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Psychophysiological studies on auditory hallucinations

Research Project

Project/Area Number 19591371
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionShowa University (2008)
Saitama Medical University (2007)

Principal Investigator

IWANAMI Akira  Showa University, 医学部・精神医学教室, 准教授 (80276518)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsauditory hallucinations / schizophrenia / ERP / N1 / corollary discharge / 幻聴 / 事象関連電位 / 思考障害 / 随伴発射 / 統合失調症
Research Abstract

事象関連電位N1成分は刺激の受容を反映し、聴覚刺激に対して約100ミリ秒後に出現する陰性成分である。幻聴の生成と関連することが想定されているcorollary dischargeのシステムによるN1成分の振幅の変化がみられるかどうか検討するため、健常者および統合失調症患者を対象として、聴覚刺激を用いて発声条件における事象関連電位の記録を行った。この結果、健常者においては、発声条件においてN1振幅の減少がみられた。これに対して統合失調症患者においては、この効果は認められなかった。この結果は、corollary dischargeの障害が統合失調症の病態に関連することを示唆している。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (7 results)

All 2009 2007

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Thought disorder and executive dysfunction in patients with schizophrenia2009

    • Author(s)
      Owashi T, Iwanami A, Nakagome K, Higuchi T, Kamijima K.
    • Journal Title

      International Journal of Neuroscience 119

      Pages: 105-123

    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Journal Article] Effects of corollary discharge on auditory N1 component of event-related potentials in healthy subjects2009

    • Author(s)
      Iwanami A, Okajima Y, Kato N.
    • Journal Title

      Clinical Neurophysiology 120 Supplement 1

    • Related Report
      2008 Final Research Report
  • [Journal Article] Auditory N1 component and corollary discharge : a topographical analysis2009

    • Author(s)
      Iwanami A, Okajima Y, Kato N.
    • Journal Title

      Clinical Neurophysiology 120 Supplement 1

    • Related Report
      2008 Final Research Report
  • [Journal Article] 統合失調症における思考障害と遂行機能2007

    • Author(s)
      尾鷲 登志美
    • Journal Title

      臨床精神医学 36

      Pages: 897-905

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effects of corollary discharge on auditory N1 component of event-related potentials in healthy subjects2009

    • Author(s)
      Iwanami A, Okajima Y, Kato N.
    • Organizer
      2009 Asian and Oceanian Congress of Clinical Neurophysiology
    • Related Report
      2008 Final Research Report
  • [Presentation] Auditory N1 component and corollary discharge : a topographical analysis2009

    • Author(s)
      Iwanami A, Okajima Y, Kato N.
    • Organizer
      2009 Asian and Oceanian Congress of Clinical Neurophysiology
    • Related Report
      2008 Final Research Report
  • [Presentation] Auditory N1 Component And Corollary Discharge : A Topographical Analysis2009

    • Author(s)
      Iwanami A, Okajima Y, Kato N
    • Organizer
      2009 Asian and Oceanian Congress of Clinical Neurophysiology
    • Place of Presentation
      Seoul
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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