• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Characterization of Abeta-like peptide other in brains of Alzheimer disease

Research Project

Project/Area Number 19591352
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

MASAYASU Okochi  Osaka University, 医学系研究科, 助教 (90335357)

Co-Investigator(Kenkyū-buntansha) TAGAMI Shinji  大阪大学, 医学系研究科, 助教 (40362735)
TAKEDA Masatoshi  大阪大学, 医学系研究科, 教授 (00179649)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsアルツハイマー病 / アミロイドβ蛋白 / Notch1 / APLP1 / 老人斑 / 不溶性蛋白 / サロゲートマーカー
Research Abstract

我々は生理的に脳内に存在するアルツハイマー病Aβと同じ仕組みで放出されたAβ様ペプチドの凝集性などの性質を検討し、Aβとの異同を論じた。その結果、(i)Nβ、APL1βペプチドなどのAβ様ペプチド群がoligomerを形成するが、(ii)fibril形成しない。また、(iii)Aβ様ペプチド群はAβのoligomerやfibril形成を修飾せず、(iv)老人斑などへの集積性が小さく不溶性分画に含まれない。面白いことに、病原性Aβ42の比較的産生を増大させるプレセニリンの変異やγセクレターゼ修飾薬の添加はAβ様ペプチドのC末端にも同じように影響した。Aβを産生する生体内の仕組みはアルツハイマー病を起因するだけではなく、広く細胞の活動を支える役割があり、Notchシグナルのような機能が今後明らかになっていくと考えられる。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (16 results)

All 2008 2007

All Journal Article (13 results) (of which Peer Reviewed: 12 results) Presentation (1 results) Book (2 results)

  • [Journal Article] Processes of beta-Amyloid and Intracellular Cytoplasmic Domain Generation by Presenilin/gamma-Secretase2008

    • Author(s)
      Tagami S, Okochi M, Fukumori A, Jiang J, Yanagida K, Nakayama T, Morihara T, Tanaka T, Kudo T, Takeda M
    • Journal Title

      Neurodegener Dis 5(3-4)

      Pages: 160-2

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-12008

    • Author(s)
      Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M
    • Journal Title

      Mol Cell Biol 28(1)

      Pages: 165-76

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Macrophage colony stimulating factor is associated with excretion of amyloid-β peptides from cerebrospinal fluid to peripheral blood2008

    • Author(s)
      Jiang, J., Okochi, M., Tagami, S., Nishitomi, K., Yanagida, K., Nakayama, T., Tatsumi, S.-I., Mori, K., Takeda, M
    • Journal Title

      Psychogeriatrics

      Pages: 188-195

    • NAID

      10027274800

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation2008

    • Author(s)
      Okamoto K, Mori Y, Komoda Y, Okamoto T, Okochi M, Takeda M, Suzuki T, Moriishi K, Matsuura Y
    • Journal Title

      J Virol 82

      Pages: 8349-8361

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Processes of beta-Amyloid and Intracellular Cytoplasmic Domain Generation by Presenilin/gamma-Secretase.2008

    • Author(s)
      Tagami S, Okochi M, Fukumori A, Jiang J, Yanagida K, Nakayama T, Morihara T, Tanaka T, Kudo T, Takeda M.
    • Journal Title

      Neurodegener Dis. 5(3-4)

      Pages: 160-2

    • Related Report
      2008 Annual Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1.2008

    • Author(s)
      Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M
    • Journal Title

      Mol Cell Biol. 28(1)

      Pages: 165-76

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macrophage colony stimulating factor is associated with excretion of amyloid-β peptides from cerebrospinal fluid to peripheral blood2008

    • Author(s)
      Jiang, J., Okochi, M., Tagami, S., Nishitomi, K., Yanagida, K., Nakayama, T., Tatsumi, S. -I., Mori, K., Takeda, M.
    • Journal Title

      Psychogeriatrics 8

      Pages: 188-195

    • NAID

      10027274800

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C viruscore protein and viral propagation.2008

    • Author(s)
      Okamoto K, Mori Y, Komoda Y, Okamoto T, Okochi M, Takeda M, Suzuki T, Moriishi K, Matsuura Y.
    • Journal Title

      J Virol 82

      Pages: 8349-8361

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008

    • Author(s)
      Okochi, M., Tagami, S., Takeda, M.
    • Journal Title

      Annual Report of Osaka University Academic Achievement 2007-2008 9

      Pages: 94-94

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アルツハイマー病の薬物療法の実際2008

    • Author(s)
      大河内正康, 武田雅俊
    • Journal Title

      カレントテラピー 26

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Regulation of Notch signaling byd ynamic changes in the precision of S3 cleavage of Notch-1.2008

    • Author(s)
      Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M
    • Journal Title

      Mol Cell Biol. 28(1)

      Pages: 165-76

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological markers as outcome measures for Alzheimer's disease interventions--real problems and future possibilities2007

    • Author(s)
      Takeda M, Okochi M, Tagami S, Tanaka T, Kudo T
    • Journal Title

      Int Psychogeriatr 19(3)

      Pages: 391-400

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biological markers as outcome measures for Alzheimer's disease interve ntions-real problems and future possibilities.2007

    • Author(s)
      Takeda M, Okochi M, Tagami S, Tanaka T, Kudo T.
    • Journal Title

      Int Psychogeriatr. 19(3)

      Pages: 391-400

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Characterization of APLP1-derived Abeta-like peptide in brains of Alzheimer disease patients2008

    • Author(s)
      Okochi, M
    • Organizer
      ICAD2008
    • Year and Date
      2008-07-24
    • Related Report
      2008 Final Research Report
  • [Book] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008

    • Author(s)
      Okochi, M., Tagami, S., Takeda, M
    • Total Pages
      94
    • Publisher
      Annual Report of Osaka University Academic Achievement 2007-2008
    • Related Report
      2008 Final Research Report
  • [Book] アルツハイマー病の薬物療法の実際2008

    • Author(s)
      大河内正康、武田雅俊
    • Publisher
      カレントテラピー
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi