13番染色体長腕の部分欠損症例の経験から、欠損部位に局在するSprouty2 (Spry2)が成長ホルモン欠損症および第5指中節骨短縮の原因遺伝子である可能性について検討した。既報例および自験例の共通欠失領域にある遺伝子の発現パターンを解析し、Spry2が13q欠失症候群におけるこの2つの表現型の有力な責任遺伝子であることがわかった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (3 results)

All 2009

All Journal Article (3 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] 奇形症候群2009

    • Author(s)
      鈴木英明
    • Journal Title

      小児科診療 72

      Pages: 45-50

    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Journal Article] Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer2009

    • Author(s)
      Iwaizumi M, Shinmura K, Mori H, Yamada H, Suzuki M, Kitayama Y, Igarashi H, Nakamura T, Suzuki H, Watanabe Y, Hishida A, Ikuma M, Sugimura H
    • Journal Title

      Gut 58

      Pages: 249-260

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human Sgol downregulation leads to chromosomal instability in colorectal cancer2009

    • Author(s)
      Iwaizumi M., et al.
    • Journal Title

      Gut 58

      Pages: 249-260

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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