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Pharmacological effect of Clozapine on emotional disfunction in a rat model of vulnerability to stress

Research Project

Project/Area Number 19591376
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionTokyo Women's Medical University

Principal Investigator

ISHIGOOKA Jun  Tokyo Women's Medical University, 医学部, 教授 (80142412)

Co-Investigator(Kenkyū-buntansha) INADA Ken  東京女子医科大学, 医学部, 講師 (90365164)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords恐怖条件づけ / ドパミン / マイクロダイアリシス / 抗精神病薬 / クロザピン / 統合失調症 / 扁桃体 / 覚せい剤過感受性 / 脆弱性 / 恐怖条件付け / 脳内微小透析法
Research Abstract

Aripiprazole and haloperidol equally suppressed the marked increase in extracellular dopamine levels in fear-conditioned rats, whereas haloperidol increased and aripiprazole decreased basal dopamine levels. The effect of antipsychotics would attenuate the dopamine fear response in the amygdala, modulating basal dopamine level.Both of haloperidol and clozapine significantly increased the basal dopamine level in the basolateral nucleus of amygdala in a dose-related fasion ; the maximum proportionate increase in the clozapine groups was significantly greater than in the haloperidol groups. The extracellular dopamine level in the basolateral amygdala was significantly elevated after conditioned fear stress. Both clozapine and haloperidol suppressed this dopamine fear response. Suppression of fear response of dopamine by clozapine and haloperidol suggests that these antipsychotic agents affect the mechanism of dopamine release, at least in the amygdala.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (12 results)

All 2010 2009 2008 2007

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (9 results)

  • [Journal Article] Action of amygdala dopamine and effect of antipsychotics.2010

    • Author(s)
      Oshibuchi H, Inada K, Ishigooka J
    • Journal Title

      Jpn. J. Neuropsychopharmacol. 30

      Pages: 93-99

    • NAID

      10029093276

    • Related Report
      2009 Final Research Report
  • [Journal Article] Aripiprazole and haloperidol suppress excessive dopamine release in the amygdala in response to conditioned fear stress, but show contrasting effects on basal dopamine release in methamphetaminesensitized rats.2009

    • Author(s)
      Oshibuchi H, Inada K, Sugawara H, Ishigooka J
    • Journal Title

      Eur J Pharmacol 615(1-3)

      Pages: 83-90

    • Related Report
      2009 Final Research Report
  • [Journal Article] Aripiprazole and haloperidol suppress excessive dopamine release in the amygdala in response to conditioned fear stress, but show contrasting effects on basal dopamine release in methamphetamine- sensitized rats.2009

    • Author(s)
      Hidehiro Oshibuchi, Ken Inada, Hiroko Sugawara, Jun Ishigooka
    • Journal Title

      Eur J Pharmacol 615

      Pages: 83-90

    • NAID

      120002361249

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Antipsychotic agents attenuate dopamine fear response in the basolateral amygdala by modulating basal dopamine release ; an in vivo microdialysis study2009

    • Author(s)
      Hidehiro Oshibuchi
    • Organizer
      22^<nd> European College of Neuropsychophar macology
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2009-09-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Antipsychotic agents attenuate dopamine fear response in the basolateral amygdala by modulating basal dopamine release; an in vivo microdialysis study.2009

    • Author(s)
      Oshibuchi H, Inada K, Sugawara H, Ishigooka J
    • Organizer
      22nd European College of Neuropsychopharmacology
    • Place of Presentation
      Istanbul, Tukey
    • Year and Date
      2009-09-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 恐怖記憶の想起における扁桃体ドパミンの動態に対する抗精神病薬の効果2009

    • Author(s)
      押淵英弘
    • Organizer
      第31回 日本生物学的精神医学会
    • Place of Presentation
      日本京都
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] The effect of antipsychotic agents to enhancement of release of dopamine in the amygdala induced by conditioned fear stress; in vivo microdialysis study.2009

    • Author(s)
      Oshibuchi H, Inada K, Sugawara H, Ishigooka J
    • Organizer
      31st academic meeting of Japanese Society of Biological Psychiatry
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2009-04-23
    • Related Report
      2009 Final Research Report
  • [Presentation] 情動記憶に対する抗精神病薬の効果2008

    • Author(s)
      押淵 英弘
    • Organizer
      日本臨床精神薬理学会 日本神経精神薬理学会 合同学会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] The effect of haloperidol to enhancement of release of 5-HT in the amygdala induced by conditioned fear stress in methamphetamine-sensitaized rat.2008

    • Author(s)
      Oshibuchi H, Inada K, Sugawara H, Ishigooka J
    • Organizer
      38th academic meeting of Japanese Society of Neuropsychopharmacology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-10-01
    • Related Report
      2009 Final Research Report
  • [Presentation] The effect of clozapine to enhancement of release of dopamine in the amygdala induced by conditioned fear stress; in vivo microdialysis study.2008

    • Author(s)
      Oshibuchi H, Inada K, Sugawara H, Ishigooka J
    • Organizer
      38th academic meeting of Japanese Society of Neuropsychopharmacology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-10-01
    • Related Report
      2009 Final Research Report
  • [Presentation] Difference in effect of haloperidol and aropiprazole on excessive release of dopamine in the amygdala induced by conditioned fear stress in methamphetamine-sensitized rats.2008

    • Author(s)
      Oshibuchi H, Sugawara H, Inada K, Ishigooka J
    • Organizer
      50th Collegium Internationale Neuro-Psychopharmacologicum
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2008-07-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 恐怖条件下メタンフェタミン感受性ラット扁桃体のドパミン過剰放出に対するハロペリドールの効果2007

    • Author(s)
      押淵 英弘
    • Organizer
      第37回 日本神経精神薬理学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-11
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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