The examination of interaction between risk factors for dementia in cerebrovascular diseases and Alzheimer's disease-related factors
Project/Area Number |
19591353
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Osaka University |
Principal Investigator |
FUKUNAGA Tomoko Osaka University, 医学系研究科, 助教 (90273630)
|
Co-Investigator(Kenkyū-buntansha) |
MORIHARA Takashi 大阪大学, 医学系研究科, 助教 (90403196)
UKAI Satoshi 和歌山県立医科大学, 医学部, 准教授 (80324763)
NAGANO Keiko 大阪大学, 医学部附属病院, 医員 (90515959)
寳学 英隆 大阪大学, 医学系研究科, 准教授 (50314323)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 認知症 / 脳血管障害 / アルツハイマー病 / 危険因子 / 認知機能 / 記憶 / 脳血管性認知症 / 危険因子解明 / 認知機能障害 / フォローアップ研究 |
Research Abstract |
脳血管障害から認知症に至る危険因子とアルツハイマー病関連因子との相互作用を認知機能と遺伝子から解明した。認知機能検査では、脳血管障害の論理的記憶の「記憶錯誤」と、アルツハイマー病の単語再認の「虚再認」とを検討し、記憶機能の詳細を明らかにした。脳血管障害のDNA検体のPPP2R2B遺伝子のSNPs解析では、アルツハイマー病と共通してPPP2R2Bがリスク遺伝子であるという結果であった。
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Dynamin 2 gene is a novelsusceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers2008
Author(s)
Aidaralieva NJ, Kamino K, Kimura R, Yamamoto M, Morihara T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Kida T, Okuda J, Uema T, Yamagata H, Miki T, Akatsu H, Kosaka K, Takeda M
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Journal Title
carriers., J Hum Genet 53
Pages: 296-302
Related Report
Peer Reviewed
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[Journal Article] Curcuminstructure-function, bioavailability, and efficacy in modelsof neuroinflammation andAlzheimer'sdisease2008
Author(s)
Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA,Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM ,Frautschy SA
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Journal Title
J Pharmacol ExpTher 326
Pages: 196-208
Related Report
Peer Reviewed
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[Journal Article] Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers.2008
Author(s)
Aidaralieva NJ, Kamino K, Kimura R, Yamamoto M, Morihara T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Kida T, Okuda J, Uema T, Yamagata H, Miki T, Akatsu H, Kosaka K, Takeda M.
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Journal Title
J Hum Genet 53(4)
Pages: 296-302
Related Report
Peer Reviewed
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[Journal Article] Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease.2008
Author(s)
Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA, Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA.
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Journal Title
J Pharmacol Exp Ther. 326(1)
Pages: 196-208
Related Report
Peer Reviewed
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