• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Dopamine system and sleep-wake regulation : molecular mechanisms of dopamine agonist induced sleep

Research Project

Project/Area Number 19591381
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionOsaka Medical College

Principal Investigator

YOSHIDA Yasushi  Osaka Medical College, 医学部, 講師 (40388260)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords睡眠覚醒調節 / ドーパミン受容体作動薬 / 眠気 / マイクロダイアリシス / ドーパミン / ドーパミン受容体動薬 / 睡眠覚醒調節機構 / 行動量
Research Abstract

本来ドーパミンは覚醒誘発に関与するが、逆説的にドーパミン受容体作動薬により突発的な眠気が生じることが問題となっている。ドーパミン受容体作動薬により睡眠と覚醒の相反する現象が生じうることについて、その脳内機構の解明のための研究をラットを用いて行った。その結果、動物の活動期(暗期)において、高用量では覚醒を誘発するが、低用量では逆説的に睡眠が増加することが判明した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (10 results)

All 2008

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy2008

    • Author(s)
      Mishima K, Yoshida Y, Nishino S, et.al.
    • Journal Title

      SLEEP 31

      Pages: 1119-1126

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy.2008

    • Author(s)
      Mishima K, Yoshida Y, Nishino S, et al.
    • Journal Title

      Sleep 31

      Pages: 1119-1126

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 臨床睡眠学睡眠障害の基礎と臨床ナルコレプシー2008

    • Author(s)
      吉田祥, 谷村洋平, 神林崇, 清水徹男
    • Journal Title

      日本臨床増刊号2 66

      Pages: 284-289

    • Related Report
      2008 Annual Research Report
  • [Journal Article] ナルコレプシーの臨床(特集2睡眠-リズム障害の臨床)2008

    • Author(s)
      吉田祥, 神林崇, 清水徹男
    • Journal Title

      脳21 11

      Pages: 448-451

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 過眠をきたす疾患の診断のポイントと対応2008

    • Author(s)
      吉田祥, 江村成就, 神林崇, 清水徹男
    • Journal Title

      日本医師会雑誌 137

      Pages: 1431-1435

    • Related Report
      2008 Annual Research Report
  • [Presentation] 睡眠-覚醒調節機構におけるオレキシンとヒスタミンとの関連について2008

    • Author(s)
      吉田祥
    • Organizer
      日本睡眠学会第33回学術集会
    • Place of Presentation
      福島県郡山市
    • Year and Date
      2008-06-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Dopamine D2/D3 agonists and daytimesleepiness : leep promotion by lowdoseof quinpirole in rats in active period2008

    • Author(s)
      Yoshida Y, Yoneda H, Nishino S, et.al.
    • Organizer
      22^<nd> Annual Meeting of the Associated Professional Sleep Societies
    • Place of Presentation
      Baltimore USA
    • Year and Date
      2008-06-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Dopamine D2/D3 agonists and daytime sleepiness : sleep promotion by low dose of quinpirole in rats in active period2008

    • Author(s)
      Yoshida Y, Yoneda H, Nishino S, et al.
    • Organizer
      22^<nd> Annual Meeting of the Associated Professional Sleep Societies.
    • Place of Presentation
      Baltimore USA.
    • Year and Date
      2008-06-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Continuous microdialysis measures of histamine with sleep recordings in freely moving mice2008

    • Author(s)
      Yoshida Y, Fujiki N, Nishino S, et.al.
    • Organizer
      22^<nd> Annual Meeting of the Associated Professional Sleep Societies
    • Place of Presentation
      Baltimore USA
    • Year and Date
      2008-06-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Continuous microdialysis measures of histamine with sleep recordings in freely moving mice.2008

    • Author(s)
      Yoshida Y, Fujiki. N, Nishino S, et al.
    • Organizer
      22^<nd> Annual Meeting of the Associated Professional Sleep Societies.
    • Place of Presentation
      Baltimore USA.
    • Year and Date
      2008-06-09
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi