Pathological mechanisms of keratinization abnormalities

• Project/Area Number: 19591294
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Asahikawa Medical College
• Principal Investigator: YAMAMOTO Akemi Asahikawa Medical College, 医学部, 准教授 (30241441)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 皮膚病理学 / 角化細胞 / 魚鱗癬 / 角化症 / 角化 / 遺伝子異常 / 免疫電顕法 / モデル動物 / 超微構造 / プロテアーゼ / 皮膚バリア

Research Abstract

We have studied mechanisms of normal keratinization and abnormal keratinization. We have found evidences to suggest that tight junctions are involved in spatially distinct degradation of corneodesmosomes and in lamellar granule transportation and secretion. We have revealed that abnormal transportation and/or secretion of lamellar granules could result in ichthyosis in two genetic diseases, CEDNIK syndrome and ARC syndrome. We found that corneodesmosin in crucial for corneocyte adhesion. We have found evidences to suggest that Rab11 may be involved in lamellar granule transportation.

Research Products

• [Journal Article] CEDNIK syndrome results from loss-of-function mutations in SNAP29. (2011)
  • Author(s): Fuchs-Telem D, Ishida-Yamamoto A, et al
  • Journal Title: Br J Dermatol 164 Pages: 53-57
  • Peer Reviewed
• [Journal Article] Tight Junctions in the Stratum Corneum Explain Spatial Differences in Corneodesmosome Degradation. (2011)
  • Author(s): Igawa S, Kishibe M, Murakami M, Honma M, TakahashiH, Iizuka H, Ishida-Yamamoto H
  • Journal Title: Exp Dermatol 20 Pages: 53-57
  • Peer Reviewed
• [Journal Article] Revised nomenclature and classification of inherited ichthyoses : Results of the First Ichthyosis Consensus Conference in Soreze 2009. (2011)
  • Author(s): Oji V, Ishida-Yamamoto A, et al
  • Journal Title: J Am Acad Dermatol. 63 Pages: 607-641
  • Peer Reviewed
• [Journal Article] Involvement of corneodesmosome degradation and lamellar granule transportation in the desquamation process (2011)
  • Author(s): Ishida-Yamamoto A, Kishibe M
  • Journal Title: Medical Molecular Morphology Volume: 43(in press)
  • NAID: 120004606768
  • Peer Reviewed
• [Journal Article] Order and disorder in corneocyte adhesion (2011)
  • Author(s): Ishida-Yamamoto A, et al.
  • Journal Title: J Dermatol Volume: 38 Pages: 1-10
  • Peer Reviewed
• [Journal Article] CEDNIK syndrome results from loss-ot-function mutations in SNAP29 (2011)
  • Author(s): Fuchs-Telem D, et al.
  • Journal Title: Br J Dermatol Volume: 164 Pages: 610-616
  • Peer Reviewed
• [Journal Article] Tight junctions in the stratum corneum explain spatial differences in corneodesmosome degradation (2011)
  • Author(s): Igawa S, et al.
  • Journal Title: Exp Dermatol Volume: 20 Pages: 53-57
  • Peer Reviewed
• [Journal Article] Perturbation of lamellar granule secretion by sodium caprate implicates epidermal tight junctions in lamellar granule function. (2010)
  • Author(s): Kuroda S, Kurasawa M, Mizukoshi K, Maeda T, Yamamoto T, Oba A, Kishibe M, Ishida-Yamamoto A
  • Journal Title: J Dermatol Sci. 59(2) Pages: 107-114
  • Peer Reviewed
• [Journal Article] Three-base deletion mutation c.120_122delGTT in ATP2A2 leads to the unique phenotype of comedonal Darier disease. (2010)
  • Author(s): Tsuruta D, Ishida-Yamamoto A, et al.
