Gene silencing of STAT6 with siRNA ameliorates contact hypersensitivity and allergic rhinitis
| Project/Area Number |
19591297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YOKOZEKI Hiroo Tokyo Medical and Dental University, 医歯学総合研究科, 教授 (90210608)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Takahiro 東京医科歯科大学, 医歯学総合研究科, 准教授 (30235361)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 皮膚炎症 / 再生学 / アレルギー性鼻炎 / サイトカイン / 干渉RNA / STAT6 / 核酸医薬 / ケモカイン / Th2 / 遺伝子療法 / アトピー性皮膚炎 / 接触皮膚炎 / TH2 |
|---|
| Research Abstract |
We established the gene therapy targeting for STAT6. We demonstrated that gene siliencing of STAT6 with siRNA ameliorates both contact hypersensitivity and allergic rhinitis by using model mouse.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article]2009
Author(s)
横関博雄
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Journal Title
EBMアレルギー疾患の治療:花粉症を合併した皮膚炎で注意すべき点は何か?(秋山一男ら編)(中外医学社)
Pages: 318-321
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