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Evaluation of brain and whole-body micro-dosing pharmacokinetics of <11>^C-labeled donepezil in rats by means of planar positron imaging system

Research Project

Project/Area Number 19591416
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

SHIMOSEGAWA Eku  Osaka University, 医学系研究科, 准教授 (30370258)

Co-Investigator(Kenkyū-buntansha) HATAZAWA Jun  大阪大学, 医学系研究科, 教授 (70198745)
INOUE Osamu  大阪大学, 医学系研究科, 教授 (50159969)
MURASE Kenya  大阪大学, 医学系研究科, 教授 (50157773)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords薬物動態 / ポジトロン / マイクロドージング / 脳
Research Abstract

対向型ポジトロンイメージング装置と陽電子放出核種標識放射性トレーサを用いて、医薬品の体内動態を解析する手法を確立することを目的として、認知症治療薬である医薬品(<11>^C-donepezil)の標識合成技術の開発およびマイクロドージング(100μg以下)における静脈投与時の動態解析を行う。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (14 results)

All 2008 2007

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (1 results)

  • [Journal Article] Chronic middle cerebral artery occlusion : a hemodynamic and metabolic study with positron-emission tomography2008

    • Author(s)
      Tanaka M, Shimosegawa E, Kajimoto K, Kimura Y, Kato H, Oku N, Hori M, Kitagawa K, Hatazawa J
    • Journal Title

      AJNR Am J Neuroradiol 29

      Pages: 1841-1846

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of brain and whole-body pharmacokinetics of <11>^C-labeled diphenylhydantoin in rats by means of planar positron imaging system2008

    • Author(s)
      Hasegawa Y, Kanai Y, Hasegawa S, Okamoto T, Matsui T, Shimosegawa E, Kurachi Y, Hatazawa J
    • Journal Title

      Ann Nucl Med 22

      Pages: 301-307

    • NAID

      10021281082

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral hemodynamics and oxygen metabolism in patients with moyamoya syndrome associated with atherosclerotic steno-occlusive arterial lesions2008

    • Author(s)
      Kato H, Shimosegawa E, Oku N, Kimura Y, Kajimoto K, Tanaka M, Hori M, Kitagawa K, Hatazawa J
    • Journal Title

      Cerebrovasc Dis 26

      Pages: 9-15

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] MRI-based correction for partial-volume effect improves detectability of intractable epileptogenic foci on 123I-iomazenil brain SPECT images2008

    • Author(s)
      Kato H, Shimosegawa E, Oku N, Kitagawa K, Kishima H, Saitoh Y, Kato A, Yoshimine T, Hatazawa J
    • Journal Title

      J Nucl Med 49

      Pages: 383-289

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of PK11195 on attenuating the enhancement of glucose utilization induced by quinolinic acid infusion in the rat brain2008

    • Author(s)
      Amitani M, Ohashi A, Hatazawa J, Gee A, Inoue O
    • Journal Title

      Synapse 62

      Pages: 253-258

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 18F-FDG-PET in patients with malignant lymphoma having long-term follow-up : staging and restaging, and evaluation of treatment response and recurrence.2008

    • Author(s)
      Isohashi K, et al.
    • Journal Title

      Ann Nucl Med 22

      Pages: 795-802

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] (18)F-FDG accumulation in the oral cavity is associated with periodontal disease and apical periodontitis : aninitial demonstration on PET/CT.2008

    • Author(s)
      Shimamoto H, et al.
    • Journal Title

      Ann Nucl Med 22

      Pages: 587-593

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic middle cerebral artery occlusion : a hemodynamic and metabolic study with positron-emission tomography.2008

    • Author(s)
      Tanaka M, et al.
    • Journal Title

      AJNR Am J Neuroradiol 29

      Pages: 1841-1846

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of brain and whole-body pharmacokinetics of 11C-labeled diphenylhydantoin in rats by means of planar positron imaging system.2008

    • Author(s)
      Hasegawa Y, et al.
    • Journal Title

      Ann Nucl Med 22

      Pages: 301-307

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral hemodynamics and oxygen metabolism in patients with moyamoya syndrome associated with atherosclerotic steno-occlusive arterial lesions.2008

    • Author(s)
      Kato H, et al.
    • Journal Title

      Cerebrovasc Dis 26

      Pages: 9-15

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MRI-based correction for partial-volume effect improves detect ability of intractable epileptogenic foci on 123I-iomazenil brain SPECT images.2008

    • Author(s)
      Ka to H, et al.
    • Journal Title

      J Nucl Med 49

      Pages: 383-389

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of PK11195 on attenuating the enhancement of glucose utilization induced by quinolinic acid infusion in the rat brain.2008

    • Author(s)
      Amitani M, et al.
    • Journal Title

      Synapse 62

      Pages: 253-258

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Brain and Whole-body Pharmacokinetics of^<11>C-labeled Diphenyl-hydantoin in Rats by Means of Planar Positron Imaging System2008

    • Author(s)
      Hasegawa Y, et. al.
    • Journal Title

      Annals of Nuclear Medicine (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラットにおけるプラナーポジトロンイメージング装置による11C-Phenytoinの薬物動態評価2007

    • Author(s)
      長谷川 雪憲、他
    • Organizer
      日本核医学会
    • Place of Presentation
      仙台市
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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