  • Journal Title: Br J Dermatol. 162(3) Pages: 687-9
  • Peer Reviewed
• [Journal Article] Perturbation of lamellar granule secretion by sodium caprate implicates epidermal tight junctions in lamellar granule function (2010)
  • Author(s): Kuroda S, et al.
  • Journal Title: J Dermatol Sci Volume: 59 Pages: 107-114
  • Peer Reviewed
• [Journal Article] Revised nomenclature and classification of inherited ichthyoses : results of the First Ichthyosis Consensus Conference in Soreze 2009 (2010)
  • Author(s): Oji V, et al.
  • Journal Title: J Am Acad Dermatol Volume: 63 Pages: 607-641
  • Peer Reviewed
• [Journal Article] Three-base deletion mutation c.120_122deIGTT in ATP2A2 leads to the unique phenotype of comedonal Darier disease (2010)
  • Author(s): Tsuruta D, et al.
  • Journal Title: Br J Dermatol Volume: 162 Pages: 687-689
  • Peer Reviewed
• [Journal Article] Three-base deletion mutation c.120_122delGTT in ATP2A2 leads to the unique phenotype of comedonal Darier disease. (2010)
  • Author(s): Tsuruta D, Akiyama M, Ishida-Yamamoto A, Imanishi H, Mizuno N, Sowa J, Kobayashi H, Ishii M, Kurokawa I, Shimizu H.
  • Journal Title: Br J Dermatol 162 Pages: 687-9
  • Peer Reviewed
• [Journal Article] 新しい角層モデル (2010)
  • Author(s): 山本明美、井川哲子、岸部麻里
  • Journal Title: 臨床皮膚科 (印刷中)
• [Journal Article] RIN2 deficiency results in macrocephaly, alopecia, cutis laxa, andscoliosis : MACS syndrome. (2009)
  • Author(s): Basel-Vanagaite L, Ishida-Yamamoto A, Sprecher E
  • Journal Title: Am J Hum Genet. 85(2) Pages: 254-63
  • Peer Reviewed
• [Journal Article] RIN2 deficiency results in macrocephaly, alopecia, cutis laxa, and scoliosis: MACS syndrome. (2009)
  • Author(s): Basel-Vanagaite L, Sarig O, Hershkovitz D, Fuchs-Telem D, Rapaport D, Gat A, Isman G, Shirazi I, Shohat M, Enk CD, Birk E, Kohlhase J, Matysiak-Scholze U, Maya I, Knopf C, Peffekoven A, Hennies HC, Bergman R, Horowitz M, Ishida-Yamamoto A, Sprecher E.
  • Journal Title: Am J Hum Genet 85 Pages: 254-63
  • Peer Reviewed
• [Journal Article] Three-base deletion mutation c.120_122delGTT in ATP2A2 leads to the unique phenotype of comedonal Darier disease. (2009)
  • Author(s): Tsuruta D, et al.
  • Journal Title: Br J Dermatol (In press)
  • Peer Reviewed
• [Journal Article] RIN2 deficiency results in macrocephaly, alopecia, cutis laxa, and scoliosis : MACS syndrome. (2009)
  • Author(s): Basel-Vanagaite L, et al.
  • Journal Title: Am J Hum Genet 85 Pages: 254-263
  • Peer Reviewed
• [Journal Article] Lamellar bodies of human epidermis : proteomics characterization by high throughput mass spectrometry and possible involvement of CLIP-170 in their trafficking/secretion. (2008)
  • Author(s): Raymond AA, Ishida-Yamamoto A, et al
  • Journal Title: Mol Cell Proteomics. 7(11) Pages: 2151-75
  • Peer Reviewed
• [Journal Article] Alopecia, neurological defects, and endocrinopathy syndrome caused by decreased expression of RBM28, a nucleolar protein associated with ribosome biogenesis. (2008)
  • Author(s): Nousbeck J, Spiegel R, Ishida-Yamamoto A, et al
  • Journal Title: Am J Hum Genet. 82(5) Pages: 1114-21
  • Peer Reviewed
• [Journal Article] Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology. (2008)
  • Author(s): Matsumoto M, Ishida-Yamamoto A, et al
  • Journal Title: Proc Natl Acad Sci U S A. 105(18) Pages: 6720-4
  • Peer Reviewed
• [Journal Article] Defective lamellar granule secretion in arthrogryposis, renal dysfunction, and cholestasis syndrome caused by a mutation in VPS33B. (2008)
  • Author(s): Hershkovitz D, Mandel H, Ishida-Yamamoto A, et al
  • Journal Title: Arch Dermatol. 144(3) Pages: 334-40
  • Peer Reviewed
• [Journal Article] KRT14 haploinsufficiency results in increased susceptibility of keratinocytes to TNF-alpha-induced apoptosis and causes Naegeli-Franceschetti-Jadassohn syndrome. (2008)
  • Author(s): Lugassy J, Ishida-Yamamoto A, et al
  • Journal Title: J Invest Dermatol. 128(6) Pages: 1517-24
  • Peer Reviewed
• [Journal Article] Lamellar bodies of human epidermis: proteomics characterization by high throughput mass spectrometry and possible involvement of CLIP-170 in their trafficking/secretion. (2008)
  • Author(s): Raymond AA, Gonzalez de Peredo A, Stella A, Ishida-Yamamoto A, Bouyssie D, Serre G, Monsarrat B, Simon M.
  • Journal Title: Mol Cell Proteomics 7 Pages: 2151-75
  • Peer Reviewed
• [Journal Article] Alopecia, neurological defects, and endocrinopathy syndrome caused by decreased expression of RBM28, a nucleolar protein associated with ribosome biogenesis. (2008)
  • Author(s): Nousbeck J, Spiegel R, Ishida-Yamamoto A, Indelman M, Shani-Adir A, Adir N, Lipkin E, Bercovici S, Geiger D, van Steensel MA, Steijlen PM, Bergman R, Bindereif A, Choder M, Shalev S, Sprecher E.
  • Journal Title: Am J Hum Genet 82 Pages: 1114-21
  • Peer Reviewed
• [Journal Article] Targeted deletion of themurine corneodesmosin gene delineates its essential role in skin and hair physiology. (2008)
  • Author(s): Matsumoto M, Zhou Y, Matsuo S, Nakanishi H, Hirose K, Oura H, Arase S, Ishida-Yamamoto A, Bando Y, Izumi K, Kiyonari H, Oshima N, Nakayama R, MatsushimaA, Hirota F, Mouri Y, Kuroda N, Sano S, Chaplin DD.
  • Journal Title: Proc Natl Acad Sci U S A 105 Pages: 6720-4
  • Peer Reviewed
• [Journal Article] Defective lamellar granule secretion inarthrogryposis, renal dysfunction, and cholestasis syndrome caused by a mutation in VPS33B. (2008)
  • Author(s): Hershkovitz D, Mandel H, Ishida-Yamamoto A, Chefetz I, Hino B, Luder A, Indelman M, Bergman R, Sprecher E.
  • Journal Title: Arch Dermatol 144 Pages: 334-40
  • Peer Reviewed
• [Journal Article] KRT14 haploinsufficiency results in increased susceptibility of keratinocytes to TNF-alpha-induced apoptosis and causes Naegeli-Franceschetti-Jadassohn syndrome. (2008)
  • Author(s): Lugassy J, McGrath JA, Itin P, Shemer R, Verbov J, Murphy HR, Ishida-Yamamoto A, Digiovanna JJ, Bercovich D, Karin N, Vitenshtein A, Uitto J, Bergman R, Richard G, Sprecher E.
  • Journal Title: J Invest Dermatol 128 Pages: 1517-24
  • Peer Reviewed
• [Journal Article] Defective lamellar granule secretion in arthrogryposis, renal dysfunction, and cholestasis syndrome caused by a mutation in VPS33B (2008)
  • Author(s): Hershkovitz D, Ishida-Ya mamoto A, et.al.
  • Journal Title: Arch Dermatol 144 Pages: 334-340
  • Peer Reviewed
• [Journal Article] Amelioration of epidermolysis bullosa by transfer of wild-tvne hone marrow cells (2008)
  • Author(s): Tolar J, Ishida-Yamamoto A., et,al.
  • Journal Title: Blood 113 Pages: 1167-74
  • Peer Reviewed
• [Journal Article] Lamellar bodies of human epidermis : Proteomic character ization by high-throughput mass spectrometry, possible involvement of CLIP-170 in their trafficking/secretion (2008)
  • Author(s): Raymond AA, Ishida-Yamamo to A., et.al.
  • Journal Title: Mol Cell Proteomics 7 Pages: 2151-75
  • Peer Reviewed
• [Journal Article] Alopecia, neurological defects, and- endocrinopathy synd rome caused by decreased expression of RBM28, a nucleolar urotein associated with ribosome biogenesis (2008)
  • Author(s): Nousbeck J, Ishida-Yamamo to A., et.al.
  • Journal Title: Am J Hum Genet 82 Pages: 1114-21
  • Peer Reviewed
• [Journal Article] Targeted deletion of the murine corneodesmosin gene del ineates its essential role in skin and hair physiology (2008)
  • Author(s): Matsumoto M, Ishida-Yamamoto A, et,al
  • Journal Title: Proc Natl Acad Sci USA 105 Pages: 6720-4
  • Peer Reviewed
• [Journal Article] KRT14 haploinsufficiency results in increased susceptibility of keratinocytes toTNF-alpha-induced a poptosis and causes Naegeli-Franceschetti-Jadassohn syndrome (2008)
  • Author(s): Lugassy J, Ishida-Yamamoto A, et.al.
  • Journal Title: J Invest Dermatol 128 Pages: 1517-24
  • Peer Reviewed
• [Journal Article] Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1. (2007)
  • Author(s): Magnusdottir E, Kalachikov S, Mizukoshi K, Savitsky D, Ishida-Yamamoto A, Panteleyev AA, Calame K
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 14988-14993
  • Peer Reviewed
• [Journal Article] Rab11 is associated with epidermal lamellar granules (2007)
  • Author(s): Ishida-Yamamoto A, Kishibe M, Takahashi H, Iizuka H
  • Journal Title: J Invest Dermatol. 127 Pages: 2166-2170
  • NAID: 120006658762
  • Peer Reviewed
• [Journal Article] Epidermal terminal differentiation depends on Blymphocyte-induced maturation protein-1 (2007)
  • Author(s): Magnusdottir E, Kalachikov S, Mizukoshi K, Savitsky D, Ishida-Yamamoto A, Panteleyev AA, Calame K.
  • Journal Title: Proc Natl Acad Sci U S A 104 Pages: 14988-93
  • Peer Reviewed
• [Journal Article] Rab11 is associated with epidermal lamellar granules. (2007)
  • Author(s): Ishida-Yamamoto A, Kishibe M, Takahashi H, Iizuka H.
  • Journal Title: J Invest Dermatol 127 Pages: 2166-70
  • NAID: 120006658762
  • Peer Reviewed
• [Journal Article] Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase. (2007)
  • Author(s): Basel-Vanagaite L, Attia R, Ishida-Yamamoto A, Rainshtein L, Ben Amitai D, Lurie R, Pasmanik-Chor M, Indelman M, Zvulunov A, Saban S, Magal N, Sprecher E, Shohat M.
  • Journal Title: Am J Hum Genet 80 Pages: 467-77
  • Peer Reviewed
• [Journal Article] Kallikrein 8 is involved in skin desquamation in cooperation with other kallikreins. (2007)
  • Author(s): Kishibe M, Bando Y, Terayama R, Namikawa K, Takahashi H, Hashimoto Y, Ishida-Yamamoto A, Jiang YP, Mitrovic B, Perez D, Iizuka H, Yoshida S.
