Dopamine system and sleep-wake regulation : molecular mechanisms of dopamine agonist induced sleep

• Project/Area Number: 19591381
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka Medical College
• Principal Investigator: YOSHIDA Yasushi Osaka Medical College, 医学部, 講師 (40388260)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 睡眠覚醒調節 / ドーパミン受容体作動薬 / 眠気 / マイクロダイアリシス / ドーパミン / ドーパミン受容体動薬 / 睡眠覚醒調節機構 / 行動量

Research Abstract

本来ドーパミンは覚醒誘発に関与するが、逆説的にドーパミン受容体作動薬により突発的な眠気が生じることが問題となっている。ドーパミン受容体作動薬により睡眠と覚醒の相反する現象が生じうることについて、その脳内機構の解明のための研究をラットを用いて行った。その結果、動物の活動期(暗期)において、高用量では覚醒を誘発するが、低用量では逆説的に睡眠が増加することが判明した。

Research Products

• [Journal Article] Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy (2008)
  • Author(s): Mishima K, Yoshida Y, Nishino S, et.al.
  • Journal Title: SLEEP 31 Pages: 1119-1126
  • Peer Reviewed
• [Journal Article] Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy. (2008)
  • Author(s): Mishima K, Yoshida Y, Nishino S, et al.
  • Journal Title: Sleep 31 Pages: 1119-1126
  • Peer Reviewed
• [Journal Article] 臨床睡眠学睡眠障害の基礎と臨床ナルコレプシー (2008)
  • Author(s): 吉田祥, 谷村洋平, 神林崇, 清水徹男
  • Journal Title: 日本臨床増刊号2 66 Pages: 284-289
• [Journal Article] ナルコレプシーの臨床(特集2睡眠-リズム障害の臨床) (2008)
  • Author(s): 吉田祥, 神林崇, 清水徹男
  • Journal Title: 脳21 11 Pages: 448-451
• [Journal Article] 過眠をきたす疾患の診断のポイントと対応 (2008)
  • Author(s): 吉田祥, 江村成就, 神林崇, 清水徹男
  • Journal Title: 日本医師会雑誌 137 Pages: 1431-1435
• [Presentation] 睡眠-覚醒調節機構におけるオレキシンとヒスタミンとの関連について (2008)
  • Author(s): 吉田祥
  • Organizer: 日本睡眠学会第33回学術集会
  • Place of Presentation: 福島県郡山市
  • Year and Date: 2008-06-26
• [Presentation] Dopamine D2/D3 agonists and daytimesleepiness : leep promotion by lowdoseof quinpirole in rats in active period (2008)
  • Author(s): Yoshida Y, Yoneda H, Nishino S, et.al.
  • Organizer: 22^<nd> Annual Meeting of the Associated Professional Sleep Societies
  • Place of Presentation: Baltimore USA
  • Year and Date: 2008-06-10
• [Presentation] Dopamine D2/D3 agonists and daytime sleepiness : sleep promotion by low dose of quinpirole in rats in active period (2008)
  • Author(s): Yoshida Y, Yoneda H, Nishino S, et al.
  • Organizer: 22^<nd> Annual Meeting of the Associated Professional Sleep Societies.
  • Place of Presentation: Baltimore USA.
  • Year and Date: 2008-06-10
• [Presentation] Continuous microdialysis measures of histamine with sleep recordings in freely moving mice (2008)
  • Author(s): Yoshida Y, Fujiki N, Nishino S, et.al.
  • Organizer: 22^<nd> Annual Meeting of the Associated Professional Sleep Societies
  • Place of Presentation: Baltimore USA
  • Year and Date: 2008-06-09
• [Presentation] Continuous microdialysis measures of histamine with sleep recordings in freely moving mice. (2008)
  • Author(s): Yoshida Y, Fujiki. N, Nishino S, et al.
  • Organizer: 22^<nd> Annual Meeting of the Associated Professional Sleep Societies.
  • Place of Presentation: Baltimore USA.
  • Year and Date: 2008-06-09