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Investigation on the methods that will overcome crossing-fiber problem of diffusion tensor tractography.

Research Project

Project/Area Number 19591429
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

YAMADA Kei  Kyoto Prefectural University of Medicine, 医学研究科, 講師 (80315960)

Co-Investigator(Kenkyū-buntansha) NISHIMURA Tsunehiko  京都府立医科大学, 大学院・医学研究科, 教授 (70237733)
酒井 晃二  京都大学, 高等教育研究開発推進センター, 助教 (20379027)
Co-Investigator(Renkei-kenkyūsha) SAKAI Koji  京都大学, 大学院・医学研究科, 助教 (20379027)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords交差線維 / 神経機能 / magnetic resonance imaging / 拡散強調画像 / 拡散異方性 / fiber tracking / tractography / fractional anisotropy
Research Abstract

The purpose of this investigation was to conduct a research on methods that will overcome the crossing-fiber problem on diffusion-tensor tractography. More specifically, we tested the feasibility of using high angular resolution diffusion imaging (HARDI)-based multi-tensor tractography to depict motor pathways. We tested this on patients with brain tumors. Ten patients were scanned using a 1.5T clinical MR unit. Data postprocessing was performed using both the conventional single- and multi-tensor methods. Motor fibers on both lesional and contralesional sides were successfully depicted by both the single-tensor and multi-tensor techniques. However, with the single-tensor model, the depiction of motor pathways was typically limited to the fibers of trunk areas. We also assessed the value of using high b-factor. This investigation indicated that the b factor between 1000 and 3000 will have less effect on the depiction of crossing fibers.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (24 results)

All 2010 2009 2008 2007

All Journal Article (15 results) (of which Peer Reviewed: 9 results) Presentation (7 results) Book (2 results)

  • [Journal Article] MR Imaging of Ventral Thalamic Nuclei.2010

    • Author(s)
      Yamada K, Akazawa K, Yuen S, Goto M, Matsushima S, Takahata A, Nakagawa M, Mineura K, Nishimura T
    • Journal Title

      AJNR Am J Neuroradiol 31

      Pages: 732-735

    • Related Report
      2009 Final Research Report
  • [Journal Article] Diffusion tensor tractography should be used with caution.2009

    • Author(s)
      Yamada K
    • Journal Title

      Proc Natl Acad Sci U S A 106

    • Related Report
      2009 Final Research Report
  • [Journal Article] Assessment of arcuate fasciculus with diffusion-tensor tractography may predict the prognosis of aphasia in patients with left middle cerebral artery infarcts.2009

    • Author(s)
      Hosomi A, Nagakane Y, Yamada K, Kuriyama N, Mizuno T, Nishimura T, Nakagawa M
    • Journal Title

      Neuroradiology 51

      Pages: 549-555

    • Related Report
      2009 Final Research Report
  • [Journal Article] Clinical MR tractography; past, present, and future.2009

    • Author(s)
      Yamada K, Akazawa K, Yuen S, Nishimura T
    • Journal Title

      Medical Mundi 53

      Pages: 9-15

    • Related Report
      2009 Final Research Report
  • [Journal Article] MR tractography: A review of its clinical applications.2009

    • Author(s)
      Yamada K, Sakai K, Akazawa K, Yuen S, Nishimura T
    • Journal Title

      Magn Reson Med Sci 8

      Pages: 165-174

    • NAID

      10026406682

    • Related Report
      2009 Final Research Report
  • [Journal Article] Diffusion tensor tractography should be used with caution.2009

    • Author(s)
      Nagakane Y, Yamada K, Ohara T, et al.
    • Journal Title

      Proc Natl Acad Sci USA. 106

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion tensor imaging may help the determination of time at onset in cerebral ischaemia.2009

    • Author(s)
      Sakai K, Yamada K, Nagakane Y, et al.
    • Journal Title

      J Neurol Neurosurg Psychiatry 80

      Pages: 986-990

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of arcuate fasciculus with diffusion-tensor tractography may predict the prognosis of aphasia in patients with left middle cerebral artery infarcts.2009

    • Author(s)
      Hosomi A, Nagakane Y, Yamada K, et al.
    • Journal Title

      Neuroradiology 51

      Pages: 549-555

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute lenticulostriate infarction presenting with skip lesions may reflect the selective vulnerability of gray and white matter.2008

    • Author(s)
      Nagakane Y, Yamada K, Ohara T, et al.
    • Journal Title

      Stroke 39

      Pages: 494-496

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incidental acute infarcts identified on diffusion-weighted images : A univ ersity hospital-based study.2008

    • Author(s)
      Yamada K, Nagakane Y. Sasaji ma H, et al.
    • Journal Title

      AJNR Am J Neuroradiol 29

      Pages: 937-940

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variability in absolute apparent diffusion coefficient values across different platforms may be substantial : A multivendor, multi-institutional CO mparison study.2008

    • Author(s)
      Sasaki M, Yamada K, Watanabe y, et al.
    • Journal Title

      Radiology 249

      Pages: 624-630

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multitensor tractography enables better depiction of motor pathways: Initial clinical experience using diffusion-weighted MR imaging with standard b-value.2007

    • Author(s)
      Yamada K, Sakai K, Hoogenraad F.G. C, Holthuizen R, Akazawa K, Ito H, Oouchi H, Matsushima S, Kubota T, Sasajima H, Mineura K, Nishimura T
    • Journal Title

      AJNR Am J Neuroradiol 28

      Pages: 1668-1673

    • Related Report
      2009 Final Research Report
  • [Journal Article] Somatotopic organization of thalamocortical projection fibers as assessed by MR tractography2007

    • Author(s)
      Yamada K
    • Journal Title

      Radiology 242

      Pages: 840-845

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MR tractography depicting damage to the arcuate fasciculus in a patient with conduction aphasia.2007

    • Author(s)
      Yamada K
    • Journal Title

      Neurology 69

      Pages: 321-322

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multitensor tractography enables better depiction of motor pathways: Initial clinical experience using diffusion-weighted MR imaging with standard b-value.2007

    • Author(s)
      Yamada K
    • Journal Title

      AJNR Am J Neuroradiol 28

      Pages: 1668-1673

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] MR imaging of ventral thalamic nuclei.2010

    • Author(s)
      Yamada K, Akazawa K, Yuen S, Goto M, Matsushima S, Takahata A, Nishimura T
    • Organizer
      18th annual meeting of International Society of Magnetic Resonance in Medicine
    • Place of Presentation
      Stockholm, USA
    • Year and Date
      2010-05-05
    • Related Report
      2009 Final Research Report
  • [Presentation] Morning categorical course Stroke : "A Brain Attack"2009

    • Author(s)
      Kei Yamada
    • Organizer
      International Society of Magnetic Resonance in Medicine
    • Place of Presentation
      Waikiki
    • Year and Date
      2009-04-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Morning categorical course Stroke: "A Brain Attack2008

    • Author(s)
      Kei Yamada
    • Organizer
      International Society of Magnetic Resonance in Medicine
    • Place of Presentation
      Toronto
    • Year and Date
      2008-05-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Crossing fiber problemを解決するのに高いb値は必要か?.2008

    • Author(s)
      赤澤健太郎、山田惠、後藤眞理子、松島成典、西村恒彦
    • Organizer
      第37回日本神経放射線学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 拡散テンソル画像における交叉線維に加えた新たな問題?Devil's advocate.2007

    • Author(s)
      山田惠、赤澤健太郎、伊藤博敏、結縁幸子、後藤眞理子、西村恒彦
    • Organizer
      第35回日本磁気共鳴医学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2007-09-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 拡散強調画像で観察する神経線維束: その現状と限界(シンポジウム)2007

    • Author(s)
      山田惠
    • Organizer
      第35回日本磁気共鳴医学学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2007-09-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Multi-tensor tractography enables better depiction of motor pathways 15th annual meeting of International Society of Magnetic Resonance in Medicine2007

    • Author(s)
      Yamada K, Sakai K, Hoogenraad FG, Holthuizen R, Akazawa K, Ito H, Oouchi H, Matsushima S, Kubota T, Nishimura T
    • Organizer
      Proc. Intl. Soc. Magn Reson Med 15 p1546
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2007-05-22
    • Related Report
      2009 Final Research Report
  • [Book] Diagnostic imaging ; In : Bernstein M ed. Neuro-Oncology : The Essentials 2nd edition ; 56-772008

    • Author(s)
      Yamada K, Sorensen AG.
    • Total Pages
      12
    • Publisher
      Thieme (New York)
    • Related Report
      2008 Annual Research Report
  • [Book] 急性期脳梗塞画像診断 実践ガイドライン2007.2007

    • Author(s)
      山田惠
    • Total Pages
      109
    • Publisher
      南江堂
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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