  • Journal Title: J Biol Chem 282 Pages: 5834-41
  • Peer Reviewed
• [Journal Article] Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1 (2007)
  • Author(s): Magnusdorrir E, Ishida-Yamamoto A, et. al.
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 14988-93
  • Peer Reviewed
• [Journal Article] Rabll is associated with epidermal lamellar granules (2007)
  • Author(s): Ishida-Yamamoto A, et. al.
  • Journal Title: J Invest Dermatol 127 Pages: 2166-70
  • Peer Reviewed
• [Journal Article] Up-regulation of loricrin expression by cell adhesion molecule nectin-1 through Rap1-ERK signaling in keratinocytes (2007)
  • Author(s): Wakamatsu K, Ishida-Yamamoto A, et. al.
  • Journal Title: J Biol Chem 282 Pages: 18173-81
  • Peer Reviewed
• [Journal Article] Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase (2007)
  • Author(s): Basel-Vanagaite L, Ishida-Yamamoto A, et. al.
  • Journal Title: Am J Hum Genet 80 Pages: 467-77
  • Peer Reviewed
• [Journal Article] Involvement of corneodesmosome degradation and lamellar granule transportation in the desquamation process
  • Author(s): Ishida-Yamamoto A, Kishibe M
  • Journal Title: Medical Molecular Morphology (in press)
  • NAID: 120004606768
  • Peer Reviewed
• [Journal Article] Order and disorder in corneocyte adhesion
  • Author(s): Ishida-Yamamoto A, et al
  • Journal Title: J Dermatol (in press)
  • Peer Reviewed
• [Journal Article] Involvement of corneodesmosome degradation and lamellar granule transportation in the desquamation process.
  • Author(s): Akemi Ishida-Yamamoto, Mari Kishibe
  • Journal Title: Medical Molecular Morphology (in press)
  • NAID: 120004606768
  • Peer Reviewed
• [Journal Article] Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology
  • Author(s): Matsumoto M, Ishida-Yamamoto A., et. al.
  • Journal Title: Proc Natl Acad Sci USA (印刷中)
  • Peer Reviewed
• [Journal Article] Defective lamellar granule secretion in arthrogryposis, renal dysfunction and cholestasis(ARC)syndrome caused by a mutation in VPS33B
  • Author(s): Hershkovitz D, Ishida-Yamamoto A, et. al.
  • Journal Title: Arch Dermatol (印刷中)
  • Peer Reviewed
• [Journal Article] KRT14 Haploinsufficiency Results in Increased Susceptibility of Keratinocytes to TNF-alpha-Induced Apoptosis and Causes Naegeli-Franceschetti-Jadassohn Syndrome
  • Author(s): Lugassy J, Ishida-Yamamoto A, et. al.
