| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
We focused on de novo synthesis of artemin (ARTN), which is a member of the glial cell line-derived neurotrophic factor related family, gene transcription in dermal fibroblast after substance P (SP)-stimulation. ARTN was accumulated in dermis of AD skin lesions, while not in that of psoriasis and healthy controls. SP-treated dermal fibroblast-derived artemin can be assumed to contribute to peripheral nerve sprouting. Furthermore, we found that ARTN contributed to development of SP-induced thermal hyperalgesia and compound 48/80-induced itch. From these results, we placed more expectations on ARTN for therapeutic target of intractable itch.
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