  • Journal Title: J Invest Dermatol (印刷中)
  • Peer Reviewed
• [Presentation] 角化異常症 (2010)
  • Author(s): 山本明美
  • Organizer: 第109回日本皮膚科学会総会
  • Place of Presentation: 大阪国際会議場、大阪府
• [Presentation] 角化細胞の分化と皮膚バリアの構築 (2009)
  • Author(s): 山本明美
  • Organizer: 第61回日本皮膚科学科西部支部学術大会、ワークショップ2
  • Place of Presentation: B-Con Plaza別府国際コンベンションセンター、別府市
  • Year and Date: 2009-10-25
• [Presentation] わかりやすくなった角化異常の機序と形態変化の関連 (2009)
  • Author(s): 山本明美、岸部麻里
  • Organizer: 第41回日本臨床分子形態学会、シンポジウム2、皮膚疾患解明の分子形態的アプローチ
  • Place of Presentation: 神戸国際会議場、神戸市
  • Year and Date: 2009-09-04
• [Presentation] A new model for sorting out ichthyosis (2009)
  • Author(s): Akemi Ishida-Yamamoto
  • Organizer: The 4th Joint Meeting of Japanese Dermatological Association and Australasian College of Dermatologists
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2009-07-10
• [Presentation] 水疱型・非水疱型魚鱗癬様紅皮症の臨床病型と本邦におけるガイドライン作成状況 (2009)
  • Author(s): 山本明美
  • Organizer: 第108回日本皮膚科学会総会 教育講演4 遺伝性水疱症・遺伝性角化症
  • Place of Presentation: 福岡国際会議場、福岡市
  • Year and Date: 2009-04-24
• [Presentation] 水疱型・非水疱型魚鱗癬様紅皮症の臨床病型と本邦におけるガイドライン作成状況 (2009)
  • Author(s): 山本明美
  • Organizer: 第108回日本皮膚科学会総会
  • Place of Presentation: 福岡国際会議場、福岡市
  • Year and Date: 2009-04-24
• [Presentation] Lamellar body trafficking in the epidermal barrier and disease (2009)
  • Author(s): Akemi Ishida-Yamamoto
  • Organizer: Gordon Research Conferences, Barrier Function of Mammalian Skin, Molecular, Biophysical & Biomechanical Understanding of Skin Barrier Formation, Functin & Disease
  • Place of Presentation: Waterville Valley, NH, USA
• [Presentation] Corneodesmosin-degradation occurs from the upper central surface area of cornified cells (2009)
  • Author(s): Akemi Ishida-Yamamoto, Satomi Igawa, Mari Kishibe, Hajime Iizuka
  • Organizer: 36th Society for Cutaneous Ultrastructure Research
  • Place of Presentation: Florence, Italy
• [Presentation] The Japanese experience on ichthyosis Ultrastructure (2009)
  • Author(s): Ishida-Yamamoto A
  • Organizer: Ichthyosis Consensus Conference
  • Place of Presentation: Soreze, France
• [Presentation] Lamellar body trafficking in the epidermal barrier and disease. (2009)
  • Author(s): Ishida-Yamamoto A
  • Organizer: Gordon Research Conferences, Barrier Function of Mammalian Skin, Molecular, Biophysical & Biomechanical Understanding of Skin Barrier Formation, Functin & Disease
  • Place of Presentation: Waterville Valley, NH, USA
• [Presentation] The Japanese experience on ichthyosis ultrastructure (2009)
  • Author(s): A Ishida-Yamamoto
  • Organizer: Ichthyosis Consensus Conference
  • Place of Presentation: Soreze, France
• [Presentation] ARC症候群における魚鱗癬の病態形成機構の電顕的検討 (2008)
  • Author(s): 山本明美、Eli Sprecher
  • Organizer: 第23回角化症研究会
  • Place of Presentation: 東京商工会議所、東京都
  • Year and Date: 2008-08-02
• [Presentation] Lamellar granules and ichthyosis (2008)
  • Author(s): A Ishida-Yamamoto
  • Organizer: 5th Joint Meeting of SSSR and SCUR, Invited Lecture
  • Place of Presentation: Otsu, Japan
• [Presentation] 正常ヒト表皮におけるRab11の発現と層板顆粒との関連 (2007)
  • Author(s): 山本明美
  • Organizer: 第22回角化症研究会
  • Place of Presentation: 東京都
  • Year and Date: 2007-08-04
• [Presentation] 層板顆粒の輸送と角化症 (2007)
  • Author(s): 山本明美
  • Organizer: 第71回日本皮膚科学会東部支部学術大会、シンポジウム4 角化症と皮膚バリア障害
  • Place of Presentation: 札幌市
• [Presentation] Distinct intracellular transport of different epidermal lamellar body molecules (2007)
  • Author(s): Akemi Ishida-Yamamoto
  • Organizer: Fist World Conference on Ichthyosis
  • Place of Presentation: Munster, Germany
• [Presentation] A recycling endosome marker Rab11 is associated with epidermal lamellar granules (2007)
  • Author(s): Ishida-Yamamoto A, Kaneta K, Kishibe M, Iizuka H
  • Organizer: 34th annual meeting of the Society for Cutaneous Ultrastructure Research
  • Place of Presentation: Praha, Czech Republic
• [Presentation] 分子と形態から解明する新しい角化異常症 (2007)
  • Author(s): 山本明美
  • Organizer: 第26回分子病理学研究会湘南シンポジウム
  • Place of Presentation: 葉山町湘南国際村(特別講演)
• [Presentation] 層板顆粒の輸送と角化症 (2007)
  • Author(s): 山本明美
  • Organizer: 第71回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 札幌市
• [Presentation] A recycling endosome marker Rabll is associated with epidermal lamellar granules (2007)
  • Author(s): Akemi Ishida-Yamamoto
  • Organizer: 34th annual meeting of the Society for Cutaneous Ultrastructure Research
  • Place of Presentation: Praha, Czech Republic
• [Presentation] 分子と形態から解明する新しい角化異常症 (2007)
  • Author(s): 山本明美
  • Organizer: 第26回分子病理学研究会湘南シンポジウム
  • Place of Presentation: 葉山町湘南国際村
• [Book] Therapy of Skin Diseases(Inherited Keratinocyte Diseases (Ichthyosis and Related Disoders) (2010)
  • Author(s): Ishida-Yamamoto A
  • Publisher: Springer-Verlag
• [Book] Therapy of Skin Diseases (2010)
  • Author(s): Ishida-Yamamoto A
  • Total Pages: 766
  • Publisher: Springer-Verlag
• [Book] Therapy of Skin Diseases(Kriege T, Bickers DR, Miyachi Y, ed, Inherited Keratinocyte Diseases (Ichthyosis and Related Disoders)) (2010)
  • Author(s): Akemi Ishida-Yamamoto
  • Publisher: Springer-Verlag
• [Book] 皮膚疾患診療実践ガイド(遺伝性掌蹠角化症) (2009)
  • Author(s): 山本明美
  • Publisher: 文光堂
• [Book] 皮膚疾患診療実践ガイド(先天性魚鱗癬様紅皮症)、第2版 (2009)
  • Author(s): 山本明美
  • Publisher: 文光堂
• [Book] 小児の皮膚トラブルFAQ(小児に角質肥厚や落屑をみたら?) (2008)
  • Author(s): 山本明美
  • Publisher: 診断と治療社
• [Book] 皮膚病臨床カラーアトラス大系 2(ロリクリン角皮症) (2008)
  • Author(s): 山本明美
  • Total Pages: 76
  • Publisher: 講談社
• [Book] スキンケアを科学する(保湿をめぐるディベート) (2008)
  • Author(s): 山本明美
  • Publisher: 南江堂
• [Book] 皮膚科診療最前線シリーズ スキンケア最前線(角層を知る) (2008)
  • Author(s): 岸部麻里、山本明美
  • Publisher: メディカルビュー社
• [Book] In What's New in皮膚科学(宮地良樹編)(掌蹠の角化を診たら何を考える?) (2007)
  • Author(s): 山本明美
  • Publisher: メディカルレビュー社
• [Book] 皮膚疾患最新の治療2007-2008(瀧川雅浩、渡辺晋一、編)(毛孔性苔癬、顔面毛包性紅斑黒皮症) (2007)
  • Author(s): 山本明美
  • Total Pages: 138
  • Publisher: 南江堂
• [Remarks] ホームページ等
  • URL: http://www.asahikawa-med.ac.jp/bureau/kikaku/kennkyuugyouseki/c09hihuka.html